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1. 发明授权

US06315907B1 Method for removing toxic shock syndrome toxin-1 in body fluids by adsorption 有权
标题翻译：通过吸附去除体液中毒性休克综合征毒素-1的方法
公开(公告)号：US06315907B1
公开(公告)日：2001-11-13
申请号：US09403281
申请日：1999-10-19
申请人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
IPC分类号： B01D1500
CPC分类号： B01J20/3242 , A61M1/3679 , B01D15/00 , B01J20/22 , B01J20/28078 , B01J20/3092 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J2220/58
摘要： An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.
摘要翻译：用于毒性休克综合征毒素-1（TSST-1）的吸附剂，其包含log P值至少为2.50的化合物，其中P是辛醇 - 水体系中的分配系数并固定在水不溶性载体上; 一种通过吸附除去TSST-1体液的方法，其包括使含有TSST-1的体液与吸附剂接触; 用于TSST-1的吸附器，其包括填充在具有用于体液的入口和出口的容器中的吸附剂和用于防止吸附剂从容器流出的装置; 并使用吸附剂。体液中的TSST-1可以被吸附剂有效地去除。

2. 发明授权

US6132610A Endotoxin adsorption system 失效
标题翻译：内毒素吸附系统
公开(公告)号：US6132610A
公开(公告)日：2000-10-17
申请号：US905710
申请日：1997-08-05
申请人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
IPC分类号： A61M1/36 , B01J39/04 , B01J47/00 , B01J47/02 , B01J47/04
CPC分类号： B01J39/04 , B01J47/003
摘要： An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.
摘要翻译：本发明的内毒素吸附系统包括具有钠作为抗衡离子的阳离子交换树脂和具有钠和一种或多种除了钠之外的金属离子作为抗衡离子的阳离子交换树脂的组合，并且不降低内毒素吸附内毒素阳离子的浓度。

3. 发明授权

US06387362B1 Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
标题翻译：用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂
公开(公告)号：US06387362B1
公开(公告)日：2002-05-14
申请号：US09043537
申请日：1998-08-14
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
IPC分类号： A61K31795
CPC分类号： B01J20/26 , A61M1/3679
摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.
摘要翻译：提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

4. 发明授权

US06127528A Process for adsorbing and removing tumor necrosis factor-.alpha. 有权
标题翻译：吸附和去除肿瘤坏死因子-α的方法
公开(公告)号：US06127528A
公开(公告)日：2000-10-03
申请号：US283964
申请日：1999-04-02
申请人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
IPC分类号： C07K14/525 , C07K1/22 , A61K38/19 , C07K1/14 , C07K14/00
CPC分类号： C07K14/525 , Y10S930/144
摘要： The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.
摘要翻译：本发明涉及能够有效地去除体液中的肿瘤坏死因子-α（TNF-α）的吸附剂，使用吸附剂的吸附剂和吸附和去除TNF-α的方法，即TNF-α的吸附剂其特征在于，在水不溶性载体上具有由式（I）表示的官能团的化合物：其中，X为阴离子官能团，A为阴离子官能团以外的取代基，n为0〜 4，在n至少为2的情况下，其数目为n的基团A可以相同或不同; 一种吸附和去除TNF-α的方法，其包括使吸附剂与体液接触; 和用于吸附TNF-α的吸附器，其中具有用于体液的入口和出口的容器并且装备有用于防止吸附剂流向容器外部的装置的吸附器装入吸附剂。

5. 发明授权

US5902877A Adsorbent of interleukins, process for removing the same, and adsorber for the same 失效
标题翻译：白细胞介素的吸附剂，其除去方法和吸附剂
公开(公告)号：US5902877A
公开(公告)日：1999-05-11
申请号：US646266
申请日：1996-05-20
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
IPC分类号： B01J20/26 , B01J20/32 , C07K14/54 , A23J1/00
CPC分类号： B01J20/3212 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3251 , C07K14/54
摘要： The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.
摘要翻译： PCT No.PCT / JP95 / 01859 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1995年9月18日PCT公布。出版物WO96 / 09115 日期：1996年3月28日本发明涉及能够有效吸附和去除体液中的白细胞介素的吸附剂，如果需要，涉及吸附和除去体液中的白细胞介素的方法。根据本发明，提供一种白细胞介素的吸附剂，其包含具有阴离子官能团的水不溶性载体，使用其的吸附，除去和回收白细胞介素的方法和使用该吸附剂的吸附剂。

6. 发明授权

US6133431A Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
标题翻译：免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置
公开(公告)号：US6133431A
公开(公告)日：2000-10-17
申请号：US117233
申请日：1998-10-20
申请人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
发明人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
IPC分类号： A61K35/14 , A61M1/36 , B01J20/32 , C07K17/00 , C07K17/02 , A61K39/00
CPC分类号： C07K17/02 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3282 , C07K17/00 , A61M1/3679 , A61M2202/0417
摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.
摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。第WO97 / 26930号公报日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

7. 发明授权

US06600014B2 Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method 失效
标题翻译：用于消除丙型肝炎病毒的吸附剂，吸附剂和吸附方法
公开(公告)号：US06600014B2
公开(公告)日：2003-07-29
申请号：US09380644
申请日：1999-11-09
申请人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
发明人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
IPC分类号： C07K1700
CPC分类号： A61M1/3633 , A61M1/3679 , A61M2205/7509 , B01J20/262 , B01J20/265 , B01J20/28078 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J2220/58 , Y10S530/81
摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.
摘要翻译：一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述吸附剂和用于除去HCV的吸附方法。一种用于除去丙型肝炎病毒的吸附剂，其包含固定在水不溶性载体上的能够吸附丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和吸附方法去除HCV。

8. 发明授权

US07056507B2 Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method 失效
标题翻译：用于消除丙型肝炎病毒的吸附剂，吸附剂和吸附方法
公开(公告)号：US07056507B2
公开(公告)日：2006-06-06
申请号：US10458297
申请日：2003-06-11
申请人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
发明人： Eiji Ogino , Michio Nomura , Takashi Asahi , Shuichi Kaneko , Akito Sakai
IPC分类号： A61K39/42 , C07K1/22 , B01D15/08
CPC分类号： A61M1/3633 , A61M1/3679 , A61M2205/7509 , B01J20/262 , B01J20/265 , B01J20/28078 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3255 , B01J20/3274 , B01J2220/58 , Y10S530/81
摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided.An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.
摘要翻译：一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述吸附剂和用于除去HCV的吸附方法。一种用于除去丙型肝炎病毒的吸附剂，其包含能够吸附固定在水不溶性载体上的丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和用于除去HCV的吸附方法。

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