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1. 发明授权

US07106763B2 Wavelength control for cavity ringdown spectrometer 有权
标题翻译：腔体振铃光谱仪的波长控制
公开(公告)号：US07106763B2
公开(公告)日：2006-09-12
申请号：US10803827
申请日：2004-03-18
申请人： Sze Tan , Bernard Fidric , Barbara Paldus , Eric Crosson
发明人： Sze Tan , Bernard Fidric , Barbara Paldus , Eric Crosson
IPC分类号： H01S3/10
CPC分类号： G01N21/39 , G01N2021/391 , G01N2021/399
摘要： A cavity ring-down spectrometer includes: a) multiple detectors for monitoring the intensity of the radiation emitted from the cavity and the wavelength of the radiation injected into the cavity; b) controllers which turn off the radiation into the cavity and precisely adjust the temperature of, and current to, the laser gain medium; and c) means for adjusting the beam path length of the optical cavit to bring the cavity into resonance with the injected radiation. Additionally, disclosed is a method for using the spectrometer to detect a target analyte.
摘要翻译：空腔衰减光谱仪包括：a）多个检测器，用于监测从空腔发射的辐射的强度和注入空腔的辐射的波长; b）控制器，其将辐射截止到腔中并精确地调节激光增益介质的温度和电流; 以及c）用于调节光学空穴的光束路径长度以使空腔与所注入的辐射共振的装置。此外，公开了使用该光谱仪检测目标分析物的方法。

2. 发明授权

US07259856B2 Method for the precise measurement of the wavelength of light 有权
标题翻译：用于精确测量光的波长的方法
公开(公告)号：US07259856B2
公开(公告)日：2007-08-21
申请号：US11059198
申请日：2005-02-16
申请人： Alexander Kachanov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Barbara Paldus
IPC分类号： G01N21/00
CPC分类号： G01N21/39
摘要： Improved cavity ring down spectroscopy is provided by binning decay time vs. wavelength data into wavelength bins defined by discontinuities in a wavelength monitor signal. Average decay times and average wavelengths are computed for each bin. The optical loss of a target analyte at the average wavelengths is determined from the corresponding average decay times.
摘要翻译：通过将波长数据分解成波长监测信号中的不连续性定义的波长段，将衰减时间与波长数据进行比较来提供改进的空腔衰减光谱。对于每个仓计算平均衰减时间和平均波长。平均波长下的目标分析物的光学损失由相应的平均衰减时间确定。

3. 发明申请

US20060165138A1 Frequency doubling of semiconductor lasers to generate 300-600 nm light 审中-公开
标题翻译：半导体激光器的倍频产生300-600nm的光
公开(公告)号：US20060165138A1
公开(公告)日：2006-07-27
申请号：US11055882
申请日：2005-02-11
申请人： Alexander Kachanov , Sze Tan , Boris Kharlamov , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Boris Kharlamov , Barbara Paldus
IPC分类号： H01S3/10 , H01S3/04
CPC分类号： H01S5/02248 , H01S5/0092 , H01S5/02438 , H01S5/06837
摘要： A novel control system for a simple and compact all-solid-state laser generating 300 nm to 600 nm nm light with continuously variable output power in the range from 1 mW to at least 120 mW. Single frequency radiation from an external cavity semiconductor laser is frequency doubled in, for example, a periodically poled MgO:LiNbO3 ridge waveguide. Our laser maintains a high quality TEM00 circular beam with M2
摘要翻译：一种用于简单紧凑的全固体激光器的新型控制系统，其产生300nm至600nmnm的光，其连续可变输出功率在1mW至至少120mW的范围内。来自外部腔半导体激光器的单频辐射在例如周期性极化的MgO：LiNbO 3脊波导中倍频。我们的激光器保持了具有M <2> <1.1的高品质TEM 圆形光束，并且非常低。在其输出功率范围内噪声小于0.06％。即使在长时间运行期间也能看到峰峰值输出功率变化小于0.1％。在一个示例中，在70mW的输出功率下操作时不会观察到转换效率的降低，并且激光具有5cm×8cm的小的占地面积。

4. 发明申请

US20060165137A1 Novel external cavity CW frequency doubling of semiconductor lasers to generate 300-600nm light 审中-公开
标题翻译：新型外腔CW倍频半导体激光器产生300-600nm光
公开(公告)号：US20060165137A1
公开(公告)日：2006-07-27
申请号：US11040889
申请日：2005-01-21
申请人： Alexander Kachanov , Boris Kharlamov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Boris Kharlamov , Sze Tan , Barbara Paldus
IPC分类号： H01S3/10 , H01S3/04
CPC分类号： H01S5/02248 , H01S5/0021 , H01S5/0092 , H01S5/02438 , H01S5/06837
摘要： A novel control system for a simple and compact all-solid-state laser generating 300 nm to 600 nm nm light with continuously variable output power in the range from 1 mW to at least 120 mW. Single frequency radiation from an external cavity semiconductor laser is frequency doubled in a periodically poled MgO:LiNbO3 waveguide. The laser maintains a high quality TEM00 circular beam with M2
摘要翻译：一种用于简单紧凑的全固体激光器的新型控制系统，其产生300nm至600nmnm的光，其连续可变输出功率在1mW至至少120mW的范围内。来自外部腔半导体激光器的单频辐射在周期性极化的MgO：LiNbO 3波导中倍频。激光器在整个输出功率范围内保持具有M≥2的高品质TEM 00圆形光束和小于0.06％的非常低的噪声。在长时间运行期间测量峰峰值输出功率变化小于0.1％。在一个示例中，在输出功率为70mW的操作下并没有观察到转换效率的劣化，并且激光器具有仅5×8cm的小占地面积。

5. 发明申请

US20060181710A1 Method for the precise measurement of the wavelength of light 有权
标题翻译：用于精确测量光的波长的方法
公开(公告)号：US20060181710A1
公开(公告)日：2006-08-17
申请号：US11059198
申请日：2005-02-16
申请人： Alexander Kachanov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Barbara Paldus
IPC分类号： G01N21/61
CPC分类号： G01N21/39
摘要： A process for measuring the absorption spectrum of a target analyte using a cavity ring down spectrometer, comprising the steps of: i) tuning the spectrometer laser so that the light transmitted from the laser into the spectrometer optical cavity is varied over a wavelength interval which encompasses both the absorption wavelength of a spectral feature of the target analyte and a plurality of the free spectral ranges of the optical cavity; ii) triggering a plurality of ringdown events; iii) for each ringdown event, recording the decay time constant and the trigger time at which the light into the cavity is shut off; iv) organizing the decay time constants, light wavelengths and trigger times as a function of trigger time; v) ordering said light wavelengths by increasing value and placing groups of wavelengths into individual bins; vi) computing the average wavelength of each bin group; vii) grouping the decay time constants and trigger times into bins that parallel said wavelength bins, with the decay time constants in each of said parallel bin being arranged by increasing trigger time; viii) computing the average decay time for each decay time bin and using this decay time average, together with the average wavelength from the parallel wavelength bin, to compute the optical loss for the target analyte at said average wavelength.
摘要翻译：一种使用空腔环形下光谱仪测量目标分析物的吸收光谱的方法，包括以下步骤：i）调谐光谱仪激光，使得从激光发射到分光计光腔中的光在波长间隔上变化，波长间隔包括目标分析物的光谱特征的吸收波长和光腔的多个自由光谱范围; ii）触发多个振铃事件; iii）对于每个振铃事件，记录衰减时间常数和将光进入腔的触发时间被切断; iv）组织衰减时间常数，光波长和触发时间作为触发时间的函数; v）通过增加值来排列所述光波长，并将波长组放置在各个箱中; vi）计算每个箱组的平均波长; vii）将衰减时间常数和触发时间分组到平行于所述波长箱的箱中，其中每个所述平行仓中的衰减时间常数通过增加触发时间来布置; viii）计算每个衰减时间段的平均衰减时间并使用该衰减时间平均值以及来自平行波长的平均波长的平均波长来计算在所述平均波长处的目标分析物的光学损耗。

6. 发明申请

US20050012931A1 Method and apparatus for rapidly and accurately determining a time constant from cavity ring-down data 审中-公开
标题翻译：用于快速，准确地确定空腔衰减数据的时间常数的方法和装置
公开(公告)号：US20050012931A1
公开(公告)日：2005-01-20
申请号：US10622323
申请日：2003-07-17
申请人： Sze Tan , Bernard Fidric , Robert Lodenkamper
发明人： Sze Tan , Bernard Fidric , Robert Lodenkamper
IPC分类号： G01J3/42 , G01N21/39 , G01N21/00
CPC分类号： G01J3/42 , G01N21/39
摘要： Methods and apparatus for decreasing the time required to calculate a ring-down time from sampled ring-down data and/or increasing the accuracy of the calculated ring-down time are provided. The time required to obtain an accurate calculation of a ring-down time is reduced by performing a linear least squares fit using an estimate B1 of the background, then using the results of the fit to estimate the error in B1. The estimated error in B1 is then used to provide an improved estimate of the ring-down time. Alternatively, the time required to accurately calculate a ring-down time is reduced by averaging consecutive data points into “bins” and performing a linear least squares fit to the resulting binned signal. The parameters obtained from the fit to the binned signal are then used to obtain an improved estimate B2 of the background, and the ring-down time is calculated by performing a linear least squares fit using B2. Another method, applicable either by itself or in combination with either of the two preceding methods, is to improve accuracy by providing a low pass filter having a bandwidth related to a shortest expected ring-down time, to filter the ring-down signal before it is sampled.
摘要翻译：提供了用于减少从采样的降噪数据计算振铃时间所需的时间和/或增加计算的关闭时间的精度的方法和装置。通过使用背景的估计B1执行线性最小二乘拟合，然后使用拟合的结果来估计B1中的误差，来减少获得准确计算消隐时间所需的时间。然后使用B1中的估计误差来提供对减振时间的改进的估计。或者，通过将连续的数据点平均成“bin”并对所得到的合并信号执行线性最小二乘法拟合来减少精确计算减振时间所需的时间。然后使用从合并信号获得的参数来获得背景的改进的估计值B2，并且通过使用B2执行线性最小二乘法拟合来计算消隐时间。另一种可以单独使用或与前述两种方法组合使用的方法之一是通过提供具有与最短期望的停机时间有关的带宽的低通滤波器来提高精度，以便在其之前对其进行滤波被采样。

7. 发明申请

US20050206903A1 Wavelength control for cavity ringdown spectrometer 有权
标题翻译：腔体振铃光谱仪的波长控制
公开(公告)号：US20050206903A1
公开(公告)日：2005-09-22
申请号：US10803827
申请日：2004-03-18
申请人： Sze Tan , Bernard Fidric
发明人： Sze Tan , Bernard Fidric
IPC分类号： G01N21/39 , G01N21/61
CPC分类号： G01N21/39 , G01N2021/391 , G01N2021/399
摘要： A cavity ring-down spectrometer includes: a) multiple detectors for monitoring the intensity of the radiation emitted from the cavity and the wavelength of the radiation injected into the cavity; b) controllers which turn off the radiation into the cavity and precisely adjust the temperature of, and current to, the laser gain medium; and c) means for adjusting the beam path length of the optical cavit to bring the cavity into resonance with the injected radiation. Additionally, disclosed is a method for using the spectrometer to detect a target analyte.
摘要翻译：空腔衰减光谱仪包括：a）多个检测器，用于监测从空腔发射的辐射的强度和注入空腔的辐射的波长; b）控制器，其将辐射截止到腔中并精确地调节激光增益介质的温度和电流; 以及c）用于调节光学空穴的光束路径长度以使空腔与所注入的辐射共振的装置。此外，公开了使用该光谱仪检测目标分析物的方法。

8. 发明授权

US07646485B2 Method and apparatus for enhancing the accuracy of CRDS measurements 有权
标题翻译：提高CRDS测量精度的方法和装置
公开(公告)号：US07646485B2
公开(公告)日：2010-01-12
申请号：US11002603
申请日：2004-12-02
申请人： Sze Tan
发明人： Sze Tan
IPC分类号： G01N21/61
CPC分类号： G01N21/39 , G01J3/28 , G01J3/42 , G01N2021/399
摘要： A method and apparatus for enhancing the accuracy of spectroscopic measurements using a cavity ringdown spectrometer (CRDS) is provided. A first aspect of the invention consists of a novel algorithm for the processing of ring-down data that significantly reduces the amplitude of an exponential fitting artifact, and thereby gives a better estimate of the actual loss. The primary cause of the artifact is the presence of an unwanted backwards-traveling wave that counter-propagates within the ringdown cavity. Scattering due to small imperfections at the cavity mirrors produces this wave and its intensity may be minimized by adjustment of the mirror positions during cavity construction. A second aspect of the invention consists of an apparatus for measuring the backscattered wave within a cavity to allow such cavity mirror adjustments to be made.
摘要翻译：提供了一种用于增强使用空腔衰减谱仪（CRDS）的光谱测量精度的方法和装置。本发明的第一方面包括一种用于处理降噪数据的新算法，其显着地减少指数拟合人造物的振幅，从而给出对实际损失的更好的估计。赝像的主要原因是存在反冲传播的不需要的向后行波。由于腔镜的小缺陷引起的散射产生这种波，并且通过在空腔构造期间通过调整反射镜位置可以最小化其强度。本发明的第二方面包括用于测量空腔内的后向散射波以允许进行这种空腔镜子调节的装置。

9. 发明申请

US20050266499A1 Method and apparatus for testing for presence or absence of select biological substances 审中-公开
标题翻译：用于测试选择生物物质存在或不存在的方法和装置
公开(公告)号：US20050266499A1
公开(公告)日：2005-12-01
申请号：US11186289
申请日：2005-07-21
申请人： Sze Tan , John Warmington , Aaron Mackay , Ai-Teck Tan
发明人： Sze Tan , John Warmington , Aaron Mackay , Ai-Teck Tan
IPC分类号： C12M1/34 , G01N33/53 , G01N33/558
CPC分类号： G01N33/558
摘要： A fluid flow test device comprising: a chromatography path of aqueous wicking material on which is deposited at an upstream site at a selected delivery time an aqueous biological sample to be tested for the presence or absence of a target material; a capture material bound to the wicking material at a test site downstream of the upstream site, the capture material having a functionality that binds to a first locus on the target material upon wicking of the target material downstream to the test site; a visual label material having a functionality that binds to a second locus on the target material, the chromatography path having a site upstream of the test site at which the visual label material is begun to wick at a predetermined point in time after the first delivery time such that the visual label material does not intermix with the aqueous biological sample within the chromatography path.
摘要翻译：一种流体流动测试装置，包括：水性芯吸材料的色谱路径，其上在选定的递送时间在上游位置沉积待测试的水性生物样品以存在或不存在目标材料; 所述捕获材料在所述上游部位的下游的测试部位与所述芯吸材料结合，所述捕获材料具有在所述靶材料下游向所述测试部位芯吸的目标材料上与所述靶材料上的第一位点结合的功能; 具有与目标材料上的第二位点结合的功能的视觉标签材料，色谱路径具有在第一次传送时间之后的预定时间点，视觉标签材料开始吸收的测试部位上游的位置使得视觉标签材料不与色谱路径内的水性生物样品混合。

10. 发明授权

US08264688B1 Method and apparatus for enhancing the accuracy of CRDS measurements 有权
标题翻译：提高CRDS测量精度的方法和装置
公开(公告)号：US08264688B1
公开(公告)日：2012-09-11
申请号：US12592559
申请日：2009-11-25
申请人： Sze Tan
发明人： Sze Tan
IPC分类号： G01N21/61
CPC分类号： G01N21/39 , G01J3/28 , G01J3/42 , G01N2021/399
摘要： A method and apparatus for enhancing the accuracy of spectroscopic measurements using a cavity ringdown spectrometer (CRDS) is provided. A first aspect of the invention consists of a novel algorithm for the processing of ring-down data that significantly reduces the amplitude of an exponential fitting artifact, and thereby gives a better estimate of the actual loss. The primary cause of the artifact is the presence of an unwanted backwards-traveling wave that counter-propagates within the ringdown cavity. Scattering due to small imperfections at the cavity mirrors produces this wave and its intensity may be minimized by adjustment of the mirror positions during cavity construction. A second aspect of the invention consists of an apparatus for measuring the backscattered wave within a cavity to allow such cavity mirror adjustments to be made.
摘要翻译：提供了一种用于增强使用空腔衰减谱仪（CRDS）的光谱测量精度的方法和装置。本发明的第一方面包括一种用于处理降噪数据的新算法，其显着地减少指数拟合人造物的振幅，从而给出对实际损失的更好的估计。赝像的主要原因是存在反冲传播的不需要的向后行波。由于腔镜的小缺陷引起的散射产生这种波，并且通过在空腔构造期间通过调整反射镜位置可以最小化其强度。本发明的第二方面包括用于测量空腔内的后向散射波以允许进行这种空腔镜子调节的装置。

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