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1. 发明授权

US08483817B2 Method and implantable medical device for assessing a degree of pulmonary edema of a patient 有权
标题翻译：用于评估患者的肺水肿程度的方法和可植入医疗装置
公开(公告)号：US08483817B2
公开(公告)日：2013-07-09
申请号：US12282912
申请日：2006-03-15
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61B5/05
CPC分类号： A61B5/0537 , A61B5/4878 , A61B2562/0219 , A61N1/3627 , A61N1/36521 , A61N1/36542
摘要： In a method and an implantable medical device for assessing a degree of pulmonary edema of a patient, at least two specific body patients of the patent are detected and at least one impedance sensing session is initiated to sense trans-thoracic impedance signals from the patient when the patient is in one of the at least two specific positions. Impedance values are obtained from the impedance signals, and a relation between respective impedance values at the at least two positions is determined. This relation is then used as a metric of pulmonary edema to assess the degree of pulmonary edema, and is provided as an output.
摘要翻译：在用于评估患者的肺水肿程度的方法和可植入医疗装置中，检测到该专利的至少两个特定身体患者，并且启动至少一个阻抗感测会话以感测来自患者的胸部阻抗信号，患者处于至少两个具体位置之一。从阻抗信号获得阻抗值，并且确定至少两个位置处的各个阻抗值之间的关系。然后将该关系用作肺水肿的度量以评估肺水肿的程度，并作为输出提供。

2. 发明授权

US08131366B2 Biventricular heart stimulator and method of controlling a biventricular heart stimulator 有权
标题翻译：双心室心脏刺激器和控制双心室心脏刺激器的方法
公开(公告)号：US08131366B2
公开(公告)日：2012-03-06
申请号：US11885326
申请日：2005-03-02
申请人： Anders Björling , Nils Holmström
发明人： Anders Björling , Nils Holmström
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： In a biventricular heart stimulator and a method for controlling such a biventricular heart stimulator, successive stimulation pulses are delivered to the ventricles of a heart such that stimulation pulses in a single heartbeat cycle are respectively first delivered to the first ventricle and then to the second ventricle. Capture or loss of capture in response to stimulation pulses delivered to one ventricle is detected. As a result of a detected loss of capture, preventative measures are taken for preventing loss of capture in the other ventricle.
摘要翻译：在双心室心脏刺激器和用于控制这种双心室心脏刺激器的方法中，连续的刺激脉冲被递送到心脏的心室，使得单个心跳周期中的刺激脉冲分别首先被传送到第一脑室，然后被传送到第二脑室。检测到响应于输送到一个脑室的刺激脉冲的捕获或丢失。由于检测到的捕获损失，采取预防措施来防止在另一脑室中的捕获损失。

3. 发明授权

US08103344B2 Method, device, implantable stimulator and dual chamber cardiac therapy system 有权
标题翻译：方法，装置，植入式刺激器和双室心脏治疗系统
公开(公告)号：US08103344B2
公开(公告)日：2012-01-24
申请号：US12446496
申请日：2006-10-31
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/36578 , A61N1/3688
摘要： In a device and method in a dual chamber pacing system operating in an atrial synchronized mode, the cardiac stimulator is connectable to a lead arrangement arranged for sensing atrial electrical and mechanical activity. Upon detection of an atrial arrhythmia based on either of sensed atrial mechanical activity, atrial electrical activity, or a combination thereof, a mode switch from an atrial synchronized ventricle stimulating mode to a non-atrial synchronized mode is triggered.
摘要翻译：在以心房同步模式操作的双室起搏系统中的装置和方法中，心脏刺激器可连接到布置用于感测心房电和机械活动的引线装置。在基于感测到的心房机械活动，心房电活动或其组合中的任一种检测到心房心律失常时，触发从心房同步心室刺激模式到非心房同步模式的模式切换。

4. 发明授权

US07953487B2 Heart stimulating device 有权
标题翻译：心脏刺激装置
公开(公告)号：US07953487B2
公开(公告)日：2011-05-31
申请号：US11917799
申请日：2005-06-16
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/00
CPC分类号： A61B5/1118 , A61B5/01 , A61N1/3627 , A61N1/36542 , A61N1/3655 , A61N1/3702
摘要： An implantable heart stimulating device for indicating congestive heart failure (CHF) has a processor, an activity sensor that generates an activity signal indicative of a patient's activity, and a blood temperature sensor that measures blood temperature inside the heart of the patient and generates a temperature signal indicative of the measured temperature. From the activity signal and the temperature signal, the processor identifies a characteristic dip in the temperature signal related to a predetermined increase in the activity signal. The processor determines a CHF indicator value indicating the degree of CHF based on the magnitude of the temperature sensor dip for at least two increased activity levels.
摘要翻译：用于指示充血性心力衰竭（CHF）的可植入心脏刺激装置具有处理器，产生指示患者活动的活动信号的活动传感器和测量患者心脏内的血液温度并产生温度的血液温度传感器指示测量温度的信号。根据活动信号和温度信号，处理器识别与活动信号的预定增加相关的温度信号中的特征下降。处理器根据至少两个增加的活动水平的温度传感器倾角的大小来确定指示CHF程度的CHF指示符值。

5. 发明授权

US07215996B2 Bi-ventricular heart stimulating device, system and method 有权
标题翻译：双心室心脏刺激装置，系统及方法
公开(公告)号：US07215996B2
公开(公告)日：2007-05-08
申请号：US10499253
申请日：2002-10-04
申请人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
发明人： Kjell Norén , Karin Ljungström , Sven Kalling , Lars Mandal , Anders Björling
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.
摘要翻译：在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值。在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。时间间隔变化，并且在许多心脏周期上监测关系。设定时间间隔使得该关系满足预定的要求。

6. 发明授权

US08000790B2 Device for adjusting the sensitivity level of an implantable medical device 有权
标题翻译：用于调节植入式医疗装置的灵敏度水平的装置
公开(公告)号：US08000790B2
公开(公告)日：2011-08-16
申请号：US10576178
申请日：2003-10-27
申请人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
发明人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac stimulation device has an atrial detector that detects atrial events of a patient's heart, and a memory in which sequences of IEGM signals are stored, having a predetermined length, and an analyzing unit that analyzes the sequences to determine if the stored sequences contain atrial events having a lower amplitude than the current sensitivity setting of the atrial detector. A control unit is connected to the atrial detector to adjust the sensitivity setting thereof to a threshold that is determined based on the aforementioned analysis of the IEGM signals.
摘要翻译：可植入心脏刺激装置具有心房检测器，其检测患者心脏的心房事件，以及存储具有预定长度的IEGM信号序列的存储器，以及分析单元，其分析序列以确定所存储的序列是否包含心房事件的振幅低于心房检测器的当前灵敏度设置。控制单元连接到心房检测器以将其灵敏度设置调整到基于上述对IEGM信号的分析确定的阈值。

7. 发明申请

US20110166472A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR SUCH A DEVICE FOR PREDICTING HF STATUS OF A PATIENT 审中-公开
标题翻译：用于预测患者HF状态的装置的可植入医疗装置和方法
公开(公告)号：US20110166472A1
公开(公告)日：2011-07-07
申请号：US13060491
申请日：2008-08-29
申请人： Anders Björling , Dorin Panescu , Wenxia Zhao
发明人： Anders Björling , Dorin Panescu , Wenxia Zhao
IPC分类号： A61B5/053
CPC分类号： A61N1/3702 , A61B5/053 , A61B5/0538 , A61B5/7275 , A61N1/3627 , A61N1/36521 , G16H20/40 , G16H50/20 , G16H50/30
摘要： In an implantable medical device, such as a pacemaker or a cardioverter/defibrillator, and a method for operating such an implantable medical device, heart conditions, such as heart failure, are detected and predicted at an early stage within a patient in whom the medical device is implanted, by monitoring a patient status, for example, HF status, and predicting a worsening of the HF status of the patient and determining a patient status index, wherein a first average and a second average is compared at predetermined sample points of time. A patient status is determined based on this patient status index, wherein a patient status index that has increased substantially monotonously during a first monitoring period is determined to be an indication of an exacerbation of patient status, and in particular, a worsening of heart failure.
摘要翻译：在诸如起搏器或心律转复/除颤器的可植入医疗装置中，以及用于操作这种可植入医疗装置的方法，在病人的早期阶段检测和预测诸如心力衰竭的心脏状况，其中医疗通过监测患者状态（例如，HF状态）以及预测患者的HF状态的恶化并确定患者状态指数来植入装置，其中在预定的采样时间点比较第一平均值和第二平均值。基于该患者状态指数确定患者身份，其中在第一监测期间基本上单调增加的患者状态指数被确定为患者状态恶化的指示，特别是心力衰竭恶化。

8. 发明申请

US20100292550A1 IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：可植入医疗器械
公开(公告)号：US20100292550A1
公开(公告)日：2010-11-18
申请号：US12809304
申请日：2007-12-21
申请人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
发明人： Hans Abrahamson , Anders Björling , Tomas Snitting , Nils Holmström
IPC分类号： A61N1/365 , A61B5/1473 , A61N1/39
CPC分类号： A61B5/053 , A61B5/14546 , A61N1/36557
摘要： An analyte measuring system has an implantable medical device having a signal source arranged for generating a current signal and electrodes for applying the current signal to a surrounding tissue in a subject body. The device measures a resulting voltage signal with the electrodes and calculates an impedance signal therefrom. The system comprises a signal processor arranged for generating an estimate of a concentration of an analyte in the tissue based on a spectrum analysis of the determined impedance signal.
摘要翻译：分析物测量系统具有植入式医疗装置，其具有布置成产生电流信号的信号源和用于将电流信号施加到被检体内的周围组织的电极。该装置用电极测量得到的电压信号并从其计算阻抗信号。该系统包括信号处理器，其被布置为基于所确定的阻抗信号的频谱分析来生成组织中的分析物的浓度的估计。

9. 发明授权

US07725189B2 Method, device, and system concerning heart stimulation 有权
标题翻译：心脏刺激的方法，装置和系统
公开(公告)号：US07725189B2
公开(公告)日：2010-05-25
申请号：US11660771
申请日：2004-08-31
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/37
CPC分类号： A61N1/371
摘要： In a cardiac stimulation method, device and system, a capture verification condition is determined. For this purpose, a number of pacing pulses are delivered to a heart chamber and signals are sensed within a time window following each pacing pulse. The sensed signals are stored and categorized as representing capture or non-capture. Using the stored signals, a weight vector is determined, that assigns different weights for different parts of each sensed signal within the time window. The weight vector is used for calculating a weighted area within the time window. The capture verification condition is determined by identifying whether the weighted area, calculated with the weight vector, of a sensed signal within the time window is above or below a predetermined value.
摘要翻译：在心脏刺激方法，装置和系统中，确定捕获验证条件。为此，将多个起搏脉冲输送到心室，并且在每个起搏脉冲之后的时间窗内感测信号。感测到的信号被存储并分类为表示捕获或非捕获。使用存储的信号，确定权重向量，其在时间窗口内为每个感测信号的不同部分分配不同的权重。权重向量用于计算时间窗口内的加权区域。通过识别在时间窗内的感测信号的权重向量计算的加权面积是否高于或低于预定值来确定捕获验证条件。

10. 发明申请

US20090204169A1 IMPLANTABLE HEART STIMULATING DEVICE AND METHOD 有权
标题翻译：可植入心脏刺激装置及方法
公开(公告)号：US20090204169A1
公开(公告)日：2009-08-13
申请号：US12299821
申请日：2006-05-16
申请人： Anders Björling
发明人： Anders Björling
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： In an implantable heart stimulating device and a method of the operation thereof, device has a control circuit that detects an evoked responses to delivered pacing pulses and to carry out an automatic capture routine. The control circuit is arranged to automatically temporarily disable the automatic capture routine on the basis of at least one of the following criteria: a1) if more than a predetermined number of threshold searches have been performed during a certain time, b1) if the evoked response signals vary more than a predetermined amount, c1) if a variable time delay with which the device operates is changed such that a pacing pulse may be delivered by the device during the evoked response time window.
摘要翻译：在可植入心脏刺激装置及其操作方法中，装置具有控制电路，其检测对发出的起搏脉冲的诱发反应并执行自动捕获程序。控制电路被设置为基于以下标准中的至少一个来自动临时禁用自动捕获程序：a1）如果在特定时间内已经执行多于预定数量的阈值搜索，则b1）如果诱发响应信号变化大于预定量，c1）如果设备操作的可变时间延迟被改变，使得在诱发响应时间窗口期间该设备可以传送起搏脉冲。

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