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1. 发明申请

US20080033149A1 Human anti-TNF antibodies and peptides 失效
标题翻译：人抗TNF抗体和肽
公开(公告)号：US20080033149A1
公开(公告)日：2008-02-07
申请号：US11891036
申请日：2007-08-08
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： C07K16/46
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

2. 发明申请

US20070298040A1 Methods of treating seronegative arthropathy with anti-TNF antibodies 审中-公开
标题翻译：用抗TNF抗体治疗血清阴性关节病的方法
公开(公告)号：US20070298040A1
公开(公告)日：2007-12-27
申请号：US11401391
申请日：2006-04-10
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/76 , Y02A50/412
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFαx-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

3. 发明授权

US07276239B2 Recombinant A2-specific TNFα-specific antibodies 失效
标题翻译：重组A2特异性TNFα特异性抗体
公开(公告)号：US07276239B2
公开(公告)日：2007-10-02
申请号：US11314941
申请日：2005-12-20
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

4. 发明申请

US20070196373A1 Anti-TNF antibodies and peptides of human tumor necrosis factor 审中-公开
标题翻译：抗TNF抗体和人肿瘤坏死因子的肽
公开(公告)号：US20070196373A1
公开(公告)日：2007-08-23
申请号：US11501162
申请日：2006-08-08
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , David Shealy
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel , David Shealy
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , Y02A50/412
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症（包括强直性脊柱炎）的体内诊断和治疗，以及编码提供了鼠和嵌合抗体，免疫测定和免疫治疗方法中产生抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法。

5. 发明授权

US07223396B2 Methods of treatment of fistulas in Crohn's disease with anti-TNF antibodies 有权
标题翻译：用抗TNF抗体治疗克罗恩病瘘的方法
公开(公告)号：US07223396B2
公开(公告)日：2007-05-29
申请号：US10319011
申请日：2002-12-12
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

6. 发明授权

US07135178B2 Methods of treating disseminated intravascular coagulation using anti-TNF antibodies 失效
标题翻译：使用抗TNF抗体治疗弥漫性血管内凝血的方法
公开(公告)号：US07135178B2
公开(公告)日：2006-11-14
申请号：US10176460
申请日：2002-06-20
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/485 , A61K31/519 , A61K31/573 , A61K38/00 , A61K45/00 , A61K45/06 , A61K2039/505 , C07K14/525 , C07K16/241 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00 , A61K2300/00
摘要： Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful for therapy of TNFα-mediated pathologies and conditions, including vascular inflammatory pathologies.
摘要翻译：抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，可用于治疗TNFα介导的病理和病症，包括血管炎症病理。

7. 发明申请

US20060140946A1 Anti-TNF chimeric antibody fragments 失效
标题翻译：抗TNF嵌合抗体片段
公开(公告)号：US20060140946A1
公开(公告)日：2006-06-29
申请号：US11143926
申请日：2005-06-02
申请人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
发明人： Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K14/525 , A61K38/00 , A61K2039/505 , C07K16/241 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, peptides, methods of making and using the antibody or peptides in immunoassays and immuno-therapeutic approaches are provided, where the anti-TNF peptide is selected from a soluble portion of TNF receptor, an anti-TNF antibody or structural analog thereof.
摘要翻译：特异于肿瘤坏死因子（TNF）的抗TNF抗体和抗TNF肽可用于许多TNF介导的病理学和病症的体内诊断和治疗，以及编码抗TNF鼠和嵌合抗体的多核苷酸提供肽，免疫测定法和免疫治疗方法中制备和使用抗体或肽的方法，其中抗TNF肽选自TNF受体的可溶性部分，抗TNF抗体或其结构类似物。

8. 发明授权

US06518401B2 Tumor necrosis factor stimulated gene 6 (TSG-6) protein 失效
标题翻译：肿瘤坏死因子刺激基因6（TSG-6）蛋白
公开(公告)号：US06518401B2
公开(公告)日：2003-02-11
申请号：US09799118
申请日：2001-03-06
申请人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae Ho Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C07K14435
CPC分类号： C07K14/4718
摘要： TSG protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided, as well as antibodies specific for the TSG-6 protein; a method for detecting the presence of TSG-6 protein in a biological sample; a method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein; a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay; a method for identifying a compound capable of inducing the expression of TSG-6 in a cell; and a method for measuring the ability of a cell to respond to TNF.
摘要翻译：提供TSG蛋白及其功能性衍生物，编码DNA，表达载体如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法，以及TSG- 6蛋白; 用于检测生物样品中TSG-6蛋白的存在的方法; 检测编码正常或突变型TSG-6蛋白的核酸的存在的方法; 使用核酸杂交或免疫测定来测量细胞中TSG-6的表达诱导的方法; 用于鉴定能够诱导细胞中TSG-6表达的化合物的方法; 以及测定细胞对TNF反应能力的方法。

9. 发明授权

US5426181A DNA encoding cytokine-induced protein, TSG-14 失效
标题翻译：编码细胞因子诱导蛋白的DNA，TSG-14
公开(公告)号：US5426181A
公开(公告)日：1995-06-20
申请号：US929580
申请日：1992-08-14
申请人： Tae H. Lee , Gene W. Lee , Jan Vilcek
发明人： Tae H. Lee , Gene W. Lee , Jan Vilcek
IPC分类号： A61K39/395 , A61K38/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/78 , C07K16/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/53 , C07H17/00 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C07K14/4718 , C07K14/78 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/75
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a polypeptide molecule, termed TSG-14, in connective tissue cells. The TSG-14 polypeptide and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the polypeptide and the DNA are provided. Antibodies specific for the TSG-14 polypeptide are disclosed, as is a method for detecting the presence of TSG-14 polypeptide in a biological sample, using the antibody or another molecule capable of binding to TSG-14 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-14 polypeptide, a method for measuring induction of expression of TSG-14 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-14 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子（如TNF和IL-1）在结缔组织细胞中诱导称为TSG-14的多肽分子的表达。提供了TSG-14多肽及其功能性衍生物，其编码的DNA，表达载体，如质粒，以及用DNA分子转化或转染的宿主细胞，以及产生多肽和DNA的方法。公开了对TSG-14多肽特异性的抗体，以及使用抗体或能够结合TSG-14如透明质酸的另一分子来检测生物样品中TSG-14多肽的存在的方法。用于检测编码正常或突变体TSG-14多肽的核酸的存在的方法，使用核酸杂交或免疫测定来测量细胞中TSG-14表达诱导的方法，鉴定能诱导的化合物的方法还提供了TSG-14在细胞中的表达，以及测定细胞对TNF反应能力的方法。

10. 发明授权

US5386013A Tumor necrosis factor-induced protein TSG-6 失效
标题翻译：肿瘤坏死因子诱导蛋白TSG-6
公开(公告)号：US5386013A
公开(公告)日：1995-01-31
申请号：US24868
申请日：1993-03-01
申请人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
发明人： Tae H. Lee , Hans-Georg Wisniewski , Jan Vilcek
IPC分类号： C12N1/21 , C07K14/47 , C07K16/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/53 , G01N33/577 , C07K13/00 , C12P21/06
CPC分类号： C07K14/4718
摘要： Pleiotropic pro-inflammatory cytokines, such as TNF and IL-1, induce expression of a protein molecule, termed TSG-6, in connective tissue cells. The TSG-6 protein and functional derivatives thereof, DNA coding therefor, expression vehicles, such as a plasmids, and host cells transformed or transfected with the DNA molecule, and methods for producing the protein and the DNA are provided. Antibodies specific for the TSG-6 protein are disclosed, as is a method for detecting the presence of TSG-6 protein in a biological sample, using the antibody or another molecule capable of binding to TSG-6 such as hyaluronic acid. A method for detecting the presence of nucleic acid encoding a normal or mutant TSG-6 protein, a method for measuring induction of expression of TSG-6 in a cell using either nucleic acid hybridization or immunoassay, a method for identifying a compound capable of inducing the expression of TSG-6 in a cell, and a method for measuring the ability of a cell to respond to TNF are also provided.
摘要翻译：多效性促炎细胞因子如TNF和IL-1在结缔组织细胞中诱导称为TSG-6的蛋白质分子的表达。提供TSG-6蛋白质及其功能性衍生物，编码它们的DNA，表达载体，例如质粒，用DNA分子转化或转染的宿主细胞，以及产生蛋白质和DNA的方法。公开了对TSG-6蛋白质特异性的抗体，以及使用抗体或能够与TSG-6如透明质酸结合的另一分子来检测生物样品中TSG-6蛋白质的存在的方法。用于检测编码正常或突变体TSG-6蛋白的核酸的存在的方法，使用核酸杂交或免疫测定法测定细胞中TSG-6表达的诱导方法，鉴定能诱导的化合物的方法还提供了TSG-6在细胞中的表达，以及测定细胞对TNF反应能力的方法。

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