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    • 3. 发明授权
    • Fluorous capping reagents and methods for peptide purification
    • 氟封端试剂和肽纯化方法
    • US07612166B2
    • 2009-11-03
    • US11597067
    • 2005-05-18
    • Krishna KumarVittorio Montanari
    • Krishna KumarVittorio Montanari
    • A61K38/00C07K1/00
    • C07K7/06C07C229/36C07C311/48C07K1/04C07K1/10C07K5/06113C07K5/1016C07K7/08
    • Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method or purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.
    • 本发明的方面涉及制备碳氟化合物的化合物,制备碳氟化合物的方法,以及化合物的混合物的纯化方法。 本发明的一个方面涉及三价碘代氟碳化合物。 本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。 本发明的另一方面涉及制备三价碘代氟碳化合物的方法。 本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。 本发明的另一方面涉及一种方法或纯化包含第一和第二化合物的混合物,通过用三价碘代氟碳处理该混合物以将氟碳基团连接到第二化合物上,使第一化合物保持不变,并通过 氟相纯化。
    • 8. 发明申请
    • Fluorous Capping Reagents and Methods for Peptide Purification
    • 氟封端试剂和肽纯化方法
    • US20080275216A1
    • 2008-11-06
    • US11597067
    • 2005-05-18
    • Krishna KumarVittorio Montanari
    • Krishna KumarVittorio Montanari
    • C07K1/14C07C313/04C07H1/06C07C17/00
    • C07K7/06C07C229/36C07C311/48C07K1/04C07K1/10C07K5/06113C07K5/1016C07K7/08
    • Aspects of the present invention relate to compounds for preparing fluorocarbon compounds, methods for preparing fluorocarbon compounds, and methods for purifying a mixture of compounds. One aspect of the present invention relates to a trivalent iodonium fluorocarbon. The trivalent iodonium fluorocarbon compound of the invention is useful for attaching a fluorocarbon group to a compound that has a nucleophilic functional group. Another aspect of the present invention relates to a method of preparing a trivalent iodonium fluorocarbon. Another aspect of the present invention relates to a method of preparing a fluorocarbon by treating a compound bearing a nucleophilic functional group with a trivalent iodonium fluorocarbon compound. Another aspect of the present invention relates to a method or purifying a mixture comprising a first and a second compound by treating the mixture with a trivalent iodonium fluorocarbon to attach a fluorocarbon group to the second compound leaving the first compound unchanged, and purifying the mixture by fluorous-phase purification.
    • 本发明的方面涉及制备碳氟化合物的化合物,制备碳氟化合物的方法,以及化合物的混合物的纯化方法。 本发明的一个方面涉及三价碘代氟碳化合物。 本发明的三价碘氟碳化合物可用于将氟碳基团连接到具有亲核官能团的化合物上。 本发明的另一方面涉及制备三价碘代氟碳化合物的方法。 本发明的另一方面涉及通过用三价碘氟碳化合物处理带有亲核官能团的化合物来制备碳氟化合物的方法。 本发明的另一方面涉及一种方法或纯化包含第一和第二化合物的混合物,通过用三价碘代氟碳处理该混合物以将氟碳基团连接到第二化合物上,使第一化合物保持不变,并通过 氟相纯化。