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1. 发明申请

US20180044665A1 METHOD OF MANUFACTURING PROTEIN ARRAY OR PEPTIDE ARRAY, METHOD OF IDENTIFYING FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE, PROTEIN ARRAY OR PEPTIDE ARRAY, AND FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE IDENTIFICATION KIT 审中-公开
公开(公告)号：US20180044665A1
公开(公告)日：2018-02-15
申请号：US15784031
申请日：2017-10-13
申请人： THE UNIVERSITY OF TOKYO , NIKON CORPORATION
发明人： Takanori ICHIKI , Shingo UENO , Hisao OSAWA
IPC分类号： C12N15/10 , C40B30/04 , C07K17/14 , G01N33/68 , C07K1/04
CPC分类号： C12N15/1075 , C07K1/04 , C07K17/14 , C40B30/04 , G01N33/6842 , G01N33/6845
摘要： There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor.

2. 发明申请

US20160289671A1 METHOD OF MANUFACTURING PROTEIN ARRAY OR PEPTIDE ARRAY, METHOD OF IDENTIFYING FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE, PROTEIN ARRAY OR PEPTIDE ARRAY, AND FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE IDENTIFICATION KIT 审中-公开
标题翻译：蛋白质阵列或肽阵列的制备方法，识别功能性蛋白质或功能肽，蛋白质阵列或肽阵列的方法和功能性蛋白质或功能肽鉴定试剂盒
公开(公告)号：US20160289671A1
公开(公告)日：2016-10-06
申请号：US14914373
申请日：2014-08-05
申请人： THE UNIVERSITY OF TOKYO , NIKON CORPORATION
发明人： Takanori ICHIKI , Shingo UENO , Hisao OSAWA
IPC分类号： C12N15/10
CPC分类号： C12N15/1075 , C07K1/04 , C07K17/14 , C40B30/04 , G01N33/6842 , G01N33/6845
摘要： There is provided a method of manufacturing a protein array or peptide array suitable for an efficient screening of a functional protein or functional peptide. The method of manufacturing a protein array or peptide array includes the steps of: (a) preparing a nucleic acid immobilized on a solid support and a cell-free synthesis system in a reactor, in which a reactor array includes the reactor having a specific aperture shape and a protein capture molecule or a peptide capture molecule provided on at least a portion of wall surface and bottom surface in the reactor; and (c) synthesizing a protein or peptide from the nucleic acid using the cell-free synthesis system and immobilizing the protein or peptide in the reactor.
摘要翻译：提供了一种制备适于有效筛选功能性蛋白质或功能性肽的蛋白质阵列或肽阵列的方法。制备蛋白质阵列或肽阵列的方法包括以下步骤：（a）在反应器中制备固定在固体支持物上的核酸和无细胞合成系统，其中反应器阵列包括具有特定孔径的反应器形状和蛋白质捕获分子或肽捕获分子，其设置在反应器的壁表面和底表面的至少一部分上; 和（c）使用无细胞合成系统从核酸合成蛋白质或肽，并将蛋白质或肽固定在反应器中。

3. 发明申请

US20160146669A1 SPECTROSCOPE AND MICROSPECTROSCOPIC SYSTEM 审中-公开
标题翻译：光谱和微观系统
公开(公告)号：US20160146669A1
公开(公告)日：2016-05-26
申请号：US14983067
申请日：2015-12-29
申请人： NIKON CORPORATION
发明人： Ryoichi SATAKA , Hisao OSAWA
IPC分类号： G01J3/44 , G01J3/02
CPC分类号： G01J3/4406 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0256 , G01J2003/1243 , G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G02B21/0064 , G02B21/0076
摘要： A spectroscope used for a microspectroscopic system includes: a collimating optical system that causes signal light to be substantially collimated light; spectroscopic optical systems and each of which includes at least one of each of spectral elements and in which a wavelength band for spectral separation varies depending on an incident angle of the signal light; at least one of each of optical receivers that detect the signal light spectrally separated by the spectroscopic optical systems; a mechanism that varies the incident angles of the signal light on the spectral elements; and a controller unit that determines the incident angles of the signal light on the spectral elements in accordance with the wavelength band for spectrally separating the signal light and controls the mechanism so as to attain the incident angles.
摘要翻译：用于微观光谱系统的分光镜包括：准直光学系统，其使信号光基本上准直的光; 分光光学系统，并且每个光谱系统包括每个光谱元素中的至少一个，并且其中用于光谱分离的波长带根据信号光的入射角度而变化; 检测由分光光学系统光谱分离的信号光的每个光接收器中的至少一个; 改变光谱元件上的信号光的入射角的机构; 以及控制器单元，其根据用于频谱分离信号光的波长带来确定信号光在光谱元件上的入射角度，并且控制该机构以便获得入射角。

4. 发明申请

US20180238803A1 STRUCTURED ILLUMINATION MICROSCOPE, OBSERVATION METHOD, AND STORAGE MEDIUM 审中-公开
公开(公告)号：US20180238803A1
公开(公告)日：2018-08-23
申请号：US15956795
申请日：2018-04-19
申请人： NIKON CORPORATION
发明人： Hisao OSAWA , Fumihiro DAKE
IPC分类号： G01N21/64 , G02B21/08 , G02B27/58 , G02B21/00 , G02B21/16
CPC分类号： G01N21/6458 , G02B21/0092 , G02B21/08 , G02B21/082 , G02B21/16 , G02B21/367 , G02B27/58
摘要： A structured illumination microscope includes: a brancher that includes a first substrate on which a plurality of pixel electrodes are provided; a second substrate opposed to the first substrate; and a ferroelectric liquid crystal disposed between the first substrate and the second substrate, and branches light from a light source into diffracted light beams; an illumination optical system that illuminates a sample with interference fringes formed by at least some of the diffracted light beams; an imaging device that forms an image of the sample irradiated with the interference fringes; a demodulator; and a controller that controls a direction and a phase of the interference fringes. In one frame period during which the imaging device takes the image, the controller applies a first voltage pattern and a second voltage pattern obtained by inverting the first voltage pattern to at least some of the pixel electrodes.

5. 发明申请

US20160216505A1 STRUCTURED ILLUMINATION MICROSCOPE DEVICE 审中-公开
标题翻译：结构化照明显微镜装置
公开(公告)号：US20160216505A1
公开(公告)日：2016-07-28
申请号：US15093177
申请日：2016-04-07
申请人： NIKON CORPORATION
发明人： Yosuke OKUDAIRA , Hisao OSAWA
IPC分类号： G02B21/36 , G02B21/06 , G02B5/18 , H04N5/225
CPC分类号： G02B21/367 , G01N21/6458 , G01N21/648 , G02B5/1828 , G02B21/0076 , G02B21/008 , G02B21/06 , G02B27/58 , H04N5/2256
摘要： A structured illumination microscope device includes acquisition unit that repeats a series of processing steps including controlling a combination of a wave vector and phase of fringes and acquiring N images; and computing unit in which processing for demodulating the image of the sample using a required M types of images from an image set of consecutive P images. The M types of images include: Q types (where Q≧3) of modulated images; and one type of modulated image having the wave vector in common with and the phase differing from at least one among the Q types of modulated images, or one unmodulated image.An arrangement of the N images satisfies the uniformity condition, meaning “intensity distribution of the fringes is spatially uniform when accumulated between the N images” and the refresh condition, meaning “the M types of images are always included in the image set”.
摘要翻译：一种结构化照明显微镜装置，包括采集单元，其重复一系列处理步骤，包括控制波矢和相位相合并获取N图像的组合; 以及计算单元，其中使用来自连续P图像的图像集合的所需M种类型的图像来解调样本的图像的处理。 M种图像包括：调制图像的Q类型（其中Q≥3）; 以及一种类型的调制图像，其具有与调制图像的Q种类型中的至少一种或一种未调制图像相同的波矢和与该相位不同的相位。 N图像的布置满足均匀性条件，意味着“在N图像之间累积时，条纹的强度分布在空间上均匀”和刷新条件，意味着“图像集中的M种类型总是包括在内”。

6. 发明申请

US20200064617A1 STRUCTURED ILLUMINATION MICROSCOPE APPARATUS AND AN IMAGE FORMING APPARATUS 审中-公开
公开(公告)号：US20200064617A1
公开(公告)日：2020-02-27
申请号：US16674631
申请日：2019-11-05
申请人： NIKON CORPORATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Yumiko OUCHI , Hisao OSAWA , Mats G. L. GUSTAFSSON , David A. AGARD
IPC分类号： G02B21/36 , G02B21/00 , G02B27/58 , G02B21/06 , G02B5/30 , H04N7/18
摘要： Polarized light which is emitted from an optical fiber becomes circular polarized light by passing through a first quarter wave plate. The circular polarized light which has entered a second quarter wave plate is converted into nearly linear polarized light which has S polarization. P polarization components are removed from the nearly linear polarized light by a polarizer, but the polarizer is not always necessary. The optical axis of the polarizer is set to be a direction which allows transmitting of S polarized light. The light that has passed through the polarizer is separated into diffracted lights by a diffraction grating, and is used as the structured illumination light.

7. 发明申请

US20160320289A1 PARTICLE ANALYSIS APPARATUS, OBSERVATION APPARATUS, PARTICLE ANALYSIS PROGRAM AND PARTICLE ANALYSIS METHOD 有权
标题翻译：颗粒分析装置，观察装置，颗粒分析程序和颗粒分析方法
公开(公告)号：US20160320289A1
公开(公告)日：2016-11-03
申请号：US15210158
申请日：2016-07-14
申请人： NIKON CORPORATION
发明人： Daishi TANAKA , Hisao OSAWA , Kuno SUZUKI
IPC分类号： G01N15/14 , G01N21/53
CPC分类号： G01N15/1459 , G01N15/00 , G01N15/1463 , G01N15/1468 , G01N21/53 , G01N2015/0003 , G01N2015/0038 , G01N2015/0065 , G01N2015/1075 , G01N2201/12
摘要： A particle analysis apparatus includes: an acquisition unit that acquires a plurality of images each captured at a different time in each of which a particle moving in a predetermined direction in a medium is imaged; and a determination unit that determines, based on a movement amount of a particle due to Brownian motion in the medium, whether or not an image of a first particle included in an image captured at a first time of the plurality of images acquired by the acquisition unit and an image of a second particle included in an image captured at a second time which is different from the first time of the plurality of images acquired by the acquisition unit are images indicating the same particle.
摘要翻译：粒子分析装置包括：获取单元，其获取每个在不同时间捕获的多个图像，每个图像中的每个都在成像介质中沿预定方向移动的粒子; 以及确定单元，其基于由所述介质中的布朗运动引起的粒子的移动量，确定包含在通过所述获取获取的所述多个图像的第一时间拍摄的图像中的第一粒子的图像单元和包括在第二时间捕获的图像中的第二粒子的图像，其与由获取单元获取的多个图像的第一次不同是指示相同粒子的图像。

8. 发明申请

US20140340677A1 SPECTROSCOPE AND MICROSPECTROSCOPIC SYSTEM 有权
标题翻译：光谱和微观系统
公开(公告)号：US20140340677A1
公开(公告)日：2014-11-20
申请号：US14448334
申请日：2014-07-31
申请人： NIKON CORPORATION
发明人： Ryoichi SATAKA , Hisao OSAWA
IPC分类号： G01J3/44 , G01J3/02
CPC分类号： G01J3/4406 , G01J3/0205 , G01J3/0208 , G01J3/0237 , G01J3/0256 , G01J2003/1243 , G01N21/64 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G02B21/0064 , G02B21/0076
摘要： A spectroscope used for a microspectroscopic system includes: a collimating optical system that causes signal light to be substantially collimated light; spectroscopic optical systems and each of which includes at least one of each of spectral elements and in which a wavelength band for spectral separation varies depending on an incident angle of the signal light; at least one of each of optical receivers that detect the signal light spectrally separated by the spectroscopic optical systems; a mechanism that varies the incident angles of the signal light on the spectral elements; and a controller unit that determines the incident angles of the signal light on the spectral elements in accordance with the wavelength band for spectrally separating the signal light and controls the mechanism so as to attain the incident angles.
摘要翻译：用于微观光谱系统的分光镜包括：准直光学系统，其使信号光基本上准直的光; 分光光学系统，并且每个光谱系统包括每个光谱元素中的至少一个，并且其中用于光谱分离的波长带根据信号光的入射角度而变化; 检测由分光光学系统光谱分离的信号光的每个光接收器中的至少一个; 改变光谱元件上的信号光的入射角的机构; 以及控制器单元，其根据用于频谱分离信号光的波长带来确定信号光在光谱元件上的入射角度，并且控制该机构以便获得入射角。

9. 发明申请

US20140092463A1 STRUCTURED ILLUMINATION APPARATUS, STRUCTURED ILLUMINATION MICROSCOPY, AND STRUCTURED ILLUMINATION METHOD 有权
标题翻译：结构照明装置，结构照明显微镜和结构照明方法
公开(公告)号：US20140092463A1
公开(公告)日：2014-04-03
申请号：US14095453
申请日：2013-12-03
申请人： NIKON CORPORATION
发明人： Tatsushi NOMURA , Hisao OSAWA , Naoki FUKUTAKE
IPC分类号： G02B21/36 , G02F1/11
CPC分类号： G02B21/367 , G02B21/14 , G02F1/113
摘要： A structured illumination apparatus includes a light modulator being disposed in a light path of an exit light flux from a light source, and in which a sonic wave propagation path is arranged in a direction traversing the exit light flux; a driving unit generating a sonic standing wave in the sonic wave propagation path by giving a driving signal for vibrating a medium of the sonic wave propagation path to the light modulator; an illuminating optical system making at least three diffracted lights of the exit light flux passed through the sonic wave propagation path to be interfered with one another, and forming interference fringes of the diffracted lights on an observational object; and a controlling unit controlling a contrast of the interference fringes by modulating a phase of at least one diffracted light among the diffracted lights in a predetermined pitch.
摘要翻译：一种结构化照明装置，包括：光调制器，其设置在来自光源的出射光束的光路中，并且在穿过出射光束的方向上布置声波传播路径; 驱动单元，通过给出用于使所述光调制器的所述声波传播路径的介质振动的驱动信号，在所述声波传播路径中产生声波驻波; 照射光学系统，使通过声波传播路径的出射光束的至少三个衍射光彼此干涉，并且在观察对象上形成衍射光的干涉条纹; 以及控制单元，通过以预定间距调制衍射光中的至少一个衍射光的相位来控制干涉条纹的对比度。

10. 发明公开

US20240122465A1 VISUAL FIELD TESTING METHOD, VISUAL FIELD TESTING DEVICE, AND VISUAL FIELD TESTING PROGRAM 审中-公开
公开(公告)号：US20240122465A1
公开(公告)日：2024-04-18
申请号：US18538297
申请日：2023-12-13
申请人： NIKON CORPORATION
发明人： Chikara NAKAMURA , Taishi AOKI , Teruo HORIKAWA , Hisao OSAWA
IPC分类号： A61B3/024
CPC分类号： A61B3/024
摘要： A visual field testing method is a visual field testing method of testing a visual field range divided into at least a first partial area and a second partial area, the method including: a step of measuring sensitivities of a plural first test points that are included in the first partial area: and a step of performing a process of estimating sensitivities of a plural second test points that are included in the first partial area and are test points other than the first test points, by using the sensitivities of the plural first test points.

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