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1. 发明授权

US4250878A Non-invasive chemical species delivery apparatus and method 失效
标题翻译：非侵入性化学物种输送装置及方法
公开(公告)号：US4250878A
公开(公告)日：1981-02-17
申请号：US963029
申请日：1978-11-22
申请人： Stephen C. Jacobsen , Jerome C. Stenehjem , Robert L. Stephen , Richard D. Luntz
发明人： Stephen C. Jacobsen , Jerome C. Stenehjem , Robert L. Stephen , Richard D. Luntz
IPC分类号： A61M37/00 , A61N1/30
CPC分类号： A61N1/0444 , A61N1/0448 , A61N1/044 , A61N1/306
摘要： A bioelectrode for non-invasive and inotophoretic delivery of chemical species (such as ions, polar molecules, etc.) into the skin of a person. The bioelectrode includes a pouch having flexible walls, at least a portion of which is composed of a microporous, permeable or semipermeable membrane. The pouch holds fluid which contains the chemical species to be delivered through the skin. An electrode is attached to the pouch so that when the pouch is placed against the skin, with the membrane portion in contact with the skin, and an electric potential is applied to the electrode, chemical species in the pouch are caused to migrate through the membrane and into the skin.
摘要翻译：用于将非化学物质（例如离子，极性分子等）的非侵入性和肌内渗透递送到人的皮肤中的生物电极。生物电极包括具有柔性壁的袋，其至少一部分由微孔，可渗透或半透膜组成。该袋包含含有要通过皮肤递送的化学物质的流体。将电极附接到袋子，使得当袋子抵靠皮肤放置时，膜部分与皮肤接触，并且电极被施加到电极，使得袋中的化学物质迁移通过膜并进入皮肤。

2. 发明授权

US4166457A Fluid self-sealing bioelectrode 失效
标题翻译：流体自密封生物电极
公开(公告)号：US4166457A
公开(公告)日：1979-09-04
申请号：US851082
申请日：1977-11-14
申请人： Stephen C. Jacobsen , Robert L. Stephen , Richard D. Luntz , Richard T. Johnson , David F. Knutti , Carl F. Mandleco
发明人： Stephen C. Jacobsen , Robert L. Stephen , Richard D. Luntz , Richard T. Johnson , David F. Knutti , Carl F. Mandleco
IPC分类号： A61B5/0402 , A61N1/30 , A61N1/32 , A61B5/04
CPC分类号： A61N1/044 , A61B5/04026 , A61N1/325 , A61N1/0448
摘要： A dry-state bioelectrode having a self-sealing receptacle for receiving electrolyte and/or medicament fluid contents. The receptacle is attached at its opening to a sheet-like flexible base member having an opening in common with the receptacle opening, the bottom of the base member being adapted for fixation at a skin surface. A portion of the skin surface is exposed to the fluid contents of the receptacle through the common opening. An injection site communicates through the wall of the receptacle and provides controlled access for filling. Upon completion of filling, the receptacle self seals, retaining the fluid contents therein for application of iontophoresis treatment or other procedures requiring use of a potential gradient. An electrode plate is supported at an interior surface of the receptacle for supplying the desired electric potential.
摘要翻译：具有用于接收电解质和/或药物流体内容物的自密封容器的干态生物电极。容器在其开口处附接到具有与容器开口共同的开口的片状柔性基底构件，基底构件的底部适于固定在皮肤表面。皮肤表面的一部分通过公共开口暴露于容器的流体内容物。注射部位通过容器的壁连通，并提供受控的填充进入。在填充完成后，容器自身密封，将流体内容物保持在其中以用于离子电渗疗法或其它需要使用电位梯度的方法。电极板被支撑在插座的内表面，用于提供所需的电位。

3. 发明授权

US4405305A Subcutaneous peritoneal injection catheter 失效
标题翻译：皮下腹腔注射导管
公开(公告)号：US4405305A
公开(公告)日：1983-09-20
申请号：US235185
申请日：1981-02-17
申请人： Robert L. Stephen , Carl Kablitz , Barry K. Hanover , Stephen C. Jacobsen , Jeffrey J. Harrow
发明人： Robert L. Stephen , Carl Kablitz , Barry K. Hanover , Stephen C. Jacobsen , Jeffrey J. Harrow
IPC分类号： A61M39/02 , A61M25/00
CPC分类号： A61M39/0208
摘要： A novel implantable, peritoneal injection catheter apparatus and method, the apparatus including an open top, fluid-receiving reservoir mounted to one end of a hollow stem and a penetrable membrane covering the open top of the receiving reservoir. The hollow stem is configurated to extend into the peritoneal cavity and includes a retaining flange system for retaining the hollow stem in fluid communication with the peritoneal cavity. The penetrable membrane serves as an injection site for inserting a hollow needle into the receiving reservoir. The penetrable membrane also includes a dome configuration that may be depressed to expel injection fluids from the reservoir into the peritoneal cavity. A substantial portion of the injection catheter is covered with a velour coating to accomodate tissue ingrowth for further securement of the catheter in the tissue of the abdominal wall.
摘要翻译：一种新颖的可植入式腹膜注射导管装置和方法，该装置包括安装在中空杆的一端的开放式顶部流体接收容器和覆盖接收容器的敞开顶部的可穿透膜。空心杆构造成延伸到腹膜腔中，并且包括用于保持中空杆与腹膜腔流体连通的保持凸缘系统。可穿透膜用作将中空针插入接收容器的注射部位。可渗透膜还包括可以被压下以将注射流体从储存器排出到腹膜腔中的圆顶构型。注射导管的大部分用丝绒涂层覆盖以容纳组织向内生长，以进一步将导管固定在腹壁的组织中。

4. 发明授权

US4180068A Bi-directional flow catheter with retractable trocar/valve structure 失效
标题翻译：双向流动导管，具有可伸缩套针/阀结构
公开(公告)号：US4180068A
公开(公告)日：1979-12-25
申请号：US895858
申请日：1978-04-13
申请人： Stephen C. Jacobsen , Robert L. Stephen , Peter Hansen
发明人： Stephen C. Jacobsen , Robert L. Stephen , Peter Hansen
IPC分类号： A61B17/34 , A61M1/00 , A61M5/158 , A61M25/00 , A61M25/06 , A61M5/00
CPC分类号： A61M25/0029 , A61B17/34 , A61M25/0032 , A61M25/0606 , A61M5/1582 , A61B17/3474 , A61B2217/005 , A61M2025/0031 , A61M2025/0034 , A61M25/0023 , A61M25/007
摘要： A bi-directional flow catheter for insertion into the body of a patient for the simultaneous introduction into and withdrawal therefrom of fluid. The catheter includes a primary tube having open distal and proximal ends, and a pair of branching tubes, each of which branch from a different side of the primary tube. The primary tube also has an opening in one side thereof to allow introduction of fluid. An elongate trocar/valve member is disposed in the primary tube and is movable longitudinally therein between an insert position and a flow position. One end of the trocar/valve member tapers to a cutting edge which protrudes from the opening in the distal end of the primary tube when the member is in the insert position. The trocar/valve member is formed to prevent communication between the side opening and the opening in the distal end of the primary tube, and to cover the passageways between the primary tube and respective ones of the branching tubes when the member is in the insert position. When the member is in the flow position, the cutting end thereof is withdrawn from the distal opening and communication is allowed between the side opening and one of the branching tubes and between the distal opening and the other of the branching tubes to thereby allow simultaneous introduction of fluid into and withdrawal of fluid from the body of a patient.
摘要翻译：一种双向流动导管，用于插入到患者的身体中以同时引入和从中抽出流体。导管包括具有开放的远端和近端的主管和一对分支管，每个分支管从主管的不同侧分支。主管还在其一侧上具有开口以允许引入流体。细长的套管针/阀构件设置在主管中并且可在插入位置和流动位置之间纵向移动。套管针/阀构件的一端在构件处于插入位置时从主管远端的开口突出的切削刃逐渐变细。套管针/阀构件被形成为防止侧开口与主管的远端中的开口之间的连通，并且当构件处于插入位置时，覆盖主管和分支管中的相应通道之间的通道。当构件处于流动位置时，其切割端从远端开口退出，并且允许在侧开口和一个分支管之间以及远端开口和另一分支管之间进行连通，从而允许同时引入的流体从患者的身体进入和从体液中排出。

5. 发明授权

US5087242A Hydratable bioelectrode 失效
标题翻译：可水电生物
公开(公告)号：US5087242A
公开(公告)日：1992-02-11
申请号：US383939
申请日：1989-07-21
申请人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jon Beck , Jin Shimada
发明人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jon Beck , Jin Shimada
IPC分类号： A61M37/00 , A61N1/04 , A61N1/30
CPC分类号： A61N1/0436
摘要： A hydratable iontophoretic bioelectrode includes a layer of material for absorbing and holding an ionized fluid when placed in contact with the fluid. A conductive sheet of material is positioned in contact with one side of the layer of material and is connectable to an electrical charged source to receive a charge of the same polarity as the polarity of ions in the fluid. A support base holds the layer of material and conductive sheets in place to enable placement of the layer of material against the skin or tissue of a person into which ions from the ionized fluid are to be delivered. This is carried out by applying the charge in question to the conductive sheet to cause the ions in the layer of material to migrate therefrom into the person's skin or tissue.

6. 发明授权

US5037380A Iontophoretic electrode with solution containment system 失效
标题翻译：离子电渗电极与溶液容纳系统
公开(公告)号：US5037380A
公开(公告)日：1991-08-06
申请号：US572477
申请日：1990-08-23
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： An iontophoretic bioelectrode includes a pouch for holding a solution, a receptacle element disposed in a wall of the pouch to allow communication therethrough from the exterior to the interior of the pouch, a pair of elongate, generally parallel prongs joined at one end and dimensioned to allow insertion thereof through the receptacle element into the interior of the container, and a solution absorbing material disposed between the prongs to absorb solution with which it makes contact.

7. 发明授权

US4915685A Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange 失效
标题翻译：用于通过离子交换在受控ph中应用药物的离子电渗疗法的方法和装置
公开(公告)号：US4915685A
公开(公告)日：1990-04-10
申请号：US64769
申请日：1987-06-19
申请人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jiri Janata
发明人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jiri Janata
IPC分类号： A61N1/30
CPC分类号： A61N1/0432 , A61N1/0448
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of a patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidificaion or alkalinization of the medicament medium and passage of electric current through the skin. In addition, the efficiency of iontophoresis decreases over time. The present invention avoids extremes in pH by removing the hydrogen or hydroxyl ions which are created during iontophoresis and creates conditions for constant delivery over prolonged periods of time.In the present invention, the medicament ions are attached to an ion exchange matrix, such as an ion exchange resin. When the medicament leaves the ion exchange matrix, the vacated active site is filled by the produced electrolysis products, thereby allowing iontophoresis to progress at a relatively constant pH.
摘要翻译：公开了通过离子电渗法施用已知量的药物的方法和装置，同时避免了在电流通过过程中由药物介质的pH极端引起的烧伤。众所周知，在常规离子电渗系统中离子电渗进行时，发生电解水以在电极和药物介质的界面产生氢或羟基离子。由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。此外，离子电渗疗法的效率随时间而降低。本发明通过除去在离子电渗疗法期间产生的氢或羟基离子来避免pH值的极端，并且产生在长时间内恒定输送的条件。在本发明中，药物离子连接到离子交换基质如离子交换树脂上。当药物离开离子交换基质时，所产生的电解产物填充空位的活性位点，从而允许离子电渗在相对恒定的pH下进行。

8. 发明授权

US4886489A Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH 失效
标题翻译：用于离子电渗疗法的流通方法和装置在受控pH下应用药物
公开(公告)号：US4886489A
公开(公告)日：1989-12-12
申请号：US64813
申请日：1987-06-19
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Robert L. Stephen
IPC分类号： A61M35/00 , A61N1/04 , A61N1/30
CPC分类号： A61N1/0432 , A61N1/0448
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of a patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidification or alkalinization of the medicament medium and passage of electric current through the skin. In addition, the efficiency of iontophoresis decreases over time. The present invention avoids extremes in pH by removing the hydrogen or hydroxyl ions which are created during iontophoresis and creates conditions for constant delivery over prolonged periods of time.In the present invention, the medicament medium adjacent the patient is periodically or constantly replaced by adding fresh medicament medium which is at the original pH. The present invention also discloses a flow-through electrode which allows new solution to constantly flow into the iontophoresis area.
摘要翻译：公开了通过离子电渗法施用已知量的药物的方法和装置，同时避免了在电流通过过程中由药物介质的pH极端引起的烧伤。众所周知，在常规离子电渗系统中离子电渗进行时，发生电解水以在电极和药物介质的界面产生氢或羟基离子。由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。此外，离子电渗疗法的效率随时间而降低。本发明通过除去在离子电渗疗法期间产生的氢或羟基离子来避免pH值的极端，并且产生在长时间内恒定输送的条件。在本发明中，通过添加处于原始pH值的新鲜药物培养基来定期或不断地替换邻近患者的药物介质。本发明还公开了一种允许新溶液不断流入离子电渗区的流通电极。

9. 发明授权

US4335716A Composition and method for prevention and treatment of dialysis induced peritonitis 失效
标题翻译：预防和治疗透析诱发腹膜炎的组合物和方法
公开(公告)号：US4335716A
公开(公告)日：1982-06-22
申请号：US208967
申请日：1980-11-21
申请人： Robert L. Stephen , Carl Kablitz , Dietz van Dura , Curtis L. Atkin , Stephen C. Jacobsen
发明人： Robert L. Stephen , Carl Kablitz , Dietz van Dura , Curtis L. Atkin , Stephen C. Jacobsen
IPC分类号： A61K33/18 , A61M1/28 , A61J7/00
CPC分类号： A61M1/287 , A61K33/18
摘要： A composition and method for use with peritoneal dialysis patients for preventing or treating dialysis induced peritonitis. The method utilizes a flush solution of normal saline to prepare the peritoneal cavity for infusion of a dilute iodine solution which operates to kill pathogenic organisms contained therein. The dilute iodine solution has a combination I.sub.2 and HIO concentration in the approximate range of 0.1 ppm to 15 ppm and requires residence time of less than five minutes to provide an effective kill. The serial application of flush and dilute iodine solutions may be applied as part of a regular peritoneal dialysis program to prevent peritonitis or may be used with greater frequency as treatment for existing dialysis induced peritonitis.
摘要翻译：用于腹膜透析患者预防或治疗透析诱发腹膜炎的组合物和方法。该方法利用生理盐水的冲洗溶液来制备用于输注稀碘溶液的腹膜腔，该碘溶液用于杀死其中所含的致病生物。稀碘溶液具有在0.1ppm至15ppm的近似范围内的组合I2和HIO浓度，并且需要少于5分钟的停留时间以提供有效杀灭。冲洗和稀释碘溶液的连续应用可以用作常规腹膜透析程序的一部分，以防止腹膜炎，或者可以以更大的频率用于现有的透析诱导的腹膜炎的治疗。

10. 发明授权

US5248295A Bioelectrode seal 失效
标题翻译：生物电极密封
公开(公告)号：US5248295A
公开(公告)日：1993-09-28
申请号：US703456
申请日：1991-05-21
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0436
摘要： An iontophoretic bioelectrode includes an enclosure forming upper sheet of material having a generally planar outer section circumscribing a raised central section which defines an interior compartment. A compliant, resilient and sticky raised barrier is formed on the underside of the outer section of the upper sheet of material to circumscribe the central section. When placed against the skin of a person, the barrier adheres to the skin to form a seal completely around the central section and interior compartment into which an ion carrying solution may then be introduced for administration, by iontophoresis, into a persons' skin.
摘要翻译：离子电渗生物电极包括形成上片材料的外壳，其具有围绕限定内部隔间的凸起中心部分的大致平坦的外部部分。在上部材料的外部部分的下侧上形成柔顺且弹性和粘性的凸起的隔离物以包围中心部分。当放置在人的皮肤上时，屏障粘附到皮肤上，以便在中心部分和内部隔室周围完全形成密封，然后可以通过离子电渗法将离子载体溶液引入其中，以通过离子电渗法进入人的皮肤。

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