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1. 发明授权

US4814328A Cephalosporin derivatives, and antibacterial agents 失效
标题翻译：头孢菌素衍生物和抗菌剂
公开(公告)号：US4814328A
公开(公告)日：1989-03-21
申请号：US911780
申请日：1986-09-26
申请人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushizima
发明人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushizima
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D217/02 , C07D501/46
CPC分类号： C07D217/02 , Y02P20/55
摘要： The compound having the formula: ##STR1## wherein R is a straight chain, branched chain or cyclic lower alkyl, a lower alkenyl or a lower alkynyl group which may be substituted by a carboxyl group, and R.sup.1 is hydrogen atom or an acetyl group; or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
摘要翻译：具有下式的化合物：其中R是可被羧基取代的直链，支链或环状低级烷基，低级链烯基或低级炔基，R 1是氢原子或乙酰基; 或其药学上可接受的盐，生理上可水解的酯或其溶剂合物。

2. 发明授权

US06251891B1 Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US06251891B1
公开(公告)日：2001-06-26
申请号：US09294091
申请日：1999-04-19
申请人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
发明人： Susumu Nakagawa , Norikazu Otake , Hideo Kiyonaga , Koji Yamada , Hideki Jona , Shigemitsu Okada , Masayuki Ogawa , Hideaki Imamura , Ryosuke Ushijima
IPC分类号： C07D47720
CPC分类号： C07D477/20
摘要： A compound represented by the general formula wherein R1 either represents a hydrogen atom or a lower alkyl group, R2 represents a hydrogen atom, an ester residue, an alkali metal or negative charge, and R3 and R4 are the same or different, and each represent a hydrogen atom or a hydrocarbonic group optionally containing hetero atom(s) selected from the group consisting of oxygen atom(s), sulfur atom(s) and nitrogen atom(s), or they are combined together with the nitrogen atom to which they bound to form a heterocyclic group, and the use thereof as an antibacterial agent.
摘要翻译：由通式化合物R1表示的化合物表示氢原子或低级烷基，R2表示氢原子，酯残基，碱金属或负电荷，R3和R4相同或不同，分别表示氢原子或任选含有选自氧原子，硫原子和氮原子的杂原子的烃基，或它们与它们所结合的氮原子结合在一起形成杂环基，其用作抗菌剂。

3. 发明授权

US5061794A Cephalosporin derivatives, and antibacterial agents 失效
标题翻译： CEPHALOSPORIN衍生物和抗菌剂
公开(公告)号：US5061794A
公开(公告)日：1991-10-29
申请号：US377086
申请日：1989-07-10
申请人： Susumu Nakagawa , Koji Yamada , Fumio Nakano , Norikazu Otake , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima , Ryuji Mitomo
发明人： Susumu Nakagawa , Koji Yamada , Fumio Nakano , Norikazu Otake , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima , Ryuji Mitomo
IPC分类号： C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/36
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125
摘要： A compound having the formula: ##STR1## wherein R is a straight chain or branched chain lower alkyl, cyclic lower alkyl, lower alkenyl (except for 1-carboxy-1-vinyl), lower alkynyl, aralkyl, phenyl or 2-pyrrolidon-3-yl group which may be substituted, and Q is ##STR2## (wherein R.sup.1 is a hydrogen atom or an acetyl group, R.sup.2 is a hydrogen atom, a carboxyl group or a carboxymethyl group, Y is a sulfur atom or an oxygen atom, Z is a sulfur atom, an oxygen atom or an imino group which may be substituted by a lower alkyl group); or a pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
摘要翻译：具有下式的化合物：其中R是直链或支链的低级烷基，环状低级烷基，低级烯基（1-羧基-1-乙烯基），低级炔基，芳烷基，苯基或2 可以被取代的吡咯烷酮-3-基，Q是氢原子或乙酰基，R2是氢原子，羧基或羧甲基， Y是硫原子或氧原子，Z是硫原子，氧原子或可被低级烷基取代的亚氨基）; 或其药学上可接受的盐，生理上可水解的酯或其溶剂合物。

4. 发明授权

US5095013A 2-(2-vinylpyrrolidinylthio)carbapenem derivatives 失效
标题翻译： 2-（2-乙烯基吡啶-2-基）卡巴因衍生物
公开(公告)号：US5095013A
公开(公告)日：1992-03-10
申请号：US562564
申请日：1990-08-03
申请人： Susumu Nakagawa , Fumio Nakano , Norikazu Otake , Ryosuke Ushijima
发明人： Susumu Nakagawa , Fumio Nakano , Norikazu Otake , Ryosuke Ushijima
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04
CPC分类号： C07D477/20 , Y02P20/55
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a methyl group, R.sup.2 is a hydrogen atom or a lower alkyl group, each of R.sup.3, R.sup.4 and R.sup.5 is a hydrogen atom or a lower alkyl group, or R.sup.3 and R.sup.4 together form a methylene group, an ethylene group or a propylene group, or R.sup.4 and R.sup.5 form together with the adjacent nitrogen atom an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a piperazinyl group or a morpholino group; or a pharmaceutically acceptable salt or ester thereof.

5. 发明授权

US5084453A 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives 失效
标题翻译： 1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
公开(公告)号：US5084453A
公开(公告)日：1992-01-28
申请号：US265458
申请日：1988-10-13
申请人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
发明人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
IPC分类号： A61K31/545 , C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/40 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/46
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125 , Y02P20/55
摘要： The present invention relates to a compound having the formula: ##STR1## wherein R is a hydrogen atom, a carboxyl-protecting group or a negative charge and Q is a hydrogen atom, a halogen atom, a hydroxyl group, an acetoxy group, a carbamoyl group, an azide group, a substituted or unsubstituted quarternary ammonio group or a substituted or unsubstituted heterocyclic thio group having at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or a non-toxic salt or physiologically hydrolyzable non-toxic ester thereof; a process for producing it; and an antibacterial agent comprising it as an active ingredient.Further, the present invention also relates to a compound having the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or an amino-protecting group, and each of R.sup.4 and R.sup.5 which may be the same or different is a hydrogen atom or a carboxyl-protecting group, or a salt thereof; and a process for producing it.

6. 发明授权

US5225406A 1-carboxy-1-vinyloxyimino aminothiazole cephalosporin derivatives 失效
标题翻译： 1-羧基-1-乙烯氧基亚氨基氨基噻唑头孢菌素衍生物
公开(公告)号：US5225406A
公开(公告)日：1993-07-06
申请号：US753943
申请日：1991-09-03
申请人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
发明人： Susumu Nakagawa , Ryuji Mitomo , Koji Yamada , Norikazu Otake , Fumio Nakano , Akira Asai , Satoru Kuroyanagi , Yoshiharu Tanaka , Moriaki Ishikawa , Ryosuke Ushijima
IPC分类号： C07D235/28 , C07D263/46 , C07D263/58 , C07D271/10 , C07D271/113 , C07D277/20 , C07D277/36 , C07D277/56 , C07D285/12 , C07D285/125 , C07D501/20 , C07D501/36 , C07D501/46 , C07D501/59
CPC分类号： C07D263/58 , C07D235/28 , C07D263/46 , C07D271/113 , C07D277/36 , C07D277/56 , C07D277/587 , C07D285/125 , Y02P20/55
摘要： The present invention relates to a compound having the formula: ##STR1## wherein R is a hydrogen atom, a carboxyl-protecting group or a negative charge and Q is a hydrogen atom, a halogen atom, a hydroxyl group, an acetoxy group, a carbamoyloxy group, an azide group, a substituted or unsubstituted quarternary ammonio group or a substituted or unsubstituted heterocyclic thio group having at least one hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, or a non-toxic salt or physiologically hydrolyzable non-toxic ester thereof; a process for producing it; and an antibacterial agent comprising it as an active ingredient.Further, the present invention also relates to a compound having the formula: ##STR2## wherein R.sup.3 is a hydrogen atom or an amino-protecting group, and each of R.sup.4 and R.sup.5 which may be the same or different is a hydrogen atom or a carboxyl-protecting group, or a salt thereof; and a process for producing it.
摘要翻译：本发明涉及具有下式的化合物：其中R是氢原子，羧基保护基或负电荷，Q是氢原子，卤原子，羟基，乙酰氧基基团，氨基甲酰氧基，叠氮基，取代或未取代的季铵基或具有至少一个选自氮原子，氧原子和硫原子的杂原子的取代或未取代的杂环硫基，或其无毒盐或其生理上可水解的无毒酯; 一个生产过程; 和含有它作为活性成分的抗菌剂。此外，本发明还涉及具有下式的化合物：其中R 3是氢原子或氨基保护基，并且R 4和R 5可以相同或不同的是氢原子或羧基保护基，或其盐; 及其生产工艺。

7. 发明授权

US4782155A Cephalosporin derivatives, processes for their preparation and antibacterial agents 失效
标题翻译：头孢菌素衍生物，其制备方法和抗菌剂
公开(公告)号：US4782155A
公开(公告)日：1988-11-01
申请号：US29903
申请日：1987-03-25
申请人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushijima
发明人： Susumu Nakagawa , Norikazu Otake , Ryosuke Ushijima
IPC分类号： C07D217/02
CPC分类号： C07D217/02
摘要： The compound having the formula: ##STR1## wherein R.sup.6 is a hydrogen atom or an alkanoyl group, or a salt thereof and a process thereof.
摘要翻译：具有下式的化合物：其中R6是氢原子或烷酰基，或其盐及其制备方法。

8. 发明授权

US5707987A Carbapenem derivatives 失效
标题翻译：卡巴培南衍生物
公开(公告)号：US5707987A
公开(公告)日：1998-01-13
申请号：US696910
申请日：1996-08-23
申请人： Susumu Nakagawa , Hiroshi Fukatsu , Ryosuke Ushijima
发明人： Susumu Nakagawa , Hiroshi Fukatsu , Ryosuke Ushijima
IPC分类号： A61K31/407 , A61K31/695 , A61P31/04 , C07D477/20 , C07D519/06 , C07F7/10 , A61K31/40 , C07D487/04
CPC分类号： C07D477/20
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a group of: ##STR2## (wherein each of A.sub.4 and A.sub.5 is a single bond, --NHSO.sub.2 -- or the like, and Het is a pyrrolinyl group, a 1,4-diazabicyclo�2.2.2!octanyl group or the like which may be substituted with a hydroxyl group, a carbamoyl lower alkyl group or the like) which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfonyl group or the like; a hydroxyl group; a di-lower alkylsulfamoyl group or the like, each of A.sub.1, A.sub.2 and A.sub.3 is a single bond or a lower alkylene group which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfamoyl group or the like; a pyridyl group or a pyridino group; and W is a sulfur atom, a single bond; or a pharmaceutically acceptable salt or ester; a process for its production and an antibacterial agent containing it as an active ingredient.
摘要翻译： PCT No.PCT / JP95 / 00280 Sec。 371日期：1996年8月23日 102（e）日期1996年8月23日PCT提交1995年2月24日PCT公布。公开号WO95 / 23150 PCT 日期：1995年8月31日具有下式的化合物：其中R 1为氢原子或低级烷基，R 2为氢原子或负电荷，R 3为氢原子或低级烷基， Ar是苯基，萘基或基团，-NHSO 2 - 等，Het是可被取代的吡咯啉基，1,4-二氮杂双环[2.2.2]辛烷基等可以被可被羟基，二低级烷基磺酰基等取代的低级烷基，低级烷基氨磺酰基等取代的羟基，氨基甲酰基低级烷基等）。羟基; 二低级烷基氨磺酰基等，A1，A2和A3各自为可以被羟基取代的低级烷基，低级烷基氨磺酰基等取代的单键或低级亚烷基基，二低级烷基氨磺酰基等; 吡啶基或吡啶基; W是硫原子，单键; 或药学上可接受的盐或酯; 其生产方法和含有它作为活性成分的抗菌剂。

9. 发明授权

US5440049A Process for producing enyne derivatives 失效
标题翻译：生产烯炔衍生物的方法
公开(公告)号：US5440049A
公开(公告)日：1995-08-08
申请号：US258772
申请日：1994-06-13
申请人： Susumu Nakagawa , Akira Asai , Satoru Kuroyanagi , Makoto Ishihara , Yoshiharu Tanaka
发明人： Susumu Nakagawa , Akira Asai , Satoru Kuroyanagi , Makoto Ishihara , Yoshiharu Tanaka
IPC分类号： C07D333/16 , B01J31/24 , C07B37/04 , C07B61/00 , C07C209/08 , C07C209/16 , C07C209/22 , C07C209/68 , C07C211/23 , C07C211/24 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/35 , C07C213/08 , C07C215/24 , C07C215/42 , C07C215/48 , C07C215/50 , C07C217/46 , C07C217/52 , C07C217/56 , C07C217/58 , C07D333/04 , C07D333/20 , C07D333/28 , C07D333/54 , C07D333/58 , C07D333/62
CPC分类号： C07D333/62 , C07C209/08 , C07C209/68 , C07C211/24 , C07C211/29 , C07C211/30 , C07C213/08 , C07C215/50 , C07D333/16 , C07D333/20 , Y02P20/55
摘要： A compound of the formula: ##STR1## wherein R.sup.11 is hydrogen, lower alkyl, haloloweralkyl, lower alkenyl, lower alkynyl or cycloalkyl and R.sup.21 is a group selected from the group consisting of: ##STR2## wherein R.sup.3 -R.sup.5, R.sup.31, R.sup.32, R.sup.41, R.sup.42 and R.sup.51 are as defined herein, and W is chlorine or bromine, is prepared by reacting a compound of the formula:Z--CH.sub.2 --CH.dbd.CH--W (I)wherein W is as defined above and Z is a leaving group, with an amine of the formula: ##STR3## wherein R.sup.11 and R.sup.21 are as defined above.
摘要翻译：下式的化合物：其中R 11是氢，低级烷基，卤代低级烷基，低级烯基，低级炔基或环烷基，R 21是选自以下的基团：其中R 11是氢，低级烷基，卤代低级烷基，低级烯基，低级炔基或环烷基， [IIIb]或其中R3-R5，R31，R32，R41，R42和R51如本文所定义，W为氯或溴的化合物通过使下式化合物：Z-CH 2 - CH = CH-W（I）其中W如上所定义，Z是离去基团，与下式的胺反应：其中R 11和R 21如上所定义。

10. 发明授权

US5264672A Miniature electrical switching unit 失效
标题翻译：微型电气开关单元
公开(公告)号：US5264672A
公开(公告)日：1993-11-23
申请号：US825110
申请日：1992-01-24
申请人： Masaru Ishii , Susumu Nakagawa
发明人： Masaru Ishii , Susumu Nakagawa
IPC分类号： H01H1/26 , H01H1/36 , H01H13/12 , H01H1/06
CPC分类号： H01H1/365 , H01R24/46 , H01R2103/00
摘要： A miniature switching unit including two fixed contact pieces arranged one above the other and fixed to terminals, respectively, and a movable contact piece. Each of the fixed contact pieces is made of springy wire members and includes parallel portions having equal inner distances, respectively. The movable contact piece in the form of a rod having a thickness slightly larger than the inner distances of the parallel portions of the fixed contact pieces and includes an intermediate insulator, an upper conductor axially, concentrically and integrally connected to the upper end of the intermediate insulator and a forward conductor axially, concentrically and integrally connected to the lower end of the intermediate insulator. The movable contact piece is held in a housing so as to be positioned in and contacting the parallel portions of the first and second fixed contact pieces and movable in a manner that the intermediate insulator moves across any one of the first and second fixed contact pieces, which are arranged one above the other.
摘要翻译：一种微型开关单元，包括分别彼此并排设置并固定到端子的两个固定接触片和可动接触片。每个固定接触片由弹性线构件制成，并且包括分别具有相等的内部距离的平行部分。杆的形式的可动接触片的厚度稍大于固定接触片的平行部分的内部距离，并且包括中间绝缘体，与中间体的上端轴向同心并且整体连接的上导体绝缘体和正向导体轴向，同心且整体地连接到中间绝缘体的下端。可移动接触片被保持在壳体中，以便定位在第一和第二固定接触片的平行部分中并且可接触第一和第二固定接触片的平行部分，并且可以以中间绝缘体移动穿过第一和第二固定接触件中的任何一个的方式移动，它们彼此排列。

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