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1. 发明授权

US08337434B2 Methods for using high intensity focused ultrasound and associated systems and devices 有权
标题翻译：使用高强度聚焦超声及相关系统和装置的方法
公开(公告)号：US08337434B2
公开(公告)日：2012-12-25
申请号：US12946727
申请日：2010-11-15
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

2. 发明授权

US06716184B2 Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound 有权
标题翻译：超声治疗头被配置为耦合到超声成像探针以促进使用低强度超声的同时成像和使用高强度聚焦超声
公开(公告)号：US06716184B2
公开(公告)日：2004-04-06
申请号：US10166795
申请日：2002-06-07
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61N700
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

3. 发明申请

US20130096431A1 METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND AND ASSOCIATED SYSTEMS AND DEVICES 审中-公开
标题翻译：使用高强度聚焦超声波和相关系统和器件的方法
公开(公告)号：US20130096431A1
公开(公告)日：2013-04-18
申请号：US13681379
申请日：2012-11-19
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61N7/00 , A61B8/12
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

4. 发明授权

US06425867B1 Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy 有权
标题翻译：经高强度聚焦超声治疗的治疗部位的无噪声实时超声成像
公开(公告)号：US06425867B1
公开(公告)日：2002-07-30
申请号：US09397471
申请日：1999-09-17
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61B800
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

5. 发明授权

US07850626B2 Method and probe for using high intensity focused ultrasound 有权
标题翻译：使用高强度聚焦超声的方法和探针
公开(公告)号：US07850626B2
公开(公告)日：2010-12-14
申请号：US11928667
申请日：2007-10-30
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61H1/00 , A61B1/00 , A61B6/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

6. 发明申请

US20110201929A1 METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND 有权
标题翻译：使用高强度聚焦超声的方法
公开(公告)号：US20110201929A1
公开(公告)日：2011-08-18
申请号：US12946727
申请日：2010-11-15
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61N7/00 , A61B8/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

7. 发明授权

US07520856B2 Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology 有权
标题翻译：图像引导高强度聚焦超声装置治疗妇产科
公开(公告)号：US07520856B2
公开(公告)日：2009-04-21
申请号：US10977339
申请日：2004-10-29
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61B8/00 , A61N7/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A frame ensures that the alignment between a high intensity focused ultrasound (HIFU) transducer designed for vaginal use and a commercially available ultrasound image probe is maintained, so that the HIFU focus remains in the image plane during HIFU therapy. A water-filled membrane placed between the HIFU transducer and the treatment site provides acoustic coupling. The coupling is evaluated to determine whether any air bubbles exist at the coupling interface, which might degrade the therapy provided by the HIFU transducer. HIFU lesions on tissue appear as hyperechoic spots on the ultrasound image in real time during application of HIFU therapy. Ergonomic testing in humans has demonstrated clear visualization of the HIFU transducer relative to the uterus and showed the potential for the HIFU transducer to treat fibroids from the cervix to the fundus through the width of the uterus.
摘要翻译：框架确保维持设计用于阴道使用的高强度聚焦超声（HIFU）换能器和商业上可获得的超声图像探针之间的对准，使得HIFU治疗期间HIFU焦点保留在图像平面中。放置在HIFU换能器和处理部位之间的充水膜提供声耦合。评估耦合以确定耦合界面是否存在任何气泡，这可能降低由HIFU传感器提供的治疗。 HIFU治疗期间组织上的HIFU损伤实时显示为超声图像上的高回声点。人体工程学测试已经证明了HIFU传感器相对于子宫的清晰可视化，并显示HIFU传感器通过子宫宽度将子宫肌瘤从子宫颈治疗到眼底的潜力。

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