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1. 发明授权

US06716184B2 Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound 有权
标题翻译：超声治疗头被配置为耦合到超声成像探针以促进使用低强度超声的同时成像和使用高强度聚焦超声
公开(公告)号：US06716184B2
公开(公告)日：2004-04-06
申请号：US10166795
申请日：2002-06-07
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61N700
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

2. 发明授权

US06425867B1 Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy 有权
标题翻译：经高强度聚焦超声治疗的治疗部位的无噪声实时超声成像
公开(公告)号：US06425867B1
公开(公告)日：2002-07-30
申请号：US09397471
申请日：1999-09-17
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61B800
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

3. 发明授权

US07722539B2 Treatment of unwanted tissue by the selective destruction of vasculature providing nutrients to the tissue 有权
标题翻译：通过选择性破坏脉管系统来为组织提供营养物来治疗不想要的组织
公开(公告)号：US07722539B2
公开(公告)日：2010-05-25
申请号：US11207554
申请日：2005-08-18
申请人： Stephen J. Carter , Shahram Vaezy , Roy W. Martin , George W. Keilman , Lawrence A. Crum
发明人： Stephen J. Carter , Shahram Vaezy , Roy W. Martin , George W. Keilman , Lawrence A. Crum
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B8/08 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B34/20 , A61B2034/2051 , A61B2090/378 , A61H23/0245
摘要： A noninvasive technique that can be used to deny blood flow to a particular region of tissue, without the inherent risks associated with invasive procedures such as surgery and minimally-invasive procedures such as embolization. Blood flow in selected portions of the vasculature can be occluded by selectively treating specific portions of the vasculature with high intensity focused ultrasound (HIFU). The occlusion denies undesired tissue the nutrients and oxygen provided by blood flow, causing necrosis in the undesired tissue. An imaging technology (such as magnetic resonance imaging, magnetic resonance angiography, ultrasound imaging, Doppler based ultrasound imaging, or computed tomographic angiography) is used to identify the undesired tissue, and the vascular structures associated with the undesired tissue. A portion of the vasculature providing blood flow to the undesired tissue is selected, and HIFU is administered to the selected portion of the vasculature to occlude blood flow through that portion of the vasculature.
摘要翻译：一种非侵入性技术，可用于阻止血液流向组织的特定区域，而不会与诸如手术和诸如栓塞的微创手术等侵入性手术相关的固有风险。通过用高强度聚焦超声（HIFU）选择性处理脉管系统的特定部分，可以阻断脉管系统选定部分的血流。闭塞阻止不需要的组织由血液流动提供的营养物质和氧气，从而引起不想要的组织中的坏死。使用成像技术（例如磁共振成像，磁共振血管造影术，超声成像，基于多普勒超声成像或计算机断层造影血管造影术）来鉴别不需要的组织以及与不想要的组织相关的血管结构。选择向不想要的组织提供血液流动的脉管系统的一部分，并且将HIFU施用于脉管系统的选定部分以阻塞通过脉管系统的那部分的血流。

4. 发明授权

US08538556B2 Enhanced implantable antenna method 有权
标题翻译：增强植入式天线方法
公开(公告)号：US08538556B2
公开(公告)日：2013-09-17
申请号：US12060818
申请日：2008-04-01
申请人： George W. Keilman , Timothy Johnson
发明人： George W. Keilman , Timothy Johnson
IPC分类号： A61N1/08
CPC分类号： H01Q1/22 , A61N1/37229 , Y10T29/49016 , Y10T29/53204
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

5. 发明授权

US08142359B2 Enhanced intraluminal flow measurement method using reference and combined signals 有权
标题翻译：使用参考和组合信号增强管腔内流量测量方法
公开(公告)号：US08142359B2
公开(公告)日：2012-03-27
申请号：US12104966
申请日：2008-04-17
申请人： George W. Keilman , Leigh Bartlett , Timothy Johnson
发明人： George W. Keilman , Leigh Bartlett , Timothy Johnson
IPC分类号： A61B8/06
CPC分类号： A61B5/026 , A61B5/0031 , A61B5/0265 , A61B5/6846 , A61B8/06 , A61B8/12 , A61B8/4472
摘要： An enhanced intraluminal flow measurement system and method is conducive for a low-power ultrasonic system that can use continuous-wave (CW) Doppler sensing and wireless RF telemetry. Applications include measurement of blood flow in situ in living organisms. Implementations include an extraluminal component located outside of a body, such as a human or animal body, containing a lumen. The extraluminal component can be wirelessly coupled via an RF magnetic field or other RF field to an implantable intraluminal component. The intraluminal component (i.e. implant) is implanted inside of the lumen of the body such as a heart or elsewhere in a vasculature (such as in a dialysis shunt). The intraluminal component can telemeter, via RF electromagnetic signals, flow data directly out of the body housing the intraluminal component to be received by the extraluminal component.
摘要翻译：增强的管腔内流量测量系统和方法有利于可以使用连续波（CW）多普勒感测和无线RF遥测的低功率超声波系统。应用包括在生物体内原位测量血流。实施方案包括位于身体外部的外阴部件，例如包含内腔的人体或动物体。管腔内部件可以经由RF磁场或其他RF场无线耦合到可植入的管腔内部件。管腔内成分（即植入物）植入体内的腔内，例如心脏或其它脉管系统（如透析分流）中。管腔内成分可以通过射频电磁信号将流量数据直接传送出外壳体内的腔内部件，以便由腔内部件接收。

6. 发明申请

US20090264761A1 ENHANCED INTRALUMINAL FLOW MEASUREMENT SYSTEM USING REFERENCE AND COMBINED SIGNALS 有权
标题翻译：使用参考和组合信号的增强的内部流量测量系统
公开(公告)号：US20090264761A1
公开(公告)日：2009-10-22
申请号：US12104949
申请日：2008-04-17
申请人： George W. Keilman , Leigh Bartlett , Timothy Johnson
发明人： George W. Keilman , Leigh Bartlett , Timothy Johnson
IPC分类号： A61B8/00 , A61B5/00 , A61N1/00
CPC分类号： A61B8/12 , A61B5/0031 , A61B8/06 , A61B8/488
摘要： An enhanced intraluminal flow measurement system and method is conducive for a low-power ultrasonic system that can use continuous-wave (CW) Doppler sensing and wireless RF telemetry. Applications include measurement of blood flow in situ in living organisms. Implementations include an extraluminal component located outside of a body, such as a human or animal body, containing a lumen. The extraluminal component can be wirelessly coupled via an RF magnetic field or other RF field to an implantable intraluminal component. The intraluminal component (i.e. implant) is implanted inside of the lumen of the body such as a heart or elsewhere in a vasculature (such as in a dialysis shunt). The intraluminal component can telemeter, via RF electromagnetic signals, flow data directly out of the body housing the intraluminal component to be received by the extraluminal component.
摘要翻译：增强的管腔内流量测量系统和方法有利于可以使用连续波（CW）多普勒感测和无线RF遥测的低功率超声波系统。应用包括在生物体内原位测量血流。实施方案包括位于身体外部的外阴部件，例如包含内腔的人体或动物体。管腔内部件可以经由RF磁场或其他RF场无线耦合到可植入的管腔内部件。管腔内成分（即植入物）植入体内的腔内，例如心脏或其它脉管系统（如透析分流）中。管腔内成分可以通过射频电磁信号将流量数据直接传送出外壳体内的腔内部件，以便由腔内部件接收。

7. 发明申请

US20090243956A1 ENHANCED IMPLANTABLE HELICAL ANTENNA SYSTEM AND METHOD 有权
标题翻译：增强的可植入式天线系统和方法
公开(公告)号：US20090243956A1
公开(公告)日：2009-10-01
申请号：US12060816
申请日：2008-04-01
申请人： George W. Keilman , Timothy Johnson
发明人： George W. Keilman , Timothy Johnson
IPC分类号： H01Q1/36
CPC分类号： H01Q7/00 , A61N1/37229 , H01Q1/362 , H01Q9/26
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

8. 发明申请

US20090234435A1 VASCULAR ANCHORING SYSTEM AND METHOD 有权
标题翻译：血管锚固系统及方法
公开(公告)号：US20090234435A1
公开(公告)日：2009-09-17
申请号：US12048053
申请日：2008-03-13
申请人： Timothy Johnson , George W. Keilman
发明人： Timothy Johnson , George W. Keilman
IPC分类号： A61F2/06
CPC分类号： A61F2/86 , A61F2/848 , A61F2/954 , A61F2/966 , A61F2002/821 , A61F2002/9665 , A61F2220/0008 , A61F2230/0008
摘要： As described herein vascular anchoring systems are used to position an implant in a vascular area such as a bifurcated vasculature with relatively high fluid flow, for instance, in an area of a pulmonary artery with associated left and right pulmonary arteries. Implementations include an anchoring trunk member having a first anchoring trunk section and a second anchoring trunk section. Further implementations include a first anchoring branch member extending from the anchoring trunk member. Still further implementations include a second anchoring branch member extending from the anchoring trunk member.
摘要翻译：如本文所描述的，血管锚定系统用于将植入物定位在诸如具有相对高的流体流动的分叉血管的血管区域中，例如在具有相关联的左肺动脉和右肺动脉的肺动脉的区域中。实施方案包括具有第一锚固干线部分和第二锚固干线部分的锚固干线部件。另外的实施方案包括从锚固树干构件延伸的第一锚定分支构件。另外的实施方式包括从锚固树干构件延伸的第二锚定分支构件。

9. 发明授权

US07568394B1 Enhanced diaphragm for pressure sensing system and method 有权
标题翻译：用于压力传感系统和方法的增强隔膜
公开(公告)号：US07568394B1
公开(公告)日：2009-08-04
申请号：US12109289
申请日：2008-04-24
申请人： George W. Keilman , Timothy Johnson
发明人： George W. Keilman , Timothy Johnson
IPC分类号： G01L7/08
CPC分类号： A61B5/0215 , A61B2562/0247 , A61B2562/028 , G01L19/0046 , G01L19/04
摘要： An enhanced pressure sensing system and method use an external diaphragm to address issues involved with accurate and prolonged measurement of fluid pressure, such as of blood flowing in a vascular structure. Some external diaphragms include a metallized layer or other highly impermeable layer to furnish a high degree of seal at least near to hermetic grade. As temperature of the intermediary fluid changes, the external diaphragm is able to move in a direction that minimizes differential pressure across the external diaphragm over an operational temperature range thereby reducing pressure change of the intermediary fluid due to change in temperature of the intermediary fluid. Relatively smooth hydrodynamic surfaces can be used as well as a bi-layer construction.
摘要翻译：增强的压力感测系统和方法使用外部膜片来解决涉及流体压力的精确和长期测量的问题，例如在血管结构中流动的血液。一些外部隔膜包括金属化层或其它高度不可渗透的层，以至少接近密封级别提供高密度的密封。当中间流体的温度变化时，外部隔膜能够在使操作温度范围内使外部隔膜两端的差压最小化的方向上移动，从而减少由于中间流体的温度变化引起的中间流体的压力变化。可以使用相对平滑的流体动力学表面以及双层结构。

10. 发明申请

US20090093761A1 Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
标题翻译：具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力
公开(公告)号：US20090093761A1
公开(公告)日：2009-04-09
申请号：US11973052
申请日：2007-10-05
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
IPC分类号： A61M5/32
CPC分类号： A61M5/427 , A61B17/3403 , A61B90/30 , A61B2090/309 , A61B2090/373 , A61N1/0452 , A61N1/0456 , A61N1/325 , A61N1/36021
摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.
摘要翻译：许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。最后，还发现减轻疼痛的机制可用于管腔扩张。

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