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1. 发明授权

US5386013A Tumor necrosis factor-induced protein TSG-6 失效
标题翻译：肿瘤坏死因子诱导蛋白TSG-6
公开(公告)号：US5386013A
公开(公告)日：1995-01-31
申请号：US24868
申请日：1993-03-01
申请人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C12N1/21 , C07K14/47 , C07K16/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/577 , C07K13/00 , C12P21/06
CPC分类号： C07K14/4718
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. The TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided. Antibodies specific for the TSG-6 protein are disclosed, as is a method for detecting the presence of TSG-6 protein in a biological sample, using the antibody or another molecule capable of binding to TSG-6 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein, a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-6 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。提供TSG-6蛋白质及其功能性衍生物，编码它们的DNA，表达载体，例如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法。公开了对TSG-6蛋白质特异性的抗体，以及使用抗体或能够与TSG-6如透明质酸结合的另一分子来检测生物样品中TSG-6蛋白质的存在的方法。用于检测编码正常或突变体TSG-6蛋白的核酸的存在的方法，使用核酸杂交或免疫测定法测定细胞中TSG-6表达的诱导方法，鉴定能诱导的化合物的方法还提供了TSG-6在细胞中的表达，以及测定细胞对TNF反应能力的方法。

2. 发明授权

US06518401B2 Tumor necrosis factor stimulated gene 6 (TSG-6) protein 失效
标题翻译：肿瘤坏死因子刺激基因6（TSG-6）蛋白
公开(公告)号：US06518401B2
公开(公告)日：2003-02-11
申请号：US09799118
申请日：2001-03-06
申请人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C07K14435
CPC分类号： C07K14/4718
摘要： TSG protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.
摘要翻译：提供TSG蛋白及其功能性衍生物，编码DNA，表达载体如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及TSG- 6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

3. 发明授权

US5846763A DNA encoding tumor necrosis factor stimulated gene 6 (TSG-6) 失效
标题翻译： DNA编码肿瘤坏死因子刺激基因6（TSG-6）
公开(公告)号：US5846763A
公开(公告)日：1998-12-08
申请号：US242097
申请日：1994-05-13
申请人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C07K14/47 , C12N1/21 , C12N5/10 , C12N15/12
CPC分类号： C07K14/4718
摘要： TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.
摘要翻译： TSG-6蛋白及其功能衍生物，编码DNA，表达载体如质粒和用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及针对 TSG-6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 用于检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

4. 发明授权

US06313091B1 Pharmaceutical compositions containing TSG-6 for treating inflammatory diseases and cancer-related pathologies and method 失效
标题翻译：含有TSG-6用于治疗炎性疾病和癌症相关病理学的药物组合物及方法
公开(公告)号：US06313091B1
公开(公告)日：2001-11-06
申请号：US09000179
申请日：1998-05-20
申请人： Hans-Georg Wisniewski , Jan Vilcek , Bruce Cronstein
发明人： Hans-Georg Wisniewski , Jan Vilcek , Bruce Cronstein
IPC分类号： A61K3800
CPC分类号： C07K14/8114 , A61K38/00 , C07K14/4718
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. TSG-6, or pharmaceutical compositions containing TSG-6, can be used to treat inflammatory diseases and disorders and cancer-related pathologies. Inflammatory diseases and disorders, or cancer related pathologies, can also be treated by introducing human cells transfected with a DNA molecule containing a DNA segment encoding TSG-6 protein, into humans to express therapeutically effective amounts of TSG-6 in vivo or by introducing a vector carrying a DNA segment encoding TSG-6 protein directly into humans in vivo.
摘要翻译：多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。 TSG-6或含有TSG-6的药物组合物可用于治疗炎性疾病和病症以及与癌症有关的病理学。炎症性疾病和病症或癌症相关的病理学也可以通过将人DNA转导到含有编码TSG-6蛋白的DNA片段的DNA分子转染到人体内来表达治疗有效量的TSG-6或通过引入将编码TSG-6蛋白质的DNA片段直接携带入人体内的载体。

5. 发明授权

US06210905B1 Tumor necrosis factor stimulated gene 6 (TSG-6) binding molecules 失效
标题翻译：肿瘤坏死因子刺激基因6（TSG-6）结合分子
公开(公告)号：US06210905B1
公开(公告)日：2001-04-03
申请号：US09206695
申请日：1998-12-07
申请人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： G01N3353
CPC分类号： C07K14/4718
摘要： TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.
摘要翻译： TSG-6蛋白及其功能衍生物，编码DNA，表达载体如质粒和用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及针对 TSG-6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 用于检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

6. 发明授权

US5426181A DNA encoding cytokine-induced protein, TSG-14 失效
标题翻译：编码细胞因子诱导蛋白的DNA，TSG-14
公开(公告)号：US5426181A
公开(公告)日：1995-06-20
申请号：US929580
申请日：1992-08-14
申请人： Tae H. Lee , Gene W. Lee , Jan Vilcek
发明人： Tae H. Lee , Gene W. Lee , Jan Vilcek
IPC分类号： A61K39/395 , A61K38/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/78 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , C07H17/00 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C07K14/4718 , C07K14/78 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a polypeptide molecule, termed TSG-14, in connective tissue cells. The TSG-14 polypeptide and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the polypeptide and the DNA are provided. Antibodies specific for the TSG-14 polypeptide are disclosed, as is a method for detecting the presence of TSG-14 polypeptide in a biological sample, using the antibody or another molecule capable of binding to TSG-14 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-14 polypeptide, a method for measuring induction of expression of TSG-14 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-14 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子（如TNF和IL-1）在结缔组织细胞中诱导称为TSG-14的多肽分子的表达。提供了TSG-14多肽及其功能性衍生物，其编码的DNA，表达载体，如质粒，以及用DNA分子转化或转染的宿主细胞，以及产生多肽和DNA的方法。公开了对TSG-14多肽特异性的抗体，以及使用抗体或能够结合TSG-14如透明质酸的另一分子来检测生物样品中TSG-14多肽的存在的方法。用于检测编码正常或突变体TSG-14多肽的核酸的存在的方法，使用核酸杂交或免疫测定来测量细胞中TSG-14表达诱导的方法，鉴定能诱导的化合物的方法还提供了TSG-14在细胞中的表达，以及测定细胞对TNF反应能力的方法。

7. 发明授权

US07179893B2 Recombinant anti-TNF-α antibodies 失效
标题翻译：重组抗TNF-α抗体
公开(公告)号：US07179893B2
公开(公告)日：2007-02-20
申请号：US11400787
申请日：2006-04-07
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： C07K16/28 , C12N5/12
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

8. 发明授权

US07179466B2 Methods of treating rheumatoid arthritis by multiple administration of anti-TNF antibodies 失效
标题翻译：通过多次施用抗TNF抗体治疗类风湿性关节炎的方法
公开(公告)号：US07179466B2
公开(公告)日：2007-02-20
申请号：US10187121
申请日：2002-06-28
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghraveb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

9. 发明授权

US07169388B2 Methods of inhibiting TNFα in patients with cancer 失效
标题翻译：抑制癌症患者TNFalpha的方法
公开(公告)号：US07169388B2
公开(公告)日：2007-01-30
申请号：US10957134
申请日：2004-09-30
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/241 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/573 , A61K38/00 , A61K39/3955 , A61K2039/505 , C07K14/525 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

10. 发明授权

US07166284B2 Methods of treating joint inflammation with anti-TNF antibodies 失效
标题翻译：用抗TNF抗体治疗关节炎症的方法
公开(公告)号：US07166284B2
公开(公告)日：2007-01-23
申请号：US10371443
申请日：2003-02-21
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

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