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    • 1. 发明授权
    • Atrichia mouse
    • Atrichia小鼠
    • US06316691B1
    • 2001-11-13
    • US09230735
    • 1999-02-03
    • Taizo KondoToshio KondoYasuhisa Shiomoto
    • Taizo KondoToshio KondoYasuhisa Shiomoto
    • A01K6700
    • A01K67/027
    • The invention relates to an atrichia mouse which grows juvenile hair but is deficient in the ability to grow pelage hair and, more particularly, to an atrichia mouse such that the spontaneous prevalence of wet and dry skin lesions is not less than 70%. at the 24th week of age, the number of mast cells in the skin is not less than about 50/linear mm at the 24th week of age, and the serum IgE level is not less than about 3500 ng/ml at the 24th week of age. The atrichia mouse of the invention finds application as an animal model of disease for the research and development of therapeutic drugs for dermatitis, among other kinds of drugs.
    • 本发明涉及一种生长未成年毛发但缺乏生长皮毛的能力的无毛小鼠,更具体地说,涉及一种无毛小鼠,使得湿和干性皮肤病变的自发发生率不低于70%。 在第24周龄时,第24周时皮肤肥大细胞数不小于约50 /线性mm,第24周时血清IgE水平不低于约3500ng / ml 年龄。 本发明的无毛小鼠作为动物模型,用于研究和开发用于皮炎的治疗药物等药物。
    • 3. 发明授权
    • Rotating drum for reclaiming molding sand and molding sand reclaiming apparatus
    • 用于回收型砂和型砂回收设备的转鼓
    • US06401798B1
    • 2002-06-11
    • US09456654
    • 1999-12-08
    • Toshio Kondo
    • Toshio Kondo
    • B02C1912
    • B22C5/10Y10S241/10
    • A molding sand reclaiming apparatus comprising an agitation tank which is provided with a fluidized bed at the inner bottom thereof and also provided with a charging port for used sand and a discharging port for reclaimed sand on the side wall thereof, a rotating shaft driven by a driving source disposed in the agitation tank; a rotating drum which is driven by the rotating shaft to agitate used sand charged into the agitation tank and peel off extraneous matters on the used sand; a classification tank which communicates with the upper part of the agitation tank via a regulating plate and is provided with a dust collecting port; and an air pressure source to fluidize the used sand charged on the fluidized bed in the agitation tank and classify, in the classification tank, the used sand into two parts of the extraneous matters peeled off by the rotating drum and the reclaimed sand, wherein scattering holes for scattering the used sand are formed in a cylinder portion constituting outside of the rotating drum.
    • 一种成型砂回收装置,包括:搅拌槽,其内底设有流化床,并且在其侧壁上设置有用于砂的加料口和再生砂的排出口,旋转轴由 驱动源设置在搅拌槽中; 由旋转轴驱动的旋转滚筒,搅拌填充到搅拌槽中的用过的砂子,并剥离用过的砂子上的外来物质; 分级罐,其经由调节板与搅拌槽的上部连通并设置有集尘口; 以及空气压力源,用于使填充在搅拌槽中的流化床上的废砂流化,并且在分级罐中将二手砂分为两部分由旋转鼓和再生砂剥离的外来物质,其中散射 用于散布用过的砂的孔形成在构成旋转滚筒外部的圆筒部中。
    • 6. 发明授权
    • Air-fuel ratio control apparatus for use in engine
    • 用于发动机的空燃比比控制装置
    • US5243952A
    • 1993-09-14
    • US804662
    • 1991-12-10
    • Kenji IkutaSyohei UdoToshio Kondo
    • Kenji IkutaSyohei UdoToshio Kondo
    • F02D41/12F02D41/14
    • F02D41/1401F02D41/1475F02D41/1477F02D41/1486F02D2041/1409F02D2041/1415F02D2041/1418F02D2041/1422F02D2041/1433F02D41/1402F02D41/1456
    • An air-fuel ratio control apparatus for an internal combustion engine which is equipped with an air-fuel ratio sensor for sensing an actual air-fuel ratio of a mixture to be introduced into the engine and a target air-fuel ratio setting section for setting a target air-fuel ratio of the engine. Also included is a controlled-amount calculating section for setting an optimal feedback gain on the basis of a predetermined dynamic model of the engine to calculate a controlled amount in accordance with the predetermined optimal feedback gain so that the actual air-fuel ratio becomes equal to the target air-fuel ratio. A fuel supply amount to the engine is determined on the basis of the calculated controlled amount, and the control responsiveness of the controlled-amount calculating section is suppressed when the engine is in a speed-decreasing state. This arrangement can adequately control the air-fuel ratio of the engine irrespective of the engine speed-decreasing state.
    • 一种用于内燃机的空燃比控制装置,其配备有用于感测引入发动机的混合物的实际空燃比的空燃比传感器和用于设定的目标空燃比设定部 发动机的目标空燃比。 还包括一个受控量计算部分,用于根据预定的发动机动力学模型来设定最佳反馈增益,以根据预定的最佳反馈增益计算受控量,使得实际空燃比变为等于 目标空燃比。 基于计算出的控制量来确定发动机的燃料供给量,并且在发动机处于减速状态时抑制受控量计算部的控制响应性。 这种布置可以适当地控制发动机的空燃比,而与发动机减速状态无关。
    • 7. 发明授权
    • Process for preparing printed-circuit board
    • 制备印刷电路板的工艺
    • US5236810A
    • 1993-08-17
    • US592245
    • 1990-10-03
    • Toshio KondoShinsuke OnishiNaozumi IwasawaSadaaki Hashimoto
    • Toshio KondoShinsuke OnishiNaozumi IwasawaSadaaki Hashimoto
    • G03F7/26H05K3/06
    • G03F7/265H05K3/064H05K2203/0793H05K2203/135
    • An improved process for preparing a printed-circuit board, which successively comprises (I) a step of forming a positive photo-sensitive resist film onto a circuit board having a conductive film according to the electrodeposition coating process, (II) a step of irradiating a full dose of an actinic ray onto the positive photo-sensitive resist film through a photomask with which the actinic ray is cut off over a conductive circuit-forming area, (III) a step of developing the resulting resist film, (IV) a step of etching away a deposited copper-clad area, and (V) removing a remaining resist film on the conductive circuit-forming area, the improvement further comprising a step of imparting the resist film in the conductive circuit-forming area an increased alkali resistance prior to development so as to obtain the printed-circuit board having high resolution with good reproductivity without being affected by variations of the developing conditions.
    • 一种制备印刷电路板的改进方法,其依次包括(I)根据电沉积涂布工艺在具有导电膜的电路板上形成正光敏抗蚀剂膜的步骤,(II)照射步骤 通过在导电电路形成区域上切割光化射线的光掩模,将正光敏抗蚀剂膜上的全剂量的光化射线,(III)显影所得抗蚀剂膜的步骤,(IV) 蚀刻掉沉积的铜包层区域的步骤,以及(V)去除导电电路形成区域上的剩余抗蚀剂膜,该改进还包括将导电电路形成区域中的抗蚀剂膜赋予增加的耐碱性的步骤 在开发之前,以获得具有高分辨率的印刷电路板,具有良好的再现性,而不受显影条件的变化的影响。
    • 9. 发明授权
    • Process for recimization of an optically active alpha-amino acid amides
and process for producing optically active alpha-amino acids
    • 用于重新获得光学活性α-氨基酸酰胺的方法和用于制备光学活性α-氨基酸的方法
    • US4918196A
    • 1990-04-17
    • US831915
    • 1986-02-21
    • Masaharu DoyaToshio KondoHideo IgarashiTakako Uchiyama
    • Masaharu DoyaToshio KondoHideo IgarashiTakako Uchiyama
    • C07D233/72C12P13/04C12P41/00
    • C12P41/006C12P13/04
    • A process for optically isomerizing an optically active alpha-amino acid amide comprising heating a D-alpha-amino acid amide or an L-alpha-amino acid amide in the presence of a strongly basic compound; and a process for producing an L-alpha-amino acid, which comprises(1) subjecting a D,L-alpha-amino acid amide or a mixture of a major amount of a D-alpha-amino acid amide and a minor amount of an L-alpha-amino acid amide to the action of a microorganism having the ability to hydrolyze the L-alpha-amino acid to obtain a hydrolyzate containing the L-alpha-amino acid and D-alpha-amino acid,(2) separating the L-alpha-amino acid from the hydrolyzate and recovering the remaining D-alpha-amino acid amide.(3) heating all or part of the recovered D-alpha-amino acid amide in the presence of a strongly basic substance to obtain a D,L-alpha-amino acid amide or a mixture of a major amount of the D-alpha-amino acid amide and a minor amount of the L-alpha-amino acid amide, and(4) recycling the D,L-alpha-amino acid amide or the mixture to step (1) as part or all of the starting material.
    • 包括光学异构化光学活性α-氨基酸酰胺的方法,包括在强碱性化合物存在下加热D-α-氨基酸酰胺或L-α-氨基酸酰胺; 以及制备L-α-氨基酸的方法,其包括(1)使D,L-α-氨基酸酰胺或主要量的D-α-氨基酸酰胺和少量的 L-α-氨基酸酰胺,具有水解L-α-氨基酸的能力的微生物的作用,得到含有L-α-氨基酸和D-α-氨基酸的水解产物,(2)分离 来自水解产物的L-α-氨基酸并回收剩余的D-α-氨基酸酰胺。 (3)在强碱性物质存在下加热全部或部分回收的D-α-氨基酸酰胺,得到D,L-α-氨基酸酰胺或大量D-α-氨基酸酰胺的混合物, 氨基酸酰胺和少量的L-α-氨基酸酰胺,和(4)将D,L-α-氨基酸酰胺或混合物循环到步骤(1)中作为起始原料的一部分或全部。
    • 10. 发明授权
    • Apparatus for measuring a flow rate of intake air for an engine
    • 用于测量发动机的进气量的流量的装置
    • US4649745A
    • 1987-03-17
    • US671615
    • 1984-11-15
    • Toshio KondoAkio KobayashiShunichiro HiromasaAkira MasudaMasahiko Miyaki
    • Toshio KondoAkio KobayashiShunichiro HiromasaAkira MasudaMasahiko Miyaki
    • G01F1/698G01F1/68
    • G01F1/6986
    • An apparatus for measuring a flow of intake air to an engine includes a bridge circuit including a heat resistor placed in an intake air path of the engine, a resistor for sensing the temperature of the intake air, and a plurality of balance resistors. A heating current is supplied to this bridge circuit through a transistor controlled by a periodical current-passage control signal generated by a microcomputer. A signal Vh, representing a temperature change of the heat resistor heated by the heating current, is detected by the microcomputer. A first correction value is computed by using a difference between the detected value from the microcomputer and a signal Vho, representing temperature of the heat resistor when the bridge circuit is balanced at normal temperature. A time width correction value .DELTA.Do1 is computed from a table on the basis of the first correction value. The correction signal .DELTA.Do1 is used for correcting the current passage time. The current passage time width as corrected is used for computing a flow of the intake air.
    • 用于测量到发动机的进气的流量的装置包括桥接电路,其包括放置在发动机的进气通道中的热电阻器,用于感测进气的温度的电阻器和多个平衡电阻器。 通过由微型计算机产生的周期性电流通过控制信号控制的晶体管,向该桥式电路供给加热电流。 由微型计算机检测表示由加热电流加热的热电阻的温度变化的信号Vh。 通过使用来自微型计算机的检测值和信号Vho之间的差来计算第一校正值,该信号Vho表示在常规温度下桥接电路平衡时的热电阻器的温度。 基于第一校正值从表中计算时间宽度校正值DELTA Do1。 校正信号DELTA Do1用于校正当前通过时间。 校正的当前通过时间宽度用于计算进气的流量。