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1. 发明授权

US06849446B2 Modified bovine adenovirus having altered tropism 有权
标题翻译：修饰的牛腺病毒具有改变的向性
公开(公告)号：US06849446B2
公开(公告)日：2005-02-01
申请号：US09871212
申请日：2001-05-31
申请人： Suresh K. Tikoo , Lorne A. Babiuk , Linong Zhang , Qiaohua Wu
发明人： Suresh K. Tikoo , Lorne A. Babiuk , Linong Zhang , Qiaohua Wu
IPC分类号： C12N15/09 , A61K35/76 , A61K39/00 , A61K48/00 , A61P31/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/04 , C12N15/861 , C12N15/00
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/6018
摘要： The present invention provides modified bovine adenoviruses comprising a modification in a capsid protein wherein said protein is associated with adenovirus tropism and wherein said modification is associated with altered tropism. The present invention provides adenovirus vectors and host cells comprising such vectors. The present invention also provides methods of making and using such adenoviruses.
摘要翻译：本发明提供了修饰的牛腺病毒，其包含衣壳蛋白中的修饰，其中所述蛋白质与腺病毒向性相关，并且其中所述修饰与改变的嗜性相关。本发明提供了腺病毒载体和包含这种载体的宿主细胞。本发明还提供了制备和使用这种腺病毒的方法。

2. 发明授权

US07335353B2 Porcine cells comprising an adenovirus E3 gene region 有权
标题翻译：包含腺病毒E3基因区的猪细胞
公开(公告)号：US07335353B2
公开(公告)日：2008-02-26
申请号：US10245603
申请日：2002-09-16
申请人： Police S. Reddy , Suresh K. Tikoo , Lorne A. Babiuk
发明人： Police S. Reddy , Suresh K. Tikoo , Lorne A. Babiuk
IPC分类号： A01N63/00 , A01N65/00 , A61K48/00 , A61K39/23 , A61K39/235 , A61K31/70 , C12N5/00 , C12N5/02 , A01N43/04
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362
摘要： The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3) is provided. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals. In addition, PAV-3 vectors can be used for gene therapy and expression of heterologous polypeptides. PAV-3 genome sequences can also be used for diagnostic purposes, to detect the presence of PAV-3 DNA in a subject or biological sample.
摘要翻译：提供猪腺病毒3型（PAV-3）基因组的完整核苷酸序列。提供了在原核细胞中通过同源重组构建感染性PAV基因组的方法。通过用重组PAV基因组转染哺乳动物细胞获得重组PAV病毒。 PAV-3基因组可用作异源核苷酸序列的表达载体，例如用于制备和施用猪或其他哺乳动物的亚单位疫苗。此外，PAV-3载体可用于基因治疗和异源多肽的表达。 PAV-3基因组序列也可用于诊断目的，以检测受试者或生物样品中PAV-3 DNA的存在。

3. 发明授权

US07560278B2 Methods to culture circovirus 有权
公开(公告)号：US07560278B2
公开(公告)日：2009-07-14
申请号：US11654869
申请日：2007-01-17
申请人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
发明人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
IPC分类号： C12N5/00 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.

4. 发明授权

US07172899B2 Methods to culture circovirus 有权
公开(公告)号：US07172899B2
公开(公告)日：2007-02-06
申请号：US10840879
申请日：2004-05-07
申请人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
发明人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
IPC分类号： C12N5/00 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.

5. 发明授权

US06794163B2 Methods to culture circovirus 有权
标题翻译：培养圆环病毒的方法
公开(公告)号：US06794163B2
公开(公告)日：2004-09-21
申请号：US10112540
申请日：2002-03-27
申请人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
发明人： Qiang Liu , Suresh K. Tikoo , Philip Willson , Lorne A. Babiuk
IPC分类号： C12P2100
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2750/10021 , C12N2750/10043 , C12N2750/10052
摘要： The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 functional protein.
摘要翻译：本发明涉及培养圆环病毒，特别是猪圆环病毒的方法。本发明提供了在表达哺乳动物腺病毒E1功能蛋白的哺乳动物细胞中培养猪圆环病毒的组合物和方法。

6. 发明授权

US07687615B2 PAV regions for encapsidation and E1 transcriptional control 有权
标题翻译： PAV区域用于壳化和E1转录控制
公开(公告)号：US07687615B2
公开(公告)日：2010-03-30
申请号：US10622869
申请日：2003-07-18
申请人： Suresh K. Tikoo
发明人： Suresh K. Tikoo
IPC分类号： C07H21/00 , A61K39/235
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5256 , C12N2710/10343 , C12N2830/30 , C12N2830/32
摘要： The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus sequence essential for encapsidation as well as methods for making and using such adenovirus vectors. The present invention discloses porcine adenovirus sequence for E1 transcriptional control and provides porcine adenovirus vectors comprising a modification(s) in the E1 transcriptional control region.
摘要翻译：本发明提供了对于壳化所必需的猪腺病毒序列，并提供了包含这种序列的腺病毒载体。本发明提供宿主细胞和包含腺病毒载体的组合物，其包含对于壳化所必需的猪腺病毒序列以及制备和使用这种腺病毒载体的方法。本发明公开了用于E1转录控制的猪腺病毒序列，并提供了包含E1转录控制区中的修饰的猪腺病毒载体。

7. 发明授权

US07264818B2 BAV packaging regions and E1 transcriptional control regions 有权
标题翻译： BAV包装区和E1转录控制区
公开(公告)号：US07264818B2
公开(公告)日：2007-09-04
申请号：US10866505
申请日：2004-06-10
申请人： Suresh K. Tikoo , Li Xing
发明人： Suresh K. Tikoo , Li Xing
IPC分类号： A61K39/23 , C12N5/10 , C12N7/00
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10323 , C12N2710/10343
摘要： The present invention relates to the identification of bovine adenovirus sequence(s) essential for encapsidation and E1 transcriptional control regions. The present invention provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise one or more BAV sequence(s) essential for encapsidation, as well as helper virus which express BAV sequences essential for encapsidation. The present invention also provides helper vectors comprising a BAV sequence essential for encapsidation which is used in a helper virus for propagating recombinant adenovirus. The present invention also provides adenovirus expression systems, host cells and compositions comprising adenovirus vectors which comprise modifications in BAV E1 transcriptional control regions. The present invention also provides methods for making adenovirus vectors comprising BAV sequence(s) essential for encapsidation as well as modifications in BAV E1 transcriptional control regions.
摘要翻译：本发明涉及鉴定用于壳化和E1转录控制区必需的牛腺病毒序列。本发明提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，所述腺病毒载体包含一个或多个用于包囊所必需的BAV序列，以及表达对于壳化所必需的BAV序列的辅助病毒。本发明还提供了辅助载体，其包含用于辅助病毒用于繁殖重组腺病毒的壳化所必需的BAV序列。本发明还提供腺病毒表达系统，宿主细胞和包含腺病毒载体的组合物，其包含BAV E1转录控制区域中的修饰。本发明还提供了制备包含BAV序列的腺病毒载体的方法，所述BAV序列对于包囊是必需的，以及在BAV E1转录控制区中的修饰。

8. 发明授权

US07569217B2 Porcine adenovirus E1 and E4 regions 有权
标题翻译：猪腺病毒E1和E4区
公开(公告)号：US07569217B2
公开(公告)日：2009-08-04
申请号：US10199550
申请日：2002-07-19
申请人： Suresh K. Tikoo
发明人： Suresh K. Tikoo
IPC分类号： C12N15/861 , C12N15/34 , C12N15/11 , C12N15/87 , C12N15/90 , C12N15/00 , A61K48/00
CPC分类号： C12N7/00 , A01K2227/108 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10361
摘要： The present invention relates to the characterization of the porcine adenovirus E1 and E4 regions. The complete nucleotide sequence of the genome of porcine adenovirus type 3 (PAV-3), providing the characterization of the PAV3 E1 region, is described herein. Methods for construction of infectious PAV genomes by homologous recombination in procaryotic cells are provided. Recombinant PAV viruses are obtained by transfection of mammalian cells with recombinant PAV genomes. The PAV-3 genome can be used as a vector for the expression of heterologous nucleotide sequences, for example, for the preparation and administration of subunit vaccines to swine or other mammals.
摘要翻译：本发明涉及猪腺病毒E1和E4区域的表征。本文描述了提供PAV3 E1区域表征的猪腺病毒3型（PAV-3）基因组的完整核苷酸序列。提供了在原核细胞中通过同源重组构建感染性PAV基因组的方法。通过用重组PAV基因组转染哺乳动物细胞获得重组PAV病毒。 PAV-3基因组可用作异源核苷酸序列表达的载体，例如用于制备和施用猪或其他哺乳动物的亚单位疫苗。

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