专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130053913A1 Method and System to Adjust Pacing Parameters Based on Systolic Interval Heart Sounds 审中-公开
标题翻译：基于收缩期间心脏声音调整起搏参数的方法和系统
公开(公告)号：US20130053913A1
公开(公告)日：2013-02-28
申请号：US13223117
申请日：2011-08-31
申请人： Steve Koh , Gene A. Bornzin , Jeffery D. Snell
发明人： Steve Koh , Gene A. Bornzin , Jeffery D. Snell
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B7/00 , A61B7/04 , A61N1/36585
摘要： A method is provided to determine pacing parameters for an implantable medical device (IMD) and collects heart sounds during the cardiac cycles. The method comprises changing a value for a pacing parameter between the cardiac cycles and analyzing a characteristic of interest from the heart sounds. The method comprises setting a desired value for the pacing parameter based on the characteristic of interest from the heart sounds. The system comprises inputs configured to be coupled to at least one lead having electrodes to sense intrinsic events and to deliver pacing pulses over cardiac cycles. The system has a sensor for collecting heart sounds during cardiac cycles and controller to control delivery of pacing pulses based on pacing parameters. The controller changes a value for at least one of the pacing parameters between the cardiac cycles and provides an analysis module to analyze a characteristic of interest from the heart sounds.
摘要翻译：提供了一种用于确定可植入医疗装置（IMD）的起搏参数并在心脏周期期间收集心脏声音的方法。该方法包括在心脏周期之间改变起搏参数的值并且从心脏声音分析感兴趣的特征。该方法包括基于来自心音的感兴趣的特征来设置起搏参数的期望值。该系统包括被配置为耦合到具有电极以感测固有事件并且在心动周期上传送起搏脉冲的至少一个引线的输入。该系统具有用于在心动周期期间收集心脏声音的传感器和控制器，以根据起搏参数控制起搏脉冲的传递。控制器改变心脏周期之间的至少一个起搏参数的值，并提供分析模块来分析来自心脏声音的兴趣特征。

2. 发明授权

US08032212B2 System and method for monitoring thoracic fluid levels based on impedance using an implantable medical device 失效
标题翻译：使用可植入医疗装置基于阻抗监测胸水液位的系统和方法
公开(公告)号：US08032212B2
公开(公告)日：2011-10-04
申请号：US12210848
申请日：2008-09-15
申请人： Gene A. Bornzin , Steve Koh , Euljoon Park
发明人： Gene A. Bornzin , Steve Koh , Euljoon Park
IPC分类号： A61B5/02 , A61B5/08 , A61B5/05 , A61N1/00
CPC分类号： A61N1/36521 , A61B5/0537 , A61B5/4869
摘要： Techniques are provided for monitoring thoracic fluid levels based on thoracic impedance (ZT) and cardiogenic impedance (ZC). In one example, the implantable device tracks the maximum time rate of change in cardiogenic impedance (i.e. max(dZC/dt)) to detect trends toward hypervolemic or hypovolemic states within the patient based on changes in heart contractility. The detection of these trends in combination with trends in thoracic impedance allows for a determination of whether the thoracic cavity of the patient is generally “too wet” or “too dry,” and thus allows for the titration of diuretics to avoid such extremes. In particular, a decrease in thoracic impedance (ZT) in combination with a decrease in max (dZC/dt) is indicative of the thorax being “too wet” (i.e. a fluid overload). Conversely, an increase in thoracic impedance (ZT) in combination with a decrease in max (dZC/dt) is indicative of the thorax being “too dry” (i.e. a fluid underload).
摘要翻译：提供了基于胸部阻抗（ZT）和心源阻抗（ZC）监测胸水水平的技术。在一个示例中，可植入装置跟踪心源性阻抗的最大时间变化率（即max（dZC / dt）），以基于心脏收缩力的变化来检测患者内的高血容量或低血容量状态的趋势。这些趋势的检测结合胸部阻抗趋势可以确定患者的胸腔通常是否“太湿”或“太干”，从而允许滴定利尿剂以避免这种极端。特别地，胸部阻抗（ZT）的降低与最大值（dZC / dt）的降低相结合表明胸部“太湿”（即流体过载）。相反，胸部阻抗（ZT）的增加与最大（dZC / dt）的降低相结合，表明胸部“太干”（即，流体欠载）。

3. 发明申请

US20100069778A1 SYSTEM AND METHOD FOR MONITORING THORACIC FLUID LEVELS BASED ON IMPEDANCE USING AN IMPLANTABLE MEDICAL DEVICE 失效
标题翻译：基于使用可植入医疗器械的阻抗监测胸腔液体水平的系统和方法
公开(公告)号：US20100069778A1
公开(公告)日：2010-03-18
申请号：US12210848
申请日：2008-09-15
申请人： Gene A. Bornzin , Steve Koh , Euljoon Park
发明人： Gene A. Bornzin , Steve Koh , Euljoon Park
IPC分类号： A61B5/053
CPC分类号： A61N1/36521 , A61B5/0537 , A61B5/4869
摘要： Techniques are provided for monitoring thoracic fluid levels based on thoracic impedance (ZT) and cardiogenic impedance (ZC). In one example, the implantable device tracks the maximum time rate of change in cardiogenic impedance (i.e. max(dZC/dt)) to detect trends toward hypervolemic or hypovolemic states within the patient based on changes in heart contractility. The detection of these trends in combination with trends in thoracic impedance allows for a determination of whether the thoracic cavity of the patient is generally “too wet” or “too dry,” and thus allows for the titration of diuretics to avoid such extremes. In particular, a decrease in thoracic impedance (ZT) in combination with a decrease in max (dZC/dt) is indicative of the thorax being “too wet” (i.e. a fluid overload). Conversely, an increase in thoracic impedance (ZT) in combination with a decrease in max (dZC/dt) is indicative of the thorax being “too dry” (i.e. a fluid underload).
摘要翻译：提供了基于胸部阻抗（ZT）和心源阻抗（ZC）监测胸水水平的技术。在一个示例中，可植入装置跟踪心源性阻抗的最大时间变化率（即max（dZC / dt）），以基于心脏收缩力的变化来检测患者内的高血容量或低血容量状态的趋势。这些趋势的检测结合胸部阻抗的趋势可以确定患者的胸腔通常是否“太湿”或“太干”，从而允许滴定利尿剂以避免这种极端。特别地，胸部阻抗（ZT）的降低与最大值（dZC / dt）的降低相结合表明胸部“太湿”（即流体过载）。相反，胸部阻抗（ZT）的增加与最大（dZC / dt）的降低相结合，表明胸部“太干”（即，流体欠载）。

4. 发明授权

US07149579B1 System and method for determining patient posture based on 3-D trajectory using an implantable medical device 有权
标题翻译：使用可植入医疗装置的基于3D轨迹确定患者姿势的系统和方法
公开(公告)号：US07149579B1
公开(公告)日：2006-12-12
申请号：US10329233
申请日：2002-12-23
申请人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
发明人： Steve Koh , Mark W. Kroll , Euljoon Park , Gene A. Bornzin
IPC分类号： A61N1/00
CPC分类号： A61N1/3925 , A61N1/36535 , A61N1/36542
摘要： Time-varying spatial signals are detected by accelerometers mounted within the patient. The signals, representative of the actual 3-D trajectory of the patient, are compared with information representative of expected trajectories retrieved from memory to identify a current patient posture, which may be either a dynamic posture such as walking or running or a change in posture such as rising from a seated position to a standing position. In this manner, a change in posture of the patient is identified based upon a full 3-D trajectory, rather than merely the orientation of the patient at the beginning and the end of the change in posture. In an example described herein, the implantable device stores information representative of expected 3-D trajectories in the form of pre-calculated comparison matrices derived from orthonormal kernels employing Laguerre functions or Lagrange functions. A technique is also described for use by an external programmer for pre-calculating comparison matrices so as to reduce the processing burden within the implanted device during posture detection.
摘要翻译：时变空间信号由安装在患者体内的加速度计检测。将代表患者的实际3-D轨迹的信号与表示从存储器检索到的预期轨迹的信息进行比较，以识别当前患者姿势，其可以是动态姿势，例如步行或跑步或姿势变化例如从就座位置升高到站立位置。以这种方式，基于完整的3-D轨迹来识别患者姿势的变化，而不仅仅是患者在姿势改变的开始和结束时的取向。在本文所描述的示例中，可植入装置以使用拉格朗日函数或拉格朗日函数的从正常内核导出的预先计算的比较矩阵的形式存储表示预期3-D轨迹的信息。还描述了一种用于外部编程器用于预计算比较矩阵的技术，以便在姿势检测期间减少植入装置内的处理负担。

5. 发明授权

US06928324B2 Stimulation device for sleep apnea prevention, detection and treatment 失效
标题翻译：睡眠呼吸暂停预防，检测和治疗的刺激装置
公开(公告)号：US06928324B2
公开(公告)日：2005-08-09
申请号：US10077048
申请日：2002-02-14
申请人： Euljoon Park , Steve Koh , Gene A. Bornzin
发明人： Euljoon Park , Steve Koh , Gene A. Bornzin
IPC分类号： A61N1/36 , A61N1/365
CPC分类号： A61N1/36585 , A61N1/3601 , A61N1/36542 , A61N1/36557
摘要： An implantable cardiac stimulation device comprises a metabolic demand sensor, an activity sensor, and one or more pulse generators. The metabolic demand sensor and activity sensor can sense metabolic demand and physical activity parameters, respectively. The pulse generators can generate cardiac pacing pulses with timing based on a comparison of the metabolic demand and physical activity parameters. The timed cardiac pacing pulses can prevent a sleep apnea condition.
摘要翻译：可植入心脏刺激装置包括代谢需求传感器，活动传感器和一个或多个脉冲发生器。代谢需求传感器和活动传感器可以分别感测代谢需求和身体活动参数。基于代谢需求和身体活动参数的比较，脉冲发生器可以产生具有定时的心脏起搏脉冲。定时的心脏起搏脉冲可以防止睡眠呼吸暂停状态。

6. 发明授权

US08731665B1 Posture detection using pressure and other physiologic sensors 有权
标题翻译：使用压力和其他生理传感器的姿势检测
公开(公告)号：US08731665B1
公开(公告)日：2014-05-20
申请号：US11923286
申请日：2007-10-24
申请人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
发明人： Xiaoyi Min , Laleh Jalali , Steve Koh , Gene A. Bornzin , Euljoon Park
IPC分类号： A61N1/00
CPC分类号： A61N1/365 , A61N1/36535
摘要： Systems and methods are provided for detecting the orientation and/or movement of a patient having an implantable cardiac stimulation device and evaluating whether a change in the patient's cardiac activity can be at least in part due to a change in the patient's orientation. In one particular embodiment, signals from an orientation sensor and/or a pressure sensor are evaluated to determine static positional orientation of the patient and determine based on the static orientation whether the patient's cardiac activity is abnormal.
摘要翻译：提供了用于检测具有可植入心脏刺激装置的患者的取向和/或运动的系统和方法，并且评估患者的心脏活动的变化是否可以至少部分地由于患者取向的改变而变化。在一个特定实施例中，评估来自定向传感器和/或压力传感器的信号以确定患者的静态位置取向，并且基于静态取向来确定患者的心脏活动是否异常。

7. 发明申请

US20130053912A1 SYSTEMS AND METHODS FOR ASSESSING HEART FAILURE AND CONTROLLING CARDIAC RESYNCHRONIZATION THERAPY USING HYBRID IMPEDANCE MEASUREMENT CONFIGURATIONS 有权
标题翻译：用于评估心脏衰竭和控制使用混合阻抗测量配置的心脏再生治疗的系统和方法
公开(公告)号：US20130053912A1
公开(公告)日：2013-02-28
申请号：US13217554
申请日：2011-08-25
申请人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
发明人： Gene A. Bornzin , Xiaoyi Min , Laurence S. Sloman , Steve Koh
IPC分类号： A61N1/368
CPC分类号： A61B5/053 , A61B5/0205 , A61B5/0538 , A61B5/686 , A61N1/36185 , A61N1/3627 , A61N1/3686
摘要： Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.
摘要翻译：提供技术用于可植入医疗装置，用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗（CRT）。混合配置利用基于右心房（RA）的阻抗测量向量和/或左心室（LV））的阻抗测量向量。在一个示例中，电流注入到装置壳体和右心室（RV）或RA中的环形电极之间。基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。以这种方式，利用多个混合阻抗测量配置，由此使用不同的矢量来注入电流并测量阻抗。

8. 发明申请

US20120215274A1 ACCELEROMETER ENHANCED IMPLANTABLE CARDIO-DEVICE 审中-公开
标题翻译：加速度计增强型可携带的设备
公开(公告)号：US20120215274A1
公开(公告)日：2012-08-23
申请号：US13032509
申请日：2011-02-22
申请人： Steve Koh , Gene A. Bornzin
发明人： Steve Koh , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/36578
摘要： An implantable medical device (“IMD”) processes and analyzes valuable clinical information regarding cardiac performance. A database or correlator is pre-customized to the specific patient, by correlating signals received by a remote accelerometer associated with heart movements with accurate heart sounds recorded from a microphone to provide a more effective and customized basis for estimating heart sound. The information is then used to better control an implantable medical device.
摘要翻译：可植入医疗设备（“IMD”）处理和分析有关心脏性能的有价值的临床信息。通过将与心脏移动相关联的远程加速度计所接收的信号与从麦克风记录的精确心脏声音相关联，以提供用于估计心脏声音的更有效和定制的基础，将数据库或相关器预先定制到特定患者。然后将该信息用于更好地控制可植入医疗装置。

9. 发明申请

US20120190991A1 System and Method for Detecting a Clinically-Significant Pulmonary Fluid Accumulation Using an Implantable Medical Device 审中-公开
标题翻译：使用可植入医疗器械检测临床上重要的肺液积聚的系统和方法
公开(公告)号：US20120190991A1
公开(公告)日：2012-07-26
申请号：US13012595
申请日：2011-01-24
申请人： Gene A. Bornzin , Steve Koh , James S. Whiting , Neal L. Eigler , Brian M. Mann
发明人： Gene A. Bornzin , Steve Koh , James S. Whiting , Neal L. Eigler , Brian M. Mann
IPC分类号： A61B5/021
CPC分类号： A61B5/4878 , A61B5/0215 , A61B5/686
摘要： Techniques are provided for detecting a clinically-significant pulmonary fluid accumulation within a patient using a pacemaker or other implantable medical device. Briefly, the device detects left atrial pressure (LAP) within the patient and tracks changes in the LAP values over time that are indicative of possible pulmonary fluid accumulation within the patient. The device determines whether the changes in LAP values are sufficiently elevated and prolonged to warrant clinical intervention using, e.g., a predictor model-based technique. If the fluid accumulation is clinically significant, the device then generates warning signals, records diagnostics, controls therapy and/or titrates diuretics. False positive detections of pulmonary edema due to transients in LAP are avoided with this technique. Pulmonary artery pressure (PAP)-based techniques are also described.
摘要翻译：提供技术用于使用起搏器或其他可植入医疗装置来检测患者内的临床上重要的肺液积聚。简而言之，该装置检测患者内的左心房压力（LAP），跟踪随时间推移的LAP值的变化，其指示患者内可能的肺液体积聚。该装置使用例如基于预测器模型的技术来确定LAP值的变化是否足够提高和延长以保证临床干预。如果液体积聚在临床上显着，那么该装置然后产生警告信号，记录诊断，控制治疗和/或滴定利尿剂。用这种技术避免了由于LAP瞬变引起的肺水肿的虚假阳性检测。还描述了基于肺动脉压（PAP）的技术。

10. 发明申请

US20130103108A1 METHOD AND APPARATUS TO INCREASE STROKE VOLUME BY SYNCHRONIZING / MODULATING HEART RATE WITH ACTIVITY RATE 审中-公开
标题翻译：通过同步/调节心跳速率来提高运动量的方法和装置
公开(公告)号：US20130103108A1
公开(公告)日：2013-04-25
申请号：US13277020
申请日：2011-10-19
申请人： Steve Koh , Gene A. Bornzin
发明人： Steve Koh , Gene A. Bornzin
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36542
摘要： A method of synchronizing a heart rate with an activity rate of a patient includes determining the activity rate of the patient. The method also includes synchronizing a pacing pulse with a phase of the activity rate to improve a cardiac stroke volume of the patient. The synchronizing includes lowering the heart rate during down motion associated with the activity rate and increasing the heart rate during an up motion associated with the activity rate when a stride rate is slower than a target heart rate.
摘要翻译：将心率同步于患者的活动率的方法包括确定患者的活动率。该方法还包括将起搏脉冲与活动率的相位同步以改善患者的心脏搏动量。同步包括在与活动速率相关联的下降运动期间降低心率，并且当步幅率低于目标心率时，在与活动速率相关联的向上运动期间增加心率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式