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1. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

2. 发明授权

US07085602B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译：可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。

3. 发明授权

US06961613B2 Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权
标题翻译：可植入双心室刺激装置和系统，以及双心室刺激和感测方法
公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
申请人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
发明人： Anders Björling , Nils Holmström , Sven-Erik Hedberg , Asa Uhrenius
IPC分类号： A61N1/368 , A61N1/37 , A61N1/365
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译：可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。

4. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

5. 发明授权

US07069076B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07069076B2
公开(公告)日：2006-06-27
申请号：US10761707
申请日：2004-01-21
申请人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
发明人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart, and IEGM signal detectors, having blanking intervals following the delivery of pacing pulses, including sensing circuits for sensing IEGM-signals from each of the heart chambers. Each of said sensed IEGM signals has a generally known morphology. A signal-reconstructing unit reconstructs the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲，以及IEGM信号检测器，其具有递送起搏脉冲之后的消隐间隔，包括用于感测来自每个心脏的IEGM信号的感测电路房间。所述感测的IEGM信号中的每一个具有通常已知的形态。信号重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号。

6. 发明授权

US07184816B2 Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
标题翻译：用于识别远场信号的心脏刺激和检测装置，系统和方法
公开(公告)号：US07184816B2
公开(公告)日：2007-02-27
申请号：US10864064
申请日：2004-06-09
申请人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
发明人： Anders Björling , Sven-Erik Hedberg , Nils Holmström
IPC分类号： A61B5/04
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译：在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。控制电路能够检测由第二电路感测的信号是否可能是远场信号。控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

7. 发明授权

US08000790B2 Device for adjusting the sensitivity level of an implantable medical device 有权
标题翻译：用于调节植入式医疗装置的灵敏度水平的装置
公开(公告)号：US08000790B2
公开(公告)日：2011-08-16
申请号：US10576178
申请日：2003-10-27
申请人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
发明人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac stimulation device has an atrial detector that detects atrial events of a patient's heart, and a memory in which sequences of IEGM signals are stored, having a predetermined length, and an analyzing unit that analyzes the sequences to determine if the stored sequences contain atrial events having a lower amplitude than the current sensitivity setting of the atrial detector. A control unit is connected to the atrial detector to adjust the sensitivity setting thereof to a threshold that is determined based on the aforementioned analysis of the IEGM signals.
摘要翻译：可植入心脏刺激装置具有心房检测器，其检测患者心脏的心房事件，以及存储具有预定长度的IEGM信号序列的存储器，以及分析单元，其分析序列以确定所存储的序列是否包含心房事件的振幅低于心房检测器的当前灵敏度设置。控制单元连接到心房检测器以将其灵敏度设置调整到基于上述对IEGM信号的分析确定的阈值。

8. 发明授权

US07979125B2 Implantable biventricular heart stimulating device and method for performing a capture threshold search 有权
标题翻译：可植入的双心室心脏刺激装置和执行捕获阈值搜索的方法
公开(公告)号：US07979125B2
公开(公告)日：2011-07-12
申请号：US12090157
申请日：2005-10-31
申请人： Anders Björling , Nils Holmström , Karin Järverud
发明人： Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3712
摘要： In an implantable biventricular heart stimulating device, and a biventricular heart stimulating method, wherein operation takes place normally with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit, and wherein a time VVcts is determined that is to be used instead of VV during a capture threshold search.
摘要翻译：在可植入的双心室心脏刺激装置和双心室心脏刺激方法中，其中手术通常由第一心室起搏电路递送或抑制的起搏脉冲与通过一个或多个第一心室起搏电路递送或抑制的起搏脉冲之间的时间VV进行第二心室起搏电路，并且其中在捕获阈值搜索期间确定要用于代替VV的时间VVcts。

9. 发明授权

US07181279B2 Implantable heart stimulating device, system and method 有权
标题翻译：植入式心脏刺激装置，系统及方法
公开(公告)号：US07181279B2
公开(公告)日：2007-02-20
申请号：US10781171
申请日：2004-02-18
申请人： Anders Björling , Nils Holmström , Karin Järverud
发明人： Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device and system operate, within a time cycle, to deliver pacing pulses with both a first and a second pacing circuit with a first time delay between these pacing pulses. The device employs a criterion with which a signal typical for a premature ventricular contraction is detected. The device also operates with a second time delay and/or with a third time delay, and, if a predefined pacing rule is fulfilled, to deliver a pacing pulse with the second time delay or said third time delay. The risk for arrhythmia in connection with a PVC is reduced.
摘要翻译：一种可植入的双心室心脏刺激装置和系统在一个时间周期内操作，以便在这些起搏脉冲之间具有第一和第二起搏电路与第一时间延迟之间输送起搏脉冲。该装置采用标准，通过该标准可以检测出早期心室收缩的典型信号。该装置还以第二时间延迟和/或第三时间延迟进行操作，并且如果满足预定的起搏规则，则以第二时间延迟或所述第三时间延迟递送起搏脉冲。与PVC相关的心律失常风险降低。

10. 发明授权

US07483742B2 Detection of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的检测
公开(公告)号：US07483742B2
公开(公告)日：2009-01-27
申请号：US10562109
申请日：2004-04-26
申请人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
发明人： Sven-Erik Hedberg , Anders Björling , Maria Torpo , Karin Ljungström
IPC分类号： A61N1/00
CPC分类号： A61B5/021 , A61B5/02154 , A61N1/3627 , A61N1/36564 , A61N1/3702 , G06F19/00
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF具有用于确定用于检测患者心脏的DHF状态的至少一个血压参数的DHF确定装置。 DHF确定装置包括：压力测量单元，用于在患者的预定工作情况下测量心动周期中的脉搏压力作为血压参数，并且比较器将测量的脉搏压力与预定参考值进行比较。起搏器包括这样的装置和控制单元，其根据所测量的脉搏压力与预定参考值的比较结果优化起搏治疗。检测舒张性心力衰竭DHF的相应方法包括以下步骤：通过将作为所述血压参数的心脏周期中的脉搏压力确定为心动周期中的脉搏压力来确定用于检测患者心脏的DHF状态的至少一个血压参数患者的预定工作情况，并将确定的脉搏压力与预定的参考值进行比较。

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