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1. 发明申请

US20160340636A1 CELL DETECTION DEVICE AND CELL DETECTION METHOD 审中-公开
标题翻译：细胞检测装置和细胞检测方法
公开(公告)号：US20160340636A1
公开(公告)日：2016-11-24
申请号：US15159089
申请日：2016-05-19
申请人： SYSMEX CORPORATION
发明人： Seiichiro TABATA , Masatoshi YANAGIDA
IPC分类号： C12M1/34 , C12M1/00
摘要： A cell detection device and a cell detection method is provided with which it is possible to efficiently acquire images of cells to be measured. Cell detection device comprises flow cell through which a measurement specimen that contains particles is caused to flow, particle detector for detecting the particles in the measurement specimen supplied to flow cell, particle sorter for sorting particles that satisfy a detection condition and other particles on the basis of the result of detection performed by particle detector, specimen supply part for supplying, to flow cell, an image-capture specimen that includes detection-condition-satisfying particles that have been sorted by particle sorter, and particle-image-capture part for capturing images of the particles in the sorted image-capture specimen supplied to flow cell.
摘要翻译：提供了一种细胞检测装置和细胞检测方法，可以有效地获取待测细胞的图像。细胞检测装置包括流通池，通过该流动池使含有颗粒的测定试样流动，用于检测供给到流通池的测定试样中的粒子的粒子检测器，基于检测条件的粒子的分选粒子等的粒子分选器由粒子检测器进行的检测结果的检测器供应部件，用于向流动池提供包括通过粒子分选器分选的检测条件满足的粒子的图像捕获样本和用于捕获的粒子图像捕获部分提供给流通池的分选图像捕获样品中的颗粒的图像。

2. 发明申请

US20130309692A1 MARKERS FOR DETECTING HUMAN FOLLICULAR HELPER T CELLS AND METHOD FOR DETECTING HUMAN FOLLICULAR HELPER T CELLS 审中-公开
标题翻译：用于检测人类有益的HELPER T细胞的标记物和用于检测人类有益的HELPER T细胞的方法
公开(公告)号：US20130309692A1
公开(公告)日：2013-11-21
申请号：US13891989
申请日：2013-05-10
申请人： Sysmex Corporation
发明人： Masatoshi YANAGIDA , Hitoshi UGA , Takahiro OKAZAWA , Yoshiaki MIYAMOTO , Masafumi IKEDA , Hirokazu KURATA
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12N5/0636 , C12Q1/6876 , C12Q2600/156 , G01N33/505
摘要： The present invention relates to polynucleotide markers and protein markers for detecting human follicular helper T cells. The present invention also relates to methods for detecting human follicular helper T cells using the markers.
摘要翻译：本发明涉及用于检测人类滤泡辅助T细胞的多核苷酸标记和蛋白质标记。本发明还涉及使用标记物检测人卵泡辅助T细胞的方法。

3. 发明申请

US20210356454A1 METHOD FOR MEASURING IMMUNOSTIMULATORY RESPONSE OF IMMUNE CELL, METHOD FOR DETERMINING ABILITY TO FORM IMMUNE SYNAPSE IN IMMUNE CELL, AND CELL ANALYZER 有权
公开(公告)号：US20210356454A1
公开(公告)日：2021-11-18
申请号：US17388223
申请日：2021-07-29
申请人： SYSMEX CORPORATION
发明人： Masatoshi YANAGIDA , Keiko MIWA , Yuma OKA
IPC分类号： G01N33/50 , G01N33/58 , G06T7/00 , G01N15/14 , G01N33/49
摘要： Disclosed is a method for measuring an immunostimulatory response of an immune cell, including (i) bringing a measurement target immune cell into contact with an immunostimulator, (ii) forming a contact surface with a substance different from the measurement target immune cell on the measurement target immune cell, (iii) bringing the measurement target immune cell into contact with a capturing body that binds to a surface antigen on the contact surface and is capable of generating an optical signal, (iv) detecting the optical signal generated from the capturing body, and (v) determining whether or not the measurement target immune cell from which the contact surface has been eliminated before detecting the optical signal has an immunostimulatory response, based on the detected optical signal.

4. 发明申请

US20210270812A1 METHOD FOR ANALYZING IMMUNE CELLS 有权
公开(公告)号：US20210270812A1
公开(公告)日：2021-09-02
申请号：US17323444
申请日：2021-05-18
申请人： SYSMEX CORPORATION
发明人： Yuma OKA , Masatoshi YANAGIDA , Keiko MIWA
IPC分类号： G01N33/50
摘要： Disclosed is a method for analyzing immune cells, comprising the steps of mixing whole blood containing immune cells with an immunostimulatory factor in vitro and labeling target molecules of the immune cells, and a step of acquiring information on localization of the target molecules on the immune cells by detecting the label.

5. 发明申请

US20200264181A1 MEASUREMENT SUCCESS/FAILURE DETERMINATION METHOD AND SAMPLE MEASUREMENT DEVICE 审中-公开
公开(公告)号：US20200264181A1
公开(公告)日：2020-08-20
申请号：US16793073
申请日：2020-02-18
申请人： SYSMEX CORPORATION
发明人： Yusuke TAKAHASHI , Masatoshi YANAGIDA , Kentaro SHIRAI , Yuichi IJIRI , Shigeki IWANAGA
IPC分类号： G01N33/574 , G01N15/14 , G01N21/64
摘要： The present invention provides a method for determining a success or failure of a measurement of a target particle contained in a measurement sample. The method includes: detecting the target particle and other particle other than the target particle in the measurement sample; and determining the success or failure of the measurement of the target particle based on at least a detection result of the other particle.

6. 发明申请

US20200173980A1 METHOD OF DETERMINING QUALITY OF CELL SEPARATION, PARTICLE DETECTION METHOD, AND PARTICLE SEPARATION APPARATUS 审中-公开
公开(公告)号：US20200173980A1
公开(公告)日：2020-06-04
申请号：US16697270
申请日：2019-11-27
申请人： SYSMEX CORPORATION
发明人： Yusuke TAKAHASHI , Kentaro SHIRAI , Masatoshi YANAGIDA , Shigeki IWANAGA , Yuichi IJIRI , Keiko YOSHIKAWA
IPC分类号： G01N33/49 , B01L3/00
摘要： A method of determining a quality of a cell separation, according to an aspect, includes: separating, by running a specimen containing a first particle and a second particle in a flow path, the specimen to a first specimen containing the first particle and a second specimen containing the second particle, based on a difference in magnitude of a force exerted on each particle contained in the specimen; measuring first information on an amount of the first specimen and second information on an amount of the second specimen; and determining a quality of the separating based on the first information and the second information.

7. 发明申请

US20200032196A1 CELL DETECTION DEVICE AND CELL DETECTION METHOD 审中-公开
公开(公告)号：US20200032196A1
公开(公告)日：2020-01-30
申请号：US16591670
申请日：2019-10-03
申请人： SYSMEX CORPORATION
发明人： Seiichiro TABATA , Masatoshi YANAGIDA
IPC分类号： C12M1/34 , G01N1/40 , G01N15/14 , C12M1/00
摘要： A cell detection device and a cell detection method is provided with which it is possible to efficiently acquire images of cells to be measured. Cell detection device comprises flow cell through which a measurement specimen that contains particles is caused to flow, particle detector for detecting the particles in the measurement specimen supplied to flow cell, particle sorter for sorting particles that satisfy a detection condition and other particles on the basis of the result of detection performed by particle detector, specimen supply part for supplying, to flow cell, an image-capture specimen that includes detection-condition-satisfying particles that have been sorted by particle sorter, and particle-image-capture part for capturing images of the particles in the sorted image-capture specimen supplied to flow cell.

8. 发明申请

US20190128793A1 CELL DETECTION METHOD AND CELL DETECTION SYSTEM 审中-公开
公开(公告)号：US20190128793A1
公开(公告)日：2019-05-02
申请号：US16177671
申请日：2018-11-01
申请人： SYSMEX CORPORATION
发明人： Kentaro SHIRAI , Yusuke TAKAHASHI , Masatoshi YANAGIDA , Shigeki IWANAGA , Tomokazu YOSHIDA , Yuichi IJIRI
IPC分类号： G01N15/14 , G06T7/00 , G06T7/70
摘要： A cell detection method and a cell detection system capable of performing target cell detection satisfactorily without interference and reducing the time required for detection of target cells are provided. The cell detection method includes a separation step of step S1 to obtain a sample containing target cells by removing at least a part of the non-target cells from a biological sample including target cells and non-target cells based on a difference in forces acting on target cells and non-target cells; a concentration step of step S3 of obtaining a measurement sample having a target cell concentration increased from the sample containing target cells; a detection of step S4 of detecting target cells by subjecting the measurement sample to an imaging flow cytometer.

9. 发明申请

US20170227446A1 PARTICLE IMAGING APPARATUS AND PARTICLE IMAGING METHOD 审中-公开
公开(公告)号：US20170227446A1
公开(公告)日：2017-08-10
申请号：US15443865
申请日：2017-02-27
申请人： Sysmex Corporation
发明人： Seiichiro TABATA , Masaki ISHISAKA , Kenji AKAMA , Yoshinobu MIURA , Masatoshi YANAGIDA
IPC分类号： G01N15/14 , G01N21/05
CPC分类号： G01N15/1434 , G01N15/1459 , G01N21/05 , G01N2015/1006 , G01N2015/149
摘要： A particle imaging apparatus comprises a flow path comprising a first flow path section, a second flow path section connected downstream of the first flow path section, and a third flow path section that is branched from the first flow path section, a particle detection unit comprising a light source and a light detector, a particle sorting unit configured to adjust a flow direction of the particle, and a particle imaging unit configured to take an image of a particle that flows in the second flow path section. The flow path is structured such that a cross-sectional area of the second flow path section is greater than a cross-sectional area of the first flow path section. The first flow path section and the second flow path section are disposed so as to be linearly aligned.

10. 发明申请

US20170152552A1 CELL SELECTION METHOD, CELL DETECTION METHOD, CELL SELECTION APPARATUS, AND CELL DETECTION APPARATUS 审中-公开
公开(公告)号：US20170152552A1
公开(公告)日：2017-06-01
申请号：US15363503
申请日：2016-11-29
申请人： Sysmex Corporation
发明人： Yusuke TAKAHASHI , Masatoshi YANAGIDA
IPC分类号： C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6841 , G01N21/6428 , G01N2021/6439 , C12Q2563/173 , C12Q2565/102 , C12Q2565/601 , C12Q2565/626
摘要： Disclosed is a cell selection method including a sample preparation step of preparing a sample by performing staining of nucleic acid in each of cells by a first fluorescent dye; and hybridization with respect to an evaluation target region in DNA in each cell by an evaluation probe including a second fluorescent dye; a light receiving step of applying light to the sample and receiving fluorescence from the first fluorescent dye and fluorescence from the second fluorescent dye; and a selection step of selecting an analysis target cell on the basis of intensity of the fluorescence from the first fluorescent dye and intensity of the fluorescence from the second fluorescent dye, wherein the first fluorescent dye is a dye that emits fluorescence having a first wavelength, and the second fluorescent dye is a dye that emits fluorescence having a second wavelength different from the first wavelength.

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