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1. 发明授权

US07892854B2 Multianalyte molecular analysis using application-specific random particle arrays 有权
标题翻译：使用应用特异性随机粒子阵列进行多分析分析
公开(公告)号：US07892854B2
公开(公告)日：2011-02-22
申请号：US10204799
申请日：2001-06-21
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kairali Podual , Chiu W. Chau
IPC分类号： G01N33/553 , C12Q1/68
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

2. 发明申请

US20080241936A1 Multianalyte Molecular Analysis Using Application-Specific Random Particle Arrays 审中-公开
标题翻译：使用应用特定随机粒子数组的多分析分子分析
公开(公告)号：US20080241936A1
公开(公告)日：2008-10-02
申请号：US11754558
申请日：2007-05-30
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kariali Podual , Chiu W. Chau , Zhi Li
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li , Kariali Podual , Chiu W. Chau , Zhi Li
IPC分类号： G01N35/00
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence of association, the strength of association, and/or the rate of association and dissociation governing the binding interactions between the binding agents and the analyte molecules. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了用于以生物测定形式应用颗粒阵列以在两类分子（分析物和结合剂）之间进行定性和/或定量分子相互作用分析的方法和装置。本文公开的方法和装置允许确定结合剂和分析物分子之间的结合相互作用的存在或不存在，缔合的强度，和/或缔合速率和解离速率。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

3. 发明授权

US08486720B2 Arrays of magnetic particles 有权
标题翻译：磁性粒子阵列
公开(公告)号：US08486720B2
公开(公告)日：2013-07-16
申请号：US10910460
申请日：2004-08-03
申请人： Sukanta Banerjee , Michael Seul , Alice X. Li
发明人： Sukanta Banerjee , Michael Seul , Alice X. Li
IPC分类号： G01N33/553
CPC分类号： C12Q1/6813 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00497 , B01J2219/005 , B01J2219/00527 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , C12Q1/6837 , C12Q1/6876 , G01N27/745 , G01N33/5434 , G01N33/54346 , G01N33/587 , G01N2035/00564 , G01N2035/00762 , G01N2446/20 , G01N2446/64 , Y10T436/11 , C12Q2565/513 , C12Q2563/143 , C12Q2563/107 , C12Q2563/155
摘要： The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
摘要翻译：本发明提供了一种通过产生磁性纳米颗粒和编码颗粒的新型亚文库从子文库生成新的编码磁性颗粒文库的方法。子库根据需要进行功能化在数组的形成中是有用的。本发明特别可用于进行多个（并行）测定以定性和/或定量分析样品中许多分析物分子的结合相互作用。

4. 发明授权

US06958245B2 Array cytometry 失效
标题翻译：阵列细胞计数
公开(公告)号：US06958245B2
公开(公告)日：2005-10-25
申请号：US09995894
申请日：2001-11-28
申请人： Michael Seul , Alice X. Li
发明人： Michael Seul , Alice X. Li
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C12Q1/68 , G01N15/14 , G01N33/543 , G02B3/00 , G21K1/00 , H05H3/04 , G01N33/546
CPC分类号： G02B3/0056 , B01J19/0046 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01L3/50273 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , B01L2400/0454 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , G01N15/1463 , G01N33/54313 , G01N2015/149 , G02B3/0012 , H05H3/04 , Y10T436/25125 , C12Q2565/501 , C12Q2563/155 , C12Q2565/607
摘要： A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements, the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.
摘要翻译：一种用于在诸如氧化硅的绝缘电极和电解质溶液之间的界面处操作胶体颗粒和生物分子的方法和装置。表面附近颗粒的光控电动组装取决于三个功能元素的组合，即AC电场引起的平面聚集体的组装; 电解质/氧化硅/硅界面的图案化以在组装过程上施加空间控制; 并通过外部照明实现对装配过程的实时控制。本发明提供一组基本操作，使得能够对几种类型的颗粒和生物分子的平面阵列的创建和放置以及阵列形状和尺寸的操纵进行交互式控制。本发明使得能够以阵列格式进行诊断测定和生化分析的样品制备和处理以及这些操作的功能整合。此外，本发明提供了用于产生具有所需性质的材料表面和用于制造表面安装光学部件的步骤。本发明还涉及一种方法和装置，以响应于时间和空间上变化的电场以及投射的照明模式，引导横向运动并将组件引导到半导体表面上的平面阵列阵列。

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