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1. 发明授权

US07085602B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译：可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。

2. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

3. 发明授权

US06961613B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
申请人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
发明人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
IPC分类号： A61N1/368 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译：可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。

4. 发明授权

US07184816B2 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US07184816B2
公开(公告)日：2007-02-27
申请号：US10864064
申请日：2004-06-09
申请人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
发明人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

5. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

6. 发明授权

US6078835A Pacemaker wherein emission of stimulation pulses is controlled dependent on stretching of the ventricular wall 失效
标题翻译：其中刺激脉冲的发射取决于心室壁的拉伸来控制起搏器
公开(公告)号：US6078835A
公开(公告)日：2000-06-20
申请号：US242278
申请日：1998-02-12
申请人： Sven-Erik Hedberg , Karin Jarverud , Kjell Noren , Staffan Bowald
发明人： Sven-Erik Hedberg , Karin Jarverud , Kjell Noren , Staffan Bowald
IPC分类号： A61N1/365
CPC分类号： A61N1/36564
摘要： A pacemaker has control circuits contained in an enclosure and a lead containing an electrical conductor connected to an electrode for delivering electrical stimulation pulses to a heart. The stretching of a wall in the ventricle, corresponding to adequate filling of the ventricle in the heart, is determined in order to identify a time of emitting the stimulation pulses. This stretching is measured indirectly by measurement of pressure in the ventricle using a pressure sensor disposed near the lead in the ventricle. The signal from the sensor is supplied via the lead to circuitry in the enclosure, wherein the signal is amplified and is supplied to an edge detector, which detects an increasing or positive edge of the signal. The edge detector compares the incoming signal with a threshold value, and when the pressure indicated by the signal increases so as to exceed the threshold value, the edge detector supplies a signal to the control circuit which, in turn, triggers the emission of a stimulation pulse from a pulse generator, with or without a delay. The aforementioned stretching can also be measured using a strain gauge or a distance sensor attached to the ventricle wall.
摘要翻译： PCT No.PCT / SE97 / 01239 Sec。 371日期1999年2月12日 102（e）1999年2月12日PCT PCT 1997年7月4日PCT公布。公开号WO98 / 06454 日期1998年2月19日起搏器具有包含在外壳中的控制电路和包含连接到电极的电导体的引线，用于将电刺激脉冲传递到心脏。为了确定发射刺激脉冲的时间，确定对应于心脏中心室充分填充的心室中的壁的拉伸。使用设置在心室中的引线附近的压力传感器通过测量心室中的压力来间接测量该拉伸。来自传感器的信号通过导线提供给外壳中的电路，其中信号被放大并被提供给检测信号的增加或上升沿的边缘检测器。边缘检测器将输入信号与阈值进行比较，并且当信号指示的压力增加以超过阈值时，边缘检测器向控制电路提供信号，该信号又触发了刺激的发射来自脉冲发生器的脉冲，有或没有延迟。上述拉伸也可以使用附着于心室壁的应变计或距离传感器来测量。

7. 发明授权

US09162066B2 Method and system for stimulating a heart 有权
标题翻译：刺激心脏的方法和系统
公开(公告)号：US09162066B2
公开(公告)日：2015-10-20
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： A first ventricle is stimulated at a stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node is computed. A similar process is used to compute a second activation time interval for the other ventricle. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined.
摘要翻译：在刺激部位刺激第一脑室，估计从刺激产生的至少一个去极化波到达AV节点的时间点，并且基本对应于至少一个去极化所需的时间间隔的第一激活时间间隔计算从第一脑室的刺激部位到AV节点的波。使用类似的过程来计算另一个心室的第二激活时间间隔。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗。

8. 发明申请

US20080091239A1 Cardiac assist device and method using epicardially placed microphone 审中-公开
标题翻译：使用心外膜放置麦克风的心脏辅助装置和方法
公开(公告)号：US20080091239A1
公开(公告)日：2008-04-17
申请号：US11582211
申请日：2006-10-16
申请人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
发明人： Anna-Karin Johansson , Kenth Nilsson , Cecilia Tuvstedt , Kjell Noren , Anders Bjorling , Andreas Blomqvist , Berit Larsson , Sven-Erik Hedberg , Karin Jarverud , Nils Holmstrom
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36514 , A61N1/3956
摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.
摘要翻译：在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

9. 发明申请

US20140257423A1 METHOD AND SYSTEM FOR STIMULATING A HEART 有权
标题翻译：用于刺激心脏的方法和系统
公开(公告)号：US20140257423A1
公开(公告)日：2014-09-11
申请号：US13508968
申请日：2011-05-31
申请人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
发明人： Sven-Erik Hedberg , Nils Holmstrom , Karin Jarverud
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682 , A61N1/3684
摘要： The present invention relates generally to implantable medical devices and more particularly to systems and methods for stimulating a heart of a patient. A first ventricle is activated by delivering stimulation to at least one stimulation site, a point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the first ventricle is estimated and a first activation time interval substantially corresponding to the time interval required for at least one depolarization wave to travel from the stimulation site in the first ventricle to the AV node using the estimated point of time for arrival of the depolarization wave and a point of time for delivery of stimulation is computed. Thereafter, the other ventricle is stimulated by delivering stimulation to at least one stimulation site. A point of time for arrival at the AV node for at least one depolarization wave resulting from the stimulation in the other ventricle is then estimated and a second activation time interval substantially corresponding to the time required for at least one depolarization wave to travel from the stimulation site in the other ventricle to the AV node using the estimated arrival of the depolarization wave and the point of time for delivery of stimulation is computed. Based on these activation time intervals and a difference between the intervals, a pacing therapy can be determined, wherein the first ventricle is paced prior to activation of the other ventricle if the activation time difference indicates that the first activation time interval is longer than the second activation time interval and the other ventricle is paced prior to activation of the first ventricle if the activation time difference indicates that the second activation time interval is longer than the first activation time interval.
摘要翻译：本发明一般涉及可植入医疗装置，更具体地涉及用于刺激患者心脏的系统和方法。通过向至少一个刺激部位递送刺激来激活第一脑室，估计到达在第一脑室刺激产生的至少一个去极化波的AV节点的时间点，并且基本对应于计算使用去极化波的到达的估计时间点和用于递送刺激的时间点的至少一个去极化波从第一脑室的刺激部位行进到AV节点所需的时间间隔。此后，通过将刺激递送至至少一个刺激部位刺激另一个心室。然后估计到达AV节点对于在另一个心室中的刺激产生的至少一个去极化波的时间点，并且基本对应于至少一个去极化波从刺激行进所需的时间的第二激活时间间隔计算使用去极化波的估计到达和输送刺激的时间点在AV节点的另一脑室中的位置。基于这些激活时间间隔和间隔之间的差异，可以确定起搏治疗，其中如果激活时间差指示第一激活时间间隔长于第二心室第二激活时间间隔，则第一心室在另一心室激活之前起搏如果所述激活时间差指示所述第二激活时间间隔长于所述第一激活时间间隔，则所述激活时间间隔和所述另一个心室在所述第一心室激活之前起步。

10. 发明申请

US20080294216A1 Implantable Cardiac Stimulator , System, Device and Method for Monitoring Cardiac Synchrony 有权
标题翻译：可植入式心脏刺激器，系统，设备和监测心脏同步的方法
公开(公告)号：US20080294216A1
公开(公告)日：2008-11-27
申请号：US12094543
申请日：2005-11-30
申请人： Karin Jarverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Jarverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location of a heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the first sensor measures said cardiac wall movements at the first cardiac wall location and emits a first sensor output signal corresponding thereto, a second sensor is positioned at a second cardiac wall location of the heart that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and the second sensor measures the cardiac wall movements at the second cardiac wall location and emits a second sensor output signal corresponding thereto. A lead arrangement is electrically connected to the first and second sensors and conducts the first and second sensor output signals therefrom to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译：在用于监测人心脏心脏同步的系统和方法中，第一传感器位于心脏的第一心脏壁位置处，所述第一心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动有关的运动，第一传感器传感器测量在第一心脏壁位置处的心脏壁运动，并且发射与其对应的第一传感器输出信号，第二传感器定位在心脏的第二心脏壁位置处，该第二心脏壁位置受到与沿着纵向的纵向瓣膜平面运动相关的运动并且第二传感器测量第二心脏壁位置处的心脏壁移动，并且发出与其对应的第二传感器输出信号。引线装置电连接到第一和第二传感器，并将第一和第二传感器输出信号传送到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在各个阀平面运动中同步的同步信号第一和第二心脏壁位置。

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