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1. 发明授权

US08415501B2 Methods and compositions for making and using polymorphs of cinacalcet 有权
标题翻译：制作和使用西那卡塞多晶型物的方法和组合物
公开(公告)号：US08415501B2
公开(公告)日：2013-04-09
申请号：US11690036
申请日：2007-03-22
申请人： Belle B. Liu , Pengzu Zhou , Nina Cauchon
发明人： Belle B. Liu , Pengzu Zhou , Nina Cauchon
IPC分类号： C07C211/00
CPC分类号： C07C211/30
摘要： The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.
摘要翻译：本发明涉及制备和使用盐酸西那卡塞的新多晶型物的方法和组合物。

2. 发明申请

US20100331548A1 SOLID-STATE FORM OF AMG 706 AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译： AMG 706的固体状态及其药物组合物
公开(公告)号：US20100331548A1
公开(公告)日：2010-12-30
申请号：US12875844
申请日：2010-09-03
申请人： Belle B. Liu , Gonzalo Alva , Nina Cauchon , Seshadri Neervannan , Pengzu Zhou
发明人： Belle B. Liu , Gonzalo Alva , Nina Cauchon , Seshadri Neervannan , Pengzu Zhou
IPC分类号： C07D401/14 , B29B9/00
CPC分类号： C07D401/14
摘要： The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.
摘要翻译：抗血管生成药物AMG 706以无定形形式提供。还提供了AMG 706药物物质，其中AMG 706以至少可检测的量存在，作为无定形AMG 706。还提供了一种AMG 706-结晶抑制剂复合物，其包含无定形AMG 706或AMG 706药物物质的颗粒本发明与一种或多种结晶抑制剂（例如聚合物）紧密结合。还提供了包含这种AMG 706-结晶抑制剂复合物和一种或多种赋形剂的药物组合物。还提供了制备本发明的无定形AMG 706，AMG 706药物物质，本发明的AMG 706-结晶抑制剂复合物和本发明的药物组合物的方法。还提供了一种治疗受试者的医疗状况或病症的方法，其中指示用抗血管生成药物治疗，包括以治疗有效量施用例如口服本发明组合物。

3. 发明授权

US07361789B1 Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis 失效
标题翻译：二氢萘化合物，组合物，其用途和合成方法
公开(公告)号：US07361789B1
公开(公告)日：2008-04-22
申请号：US11191892
申请日：2005-07-27
申请人： Qi Yan , Carlos Orihuela , Bo Shen , Ying Chen , Xin Wang , John Ng , Ruizhi Ji , Pengzu Zhou
发明人： Qi Yan , Carlos Orihuela , Bo Shen , Ying Chen , Xin Wang , John Ng , Ruizhi Ji , Pengzu Zhou
IPC分类号： C07C211/03 , C07C209/26 , C07C209/28
CPC分类号： C07C211/30
摘要： The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
摘要翻译：本发明涉及新的二氢萘化合物，组合物，使用该二氢萘化合物的方法及其制备方法。本发明还涉及制备这些化合物的新型全合成方法。此外，本发明涉及使用手性分离技术分离和纯化这些化合物的异构体的量的方法。本发明还涉及在不需要手性分离技术的情况下生产量的单一等长化合物的方法。

4. 发明申请

US20080108664A1 Solid-state form of AMG 706 and pharmaceutical compositions thereof 审中-公开
标题翻译： AMG 706的固体形式及其药物组合物
公开(公告)号：US20080108664A1
公开(公告)日：2008-05-08
申请号：US11636183
申请日：2006-12-07
申请人： Belle B. Liu , Gonzalo Alva , Nina Cauchon , Seshadri Neervannan , Pengzu Zhou
发明人： Belle B. Liu , Gonzalo Alva , Nina Cauchon , Seshadri Neervannan , Pengzu Zhou
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14
摘要： The anti-angiogenic drug AMG 706 is provided in amorphous form. Also provided is AMG 706 drug substance wherein the AMG 706 is present, in at least a detectable amount, as amorphous AMG 706. Also provided is an AMG 706-crystallization inhibitor composite comprising particles of amorphous AMG 706 or a AMG 706 drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such an AMG 706-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous AMG 706, AMG 706 drug substance of the invention, an AMG 706-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention. Also provided is a method of treating a medical condition or disorder in a subject where treatment with an anti-angiogenic is indicated, comprising administering, for example orally, a composition of the invention in a therapeutically effective amount.
摘要翻译：抗血管生成药物AMG 706以无定形形式提供。还提供了AMG 706药物物质，其中AMG 706以至少可检测的量存在，作为无定形AMG 706。还提供了一种AMG 706-结晶抑制剂复合物，其包含无定形AMG 706或AMG 706药物物质的颗粒本发明与一种或多种结晶抑制剂（例如聚合物）紧密结合。还提供了包含这种AMG 706-结晶抑制剂复合物和一种或多种赋形剂的药物组合物。还提供了制备本发明的无定形AMG 706，AMG 706药物物质，本发明的AMG 706-结晶抑制剂复合物和本发明的药物组合物的方法。还提供了一种治疗受试者的医疗状况或病症的方法，其中指示用抗血管生成药物治疗，包括以治疗有效量施用例如口服本发明组合物。

5. 发明申请

US20070238790A1 METHODS AND COMPOSITIONS FOR MAKING AND USING POLYMORPHS OF CINACALCET 有权
标题翻译：制备和使用CINACALCET聚合物的方法和组合物
公开(公告)号：US20070238790A1
公开(公告)日：2007-10-11
申请号：US11690036
申请日：2007-03-22
申请人： Belle Liu , Pengzu Zhou , Nina Cauchon
发明人： Belle Liu , Pengzu Zhou , Nina Cauchon
IPC分类号： A61K31/137
CPC分类号： C07C211/30
摘要： The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.
摘要翻译：本发明涉及制备和使用盐酸西那卡塞的新多晶型物的方法和组合物。

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