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1. 发明授权

US5426181A DNA encoding cytokine-induced protein, TSG-14 失效
标题翻译：编码细胞因子诱导蛋白的DNA，TSG-14
公开(公告)号：US5426181A
公开(公告)日：1995-06-20
申请号：US929580
申请日：1992-08-14
申请人： Tae H. Lee , Gene W. Lee , Jan Vilcek
发明人： Tae H. Lee , Gene W. Lee , Jan Vilcek
IPC分类号： A61K39/395 , A61K38/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/78 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , C07H17/00 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C07K14/4718 , C07K14/78 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a polypeptide molecule, termed TSG-14, in connective tissue cells. The TSG-14 polypeptide and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the polypeptide and the DNA are provided. Antibodies specific for the TSG-14 polypeptide are disclosed, as is a method for detecting the presence of TSG-14 polypeptide in a biological sample, using the antibody or another molecule capable of binding to TSG-14 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-14 polypeptide, a method for measuring induction of expression of TSG-14 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-14 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子（如TNF和IL-1）在结缔组织细胞中诱导称为TSG-14的多肽分子的表达。提供了TSG-14多肽及其功能性衍生物，其编码的DNA，表达载体，如质粒，以及用DNA分子转化或转染的宿主细胞，以及产生多肽和DNA的方法。公开了对TSG-14多肽特异性的抗体，以及使用抗体或能够结合TSG-14如透明质酸的另一分子来检测生物样品中TSG-14多肽的存在的方法。用于检测编码正常或突变体TSG-14多肽的核酸的存在的方法，使用核酸杂交或免疫测定来测量细胞中TSG-14表达诱导的方法，鉴定能诱导的化合物的方法还提供了TSG-14在细胞中的表达，以及测定细胞对TNF反应能力的方法。

2. 发明授权

US5386013A Tumor necrosis factor-induced protein TSG-6 失效
标题翻译：肿瘤坏死因子诱导蛋白TSG-6
公开(公告)号：US5386013A
公开(公告)日：1995-01-31
申请号：US24868
申请日：1993-03-01
申请人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C12N1/21 , C07K14/47 , C07K16/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/577 , C07K13/00 , C12P21/06
CPC分类号： C07K14/4718
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. The TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided. Antibodies specific for the TSG-6 protein are disclosed, as is a method for detecting the presence of TSG-6 protein in a biological sample, using the antibody or another molecule capable of binding to TSG-6 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein, a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-6 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。提供TSG-6蛋白质及其功能性衍生物，编码它们的DNA，表达载体，例如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法。公开了对TSG-6蛋白质特异性的抗体，以及使用抗体或能够与TSG-6如透明质酸结合的另一分子来检测生物样品中TSG-6蛋白质的存在的方法。用于检测编码正常或突变体TSG-6蛋白的核酸的存在的方法，使用核酸杂交或免疫测定法测定细胞中TSG-6表达的诱导方法，鉴定能诱导的化合物的方法还提供了TSG-6在细胞中的表达，以及测定细胞对TNF反应能力的方法。

3. 发明授权

US07179893B2 Recombinant anti-TNF-α antibodies 失效
标题翻译：重组抗TNF-α抗体
公开(公告)号：US07179893B2
公开(公告)日：2007-02-20
申请号：US11400787
申请日：2006-04-07
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： C07K16/28 , C12N5/12
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

4. 发明授权

US07179466B2 Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies 失效
标题翻译：通过多次施用抗TNF抗体治疗类风湿性关节炎的方法
公开(公告)号：US07179466B2
公开(公告)日：2007-02-20
申请号：US10187121
申请日：2002-06-28
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

5. 发明授权

US07169388B2 Methods of inhibiting TNFα in patients with cancer 失效
标题翻译：抑制癌症患者TNFalpha的方法
公开(公告)号：US07169388B2
公开(公告)日：2007-01-30
申请号：US10957134
申请日：2004-09-30
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

6. 发明授权

US07166284B2 Methods of treating joint inflammation with anti-TNF antibodies 失效
标题翻译：用抗TNF抗体治疗关节炎症的方法
公开(公告)号：US07166284B2
公开(公告)日：2007-01-23
申请号：US10371443
申请日：2003-02-21
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

7. 发明申请

US20070009524A1 METHODS OF TREATING INFLAMMATION ASSOCIATED WITH VIRAL INFECTION WITH ANTI-TNF ANTIBODIES 失效
标题翻译：用抗TNF抗体治疗与病毒感染相关的炎症的方法
公开(公告)号：US20070009524A1
公开(公告)日：2007-01-11
申请号：US10043436
申请日：2002-01-10
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

8. 发明授权

US06991791B2 Anti-TNF antibodies and peptides of human tumor necrosis factor 失效
公开(公告)号：US06991791B2
公开(公告)日：2006-01-31
申请号：US09766535
申请日：2001-01-18
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

9. 发明申请

US20050260201A1 Methods of treating rheumatoid arthritis using anti-TNF receptor fusion proteins 审中-公开
标题翻译：使用抗TNF受体融合蛋白治疗类风湿关节炎的方法
公开(公告)号：US20050260201A1
公开(公告)日：2005-11-24
申请号：US11053749
申请日：2005-02-07
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , Bernard Scallon
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , Bernard Scallon
IPC分类号： A61K38/17 , A61K39/395 , C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

10. 发明授权

US5919452A Methods of treating TNF.alpha.-mediated disease using chimeric anti-TNF antibodies 失效
标题翻译：使用嵌合抗TNF抗体治疗TNFα介导的疾病的方法
公开(公告)号：US5919452A
公开(公告)日：1999-07-06
申请号：US192861
申请日：1994-02-04
申请人： Junming Le , Jan Vilcek , Peter Dadonna , John Ghrayeb , David Knight , Scott Seigal
发明人： Junming Le , Jan Vilcek , Peter Dadonna , John Ghrayeb , David Knight , Scott Seigal
IPC分类号： A61K38/00 , C07K14/525 , C07K16/24 , A61K39/395
CPC分类号： C07K14/525 , C07K16/241 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2319/00
摘要： Treatment of tumor necrosis factor, TNF, mediated pathologies is provided by administering anti-TNF compounds, such as anti-TNF antibodies and anti-TNF peptides, which compounds are specific for tumor necrosis factor-.alpha. (TNF.alpha.) or tumor necrosis factor-.beta. (TNF.beta.) and which are useful for in vivo therapy or diagnosis of TNF.alpha.-mediated pathologies and conditions, wherein the anti-TNF compound is selected from the group consisting of at least one of an immunoglobulin variable region, a fragment of a TNF receptor and an anti-TNF peptide, such as a structural analog of a anti-TNF antibody fragment or a TNF receptor fragment.
摘要翻译：肿瘤坏死因子，肿瘤坏死因子介导的病理学的治疗是通过施用抗TNF化合物，例如抗TNF抗体和抗TNF肽来提供的，该化合物对肿瘤坏死因子-α（TNFα）或肿瘤坏死因子-α β（TNFβ），其可用于TNFα介导的病理学和病症的体内治疗或诊断，其中所述抗TNF化合物选自免疫球蛋白可变区， TNF受体和抗TNF肽，例如抗TNF抗体片段或TNF受体片段的结构类似物。

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