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1. 发明授权

US07510536B2 Ultrasound guided high intensity focused ultrasound treatment of nerves 有权
标题翻译：超声引导高强度聚焦超声治疗神经
公开(公告)号：US07510536B2
公开(公告)日：2009-03-31
申请号：US11016701
申请日：2004-12-16
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61H1/00 , A61B8/00
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于逆转阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，同步到HIFU治疗超声成像用于提供神经结构的实时超声图像引导HIFU疗法。

2. 发明申请

US20070239011A1 APPARATUS FOR DELIVERING HIGH INTENSITY FOCUSED ULTRASOUND ENERGY TO A TREATMENT SITE INTERNAL TO A PATIENT'S BODY 审中-公开
标题翻译：将高强度聚焦超声能量的装置应用于患者体内的治疗场
公开(公告)号：US20070239011A1
公开(公告)日：2007-10-11
申请号：US11623705
申请日：2007-01-16
申请人： Michael Lau , Shahram Vaezy , Alexander Lebedev , Michael J. Connolly
发明人： Michael Lau , Shahram Vaezy , Alexander Lebedev , Michael J. Connolly
IPC分类号： A61H1/00 , A61B8/00
CPC分类号： A61B8/12 , A61B1/00165 , A61B8/445 , A61B2017/4216 , A61N7/022 , A61N2007/0078
摘要： An apparatus for delivering HIFU energy may include a probe with a plurality of leaves that provide a bowl-shaped HIFU therapy transducer. In once case, pins may slide within grooves in the leaves to deploy the leaves. In another case, spines may be configured to slide in a channel defined in each leaf. In other cases, a spring or a shape memory alloy may be used to deploy the leaves. In another implementation, a probe may be fitted with a flexible material that couples the HIFU therapy transducer to the probe and allows the transducer to be drawn to the side of the probe for insertion. In another implementation, a probe may have one or more inflatable bladders that form the HIFU therapy transducer. In yet another implementation, a probe may have an imaging component and a HIFU therapy transducer disposed thereon that rotate, as a unit, about a hinge.
摘要翻译：用于递送HIFU能量的装置可以包括具有提供碗形HIFU治疗换能器的多个叶片的探针。在一次的情况下，销可以在叶片中的凹槽内滑动以部署叶片。在另一种情况下，脊可以被配置成在每个叶中限定的通道中滑动。在其他情况下，可以使用弹簧或形状记忆合金来部署叶片。在另一个实施方案中，探针可以装配有将HIFU治疗换能器耦合到探针的柔性材料，并允许将换能器拉到探针侧以进行插入。在另一实施方案中，探针可以具有形成HIFU治疗换能器的一个或多个可充气气囊。在另一个实施方案中，探针可以具有设置在其上的成像组件和HIFU治疗换能器，作为一个单元围绕铰链旋转。

3. 发明申请

US20060264748A1 Interference-free ultrasound imaging during HIFU therapy, using software tools 有权
标题翻译： HIFU治疗期间无干扰超声成像，使用软件工具
公开(公告)号：US20060264748A1
公开(公告)日：2006-11-23
申请号：US11229000
申请日：2005-09-16
申请人： Shahram Vaezy , Robert Held , Siddhartha Sikdar , Ravi Managuli , Vesna Zderic
发明人： Shahram Vaezy , Robert Held , Siddhartha Sikdar , Ravi Managuli , Vesna Zderic
IPC分类号： A61B8/00
CPC分类号： A61B8/14 , A61B8/12 , A61B8/4488 , A61B8/463 , A61B8/465 , A61B8/467 , A61B8/469 , A61B8/54 , G01S7/52074 , G01S7/52077 , G01S15/899 , G01S15/8995
摘要： Disclosed herein is a method for obtaining a composite interference-free ultrasound image when non-imaging ultrasound waves would otherwise interfere with ultrasound imaging. A conventional ultrasound imaging system is used to collect frames of ultrasound image data in the presence of non-imaging ultrasound waves, such as high-intensity focused ultrasound (HIFU). The frames are directed to a processor that analyzes the frames to identify portions of the frame that are interference-free. Interference-free portions of a plurality of different ultrasound image frames are combined to generate a single composite interference-free ultrasound image that is displayed to a user. In this approach, a frequency of the non-imaging ultrasound waves is offset relative to a frequency of the ultrasound imaging waves, such that the interference introduced by the non-imaging ultrasound waves appears in a different portion of the frames.
摘要翻译：本文公开了一种当非成像超声波将干扰超声成像时获得无复合干扰超声图像的方法。在非成像超声波（例如高强度聚焦超声（HIFU））的存在下，常规的超声成像系统用于收集超声图像数据的帧。这些帧被引导到处理器，该处理器分析帧以识别不干扰的帧的部分。组合多个不同的超声图像帧的无干扰部分以产生向用户显示的单个无复合干扰的超声图像。在该方法中，非成像超声波的频率相对于超声波成像波的频率偏移，使得由非成像超声波引入的干扰出现在帧的不同部分中。

4. 发明申请

US20060235303A1 Acoustic coupler using an independent water pillow with circulation for cooling a transducer 失效
标题翻译：声学耦合器使用独立的水枕头与循环冷却传感器
公开(公告)号：US20060235303A1
公开(公告)日：2006-10-19
申请号：US11229005
申请日：2005-09-16
申请人： Shahram Vaezy , Thuc Nguyen , Vesna Zderic , Jessica Foley
发明人： Shahram Vaezy , Thuc Nguyen , Vesna Zderic , Jessica Foley
IPC分类号： A61B8/14
CPC分类号： A61B8/4281 , A61B8/12 , A61B8/546 , A61B17/2251 , A61B2018/00011 , A61B2562/168 , A61N7/022 , G10K11/02
摘要： A water pillow for coupling acoustic energy into tissue. The pillow is configured to conform to a transducer to facilitate coupling of ultrasound energy. The pillow includes a pouch that accommodates the transducer to enable a snug fit between the pillow and the transducer. The pillow includes a liquid inlet and outlet to facilitate liquid circulation for cooling, is biocompatible, has a low attenuation, is conformal to the shape of the transducer, facilitates use of an adjustable pressure to achieve various standoffs, includes an integral pouch to facilitate an interference fit to the transducer, facilitates water circulation for cooling, is sterilizeable, and is disposable. Either the surface of the pillow adapted to conform to a tissue interface, or the surface of the pillow adapted to conform to the transducer, or both, can include pores configured to weep liquid to facilitate acoustic coupling of the pillow with the transducer and/or tissue.
摘要翻译：用于将声能耦合到组织中的水枕头。枕头被配置成符合换能器以便于耦合超声能量。枕头包括一个可容纳传感器的小袋，以便在枕头和换能器之间进行贴合。枕头包括液体入口和出口，以促进液体循环冷却，是生物相容的，具有低衰减，与换能器的形状保持一致，便于使用可调节的压力来实现各种支座，包括一个整体的袋子，以便于过盈配合传感器，便于水循环冷却，可灭菌，并且是一次性的。枕头的适于符合组织界面的表面或适于换能器的枕头的表面或两者都可以包括被构造成使液体流失以促进枕头与换能器的声耦合的孔和/或组织。

5. 发明授权

US06315741B1 Method and apparatus for medical procedures using high-intensity focused ultrasound 有权
标题翻译：使用高强度聚焦超声的医疗手术方法和装置
公开(公告)号：US06315741B1
公开(公告)日：2001-11-13
申请号：US09390506
申请日：1999-09-03
申请人： Roy W. Martin , Lawrence A. Crum , Shahram Vaezy , Stephen J. Carter , W. Scott Helton , Michael Gaps , Peter J. Kaczkowski , Andrew Proctor , George Keilman
发明人： Roy W. Martin , Lawrence A. Crum , Shahram Vaezy , Stephen J. Carter , W. Scott Helton , Michael Gaps , Peter J. Kaczkowski , Andrew Proctor , George Keilman
IPC分类号： A61B1722
CPC分类号： A61B17/22004 , A61B8/14 , A61B8/4209 , A61B8/4218 , A61B8/4254 , A61B8/4281 , A61B8/4461 , A61B17/2251 , A61B17/2255 , A61B17/320068 , A61B17/320092 , A61B90/50 , A61B2017/12004 , A61B2017/22008 , A61B2017/320052 , A61B2090/0472 , A61N7/02 , A61N2007/0065 , A61N2007/0069 , A61N2007/0078 , A61N2007/0091 , A61N2007/027
摘要： Methods and apparatus for enabling substantially bloodless surgery and for stemming hemorrhaging. High intensity focused ultrasound (“HIFU”) is used to form cauterized tissue regions prior to surgical incision, for example, forming a cauterized tissue shell around a tumor to be removed. The procedure is referred to as “presurgical volume cauterization.” In one embodiment, the method is particularly effective for use in surgical lesion removal or resection of tissue having a highly vascularized constitution, such as the liver or spleen, and thus a propensity for hemorrhaging. In further embodiments, methods and apparatus for hemostasis using HIFU is useful in both surgical, presurgical, and medical emergency situations. In an apparatus embodiment, a telescoping, acoustic coupler is provided such that depth of focus of the HIFU energy is controllable. In other embodiments, apparatus characterized by portability are demonstrated, useful for emergency medical situations.
摘要翻译：用于实质上无血的手术和用于阻止出血的方法和装置。高强度聚焦超声（“HIFU”）用于在手术切口之前形成烧灼的组织区域，例如，在要移除的肿瘤周围形成烧灼的组织壳。该手术被称为“术前体积烧灼”。在一个实施方案中，该方法特别有效地用于手术损伤去除或切除具有高度血管化构成的组织，例如肝脏或脾脏，并因此用于出血倾向。在另外的实施例中，使用HIFU止血的方法和装置在外科手术，手术前和医疗紧急情况下都是有用的。在设备实施例中，提供伸缩式声学耦合器，使得HIFU能量的焦深可以控制。在其他实施例中，证明了便携性特征的装置，用于紧急医疗情况。

6. 发明授权

US08337434B2 Methods for using high intensity focused ultrasound and associated systems and devices 有权
标题翻译：使用高强度聚焦超声及相关系统和装置的方法
公开(公告)号：US08337434B2
公开(公告)日：2012-12-25
申请号：US12946727
申请日：2010-11-15
申请人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
发明人： Shahram Vaezy , Arthur H. Chan , Victor Y. Fujimoto , Donald E. Moore , Roy W. Martin
IPC分类号： A61H1/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

7. 发明申请

US20120316426A1 IMAGE GUIDED HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT OF NERVES 审中-公开
标题翻译：图像指导高强度聚焦超声治疗神经
公开(公告)号：US20120316426A1
公开(公告)日：2012-12-13
申请号：US13590146
申请日：2012-08-20
申请人： Jessica L. Foley , Shahram Vaezy , James W. Little
发明人： Jessica L. Foley , Shahram Vaezy , James W. Little
IPC分类号： A61N7/02 , A61B5/055 , A61B8/12 , A61B8/13
CPC分类号： A61B8/13 , A61B5/0035 , A61B8/0808 , A61B8/4209 , A61B8/4254 , A61B8/4272 , A61B8/4281 , A61B2017/320069 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于可逆地阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

8. 发明申请

US20080051656A1 METHOD FOR USING HIGH INTENSITY FOCUSED ULTRASOUND 有权
标题翻译：使用高强度聚焦超声的方法
公开(公告)号：US20080051656A1
公开(公告)日：2008-02-28
申请号：US11928667
申请日：2007-10-30
申请人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
发明人： Shahram Vaezy , Arthur Chan , Victor Fujimoto , Donald Moore , Roy Martin
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/08 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/4218 , A61B8/462 , A61B2017/2253 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： A plurality of concepts related to HIFU therapy are disclosed, including a technique to spatially track and display the relative positions of a HIFU focal point and an imaging plane from an ultrasound imager, so that a clinician can ensure that the HIFU focus remains in the image plane during HIFU therapy, thereby facilitating image guided HIFU therapy. Also disclosed are a plurality of transvaginal probes that include a HIFU transducer optimized for the treatment of uterine fibroids. In one embodiment, the probe includes a piezoceramic crystal bonded to an aluminum lens, to achieve a HIFU transducer having a focal length of about 4 cm. In another embodiment, the probe includes a generally spoon-shaped transducer including a plurality of individual emitter elements. Still another concept disclosed herein is a method for evaluating a quality of a coupling between a liquid-filled volume encompassing a HIFU transducer and a tissue interface.
摘要翻译：公开了与HIFU治疗相关的多个概念，包括从超声成像器空间跟踪和显示HIFU焦点和成像平面的相对位置的技术，使得临床医生可以确保HIFU焦点保留在图像中在HIFU治疗期间平面，从而促进图像引导的HIFU治疗。还公开了多个经阴道探针，其包括优化用于治疗子宫肌瘤的HIFU换能器。在一个实施例中，探针包括结合到铝透镜的压电陶瓷晶体，以实现焦距为约4cm的HIFU换能器。在另一个实施例中，探针包括一般包括多个单个发射器元件的匙形换能器。本文公开的另一概念是用于评估包含HIFU换能器的液体填充体与组织界面之间的耦合质量的方法。

9. 发明申请

US20050240126A1 Ultrasound guided high intensity focused ultrasound treatment of nerves 有权
标题翻译：超声引导高强度聚焦超声治疗神经
公开(公告)号：US20050240126A1
公开(公告)日：2005-10-27
申请号：US11016701
申请日：2004-12-16
申请人： Jessica Foley , Shahram Vaezy , James Little
发明人： Jessica Foley , Shahram Vaezy , James Little
IPC分类号： A61B19/00 , A61H1/00 , A61H1/02 , A61H5/00 , A61N7/02
CPC分类号： A61B8/06 , A61B8/0816 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/4281 , A61B8/4444 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2018/00434 , A61B2090/378 , A61N7/02
摘要： A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic affect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversible a block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.
摘要翻译：一种使用高强度聚焦超声（HIFU）治疗神经结构以达到理想的治疗效果的方法。根据施用的HIFU的剂量，它可以对神经结构具有可逆或不可逆的作用。例如，相对高剂量的HIFU可用于永久性阻断神经功能，提供切断神经以治疗严重痉挛状态的非侵入性替代方案。相对较低剂量的HIFU可用于逆转阻断神经功能，减轻疼痛，达到麻醉效果，或达到美容效果。如果感觉神经对于自愿功能不是必需的，而是涉及与肿瘤或骨癌相关的疼痛，HIFU可用于非侵入性地破坏这种感觉神经以缓解没有药物的疼痛。优选地，与HIFU治疗同步的超声成像被用于提供神经结构的实时超声图像引导的HIFU治疗。

10. 发明授权

US06716184B2 Ultrasound therapy head configured to couple to an ultrasound imaging probe to facilitate contemporaneous imaging using low intensity ultrasound and treatment using high intensity focused ultrasound 有权
标题翻译：超声治疗头被配置为耦合到超声成像探针以促进使用低强度超声的同时成像和使用高强度聚焦超声
公开(公告)号：US06716184B2
公开(公告)日：2004-04-06
申请号：US10166795
申请日：2002-06-07
申请人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
发明人： Shahram Vaezy , Roy W. Martin , Stephen J. Carter , George W. Keilman , Victor Y. Fujimoto , Lawrence A. Crum
IPC分类号： A61N700
CPC分类号： A61B8/4488 , A61B8/06 , A61B8/0833 , A61B8/12 , A61B8/4209 , A61B8/4254 , A61B8/445 , A61B8/4483 , A61B8/481 , A61B8/483 , A61B2017/4216 , A61B2090/378 , A61N7/02
摘要： Method and apparatus for the simultaneous use of ultrasound on a probe for imaging and therapeutic purposes. The probe limits the effects of undesirable interference noise in a display by synchronizing high intensity focused ultrasound (HIFU) waves with an imaging transducer to cause the noise to be displayed in an area of the image that does not overlap the treatment site. In one embodiment, the HIFU is first energized at a low power level that does not cause tissue damage, so that the focal point of the HIFU can be identified by a change in the echogenicity of the tissue caused by the HIFU. Once the focal point is properly targeted on a desired treatment site, the power level is increased to a therapeutic level. The location of each treatment site is stored and displayed to the user to enable a plurality of spaced-apart treatment sites to be achieved. As the treatment progresses, any changes in the treatment site can be seen in the real time, noise-free image. A preferred application of the HIFU waves is to cause lesions in blood vessels, so that the supply of nutrients and oxygen to a region, such as a tumor, is interrupted. The tumor will thus eventually be destroyed. In a preferred embodiment, the HIFU is used to treat disorders of the female reproductive system, such as uterine fibroids. The HIFU treatment can be repeated at spaced-apart intervals, until any remaining fibroid tissue is destroyed.
摘要翻译：用于在探针上同时使用超声波用于成像和治疗目的的方法和装置。该探针通过将高强度聚焦超声波（HIFU）波与成像换能器同步来将显示中的不期望的干扰噪声的影响限制在使得噪声显示在不与治疗部位重叠的图像区域中。在一个实施例中，HIFU首先在不会导致组织损伤的低功率水平下通电，使得可以通过由HIFU引起的组织的回波反射性的变化来识别HIFU的焦点。一旦焦点适当地对准所需的治疗部位，功率水平就提高到治疗水平。每个治疗部位的位置被存储并显示给使用者，以实现多个间隔开的治疗部位。随着治疗的进行，治疗部位的任何变化都可以在实时，无噪音的图像中看到。 HIFU波的优选应用是引起血管中的损伤，使得诸如肿瘤等区域的营养物和氧气供应被中断。因此肿瘤最终将被破坏。在优选的实施方案中，HIFU用于治疗女性生殖系统的疾病，例如子宫肌瘤。可以间隔间隔重复HIFU治疗，直到残留的纤维组织被破坏为止。

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