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1. 发明授权

US07361324B2 Precipitated calcium carbonate 失效
标题翻译：沉淀碳酸钙
公开(公告)号：US07361324B2
公开(公告)日：2008-04-22
申请号：US10872903
申请日：2004-06-21
申请人： Sung-Tsuen Liu , Michael Robert Hart
发明人： Sung-Tsuen Liu , Michael Robert Hart
IPC分类号： C01F11/18
CPC分类号： C01F11/181 , C01P2002/76 , C01P2004/03 , C01P2004/51 , C01P2004/61 , C01P2004/62 , D21H19/385 , D21H21/52
摘要： A method for forming calcium carbonate is provided, the method comprising the steps of: (a) milling calcium hydroxide; (b) providing a reactor vessel containing a slurry of the milled calcium hydroxide; and (c) carbonating the slurry of the milled calcium hydroxide by introducing carbon dioxide into the reactor vessel to form basic calcium carbonate by a precipitation reaction, wherein the initial reaction temperature is from about 8° C. to about 15° C.
摘要翻译：提供了形成碳酸钙的方法，该方法包括以下步骤：（a）研磨氢氧化钙; （b）提供含有碾磨的氢氧化钙浆料的反应器容器; 和（c）通过将二氧化碳引入反应器容器中以沉淀反应形成碱式碳酸钙，使研磨的氢氧化钙的淤浆碳酸化，其中初始反应温度为约8℃至约15℃。

2. 发明授权

US08962037B2 Dicalcium phosphate ceramics, dicalcium phosphate/hydroxyapatite biphasic ceramics and method of manufacturing the same 有权
标题翻译：磷酸二钙陶瓷，磷酸二钙/羟基磷灰石双相陶瓷及其制造方法
公开(公告)号：US08962037B2
公开(公告)日：2015-02-24
申请号：US13023318
申请日：2011-02-08
申请人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Wan-Ting Huang
发明人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Wan-Ting Huang
IPC分类号： A01N59/24 , A61K6/083 , C01B15/16 , C04B35/447 , A61L27/12 , A61L27/56 , C01B25/32 , C04B38/04 , C04B111/00
CPC分类号： C04B35/447 , A61L27/12 , A61L27/56 , A61L2430/02 , A61L2430/12 , C01B25/32 , C04B38/04 , C04B2111/00836 , C04B2235/3212 , C04B2235/5427 , C04B2235/606
摘要： The present invention discloses a method of manufacturing pure dicalcium phosphate ceramics or dicalcium phosphate/hydroxyapaite (HA) biphasic ceramics for medical applications in hard tissue areas to be used as implant materials. These ceramic implant materials are in granular form or in block form, and are prepared by using an acidic phosphate compound, a basic calcium phosphate compound comprising HA, and water. The dicalcium phosphate ceramic comprises either dicalcium phosphate dihydrate (CaHPO4.2H2O, DCPD) or dicalcium anhydrous (CaHPO4, DCPA). Wherein, when the acidic phosphate compound is provided in an amount stoichiometrically equal to or in excess relative to the basic calcium phosphate compound, a reaction product is the DCPD or DCPA ceramic; when the acidic phosphate compound is provided in the amount stoichiometrically less than the basic calcium phosphate compound, the reaction product is the DCPD/HA or DCPA/HA biphasic ceramic.
摘要翻译：本发明公开了一种制造纯磷酸二钙陶瓷或磷酸二钙/羟基磷灰石（HA）双相陶瓷的方法，用于在硬组织区域中用作植入材料的医疗应用。这些陶瓷植入材料为颗粒形式或块状，并且通过使用酸性磷酸盐化合物，包含HA的碱式磷酸钙化合物和水来制备。磷酸二钙陶瓷包括磷酸二钙二水合物（CaHPO 4·2H 2 O，DCPD）或无水二钙（CaHPO 4，DCPA）。其中，当酸性磷酸盐化合物以相对于碱式磷酸钙化合物的化学计量等于或过量的量提供时，反应产物是DCPD或DCPA陶瓷; 当酸化磷酸盐化合物以化学计量比碱性磷酸钙化合物的量提供时，反应产物是DCPD / HA或DCPA / HA双相陶瓷。

3. 发明申请

US20050106110A1 Stabilized vaterite 审中-公开
标题翻译：稳定的球ite
公开(公告)号：US20050106110A1
公开(公告)日：2005-05-19
申请号：US10717310
申请日：2003-11-19
申请人： Sung-Tsuen Liu
发明人： Sung-Tsuen Liu
IPC分类号： A61K8/19 , A61Q11/00 , C01F11/18 , C01F5/24 , A61K7/16
CPC分类号： C01F11/183 , A61K8/19 , A61K2800/412 , A61Q11/00 , C01F11/18 , C01F11/185 , C01P2004/50 , C01P2004/61 , C01P2004/62 , C01P2006/21
摘要： A precipitated calcium carbonate provides excellent cleaning properties without being excessively abrasive. The precipitated calcium carbonate has a vaterite crystalline form, a primary particle size of about 0.2 μm to about 3 μm, and an aggregate particle size of less than about 4 μm.
摘要翻译：沉淀碳酸钙提供优异的清洁性能，而不会过度磨蚀。沉淀的碳酸钙具有球霰石结晶形式，初级粒径为约0.2μm至约3μm，骨料粒度小于约4μm。

4. 发明授权

US08414930B2 Surgical calcium phosphate citrate-containing cement and method of manufacturing the same 有权
标题翻译：手术中含磷酸钙的柠檬酸钙水泥及其制造方法相同
公开(公告)号：US08414930B2
公开(公告)日：2013-04-09
申请号：US13004560
申请日：2011-01-11
申请人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
发明人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
IPC分类号： C04B35/00
CPC分类号： A61L24/0084 , A61L24/0015 , A61L24/0042 , A61L24/0089
摘要： The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.
摘要翻译：本发明公开了一种外科手术水泥及其制造方法。手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。

5. 发明授权

US6156117A Polymer structured clay pigment and method of preparing the same 有权
标题翻译：聚合物结构粘土颜料及其制备方法
公开(公告)号：US6156117A
公开(公告)日：2000-12-05
申请号：US144872
申请日：1998-09-01
申请人： Gary M. Freeman , Sung-Tsuen Liu
发明人： Gary M. Freeman , Sung-Tsuen Liu
IPC分类号： C09C1/42 , C09C3/10 , D21H19/40 , C09C1/00 , C09C1/40
CPC分类号： D21H19/40 , C09C1/42 , C09C3/10 , C01P2004/61 , C01P2004/62 , C01P2006/22 , C01P2006/60 , C01P2006/82
摘要： A method of preparing a polymer structured pigment slurry which comprises providing an anionic, aqueous slurry including a plurality of solid mineral particles, adding a low molecular weight, cationic polymer in an amount of less than about 0.20% by weight to the slurry and then adding a small amount of an inorganic dispersant to the polymer treated pigment slurry. The Malvern median particle size of the mineral particles treated with the polycationic polymer is less than about 20% larger than the Malvern median particle size of the untreated mineral particles.
摘要翻译：一种制备聚合物结构颜料浆料的方法，其包括提供包含多个固体矿物颗粒的阴离子水性浆料，向所述浆料中加入少于约0.20重量％的低分子量阳离子聚合物，然后加入少量的无机分散剂用于聚合物处理的颜料浆料。用聚阳离子聚合物处理的矿物颗粒的Malvern中值粒径小于未处理矿物颗粒的Malvern中值粒度的约20％。

6. 发明授权

US5218035A Phosphate-containing surgical cements 失效
标题翻译：含磷酸盐的外科手术水泥
公开(公告)号：US5218035A
公开(公告)日：1993-06-08
申请号：US829891
申请日：1992-02-03
申请人： Sung-Tsuen Liu
发明人： Sung-Tsuen Liu
IPC分类号： A61L24/02 , C04B28/28 , C04B28/34
CPC分类号： A61L24/02 , A61K6/0023 , A61K6/0038 , A61K6/0067 , A61K6/0085 , A61K6/0215 , A61K6/0625 , A61K6/0675 , C04B28/34 , C04B2111/00836
摘要： New surgical cements for use in medical applications such as orthopedic and maxillofacial surgeries and dental applications are disclosed. These surgical cements comprise a hardened cement formed from a mixture comprising a cementing component selected from the group consisting of ceramics having the formulaw(RO)--x(R.sub.2 O)--y(P.sub.2 O.sub.5)--z(X)wherein RO is selected from the group consisting of CaO and mixtures of CaO and MgO, R.sub.2 O is selected from the group consisting of alkali metal oxides and mixtures thereof, X is selected from the group consisting of SO.sub.4 and Cl, and w, x, y and z are the mole fractions of the respective constituents in the ceramic, when X is SO.sub.4, w is in the range of about 0.25 to about 0.5, x is in the range of about 0.05 to about 0.4, y is in the range of about 0.05 to about 0.25 and z is in the range of about 0.01 to about 0.25, and when X is Cl, w is in the range of about 0.25 to about 0.5, x is in the range of about 0.05 to about 0.5, y is in the range of about 0.1 to about 0.25 and z is in the range of about 0.01 to about 0.4 and mixtures thereof; a setting component selected from the group consisting of polyfunctional carboxylic acids containing 2 to about 10 carbon atoms, salts thereof, monobasic phosphate salts and mixtures thereof; and water in an amount effective to form a paste from the mixture which paste hardens into the hardened cement which is biocompatible.
摘要翻译：公开了用于诸如矫形和颌面手术以及牙齿应用的医疗应用的新的外科手术水泥。这些外科手术水泥包括由混合物形成的硬化水泥，所述混合物包含选自具有式w（RO）-x（R2O）-y（P2O5）-z（X）的陶瓷的粘合剂组分，其中RO选自由CaO和CaO和MgO的混合物组成的组，R2O选自碱金属氧化物及其混合物，X选自SO 4和Cl，w，x，y和z是摩尔分数的陶瓷中的各成分，当X是SO 4时，w在约0.25至约0.5的范围内，x在约0.05至约0.4的范围内，y在约0.05至约0.25的范围内，并且z 在约0.01至约0.25的范围内，并且当X是Cl时，w在约0.25至约0.5的范围内，x在约0.05至约0.5的范围内，y在约0.1至约0.25和z在约0.01至约0.4的范围内及其混合物; 选自由2至约10个碳原子的多官能羧酸组成的组的固化组分，其盐，一元磷酸盐及其混合物; 和水，其量有效地从混合物形成糊料，糊料硬化到生物相容的硬化水泥中。

7. 发明授权

US5149368A Resorbable bioactive calcium phosphate cement 失效
标题翻译：可再生生物活性磷酸钙水泥
公开(公告)号：US5149368A
公开(公告)日：1992-09-22
申请号：US639536
申请日：1991-01-10
申请人： Sung-Tsuen Liu , Harvey H. Chung
发明人： Sung-Tsuen Liu , Harvey H. Chung
IPC分类号： A61F2/00 , A61L24/02 , A61L27/12 , C04B28/34
CPC分类号： C04B28/344 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61L24/02 , A61L27/12 , C04B28/34 , A61F2310/00293 , C04B2111/00836
摘要： This invention provides a calcium phosphate cement with relatively high surface pH which is very beneficial from the biocompatibility point of view. When calcium phosphate salts react with an acidic reagent to form cement, it normally involves the dissolution and recrystallization process. The acidity of the setting cements depends strongly on the nature of the calcium phosphate salt used, the acidity of the setting reagent, and the reaction rate. The present invention uses high alkaline calcium phosphate ceramics such as tetracalcium phosphate alone or together with calcium phosphate ceramics such as .alpha.-tricalcium phosphate as base cementing powder to increase the surface pH of the setting cement.
摘要翻译：本发明提供了一种具有相对较高表面pH值的磷酸钙水泥，从生物相容性的角度来看是非常有益的。当磷酸钙盐与酸性试剂反应形成水泥时，通常涉及溶解和重结晶过程。凝固水泥的酸度主要取决于所用磷酸钙盐的性质，凝固剂的酸度和反应速率。本发明使用高碱性磷酸钙陶瓷，例如单独的四磷酸钙或磷酸钙陶瓷如α-磷酸三钙作为基础固结粉，以增加固化水泥的表面pH。

8. 发明授权

US07273596B2 Method of producing granulated anhydrous dicalcium phosphate 失效
标题翻译：造粒无水磷酸二钙的方法
公开(公告)号：US07273596B2
公开(公告)日：2007-09-25
申请号：US11201048
申请日：2005-08-10
申请人： Sung-Tsuen Liu
发明人： Sung-Tsuen Liu
IPC分类号： C01B25/32
CPC分类号： C01B25/322
摘要： A new and useful method of simultaneously producing and granulating anhydrous dicalcium phosphate is provided. Such a method entails the reaction of concentrated phosphoric acid with a powdered material of lime and/or calcium carbonate in substantially equal stoichiometric amounts, with subsequent, mixing, drying, milling, and sieving to provide the correct target particle size range for the resultant granulated materials. Such specifically produced granulated anhydrous dicalcium phosphate materials exhibit very high available calcium levels, excellent flow characteristics, and very high capability for compression into tablets. Products including such particularly produced granulated anhydrous dicalcium phosphate materials are also encompassed within this invention.
摘要翻译：提供了一种同时生产和制粒无水磷酸氢钙的新型有用的方法。这种方法需要浓缩的磷酸与石灰和/或碳酸钙的粉末材料以基本相等的化学计量的量进行反应，随后进行混合，干燥，研磨和筛分以提供所得颗粒状的正确的目标粒度范围材料这种特制的粒状无水磷酸二钙材料表现出非常高的可用钙水平，优异的流动特性和非常高的压缩成片剂的能力。包括这种特别生产的粒状无水磷酸二钙材料的产品也包括在本发明内。

9. 发明授权

US06989142B2 Precipitated calcium carbonate 失效
标题翻译：沉淀碳酸钙
公开(公告)号：US06989142B2
公开(公告)日：2006-01-24
申请号：US10365992
申请日：2003-02-13
申请人： Sung-Tsuen Liu , Michel J. Martin , William C. Fultz , Patrick D. McGill
发明人： Sung-Tsuen Liu , Michel J. Martin , William C. Fultz , Patrick D. McGill
IPC分类号： A61K7/16 , C01B31/24 , C01F5/24 , C01F11/18
CPC分类号： A61Q11/00 , A61K8/19 , A61K2800/412 , C01P2004/03 , C01P2004/50 , C01P2004/61 , C01P2006/22 , C09C1/021
摘要： An abrasive precipitated calcium carbonate is provided that provides excellent cleaning properties without being excessively abrasive or damaging to gums or tooth surfaces. The abrasive, precipitated calcium carbonate has a primary particle size of about 1 μm to about 4 μm, and an aggregate size of about 3 μm to about 10 μm. Also disclosed is a method for forming calcium carbonate comprising the steps of: providing a reaction medium; introducing carbon dioxide and the calcium hydroxide slurry simultaneously into a reaction medium to form calcium carbonate while maintaining constant pH during calcium carbonate precipitation; and optionally drying the calcium carbonate slurry to form a dried calcium carbonate product. Also disclosed is a dentifrice containing the aforementioned abrasive, precipitated calcium, and one or more ingredients selected from the group consisting of humectants, thickening agents, binders, gums, stabilizing agents, antibacterial agents, fluorides, sweeteners, and surfactants.
摘要翻译：提供研磨沉淀碳酸钙，其提供优异的清洁性能，而不会过度磨损或损坏牙龈或牙齿表面。研磨沉淀碳酸钙的初级粒度为约1〜4μm，骨料粒径为3〜10μm左右。还公开了一种形成碳酸钙的方法，包括以下步骤：提供反应介质; 将二氧化碳和氢氧化钙浆料同时引入反应介质中以形成碳酸钙，同时在碳酸钙沉淀过程中保持恒定的pH; 并任选地干燥碳酸钙浆料以形成干燥的碳酸钙产品。还公开了含有上述磨料，沉淀的钙和选自保湿剂，增稠剂，粘合剂，树胶，稳定剂，抗菌剂，氟化物，甜味剂和表面活性剂的一种或多种成分的洁齿剂。

10. 发明授权

US06417166B2 Thin mineralized collagen membrane and method of making same 失效
标题翻译：薄矿化胶原膜及其制备方法
公开(公告)号：US06417166B2
公开(公告)日：2002-07-09
申请号：US09861113
申请日：2001-05-19
申请人： Sung-Tsuen Liu
发明人： Sung-Tsuen Liu
IPC分类号： A61K3801
CPC分类号： A61K38/39 , A61K9/7007 , A61K38/1875 , A61K47/02 , A61L31/127 , A61K2300/00 , C08L89/06
摘要： A strong, thin flexible mineralized collagen membrane is disclosed that is useful for such medical applications as a barrier for guided tissue regeneration, periodontal defect repair, bone grafts and skin wound repair. The mineralized collagen membrane comprises a substantially homogeneous mineralized collagen composite consisting essentially of about 30% to about 70% by weight of a collagen component and about 30% to about 70% by weight of a calcium phosphate minerals component precipitated from a collagen slurry by a soluble calcium ion-containing solution and a soluble phosphate ion-containing solution. The calcium phosphate minerals component has a mole ratio of calcium to phosphate in the range of about 1.0 to about 2.0. The thin mineralized collagen membrane has a bulk density of the membrane of at least about 1.0 g/cm3 and has a thickness not greater than about 0.5 mm and preferably not greater than about 0.3 mm. A corresponding method of making the mineralized collagen membrane includes casting washed mineralized collagen slurry as a thin, flat sheet onto a surface, such as a sieve or filter paper, air drying the sheet and removing it from the surface as the thin mineralized collagen membrane.
摘要翻译：公开了一种强而薄的柔性矿化胶原膜，其可用于诸如用于引导组织再生，牙周缺损修复，骨移植和皮肤伤口修复的屏障的医疗应用。矿化胶原膜包含基本上均匀的矿化胶原复合材料，其基本上由约30％至约70％重量的胶原组分和约30％至约70％重量的由胶原浆液沉淀的磷酸钙矿物质组分可溶性含钙离子溶液和可溶性磷酸根离子溶液。磷酸钙矿物质组分的钙与磷酸盐的摩尔比在约1.0至约2.0的范围内。薄的矿化胶原膜具有至少约1.0g / cm 3的膜的堆积密度，并且具有不大于约0.5mm，优选不大于约0.3mm的厚度。制造矿化胶原膜的相应方法包括将薄的平版胶片作为薄的平版胶片浇注到诸如筛子或滤纸的表面上，将薄片空气干燥并将其从表面除去，作为薄的矿化胶原膜。

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