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1. 发明申请

US20050124001A1 Method of producing highly functionalized 1,3-diamino-propan-2-ols from solid support 有权
标题翻译：从固体支持物制备高度官能化的1,3-二氨基 - 丙-2-醇的方法
公开(公告)号：US20050124001A1
公开(公告)日：2005-06-09
申请号：US11006145
申请日：2004-12-07
申请人： Steve Coats , Dennis Hlasta , Mark Schulz
发明人： Steve Coats , Dennis Hlasta , Mark Schulz
IPC分类号： C07C233/37 , C07C233/40 , C07C233/62 , C07C233/78 , C07C235/50 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/34 , C07C271/20 , C07C303/40 , C07C311/37 , C07C315/04 , C07C317/44 , C07C319/20 , C07C323/60 , C07D207/50 , C07D213/38 , C07D215/54 , C07D295/13 , C07D307/22 , C07D333/20 , G01N33/53 , C07D211/26 , C07D265/30
CPC分类号： C07C315/04 , C07B2200/11 , C07C233/37 , C07C233/40 , C07C233/62 , C07C233/78 , C07C235/50 , C07C235/84 , C07C237/20 , C07C237/22 , C07C237/34 , C07C271/20 , C07C303/40 , C07C319/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/50 , C07D213/38 , C07D215/54 , C07D295/13 , C07D307/22 , C07D333/20 , C40B40/04 , C40B50/14 , C07C317/44 , C07C323/60 , C07C311/37
摘要： The invention is directed to compounds and methods of synthesizing hydroxyethlamino amides and their use in treatment of aspartyl protease mediated diseases and conditions.
摘要翻译：本发明涉及合成羟乙基氨基酰胺的化合物和方法及其在治疗天冬氨酰蛋白酶介导的疾病和病症中的用途。

2. 发明申请

US20060079687A1 Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) 有权
标题翻译：可用作β-分泌酶（BACE）抑制剂的新型2-氨基 - 喹唑啉衍生物
公开(公告)号：US20060079687A1
公开(公告)日：2006-04-13
申请号：US11197669
申请日：2005-08-04
申请人： Ellen Baxter , Francois Bischoff , Robert Boyd , Mirielle Braeken , Steve Coats , Yifang Huang , Alfonzo Jordan , Chi Luo , Marc Mercken , Serge Maria Pieters , Allen Reitz , Charles Reynolds , Tina Ross , Brett Tounge , Mark Schulz , Hans De Winter
发明人： Ellen Baxter , Francois Bischoff , Robert Boyd , Mirielle Braeken , Steve Coats , Yifang Huang , Alfonzo Jordan , Chi Luo , Marc Mercken , Serge Maria Pieters , Allen Reitz , Charles Reynolds , Tina Ross , Brett Tounge , Mark Schulz , Hans De Winter
IPC分类号： C07D239/84 , C07D403/02
CPC分类号： C07D413/06 , C07D239/84 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06
摘要： The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
摘要翻译：本发明涉及新的2-氨基-3,4-二氢 - 喹唑啉衍生物，含有它们的药物组合物及其在治疗阿尔茨海默病（AD）和相关病症中的用途。本发明的化合物是β-分泌酶的抑制剂，也称为β-位点切割酶和BACE。

3. 发明申请

US20130134992A1 SENSOR SLEEVE FOR HEALTH MONITORING AN ARTICLE 审中-公开
标题翻译：传感器用于健康监测系统
公开(公告)号：US20130134992A1
公开(公告)日：2013-05-30
申请号：US13697435
申请日：2011-05-12
申请人： Xiangdong Zhu , Peter V. Buca , Jay Lee , Mark Schulz , Surya Sundaramurthy , Vesselin Shanov
发明人： Xiangdong Zhu , Peter V. Buca , Jay Lee , Mark Schulz , Surya Sundaramurthy , Vesselin Shanov
IPC分类号： G01R27/26 , G01L9/00
CPC分类号： G01R27/2605 , G01L9/003 , G01M3/18 , G01M3/182 , G01N27/20 , G01N27/24
摘要： A sensor sleeve (10) for use in detecting a failure in an article (18) (e.g., a hydraulic hose), the sensor sleeve includes an insulator layer (12) that separates two electrode layers (14, 16). As such, the electrode layers deform to contact each other, which changes the impedance as measured across the electrode layers. The sensor sleeve is designed to change electrical impedance (resistance) due to fluid pressure initiating a hole through the sensor itself. The sensor sleeve will detect the fluid leak when the hole penetrates the sensor and brings the two elastic electrodes in contact with each other and/or the fluid, which when the fluid is conductive fluid, creates a signal path between the first electrode layer and the second electrode layer, which also changes the impedance as measured across the electrode layers.
摘要翻译：一种用于检测物品（18）（例如液压软管）故障的传感器套筒（10），传感器套筒包括分离两个电极层（14,16）的绝缘体层（12）。因此，电极层变形成彼此接触，这改变了跨越电极层测量的阻抗。传感器套筒被设计成改变由于流体压力通过传感器本身启动孔的电阻抗（电阻）。当孔穿透传感器并使两个弹性电极彼此接触和/或流体时，传感器套筒将检测流体泄漏，当液体是导电流体时，传感器套筒将在第一电极层和第二电极层之间产生信号路径第二电极层，其也改变跨越电极层测量的阻抗。

4. 发明申请

US20080045535A1 Prokineticin 2 receptor antagonists 审中-公开
标题翻译：原肌动蛋白2受体拮抗剂
公开(公告)号：US20080045535A1
公开(公告)日：2008-02-21
申请号：US11375242
申请日：2006-03-14
申请人： Steven Coats , Alexey Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet Ralbovsky , Mark Schulz
发明人： Steven Coats , Alexey Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet Ralbovsky , Mark Schulz
IPC分类号： A61K31/53 , A61K31/513 , A61P1/04 , A61P35/00 , C07D239/54 , C07D239/545 , C07D239/60 , C07D251/08
CPC分类号： C07D239/54 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D417/06
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.
摘要翻译：本发明涉及某些新的式（I）化合物：以及用于制备这些化合物，组合物，中间体及其衍生物以及用于治疗促动素原2或原激素2受体介导的病症的方法。

5. 发明申请

US20080095695A1 COMPOSITE CATALYST AND METHOD FOR MANUFACTURING CARBON NANOSTRUCTURED MATERIALS 有权
标题翻译：复合催化剂及制备碳纳米管材料的方法
公开(公告)号：US20080095695A1
公开(公告)日：2008-04-24
申请号：US11734143
申请日：2007-04-11
申请人： Vesselin Shanov , Andrew Gorton , Yeo-Heung Yun , Mark Schulz
发明人： Vesselin Shanov , Andrew Gorton , Yeo-Heung Yun , Mark Schulz
IPC分类号： D01F9/12 , B01J23/10 , B01J23/40
CPC分类号： C01B32/162 , B01J21/185 , B01J23/40 , B01J23/63 , B01J23/74 , B01J23/83 , B01J35/0013 , B01J37/0217 , B01J37/0221 , B01J37/0226 , B01J37/0238 , B01J37/0244 , B01J37/08 , B01J37/088 , B01J37/348 , B01J37/349 , B82Y30/00 , B82Y40/00 , C01B2202/06 , C01B2202/08 , C01B2202/34 , D01F9/12 , D01F9/127 , D01F9/1273 , Y10S977/752
摘要： A method of forming a carbon nanotube array on a substrate is disclosed. One embodiment of the method comprises depositing a composite catalyst layer on the substrate, oxidizing the composite catalyst layer, reducing the oxidized composite catalyst layer, and growing the array on the composite catalyst layer. The composite catalyst layer may comprise a group VIII element and a non-catalytic element deposited onto the substrate from an alloy. In another embodiment, the composite catalyst layer comprises alternating layers of iron and a lanthanide, preferably gadolinium or lanthanum. The composite catalyst layer may be reused to grow multiple carbon nanotube arrays without additional processing of the substrate. The method may comprise bulk synthesis by forming carbon nanotubes on a plurality of particulate substrates having a composite catalyst layer comprising the group VIII element and the non-catalytic element. In another embodiment, the composite catalyst layer is deposited on both sides of the substrate.
摘要翻译：公开了一种在基片上形成碳纳米管阵列的方法。该方法的一个实施方案包括在基底上沉积复合催化剂层，氧化复合催化剂层，还原氧化复合催化剂层，并在复合催化剂层上生长阵列。复合催化剂层可以包含从合金沉积到基材上的VIII族元素和非催化元素。在另一个实施方案中，复合催化剂层包含铁和镧系元素，优选钆或镧的交替层。复合催化剂层可以重新用于生长多个碳纳米管阵列而不需要对衬底进行额外处理。该方法可以包括通过在具有包含VIII族元素和非催化元素的复合催化剂层的多个颗粒基材上形成碳纳米管来进行本体合成。在另一个实施方案中，复合催化剂层沉积在基材的两侧。

6. 发明申请

US20080017701A1 CENTRALIZED MANAGEMENT OF REPLACEMENT VEHICLE LABELS 有权
标题翻译：更换车辆标签的集中管理
公开(公告)号：US20080017701A1
公开(公告)日：2008-01-24
申请号：US11866188
申请日：2007-10-02
申请人： Mark Schulz , Jeffrey Janssen , John Gozum , Gary Asmus
发明人： Mark Schulz , Jeffrey Janssen , John Gozum , Gary Asmus
IPC分类号： G06F7/00
CPC分类号： G06Q10/06
摘要： A central labeling data (CLD) management system provides centralized management, assembly, and distribution of labeling data for use in generating replacement labels for damaged vehicles. For example, the CLD management system includes a database that stores label data for a plurality of vehicles produced by a plurality of different manufacturers. The CLD management system presents an interface to receive an electronic communication from a client computing device associated with a repair shop. The electronic communication includes a request for label data associated with an original vehicle label. The CLD management system retrieves the requested label data from the database and communicates the label data to an output device for printing a new vehicle label for use by the repair shop.
摘要翻译：中央标签数据（CLD）管理系统提供集中管理，组装和分发标签数据，用于为损坏的车辆生成替换标签。例如，CLD管理系统包括存储由多个不同制造商生产的多个车辆的标签数据的数据库。 CLD管理系统提供接口，用于从与修理车间相关联的客户端计算设备接收电子通信。电子通信包括与原始车辆标签相关联的标签数据的请求。 CLD管理系统从数据库检索所请求的标签数据，并将标签数据传送到输出设备，以打印新的车辆标签供维修店使用。

7. 发明申请

US20070015207A1 Triazolopyrimidine derivatives 有权
标题翻译：三唑并嘧啶衍生物
公开(公告)号：US20070015207A1
公开(公告)日：2007-01-18
申请号：US11329642
申请日：2006-01-11
申请人： Donald Ludovici , Richard Connors , Steven Coats , Li Liu , Bart De Corte , Dana Johnson , Mark Schulz
发明人： Donald Ludovici , Richard Connors , Steven Coats , Li Liu , Bart De Corte , Dana Johnson , Mark Schulz
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C12N5/06 , C07D487/02 , C07K16/40 , C12N9/12
CPC分类号： C07K14/4738 , C07D487/04 , C12N9/1205 , C12Q1/485 , G01N2500/02
摘要： The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.
摘要翻译：本发明涉及已发现对丝氨酸 - 酪氨酸和酪氨酸激酶具有抑制活性的式（I）三唑并嘧啶衍生物的发现。

8. 发明授权

US08426429B2 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE) 有权
公开(公告)号：US08426429B2
公开(公告)日：2013-04-23
申请号：US11197608
申请日：2005-08-04
申请人： Ellen Baxter , Robert Boyd , Steven J. Coats , Alfonzo D. Jordan , Allen B. Reitz , Charles H. Reynolds , Mark Schulz , Malcolm Scott
发明人： Ellen Baxter , Robert Boyd , Steven J. Coats , Alfonzo D. Jordan , Allen B. Reitz , Charles H. Reynolds , Mark Schulz , Malcolm Scott
IPC分类号： A61K31/517 , C07D239/88 , C07D239/94 , C07D401/06 , A61K31/535 , C07D265/30
CPC分类号： C07D215/227 , C07D401/06 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/06
摘要： The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.

9. 发明申请

US20120028997A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS 有权
公开(公告)号：US20120028997A1
公开(公告)日：2012-02-02
申请号：US12970461
申请日：2010-12-16
申请人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
发明人： Steven J. Coats , Alexey B. Dyatkin , Wei He , Joseph Lisko , Tamara Miskowski , Janet L. Ralbovsky , Mark Schulz
IPC分类号： A61K31/515 , C07D401/06 , C07D403/12 , A61P1/12 , A61P1/00 , A61P35/00 , A61P29/00 , C07D401/12 , A61K31/513
CPC分类号： C07D251/26 , C07D251/46 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/14 , C07D417/14 , C07D487/04
摘要： The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.

10. 发明申请

US20070246155A1 Embossed Masking Sheet With Pressure Sensitive Adhesive Regions 审中-公开
标题翻译：压敏胶带压敏胶带
公开(公告)号：US20070246155A1
公开(公告)日：2007-10-25
申请号：US11573701
申请日：2005-08-09
申请人： Jeffrey Janssen , Patrick Hager , Mark Schulz
发明人： Jeffrey Janssen , Patrick Hager , Mark Schulz
IPC分类号： B05B15/04
CPC分类号： C09J7/38 , B05B12/24 , B05B16/40 , C09J2201/32 , C09J2203/31 , Y10T156/1043
摘要： The method of the present invention is directed to masking or protecting a substrate utilizing a protection sheet (10) having a contact surface containing a plurality of protrusions (14) spaced apart by a plurality valleys (12), and an opposing back surface containing a plurality of hollow portions corresponding to the protrusions (14). The valleys (12) of the contact surface of the protection sheet (10) are coated with a pressure sensitive adhesive (16), while the protrusions (14) provide spacing which prevents premature sticking of the protection sheet (10) onto the substrate. The invention is particularly suited for use in automotive repair applications.
摘要翻译：本发明的方法涉及使用具有包含多个由多个谷（12）间隔开的多个突起（14）的接触表面的保护片（10）来掩蔽或保护基底，以及相对的背面，对应于突起（14）的多个中空部分。保护片（10）的接触表面的谷（12）涂覆有压敏粘合剂（16），而突起（14）提供间隔，防止保护片（10）过早粘附到基底上。本发明特别适用于汽车修理应用。

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