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1. 发明申请

US20050266499A1 Method and apparatus for testing for presence or absence of select biological substances 审中-公开
标题翻译：用于测试选择生物物质存在或不存在的方法和装置
公开(公告)号：US20050266499A1
公开(公告)日：2005-12-01
申请号：US11186289
申请日：2005-07-21
申请人： Sze Tan , John Warmington , Aaron Mackay , Ai-Teck Tan
发明人： Sze Tan , John Warmington , Aaron Mackay , Ai-Teck Tan
IPC分类号： C12M1/34 , G01N33/53 , G01N33/558
CPC分类号： G01N33/558
摘要： A fluid flow test device comprising: a chromatography path of aqueous wicking material on which is deposited at an upstream site at a selected delivery time an aqueous biological sample to be tested for the presence or absence of a target material; a capture material bound to the wicking material at a test site downstream of the upstream site, the capture material having a functionality that binds to a first locus on the target material upon wicking of the target material downstream to the test site; a visual label material having a functionality that binds to a second locus on the target material, the chromatography path having a site upstream of the test site at which the visual label material is begun to wick at a predetermined point in time after the first delivery time such that the visual label material does not intermix with the aqueous biological sample within the chromatography path.
摘要翻译：一种流体流动测试装置，包括：水性芯吸材料的色谱路径，其上在选定的递送时间在上游位置沉积待测试的水性生物样品以存在或不存在目标材料; 所述捕获材料在所述上游部位的下游的测试部位与所述芯吸材料结合，所述捕获材料具有在所述靶材料下游向所述测试部位芯吸的目标材料上与所述靶材料上的第一位点结合的功能; 具有与目标材料上的第二位点结合的功能的视觉标签材料，色谱路径具有在第一次传送时间之后的预定时间点，视觉标签材料开始吸收的测试部位上游的位置使得视觉标签材料不与色谱路径内的水性生物样品混合。

2. 发明申请

US20080187988A1 CYTOPLASMIC ANTIGENS FOR DETECTION OF CANDIDA 审中-公开
标题翻译：用于检测坎迪达的CYTOPLASMIC抗原
公开(公告)号：US20080187988A1
公开(公告)日：2008-08-07
申请号：US11928632
申请日：2007-10-30
申请人： John Warmington , Denis Ballantyne
发明人： John Warmington , Denis Ballantyne
IPC分类号： C12N1/06
CPC分类号： G01N33/56961 , C07K14/40 , G01N33/571 , G01N2333/40
摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.
摘要翻译：本发明涉及诊断念珠菌感染的方法和手段。特别地，本发明涉及一种通过测量存在于患有或怀疑患有念珠菌感染的受试者的生物样品中的念珠菌细胞质抗原的抗体水平来诊断念珠菌感染的方法。

3. 发明申请

US20090030054A1 CYTOPLASMIC ANTIGENS FOR DETECTION OF CANDIDA 审中-公开
标题翻译：用于检测坎迪达的CYTOPLASMIC抗原
公开(公告)号：US20090030054A1
公开(公告)日：2009-01-29
申请号：US12242663
申请日：2008-09-30
申请人： John Warmington , Denis Ballantyne
发明人： John Warmington , Denis Ballantyne
IPC分类号： A61K31/4196 , C12M1/34 , A61P31/10 , G01N33/53
CPC分类号： G01N33/56961 , C07K14/40 , G01N33/571 , G01N2333/40
摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.
摘要翻译：本发明涉及诊断念珠菌感染的方法和手段。特别地，本发明涉及一种通过测量存在于患有或怀疑患有念珠菌感染的受试者的生物样品中的念珠菌细胞质抗原的抗体水平来诊断念珠菌感染的方法。

4. 发明申请

US20060105406A1 Cytoplasmic antigens for detection of Candida 审中-公开
标题翻译：用于检测念珠菌的细胞质抗原
公开(公告)号：US20060105406A1
公开(公告)日：2006-05-18
申请号：US11316739
申请日：2005-12-27
申请人： John Warmington , Denis Ballantyne
发明人： John Warmington , Denis Ballantyne
IPC分类号： G01N33/569 , G01N33/53
CPC分类号： G01N33/56961 , C07K14/40 , G01N33/571 , G01N2333/40
摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.
摘要翻译：本发明涉及诊断念珠菌感染的方法和手段。特别地，本发明涉及一种通过测量存在于患有或怀疑患有念珠菌感染的受试者的生物样品中的念珠菌细胞质抗原的抗体水平来诊断念珠菌感染的方法。

5. 发明授权

US06916626B1 Detection of Candida 失效
标题翻译：检测念珠菌
公开(公告)号：US06916626B1
公开(公告)日：2005-07-12
申请号：US09841188
申请日：2001-04-25
申请人： John Warmington , Denis Ballantyne
发明人： John Warmington , Denis Ballantyne
IPC分类号： G01N33/53 , C07K14/40 , G01N33/48 , G01N33/531 , G01N33/543 , G01N33/569 , G01N33/571 , G01N33/573 , C12P19/34 , C12Q1/32 , C12Q1/68
CPC分类号： G01N33/56961 , C07K14/40 , G01N33/571 , G01N2333/40
摘要： The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the steps of obtaining a biological sample from a subject at risk of, or suspected to be suffering from, Candida infection, contacting the sample with a mannose depleted antigen composition comprising a soluble cytoplasmic antigen preparation comprising antigens of molecular weight 55 kDa, 30 kDa and 20 kDa and detecting the antigen/antibody reaction.
摘要翻译：本发明涉及诊断念珠菌感染的方法和手段。特别地，本发明涉及一种诊断念珠菌感染的方法，其包括以下步骤：从患有或怀疑患有念珠菌感染风险的受试者获得生物样品，使样品与含有甘露糖的抗原组合物接触，所述组合物包含包含分子量为55kDa，30kDa和20kDa的抗原的可溶性细胞质抗原制剂，并检测抗原/抗体反应。

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