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1. 发明申请

US20060165138A1 Frequency doubling of semiconductor lasers to generate 300-600 nm light 审中-公开
标题翻译：半导体激光器的倍频产生300-600nm的光
公开(公告)号：US20060165138A1
公开(公告)日：2006-07-27
申请号：US11055882
申请日：2005-02-11
申请人： Alexander Kachanov , Sze Tan , Boris Kharlamov , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Boris Kharlamov , Barbara Paldus
IPC分类号： H01S3/10 , H01S3/04
CPC分类号： H01S5/02248 , H01S5/0092 , H01S5/02438 , H01S5/06837
摘要： A novel control system for a simple and compact all-solid-state laser generating 300 nm to 600 nm nm light with continuously variable output power in the range from 1 mW to at least 120 mW. Single frequency radiation from an external cavity semiconductor laser is frequency doubled in, for example, a periodically poled MgO:LiNbO3 ridge waveguide. Our laser maintains a high quality TEM00 circular beam with M2
摘要翻译：一种用于简单紧凑的全固体激光器的新型控制系统，其产生300nm至600nmnm的光，其连续可变输出功率在1mW至至少120mW的范围内。来自外部腔半导体激光器的单频辐射在例如周期性极化的MgO：LiNbO 3脊波导中倍频。我们的激光器保持了具有M <2> <1.1的高品质TEM 圆形光束，并且非常低。在其输出功率范围内噪声小于0.06％。即使在长时间运行期间也能看到峰峰值输出功率变化小于0.1％。在一个示例中，在70mW的输出功率下操作时不会观察到转换效率的降低，并且激光具有5cm×8cm的小的占地面积。

2. 发明申请

US20060165137A1 Novel external cavity CW frequency doubling of semiconductor lasers to generate 300-600nm light 审中-公开
标题翻译：新型外腔CW倍频半导体激光器产生300-600nm光
公开(公告)号：US20060165137A1
公开(公告)日：2006-07-27
申请号：US11040889
申请日：2005-01-21
申请人： Alexander Kachanov , Boris Kharlamov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Boris Kharlamov , Sze Tan , Barbara Paldus
IPC分类号： H01S3/10 , H01S3/04
CPC分类号： H01S5/02248 , H01S5/0021 , H01S5/0092 , H01S5/02438 , H01S5/06837
摘要： A novel control system for a simple and compact all-solid-state laser generating 300 nm to 600 nm nm light with continuously variable output power in the range from 1 mW to at least 120 mW. Single frequency radiation from an external cavity semiconductor laser is frequency doubled in a periodically poled MgO:LiNbO3 waveguide. The laser maintains a high quality TEM00 circular beam with M2
摘要翻译：一种用于简单紧凑的全固体激光器的新型控制系统，其产生300nm至600nmnm的光，其连续可变输出功率在1mW至至少120mW的范围内。来自外部腔半导体激光器的单频辐射在周期性极化的MgO：LiNbO 3波导中倍频。激光器在整个输出功率范围内保持具有M≥2的高品质TEM 00圆形光束和小于0.06％的非常低的噪声。在长时间运行期间测量峰峰值输出功率变化小于0.1％。在一个示例中，在输出功率为70mW的操作下并没有观察到转换效率的劣化，并且激光器具有仅5×8cm的小占地面积。

3. 发明授权

US07259856B2 Method for the precise measurement of the wavelength of light 有权
标题翻译：用于精确测量光的波长的方法
公开(公告)号：US07259856B2
公开(公告)日：2007-08-21
申请号：US11059198
申请日：2005-02-16
申请人： Alexander Kachanov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Barbara Paldus
IPC分类号： G01N21/00
CPC分类号： G01N21/39
摘要： Improved cavity ring down spectroscopy is provided by binning decay time vs. wavelength data into wavelength bins defined by discontinuities in a wavelength monitor signal. Average decay times and average wavelengths are computed for each bin. The optical loss of a target analyte at the average wavelengths is determined from the corresponding average decay times.
摘要翻译：通过将波长数据分解成波长监测信号中的不连续性定义的波长段，将衰减时间与波长数据进行比较来提供改进的空腔衰减光谱。对于每个仓计算平均衰减时间和平均波长。平均波长下的目标分析物的光学损失由相应的平均衰减时间确定。

4. 发明申请

US20060181710A1 Method for the precise measurement of the wavelength of light 有权
标题翻译：用于精确测量光的波长的方法
公开(公告)号：US20060181710A1
公开(公告)日：2006-08-17
申请号：US11059198
申请日：2005-02-16
申请人： Alexander Kachanov , Sze Tan , Barbara Paldus
发明人： Alexander Kachanov , Sze Tan , Barbara Paldus
IPC分类号： G01N21/61
CPC分类号： G01N21/39
摘要： A process for measuring the absorption spectrum of a target analyte using a cavity ring down spectrometer, comprising the steps of: i) tuning the spectrometer laser so that the light transmitted from the laser into the spectrometer optical cavity is varied over a wavelength interval which encompasses both the absorption wavelength of a spectral feature of the target analyte and a plurality of the free spectral ranges of the optical cavity; ii) triggering a plurality of ringdown events; iii) for each ringdown event, recording the decay time constant and the trigger time at which the light into the cavity is shut off; iv) organizing the decay time constants, light wavelengths and trigger times as a function of trigger time; v) ordering said light wavelengths by increasing value and placing groups of wavelengths into individual bins; vi) computing the average wavelength of each bin group; vii) grouping the decay time constants and trigger times into bins that parallel said wavelength bins, with the decay time constants in each of said parallel bin being arranged by increasing trigger time; viii) computing the average decay time for each decay time bin and using this decay time average, together with the average wavelength from the parallel wavelength bin, to compute the optical loss for the target analyte at said average wavelength.
摘要翻译：一种使用空腔环形下光谱仪测量目标分析物的吸收光谱的方法，包括以下步骤：i）调谐光谱仪激光，使得从激光发射到分光计光腔中的光在波长间隔上变化，波长间隔包括目标分析物的光谱特征的吸收波长和光腔的多个自由光谱范围; ii）触发多个振铃事件; iii）对于每个振铃事件，记录衰减时间常数和将光进入腔的触发时间被切断; iv）组织衰减时间常数，光波长和触发时间作为触发时间的函数; v）通过增加值来排列所述光波长，并将波长组放置在各个箱中; vi）计算每个箱组的平均波长; vii）将衰减时间常数和触发时间分组到平行于所述波长箱的箱中，其中每个所述平行仓中的衰减时间常数通过增加触发时间来布置; viii）计算每个衰减时间段的平均衰减时间并使用该衰减时间平均值以及来自平行波长的平均波长的平均波长来计算在所述平均波长处的目标分析物的光学损耗。

5. 发明授权

US07265842B2 Method for detecting a gaseous analyte present as a minor constituent in an admixture 有权
标题翻译：用于检测在混合物中作为次要成分存在的气态分析物的方法
公开(公告)号：US07265842B2
公开(公告)日：2007-09-04
申请号：US10966314
申请日：2004-10-14
申请人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
发明人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
IPC分类号： G01J5/02 , G01J1/42 , G01N21/00
CPC分类号： G01N21/39
摘要： A gaseous target analyte present as a minor constituent in an admixture with at least one other gaseous species can be detected using a cavity enhanced optical spectrometer by a process comprising the steps of: i) identifying a plurality of strong spectral absorption peaks of the target analyte which are present within the scanning range of the spectrometer, ii) determining for the identified peaks the pressure region above which the peak width increases substantially with increasing pressure and below which the peak width is substantially independent of pressure, iii) determining which of the peaks identified in step i) are, within the pressure region determined in step ii), free from spectral interference by any of the other components of the admixture. iv) measuring the spectrum of the admixture at the pressure region identified in step ii).
摘要翻译：可以使用空腔增强型光谱仪通过包括以下步骤的方法检测与至少一种其它气态物质混合物中作为次要成分存在的气态目标分析物：i）鉴定目标分析物的多个强光谱吸收峰它们存在于光谱仪的扫描范围内，ii）确定所识别的峰的压力区域，在该压力区域上，峰宽度随着压力的增加而基本上增加并且低于该压力峰值宽度基本上与压力无关，iii）确定哪个峰值在步骤i）中确定的压力区域在步骤ii）中确定的压力区域内，不受混合物中任何其它组分的光谱干扰。 iv）测量在步骤ii）中鉴定的压力区域上的混合物的光谱。

6. 发明申请

US20050254056A1 System and method for controlling the light source of a cavity ringdown spectrometer 审中-公开
标题翻译：用于控制腔室振铃光谱仪的光源的系统和方法
公开(公告)号：US20050254056A1
公开(公告)日：2005-11-17
申请号：US10845338
申请日：2004-05-13
申请人： Alexander Kachanov , Barbara Paldus , Serguei Koulikov
发明人： Alexander Kachanov , Barbara Paldus , Serguei Koulikov
IPC分类号： G01J3/10 , G01J3/42 , G01N21/39 , G01N21/61
CPC分类号： G01N21/39 , G01J3/0205 , G01J3/0218 , G01J3/0232 , G01J3/0256 , G01J3/10 , G01J3/42 , G01N2021/399
摘要： A system and method for controlling the light source of a cavity ring-down spectrometer (CRDS). The system comprises a resonant optical cavity having at least two high reflectivity mirrors; a source for providing a continuous wave optical signal into the optical cavity, the source comprising an electrically pumped semiconductor gain medium; and a SOA interposed between the optical signal source and the optical cavity. The SOA receives the optical signal and transmits it to the resonant optical cavity. The system also includes a first detector for monitoring the intensity of radiation emitted from said cavity and generating a first detection signal based thereon; and at least a first controller for deactivating the optical signal based on a comparison of the first detection signal and a predetermined threshold and for thereafter reactivating the optical signal after a delay period in excess of the ring-down time of the optical cavity, the deactivating and reactivating being achieved by respectively turning off and then turning on electrical current to the SOA.
摘要翻译：一种用于控制腔室振荡光谱仪（CRDS）的光源的系统和方法。该系统包括具有至少两个高反射镜的谐振光学腔; 用于向所述光腔提供连续波光信号的源，所述源包括电泵浦的半导体增益介质; 以及置于光信号源和光腔之间的SOA。 SOA接收光信号并将其传输到谐振光腔。该系统还包括第一检测器，用于监测从所述空腔发射的辐射的强度，并基于此产生第一检测信号; 以及至少第一控制器，用于基于第一检测信号和预定阈值的比较来停用光信号，并且此后在超过光腔的衰减时间的延迟周期之后重新激活光信号，停用并通过分别关闭然后接通电流到SOA来实现重新启动。

7. 发明申请

US20060082778A1 Method for increasng the dynamic range of a cavity enhanced optical spectrometer 有权
标题翻译：增加腔增强光谱仪的动态范围的方法
公开(公告)号：US20060082778A1
公开(公告)日：2006-04-20
申请号：US10966314
申请日：2004-10-14
申请人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
发明人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
IPC分类号： G01N21/00
CPC分类号： G01N21/39
摘要： A gaseous target analyte present as a minor constituent in an admixture with at least one other gaseous species can be detected using a cavity enhanced optical spectrometer by a process comprising the steps of: i) identifying a plurality of strong spectral absorption peaks of the target analyte which are present within the scanning range of the spectrometer, ii) determining for the identified peaks the pressure region above which the peak width increases substantially with increasing pressure and below which the peak width is substantially independent of pressure, iii) determining which of the peaks identified in step i) are, within the pressure region determined in step ii), free from spectral interference by any of the other components of the admixture. iv) measuring the spectrum of the admixture at the pressure region identified in step ii).
摘要翻译：可以使用空腔增强型光谱仪通过包括以下步骤的方法检测与至少一种其它气态物质混合物中作为次要成分存在的气态目标分析物：i）鉴定目标分析物的多个强光谱吸收峰它们存在于光谱仪的扫描范围内，ii）确定所识别的峰的压力区域，在该压力区域上，峰宽度随着压力的增加而基本上增加并且低于该压力峰值宽度基本上与压力无关，iii）确定哪个峰值在步骤i）中确定的压力区域在步骤ii）中确定的压力区域内，不受混合物中任何其它组分的光谱干扰。 iv）测量在步骤ii）中鉴定的压力区域上的混合物的光谱。

8. 发明申请

US20060084180A1 Method for increasing the dynamic range of a cavity enhanced optical spectrometer 审中-公开
标题翻译：增加腔增强型光谱仪的动态范围的方法
公开(公告)号：US20060084180A1
公开(公告)日：2006-04-20
申请号：US10966315
申请日：2004-10-14
申请人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
发明人： Barbara Paldus , Bruce Richman , Alexander Kachanov , Eric Crosson
IPC分类号： G01N24/00
CPC分类号： G01N21/3504 , G01N21/39
摘要： Target analytes present in low concentration as components in a gaseous admixture can be detected using a cavity enhanced optical spectrometer by a process comprising: i) identifying from the spectrum of the pure target analyte a series of absorption peaks free from spectral interference by peaks of any additional gaseous species which are present, the first member of the series being the strongest spectral absorption peak of said target analyte ii) identifying one or more successive peaks of the series which have an absorption that is weaker than the immediately previously identified peak of the series, iii) performing a spectral scan at the wavelengths of the peaks identified in steps i) and ii), and iv) calculating the concentration of the target analyte from the spectral scan of the admixture performed at the wavelength determined in step iii).
摘要翻译：以气体混合物中的组分存在的目标分析物可以使用空腔增强型光谱仪通过以下方法来检测，所述方法包括：i）从纯的目标分析物的光谱中鉴定出一系列没有光谱干扰的吸收峰，存在的另外的气体物质，该系列的第一个成员是所述目标分析物的最强光谱吸收峰。ii）识别该系列的一个或多个连续的峰，其吸收比紧接着之前鉴定的该序列峰，iii）在步骤i）和ii）中确定的峰的波长处执行光谱扫描，以及iv）从在步骤iii）中确定的波长执行的混合物的光谱扫描计算目标分析物的浓度。

9. 发明授权

US07106763B2 Wavelength control for cavity ringdown spectrometer 有权
标题翻译：腔体振铃光谱仪的波长控制
公开(公告)号：US07106763B2
公开(公告)日：2006-09-12
申请号：US10803827
申请日：2004-03-18
申请人： Sze Tan , Bernard Fidric , Barbara Paldus , Eric Crosson
发明人： Sze Tan , Bernard Fidric , Barbara Paldus , Eric Crosson
IPC分类号： H01S3/10
CPC分类号： G01N21/39 , G01N2021/391 , G01N2021/399
摘要： A cavity ring-down spectrometer includes: a) multiple detectors for monitoring the intensity of the radiation emitted from the cavity and the wavelength of the radiation injected into the cavity; b) controllers which turn off the radiation into the cavity and precisely adjust the temperature of, and current to, the laser gain medium; and c) means for adjusting the beam path length of the optical cavit to bring the cavity into resonance with the injected radiation. Additionally, disclosed is a method for using the spectrometer to detect a target analyte.
摘要翻译：空腔衰减光谱仪包括：a）多个检测器，用于监测从空腔发射的辐射的强度和注入空腔的辐射的波长; b）控制器，其将辐射截止到腔中并精确地调节激光增益介质的温度和电流; 以及c）用于调节光学空穴的光束路径长度以使空腔与所注入的辐射共振的装置。此外，公开了使用该光谱仪检测目标分析物的方法。

10. 发明授权

US09267100B2 Composite sensor assemblies for single use bioreactors 有权
标题翻译：用于单次生物反应器的复合传感器组件
公开(公告)号：US09267100B2
公开(公告)日：2016-02-23
申请号：US13385100
申请日：2012-02-02
申请人： Mark Selker , Timothy Johnston , Barbara Paldus
发明人： Mark Selker , Timothy Johnston , Barbara Paldus
IPC分类号： C12M1/00 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/85
CPC分类号： C12M27/14 , C12M23/00 , C12M29/00 , C12M29/06 , G01N21/359 , G01N21/552 , G01N21/65 , G01N21/8507
摘要： A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises: i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof; ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
摘要翻译：一种用于监测适用于聚合物生物过程容器或与下游设备的生物过程的复合传感器组件，包括：i）包含具有中空管状部分和底板部分的高表面张力热塑性塑料的端口，板部分在其壁的孔处易于密封到生物反应器容器; ii）包括电和/或光学测量部件的通常不透明的聚合物监测传感器组件。传感器组件装配在端口的中空管状部分的孔内，并且粘合地保持在其中。

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