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1. 发明授权

US4865733A Cell separator device 失效
标题翻译：细胞分离装置
公开(公告)号：US4865733A
公开(公告)日：1989-09-12
申请号：US28571
申请日：1987-03-20
申请人： Sumiaki Tsuru , Shoichi Mori , Noriko Komatsu , Shigeo Fujii
发明人： Sumiaki Tsuru , Shoichi Mori , Noriko Komatsu , Shigeo Fujii
IPC分类号： G01N33/50 , A61K35/14 , B01J20/04 , C12M1/00 , C12M3/00 , C12N5/00 , C12N5/04 , C12N5/06 , C12Q1/04 , C12Q1/24 , D01F9/08 , D01F9/10
CPC分类号： C12Q1/24 , B01J20/048 , B01J20/28004 , B01J20/28028 , B01J20/2803 , B01J20/28052 , B01J20/3042 , B01J20/3078
摘要： A cell separator which can separate cells, especially lymphocytes, with high selectivity and high efficiency without changing the cell population ratio of the cells. The cell separator comprises fibrous material containing fibers including hydroxyl apatite.
摘要翻译：一种细胞分离器，其可以以高选择性和高效率分离细胞，特别是淋巴细胞，而不改变细胞的细胞群比例。细胞分离器包括含有羟基磷灰石的纤维的纤维材料。

2. 发明授权

US5164186A Drug-releaser 失效
标题翻译：药物释放者
公开(公告)号：US5164186A
公开(公告)日：1992-11-17
申请号：US617376
申请日：1990-11-21
申请人： Sumiaki Tsuru , Ichiro Masuno
发明人： Sumiaki Tsuru , Ichiro Masuno
IPC分类号： A61K9/00 , A61K9/20
CPC分类号： A61K9/0024 , A61K9/2009 , A61K9/2027 , A61K9/205
摘要： Disclosed is a drug-releaser comprising a porous body of biocompatibility filled with a medicine. Specifically, such porous body is made of baked calcium phosphate, 2-hydroxyethylmethacrylate, chitin, chitosan or their delivatives. Implantation or artery-injection of such drug-releaser causes a discernible curing effect on affected parts of the living body without causing any irritativeness. The steady release of the medicine from HAP particles to affected parts and the blockade of surrounding capillary vessels leading to such affected parts causes a remarkable tumor inhibitory effect.
摘要翻译：公开了一种药物释放剂，其包含填充有药物的生物相容性的多孔体。具体地说，这种多孔体由焙烧的磷酸钙，甲基丙烯酸2-羟基乙酯，壳多糖，壳聚糖或其衍生物制成。这种药物释放剂的植入或动脉注射对生物体的受影响部位产生明显的固化作用，而不引起任何刺激性。药物从HAP颗粒稳定释放到受影响的部位，以及阻断周围的毛细血管，导致这些受影响的部位导致显着的肿瘤抑制作用。

3. 发明授权

US5085781A Separating agent, separator and method of separating cell or virus 失效
标题翻译：分离剂，分离器和分离细胞或病毒的方法
公开(公告)号：US5085781A
公开(公告)日：1992-02-04
申请号：US486220
申请日：1990-02-28
申请人： Sumiaki Tsuru , Akihiko Yokoo , Takeshi Ichitsuka , Tsuneo Hiraide
发明人： Sumiaki Tsuru , Akihiko Yokoo , Takeshi Ichitsuka , Tsuneo Hiraide
IPC分类号： C12N1/02 , C12N7/02
CPC分类号： C12N7/00 , C12N1/02 , C12N2710/00051 , Y10T436/25375
摘要： A separating agent which includes a polyvinyl acetal resin having open cell structure and an average pore size of from about 10 to about 1000 micrometers; and, porous calcium phosphate granules having open cell structure, and also having two distributions of pore size wherein one distribution has micropores ranging from about 20 to about 500 nm in average pore size and the other distribution has small pores ranging from about 1 to about 50 micrometers in average pore size. Alternatively, the separating agent includes a polyvinyl acetal resin having open cell structure and having an average pore size of from about 10 to about 1000 micrometers as a first element, and a layer of porous calcium phosphate granules having an average granule size of from about 10 to about 2000 micrometers as a second element applied onto the first element. The separating agents may be used in a separator, and may be employed in separating methods. The separating agents, separator, and separating methods can be advantageously used to isolate a target cell or virus from a biological fluid in the fields of medical science and biochemistry. The distribution of target cell or virus subsets is not altered by the separation.
摘要翻译：一种分离剂，其包含具有开孔形式的平均孔径为约10至约1000微米的聚乙烯醇缩醛树脂; 和具有开孔结构的多孔磷酸钙颗粒，并且还具有两个孔径分布，其中一个分布的平均孔径为约20至约500nm的微孔，另一分布具有约1至约50的小孔微米的平均孔径。或者，分离剂包括具有开孔结构并具有作为第一元素的约10至约1000微米的平均孔径的聚乙烯醇缩醛树脂和平均颗粒尺寸为约10的多孔磷酸钙颗粒层至约2000微米，作为施加到第一元件上的第二元件。分离剂可以用于分离器中，并且可以用于分离方法中。分离剂，分离器和分离方法可以有利地用于在医学和生物化学领域从生物流体中分离靶细胞或病毒。目标细胞或病毒子集的分布不会因分离而改变。

4. 发明授权

US5776758A Cysteine protease derived from parasitic helminths 失效
标题翻译：衍生自寄生蠕虫的半胱氨酸蛋白酶
公开(公告)号：US5776758A
公开(公告)日：1998-07-07
申请号：US451409
申请日：1995-05-26
申请人： Fusanori Hamajima , Mikio Yamamoto , Sumiaki Tsuru , Kazuo Yamagami
发明人： Fusanori Hamajima , Mikio Yamamoto , Sumiaki Tsuru , Kazuo Yamagami
IPC分类号： A61K35/56 , A61K38/00 , A61K38/46 , A61P37/06 , C12N1/21 , C12N9/64 , C12N15/09 , C12N15/57 , C12N9/50
CPC分类号： C12N9/641 , A61K38/00
摘要： The immunosuppressive drug of the present invention can suppress both delayed-type hypersensitivity and antibody production against specific antigens and graft tissues and induce immunological tolerance to them by several administrations, instead of long continuous administration. Cysteine protease, a secretory protein accumulated in the tissue of parasitic helminths, is extracted and purified. The cysteine protease is administered to a mammal and then tissue is implanted to the mammal. The immune response of the mammal against the tissue implant is suppressed even one year later.
摘要翻译：本发明的免疫抑制药物可以抑制针对特异性抗原和移植组织的延迟型超敏反应和抗体产生，并且通过多次施用来诱导对它们的免疫耐受性，而不是长时间连续施用。提取并纯化半胱氨酸蛋白酶，其是寄生蠕虫组织中积聚的分泌蛋白质。向哺乳动物施用半胱氨酸蛋白酶，然后将组织植入哺乳动物。哺乳动物对组织植入物的免疫反应甚至在一年后被抑制。

5. 发明授权

US5545240A Deodorants and gas filters therefor 失效
标题翻译：除臭剂和气体过滤器
公开(公告)号：US5545240A
公开(公告)日：1996-08-13
申请号：US388903
申请日：1995-02-14
申请人： Sumiaki Tsuru , Akihiko Yokoo , Takeshi Sakurai , Tetsuro Ogawa
发明人： Sumiaki Tsuru , Akihiko Yokoo , Takeshi Sakurai , Tetsuro Ogawa
IPC分类号： A61L9/01 , B01D39/08 , B01D53/02 , B01D53/04 , B01D53/58 , B01D53/92 , B01J20/04 , B01D45/00
CPC分类号： A61L9/01 , B01D39/086 , B01D53/02 , B01D53/0415 , B01D53/58 , B01D53/922 , B01J20/048 , B01J20/22 , B01J20/28004 , B01J20/28054 , B01J20/28059 , B01J20/3208 , B01J20/3236 , B01D2239/0407 , B01D2239/045 , B01D2239/0457 , B01D2239/0464 , B01D2239/0471 , B01D2239/0618 , B01D2239/0654 , B01D2239/1208 , B01D2239/1241 , B01D2251/404 , B01D2251/61 , B01D2253/104 , B01D2253/106 , B01D2253/108 , B01D2253/25 , B01D2253/304 , B01D2253/308 , B01D2253/311 , B01D2253/342 , B01D2257/502 , B01D2257/702 , B01D2257/90 , B01D2257/91 , B01D2257/93 , B01D2259/4566 , B01D53/0446 , B01J2220/4831 , Y10S55/05 , Y10S55/30
摘要： Deodorant comprising 5 to 100% by weight of a calcium phosphate compound having a molar ratio of Ca/P of 0.8 to 2.0, a deodorant sheet and filter sheet containing such calcium phosphate compound, and a functional paper containing 10 to 80% by weight of a calcium phosphate compound. A filtering medium for an exhaust gas comprises a ceramic material containing 5 to 100% by weight of a calcium phosphate compound, as well as a filter cartridge and exhaust gas filter containing the filtering medium. Based on the excellent properties of the incorporated calcium phosphate compound, the agents and products according to the present invention exhibit a highly improved adsorptivity to oil-soluble substances, odor substances, animal or vegetable cells, viruses, biopolymeric substances or other substances, and therefore can be advantageously used in various fields of technology. For example, the functional paper can be used as a deodorant, filter medium and adsorbent as well as a flame-retardant paper. The filtering medium, filter cartridge and filter can be used in an exhaust system to purify an exhaust gas produced therein.
摘要翻译：包含5至100重量％的Ca / P摩尔比为0.8至2.0的磷酸钙化合物，除臭剂片和含有这种磷酸钙化合物的滤片以及含有10至80重量％的磷酸钙化合物的功能性纸的除臭剂一种磷酸钙化合物。用于排气的过滤介质包括含有5至100重量％的磷酸钙化合物的陶瓷材料，以及包含过滤介质的过滤器滤芯和废气过滤器。基于掺入的磷酸钙化合物的优异性质，根据本发明的试剂和产品显示出对油溶性物质，气味物质，动植物细胞，病毒，生物聚合物或其它物质的吸附性的高度改善，因此可以有利地用于各种技术领域。例如，功能纸可以用作除臭剂，过滤介质和吸附剂以及阻燃纸。过滤介质，滤筒和过滤器可用于排气系统中以净化其中产生的废气。

6. 发明授权

US5352418A Filtering material and method of producing the same 失效
标题翻译：过滤材料及其制造方法
公开(公告)号：US5352418A
公开(公告)日：1994-10-04
申请号：US973010
申请日：1992-11-05
申请人： Sumiaki Tsuru
发明人： Sumiaki Tsuru
IPC分类号： B01D39/00 , B01D39/08 , B01D39/14 , B01D53/04 , B01D53/38 , B01D53/81 , B01J20/04 , B01J20/28 , A62B7/08 , B05D5/00
CPC分类号： B01J20/28033 , B01D39/08 , B01J20/048 , B01J20/28026 , B01J20/2803 , B01J20/3042 , B01J20/3078 , B01J20/3208 , B01J20/3236 , B01D2239/0442 , B01D2239/045 , B01D2239/0471 , B01D2239/0695 , B01D2239/08 , B01D2239/1241
摘要： A filtering material employable for a variety of application fields in the form of a sanitary mask, a deodoring filter or the like comprises calcium phosphate particles, .beta.-1,3-glucan and a band-shaped raw material, and the calcium phosphate particles each serving as a filtering medium are caused to adhere to the sheet-shaped raw material with the aid of the .beta.-1,3-glucan serving as a binder. A method of producing a filtering material is practiced by way of a first step of stirring a predetermined quantity of calcium phosphate particles and a predetermined .beta.-1,3-glucan in hot water at a high speed to prepare an aqueous treatment solution, a second step of dipping a sheet-shaped raw material in the aqueous treatment solution and taking up the sheet-shaped raw material, and a third step of drying the sheet-shaped raw material after completion of the taking-up operation. A second step of spraying the aqueous treatment solution over the sheet-shaped raw material may be substituted for the aforementioned second step. In addition, a step of allowing the aqueous treatment solution to adhere to the sheet-shaped raw material with the aid of a rolling roller may be substituted for the aforementioned second step. An aqueous preliminary treatment solution having a predetermined quantity of .beta.-1,3-glucan uniformly dispersed in hot water may be substituted for the aforementioned aqueous treatment solution. In this case, calcium phosphate particles are caused to adhere to the sheet-shaped raw material before the aqueous preliminary treatment solution is completely dried.
摘要翻译：可用于卫生面罩，除臭过滤器等形式的各种应用领域的过滤材料包括磷酸钙颗粒，β-1,3-葡聚糖和带状原料，每个磷酸钙颗粒在作为粘合剂的β-1,3-葡聚糖的帮助下，作为过滤介质使其粘附在片状原料上。过滤材料的制造方法是通过在高温下搅拌规定量的磷酸钙粒子和规定的β-1,3-葡聚糖的步骤，以高速搅拌，制备水溶液，第二步将片状原料浸渍在水处理液中并卷取片状原料的步骤，以及在完成卷取操作之后干燥片状原料的第三步骤。将水性处理液喷涂在片状原料上的第二工序可以代替上述的第二工序。此外，借助于滚动辊使水溶液粘附到片状原料的步骤可以代替上述第二步骤。将具有均匀分散在热水中的预定量的β-1,3-葡聚糖的预处理水溶液替代上述水处理溶液。在这种情况下，在预处理水溶液完全干燥之前，使磷酸钙颗粒附着在片状原料上。

7. 发明授权

US5296254A Method of producing a filtering material 失效
标题翻译：生产过滤材料的方法
公开(公告)号：US5296254A
公开(公告)日：1994-03-22
申请号：US896042
申请日：1992-06-08
申请人： Sumiaki Tsuru
发明人： Sumiaki Tsuru
IPC分类号： A61L2/16 , A61L9/01 , A61L9/12 , B01D15/00 , B01D39/08 , B01D39/14 , B01D53/04 , B01D53/38 , B01D53/81 , B01J20/04 , B01J20/28 , B05D5/00 , A62B11/00
CPC分类号： B01J20/28033 , B01D39/083 , B01J20/048 , B01J20/28026 , B01J20/2803 , B01J20/3042 , B01J20/3078 , B01J20/3208 , B01J20/3236 , B01D2239/045 , B01D2239/0464 , B01D2239/0478 , B01D2239/0618 , B01D2239/10 , B01D2239/1241
摘要： To produce a filtering material for adsorptively capturing very fine particles such as fungus, pollen, virus, bacteria or the like at a high efficiency, an aqueous treatment solution is first prepared by dissolving porous apatite particles of 0.5 to 40% by weight, preferably, 0.5 to 30% by weight and a water soluble glucan of 0.5 to 15% by weight in water. A sheet-shaped raw material is then coated with the treatment solution with the aid of a rotating drum of which part is always dipped in the treatment solution, and thereafter, the sheet-shaped raw material having the treatment solution coated thereon is dried. Alternatively, an aqueous treatment solution prepared by dissolving only a water soluble glucan of 0.5 to 25% by weight in water may be substituted for the aforementioned aqueous treatment solution. In this case, after a sheet-shaped raw material is coated with the treatment solution, porous apatite particles are deposited on the sheet-shaped raw material by employing a dispersing process or a spraying process before the treatment solution coated on the sheet-shaped raw material is kept still wet. Subsequently, the sheet-shaped raw material having the treatment solution coated thereon and the porous apatite particles deposited thereon is dried.
摘要翻译：为了生产用于高效吸附捕获真菌，花粉，病毒，细菌等非常细小的颗粒的过滤材料，首先通过将0.5至40重量％的多孔磷灰石颗粒溶解， 0.5〜30重量％，水溶性葡聚糖为0.5〜15重量％。然后借助于其中总是浸在处理溶液中的部分的旋转滚筒，用处理溶液涂覆片状原料，然后干燥其上涂有处理液的片状原料。或者，通过仅将0.5〜25重量％的水溶性葡聚糖溶解在水中制备的水性处理溶液可以代替上述水处理溶液。在这种情况下，在用处理液涂布片状原料之后，在涂布在片状原料上的处理液之前，通过使用分散工序或喷涂工序将多孔磷灰石粒子沉积在片状原料上材料保持湿润。随后，将其上涂覆有处理溶液的片状原料和沉积在其上的多孔磷灰石颗粒干燥。

8. 发明授权

US5143752A Filtering material of apatite and glucan used for surgical masks and method of making it 失效
标题翻译：用于手术口罩的磷灰石和葡聚糖的过滤材料及其制备方法
公开(公告)号：US5143752A
公开(公告)日：1992-09-01
申请号：US828359
申请日：1992-01-30
申请人： Tooru Nakajima , Sumiaki Tsuru
发明人： Tooru Nakajima , Sumiaki Tsuru
IPC分类号： A41D13/11 , B01D39/08 , B01D39/20 , B01J20/04 , B01J20/28
CPC分类号： B01J20/2803 , A41D13/11 , B01D39/083 , B01D39/1607 , B01D39/2079 , B01J20/048 , B01J20/22 , B01J20/28026 , B01J20/28028 , B01J20/28033 , B01J20/3208 , B01J20/3236 , B01D2239/0407 , B01D2239/0478 , B01D2239/086 , B01J2220/4831 , Y10T442/2508 , Y10T442/2525
摘要： A filtering material for effectively adsorbing not only conventional foreign material such as dust, odoring gaseous substance but also very fine foreign material such as virus, bacteria, fungus, pollen or the like is disclosed. The filtering material includes as essential components porous apatite particles, a water soluble glucan and a sheet-shaped raw material in which the porous apatite particles are included with the aid of the water soluble glucan serving as a binder. A method of producing a filtering material of the foregoing kind is practiced by way of a step of preparing an aqueous treatment solution in which porous apatite particles of 0.5 to 40% by weight and a water soluble glucan of 0.5 to 15% by weight are dispersively dissolved, a step of immersing a sheet-shaped raw material in the aqueous treatment solution, and a step of drying the sheet-shaped raw material while the porous apatite particles are included in the sheet-shaped raw material with the aid of the water soluble glucan serving as a binder. Alternatively, a step of spraying the aqueous treatment solution to surfaces of a sheet-shaped raw material may be substituted for the step of immersing a sheet-shaped raw material in the aqueous treatment solution. It is preferable from the viewpoint of practice use that the porous apatite particles make up between 0.5 and 30% of the treatment solution.
摘要翻译：公开了一种过滤材料，不仅有效吸附诸如灰尘，气味物质等常规外来物质，而且非常细小的外来物质如病毒，细菌，真菌，花粉等。过滤材料包括作为主要组分的多孔磷灰石颗粒，水溶性葡聚糖和片状原料，其中通过用作粘合剂的水溶性葡聚糖来包含多孔磷灰石颗粒。制备上述过滤材料的方法是通过制备水性处理溶液的步骤，其中将0.5至40重量％的多孔磷灰石颗粒和0.5至15重量％的水溶性葡聚糖分散地溶解，将片状原料浸渍在水性处理液中的工序，使片状原料干燥的工序，同时利用水溶性的方法将多孔磷灰石颗粒包含在片状原料中葡聚糖作为粘合剂。或者，将水性处理液喷射到片状原料的表面的步骤可以代替将片状原料浸渍在水处理溶液中的步骤。从实践的观点出发，优选多孔磷灰石粒子占处理液的0.5〜30％。

9. 发明申请

US20060029627A1 Antipruritic composition and wound-healing-promoting composition 审中-公开
标题翻译：止痒组合物和伤口愈合促进组合物
公开(公告)号：US20060029627A1
公开(公告)日：2006-02-09
申请号：US11249387
申请日：2005-10-14
申请人： Yuuzou Tsuchida , Kotarou Tsuchida , Kenjirou Tsuchida , Sumiaki Tsuru
发明人： Yuuzou Tsuchida , Kotarou Tsuchida , Kenjirou Tsuchida , Sumiaki Tsuru
IPC分类号： A61K36/899
CPC分类号： A61Q19/00 , A61K8/97 , A61K9/06 , A61K36/899 , A61Q17/00
摘要： An antipruritic composition and a wound-healing-promoting composition which comprise Sasa albo-marginata (13ambooseae Sasa) extract in an amount ranging from 1 to 10% by mass as expressed in terms of the solid content thereof. The composition of the present invention comprises the Sasa albo-marginata extract in a concentration substantially higher than that observed for the conventional composition and accordingly, the composition shows high antipruritic effect against skin diseases such as atopy, which have conventionally been considered to be difficult to treat and/or alleviate and the composition likewise shows an excellent wound-healing-promoting effect.
摘要翻译：提取物，其含量为1〜10质量％，其固形物含量为1〜10质量％的沙棘（Sasa albo-limata）（13ambooseae Sasa）提取物的止痒组合物和伤口愈合促进组合物。本发明的组合物包含浓度显着高于常规组合物观察到的莎草精华提取物，因此，该组合物对常规被认为是难以进行的皮肤疾病如特应性显示出高抗止痒作用治疗和/或缓解，并且组合物同样显示出优异的伤口愈合促进作用。

10. 发明授权

US5597619A Filtering material and method of producing the same 失效
标题翻译：过滤材料及其制造方法
公开(公告)号：US5597619A
公开(公告)日：1997-01-28
申请号：US419758
申请日：1995-04-10
申请人： Sumiaki Tsuru
发明人： Sumiaki Tsuru
IPC分类号： A61L2/16 , A61L9/01 , B01D15/00 , B01D39/00 , B01D39/08 , B01D39/14 , B01D39/18 , B01D53/04 , B01D53/38 , B01D53/81 , B01J20/04 , B01J20/28 , B05D5/00 , B05D1/36 , B05D1/40
CPC分类号： B01J20/28033 , B01D39/083 , B01D39/1623 , B01D39/18 , B01J20/048 , B01J20/22 , B01J20/2803 , B01J20/3042 , B01J20/3208 , B01J20/3236 , B01D2239/0442 , B01D2239/0471 , B01D2239/0618 , B01D2239/064 , B01D2239/0695 , B01D2239/08 , B01D2239/10 , B01D2239/1241 , B01J2220/4831
摘要： A filtering material employable as a basic material for a sanitary mask, a deodorizing filter or the like includes as essential components calcium phosphate particles, a water soluble glucan and a sheet-shaped raw material, and the calcium phosphate particles are caused to adhere to the sheet-shaped raw material with the aid of the water soluble glucan serving as a binder. A method of a filtering material is typically practiced by way of a first step of dispersing a predetermined quantity of calcium phosphate particles and a predetermined quantity of water soluble glucan in water to prepare an aqueous treatment solution, a second step of dipping a sheet-shaped raw material in the aqueous treatment solution and taking up the sheet-shaped raw material coated with the aqueous treatment solution and a third step of drying the sheet-shaped raw material coated with the aqueous treatment solution. The method of producing a filtering material may be practiced by way of a first step of dissolving a predetermined quantity of water soluble glucan in water to prepare an aqueous preliminary treatment solution, a second step of adhering the aqueous preliminary treatment solution to a sheet-shaped raw material, a third step of adhering calcium phosphate particles to the sheet-shaped raw material before the sheet-shaped raw material having the aqueous preliminary treatment solution adhering thereto is completely dried, and a fourth step of drying the sheet-shaped raw material.
摘要翻译：可用作卫生罩，除臭过滤器等的基本材料的过滤材料包括作为必需组分的磷酸钙颗粒，水溶性葡聚糖和片状原料，并且使磷酸钙颗粒粘附到借助水溶性葡聚糖作为粘合剂的片状原料。过滤材料的方法通常通过将预定量的磷酸钙颗粒和预定量的水溶性葡聚糖分散在水中的第一步骤来制备水处理溶液，第二步是将片状处理水溶液中的原料，并浸渍涂布有水处理溶液的片状原料，以及干燥涂布有水性处理溶液的片状原料的第三工序。过滤材料的制造方法可以通过将规定量的水溶性葡聚糖溶解在水中而制备水性预处理溶液的第一工序来实施，第二工序是将水性预处理液粘接到片状原料，在将具有附着有预处理水溶液的片状原料完全干燥之前，将磷酸钙颗粒粘附到片状原料的第三步骤，以及干燥片状原料的第四步骤。

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