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1. 发明申请

US20120190991A1 System and Method for Detecting a Clinically-Significant Pulmonary Fluid Accumulation Using an Implantable Medical Device 审中-公开
标题翻译：使用可植入医疗器械检测临床上重要的肺液积聚的系统和方法
公开(公告)号：US20120190991A1
公开(公告)日：2012-07-26
申请号：US13012595
申请日：2011-01-24
申请人： Gene A. Bornzin , Steve Koh , James S. Whiting , Neal L. Eigler , Brian M. Mann
发明人： Gene A. Bornzin , Steve Koh , James S. Whiting , Neal L. Eigler , Brian M. Mann
IPC分类号： A61B5/021
CPC分类号： A61B5/4878 , A61B5/0215 , A61B5/686
摘要： Techniques are provided for detecting a clinically-significant pulmonary fluid accumulation within a patient using a pacemaker or other implantable medical device. Briefly, the device detects left atrial pressure (LAP) within the patient and tracks changes in the LAP values over time that are indicative of possible pulmonary fluid accumulation within the patient. The device determines whether the changes in LAP values are sufficiently elevated and prolonged to warrant clinical intervention using, e.g., a predictor model-based technique. If the fluid accumulation is clinically significant, the device then generates warning signals, records diagnostics, controls therapy and/or titrates diuretics. False positive detections of pulmonary edema due to transients in LAP are avoided with this technique. Pulmonary artery pressure (PAP)-based techniques are also described.
摘要翻译：提供技术用于使用起搏器或其他可植入医疗装置来检测患者内的临床上重要的肺液积聚。简而言之，该装置检测患者内的左心房压力（LAP），跟踪随时间推移的LAP值的变化，其指示患者内可能的肺液体积聚。该装置使用例如基于预测器模型的技术来确定LAP值的变化是否足够提高和延长以保证临床干预。如果液体积聚在临床上显着，那么该装置然后产生警告信号，记录诊断，控制治疗和/或滴定利尿剂。用这种技术避免了由于LAP瞬变引起的肺水肿的虚假阳性检测。还描述了基于肺动脉压（PAP）的技术。

2. 发明授权

US07402899B1 Hermetically sealable silicon system and method of making same 有权
标题翻译：密封硅系统及其制作方法
公开(公告)号：US07402899B1
公开(公告)日：2008-07-22
申请号：US11622647
申请日：2007-01-12
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： H01L21/30
CPC分类号： H01L23/10 , B81B7/0077 , H01L2924/0002 , H01L2924/01079 , H01L2924/09701 , H01L2924/00
摘要： A device and method for hermetically sealing a medical device is provided. In one aspect, a silicon device is coupled to a sensor, such as a pressure transducer, which benefits from having direct contact with its environment, which in many cases, is the human body. Thus, a method to hermetically seal the non-sensing portion of a silicon device while allowing the sensing portion (e.g. the pressure transducer) to have direct contact with the body is provided. In one aspect, a silicon chip, a gold preform and a metallic housing are each primed for sealing and are assembled. The assembly is then heated to react the gold preform to the silicon chip and to form a molten gold-silicon alloy in-situ to bind the metallic housing to the non-sensing portion of the silicon chip. In this way, the non-sensing portion of the silicon chip is hermetically sealed and protected from exposure, while still permitting exposure of the sensing portion to the environment.
摘要翻译：提供一种用于密封医疗装置的装置和方法。在一个方面，硅器件耦合到诸如压力传感器的传感器，其受益于与其环境的直接接触，其在许多情况下是人体。因此，提供了一种使允许感测部分（例如压力传感器）与身体直接接触的硅器件的非感测部分密封的方法。在一个方面，硅芯片，金预成型件和金属外壳各自用于密封并组装。然后将组件加热以使金预成型件与硅芯片反应，并原位形成熔融的金 - 硅合金，以将金属外壳固定到硅芯片的非感测部分。以这种方式，硅芯片的非感测部分被气密地密封并防止暴露，同时仍然允许感测部分暴露于环境中。

3. 发明授权

US09060696B2 Implantable pressure transducer system optimized to correct environmental factors 有权
标题翻译：植入式压力传感器系统优化，以纠正环境因素
公开(公告)号：US09060696B2
公开(公告)日：2015-06-23
申请号：US11116138
申请日：2005-04-27
申请人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
发明人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
IPC分类号： A61B5/0215 , A61M25/04 , A61M25/02
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.
摘要翻译：本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

4. 发明授权

US08303511B2 Implantable pressure transducer system optimized for reduced thrombosis effect 有权
标题翻译：植入式压力传感器系统优化减少血栓形成的作用
公开(公告)号：US08303511B2
公开(公告)日：2012-11-06
申请号：US11111691
申请日：2005-04-21
申请人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
发明人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
IPC分类号： A61B5/02 , A61B5/00 , A61M31/00
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures are also provided.
摘要翻译：本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

5. 发明申请

US20120035590A1 SYSTEM AND METHOD FOR MANIPULATING INSERTION PATHWAYS FOR ACCESSING TARGET SITES 有权
标题翻译：用于操纵目标站点的插入路径的系统和方法
公开(公告)号：US20120035590A1
公开(公告)日：2012-02-09
申请号：US13248922
申请日：2011-09-29
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： A61M25/09
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.
摘要翻译：提供了一种通过将导丝从身体上的初始插入位置传递到身体上的不同插入位置来访问身体中的目标部位的方法。一方面，还提供了用于将诸如传感器引线的医疗装置或部件从初始插入位置转移到另一插入位置的方法。提供了足够的长度，柔软度和变形性的导线，以执行从一个插入位点到另一个插入位点的转移。在一个方面，导丝包括可移除的芯心，以增加刚性，便于插入和/或提高可操纵性。还提供了一种套件或系统，其包括用于执行导丝或设备转移的导引器，导线和导管。

6. 发明申请

US20120041422A1 SYSTEM AND METHOD FOR MANIPULATING INSERTION PATHWAYS FOR ACCESSING TARGET SITES 审中-公开
公开(公告)号：US20120041422A1
公开(公告)日：2012-02-16
申请号：US13248938
申请日：2011-09-29
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： A61M25/09
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.

7. 发明授权

US07509169B2 Implantable pressure transducer system optimized for anchoring and positioning 有权
标题翻译：植入式压力传感器系统优化锚固和定位
公开(公告)号：US07509169B2
公开(公告)日：2009-03-24
申请号：US11115991
申请日：2005-04-27
申请人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
发明人： Neal L. Eigler , Brian M. Mann , James S. Whiting , Werner Hafelfinger
IPC分类号： A61N1/00
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/042 , A61B5/6869 , A61B8/12 , A61B17/3468 , A61M25/0108 , A61M25/04 , A61M31/002 , A61M2025/0233 , A61N1/362 , A61N2001/0578
摘要： This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.
摘要翻译：本发明一般涉及用于优化性能并最小化与诸如压力传感器的植入传感器有关的并发症的系统和方法，以便在医疗患者中检测，诊断和治疗心血管疾病。还提供了用于将植入的传感器锚定到各种身体结构的系统和方法。

8. 发明授权

US08142363B1 Cardiac rhythm management lead with omni-directional pressure sensing 有权
标题翻译：心律管理带领全方位压力感应
公开(公告)号：US08142363B1
公开(公告)日：2012-03-27
申请号：US11776225
申请日：2007-07-11
申请人： Neal L. Eigler , James S. Whiting , Brian M. Mann , Werner Hafelfinger , Xiangqun Chen , Phong D. Doan
发明人： Neal L. Eigler , James S. Whiting , Brian M. Mann , Werner Hafelfinger , Xiangqun Chen , Phong D. Doan
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61B5/042 , A61B5/0215 , A61B5/0468 , A61B5/686 , A61B5/6882 , A61B5/6885 , A61B2562/0247 , A61N1/056 , A61N1/36564
摘要： Embodiments include a cardiac rhythm management system having a lead that includes an omni-directional pressure sensor that is configured to resist tissue in-growth and provide reliable and consistent pressure readings from within a patient's vasculature. Embodiments of the cardiac rhythm management lead may also include a variety of pacing and shocking electrodes.
摘要翻译：实施例包括具有引线的心律管理系统，其包括全向压力传感器，其被配置为抵抗组织生长并且提供来自患者脉管系统内的可靠且一致的压力读数。心律管理引线的实施例还可以包括各种起搏和震动电极。

9. 发明申请

US20120046528A1 SYSTEM AND METHOD FOR DETECTING AND TREATING CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于检测和治疗心血管疾病的系统和方法
公开(公告)号：US20120046528A1
公开(公告)日：2012-02-23
申请号：US12857914
申请日：2010-08-17
申请人： Neal L. Eigler , James S. Whiting , Brian M. Mann
发明人： Neal L. Eigler , James S. Whiting , Brian M. Mann
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/0538 , A61B5/021
摘要： A system for detecting and treating congestive heart failure includes an implantable module, such as a pacemaker, and a patient advisory module. The system is configured to measure thoracic impedance and to provide the patient with instructions in order to improve the accuracy of the thoracic impedance measurement as well as treating symptoms of congestive heart failure.
摘要翻译：用于检测和治疗充血性心力衰竭的系统包括诸如起搏器的可植入模块和患者咨询模块。该系统被配置为测量胸部阻抗并向患者提供指令，以便提高胸部阻抗测量的准确性以及治疗充血性心力衰竭的症状。

10. 发明授权

US08235916B2 System and method for manipulating insertion pathways for accessing target sites 有权
标题翻译：用于操作用于访问目标站点的插入路径的系统和方法
公开(公告)号：US08235916B2
公开(公告)日：2012-08-07
申请号：US13248922
申请日：2011-09-29
申请人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
发明人： James S. Whiting , Neal L. Eigler , Brian M. Mann , Werner Hafelfinger
IPC分类号： A61B5/00 , A61B19/00 , A61M31/00 , A61M37/00 , A61M1/00
CPC分类号： A61B17/3468 , A61B2017/00243 , A61M25/01 , A61M25/09 , A61M2025/0681 , A61N1/056
摘要： A method for accessing a target site in the body by transferring a guidewire from an initial insertion site on the body to a different insertion site on the body is provided. In one aspect, a method for transferring a medical device or component, such as a sensor lead, from an initial insertion site to another insertion site is also provided. A guidewire of sufficient length, pliancy and deformability to perform a transfer from one insertion site to another insertion site is provided. In one aspect, the guidewire comprises a removable core mandrel to increase rigidity, facilitate insertion and/or improve steerability. A kit or system, comprising introducers, guidewires and catheters for performing a guidewire or device transfer is also provided.
摘要翻译：提供了一种通过将导丝从身体上的初始插入位置传递到身体上的不同插入位置来访问身体中的目标部位的方法。一方面，还提供了用于将诸如传感器引线的医疗装置或部件从初始插入位置转移到另一插入位置的方法。提供了足够的长度，柔软度和变形性的导线，以执行从一个插入位点到另一个插入位点的转移。在一个方面，导丝包括可移除的芯心，以增加刚性，便于插入和/或提高可操纵性。还提供了一种套件或系统，其包括用于执行导丝或设备转移的导引器，导线和导管。

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