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1. 发明授权

US4886489A Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH 失效
标题翻译：用于离子电渗疗法的流通方法和装置在受控pH下应用药物
公开(公告)号：US4886489A
公开(公告)日：1989-12-12
申请号：US64813
申请日：1987-06-19
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Robert L. Stephen
IPC分类号： A61M35/00 , A61N1/04 , A61N1/30
CPC分类号： A61N1/0432 , A61N1/0448
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of a patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidification or alkalinization of the medicament medium and passage of electric current through the skin. In addition, the efficiency of iontophoresis decreases over time. The present invention avoids extremes in pH by removing the hydrogen or hydroxyl ions which are created during iontophoresis and creates conditions for constant delivery over prolonged periods of time.In the present invention, the medicament medium adjacent the patient is periodically or constantly replaced by adding fresh medicament medium which is at the original pH. The present invention also discloses a flow-through electrode which allows new solution to constantly flow into the iontophoresis area.
摘要翻译：公开了通过离子电渗法施用已知量的药物的方法和装置，同时避免了在电流通过过程中由药物介质的pH极端引起的烧伤。众所周知，在常规离子电渗系统中离子电渗进行时，发生电解水以在电极和药物介质的界面产生氢或羟基离子。由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。此外，离子电渗疗法的效率随时间而降低。本发明通过除去在离子电渗疗法期间产生的氢或羟基离子来避免pH值的极端，并且产生在长时间内恒定输送的条件。在本发明中，通过添加处于原始pH值的新鲜药物培养基来定期或不断地替换邻近患者的药物介质。本发明还公开了一种允许新溶液不断流入离子电渗区的流通电极。

2. 发明授权

US5087242A Hydratable bioelectrode 失效
标题翻译：可水电生物
公开(公告)号：US5087242A
公开(公告)日：1992-02-11
申请号：US383939
申请日：1989-07-21
申请人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jon Beck , Jin Shimada
发明人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jon Beck , Jin Shimada
IPC分类号： A61M37/00 , A61N1/04 , A61N1/30
CPC分类号： A61N1/0436
摘要： A hydratable iontophoretic bioelectrode includes a layer of material for absorbing and holding an ionized fluid when placed in contact with the fluid. A conductive sheet of material is positioned in contact with one side of the layer of material and is connectable to an electrical charged source to receive a charge of the same polarity as the polarity of ions in the fluid. A support base holds the layer of material and conductive sheets in place to enable placement of the layer of material against the skin or tissue of a person into which ions from the ionized fluid are to be delivered. This is carried out by applying the charge in question to the conductive sheet to cause the ions in the layer of material to migrate therefrom into the person's skin or tissue.

3. 发明授权

US5037380A Iontophoretic electrode with solution containment system 失效
标题翻译：离子电渗电极与溶液容纳系统
公开(公告)号：US5037380A
公开(公告)日：1991-08-06
申请号：US572477
申请日：1990-08-23
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： An iontophoretic bioelectrode includes a pouch for holding a solution, a receptacle element disposed in a wall of the pouch to allow communication therethrough from the exterior to the interior of the pouch, a pair of elongate, generally parallel prongs joined at one end and dimensioned to allow insertion thereof through the receptacle element into the interior of the container, and a solution absorbing material disposed between the prongs to absorb solution with which it makes contact.

4. 发明授权

US4915685A Methods and apparatus for iontophoresis application of medicaments at a controlled ph through ion exchange 失效
标题翻译：用于通过离子交换在受控ph中应用药物的离子电渗疗法的方法和装置
公开(公告)号：US4915685A
公开(公告)日：1990-04-10
申请号：US64769
申请日：1987-06-19
申请人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jiri Janata
发明人： Tomasz J. Petelenz , Stephen C. Jacobsen , Robert L. Stephen , Jiri Janata
IPC分类号： A61N1/30
CPC分类号： A61N1/0432 , A61N1/0448
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of a patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidificaion or alkalinization of the medicament medium and passage of electric current through the skin. In addition, the efficiency of iontophoresis decreases over time. The present invention avoids extremes in pH by removing the hydrogen or hydroxyl ions which are created during iontophoresis and creates conditions for constant delivery over prolonged periods of time.In the present invention, the medicament ions are attached to an ion exchange matrix, such as an ion exchange resin. When the medicament leaves the ion exchange matrix, the vacated active site is filled by the produced electrolysis products, thereby allowing iontophoresis to progress at a relatively constant pH.
摘要翻译：公开了通过离子电渗法施用已知量的药物的方法和装置，同时避免了在电流通过过程中由药物介质的pH极端引起的烧伤。众所周知，在常规离子电渗系统中离子电渗进行时，发生电解水以在电极和药物介质的界面产生氢或羟基离子。由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。此外，离子电渗疗法的效率随时间而降低。本发明通过除去在离子电渗疗法期间产生的氢或羟基离子来避免pH值的极端，并且产生在长时间内恒定输送的条件。在本发明中，药物离子连接到离子交换基质如离子交换树脂上。当药物离开离子交换基质时，所产生的电解产物填充空位的活性位点，从而允许离子电渗在相对恒定的pH下进行。

5. 发明授权

US5248295A Bioelectrode seal 失效
标题翻译：生物电极密封
公开(公告)号：US5248295A
公开(公告)日：1993-09-28
申请号：US703456
申请日：1991-05-21
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0436
摘要： An iontophoretic bioelectrode includes an enclosure forming upper sheet of material having a generally planar outer section circumscribing a raised central section which defines an interior compartment. A compliant, resilient and sticky raised barrier is formed on the underside of the outer section of the upper sheet of material to circumscribe the central section. When placed against the skin of a person, the barrier adheres to the skin to form a seal completely around the central section and interior compartment into which an ion carrying solution may then be introduced for administration, by iontophoresis, into a persons' skin.
摘要翻译：离子电渗生物电极包括形成上片材料的外壳，其具有围绕限定内部隔间的凸起中心部分的大致平坦的外部部分。在上部材料的外部部分的下侧上形成柔顺且弹性和粘性的凸起的隔离物以包围中心部分。当放置在人的皮肤上时，屏障粘附到皮肤上，以便在中心部分和内部隔室周围完全形成密封，然后可以通过离子电渗法将离子载体溶液引入其中，以通过离子电渗法进入人的皮肤。

6. 发明授权

US4979938A Method of iontophoretically treating acne, furuncles and like skin disorders 失效
标题翻译：离子电渗治疗痤疮，fur疮等皮肤疾病的方法
公开(公告)号：US4979938A
公开(公告)日：1990-12-25
申请号：US350227
申请日：1989-05-11
申请人： Robert L. Stephen , Tomasz J. Petelenz , Stephen C. Jacobsen
发明人： Robert L. Stephen , Tomasz J. Petelenz , Stephen C. Jacobsen
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A method is disclosed for treating acne, boils and similar skin disorders which are characterized by closed, blocked channels in the epidermis of the skin. The method comprises applying an applicator electrode on the skin of the person to be treated; providing a relatively small amount of water containing dissolved ions in contact with the applicator electrode and the affected tissue; applying a dispersive electrode on the skin of the person to be treated; applying a voltage differential to the applicator and dispersive electrodes such that the applicator electrode has a negative charge and the dispersive electrode has a positive charge; producing hydroxyl ions at the applicator electrode to develop a strongly alkaline solution therein, and driving the ions down the channels of the affected tissue by iontophoresis; continuing the application of the voltage differential to the applicator and dispersive electrodes for a time sufficient to disrupt the blockage of the channels in the affected tissue and to establish drainage from the channels.

7. 发明授权

US4968297A Iontophoretic electrode with solution containment system 失效
标题翻译：离子电渗电极与溶液容纳系统
公开(公告)号：US4968297A
公开(公告)日：1990-11-06
申请号：US349489
申请日：1989-05-09
申请人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
发明人： Stephen C. Jacobsen , Tomasz J. Petelenz , Jon Beck , Robert L. Stephen
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0448
摘要： A solution containment system for use in connection with an iontophoretic bioelectrode having a solution containing receptacle. The solution containment system includes a nipple formed in the wall of the receptacle, a capsule disposed in the nipple, and a liquid absorbing material contained in the capsule. The capsule is burstable when squeezed so that the liquid absorbing material is released into the interior of the receptacle to absorb any solution left over from use of the bioelectrode.

8. 发明授权

US4752285A Methods and apparatus for iontophoresis application of medicaments 失效
标题翻译：离子电渗法应用药物的方法和装置
公开(公告)号：US4752285A
公开(公告)日：1988-06-21
申请号：US841329
申请日：1986-03-19
申请人： Tomasz J. Petelenz , Robert L. Stephen , Stephen C. Jacobsen
发明人： Tomasz J. Petelenz , Robert L. Stephen , Stephen C. Jacobsen
IPC分类号： A61K9/00 , A61N1/30
CPC分类号： A61N1/0432
摘要： Methods and apparatus for administering known quantities of medicaments by iontophoresis while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current are disclosed. It has been found that, as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidification or alkalinization of the medicament medium and passage of electric current through the skin. The present invention also avoids the production of other competing ions by employing a reactive electrode. The electrode and the medicament are chosen such that the electrode will react with the complementary ion (the ion which forms upon the dissociation of the medicament in solution) to form an insoluble material.
摘要翻译：公开了用于通过离子电渗疗法施用已知量的药物的方法和装置，同时避免在电流通过期间由药物介质的pH极端引起的烧伤。已经发现，随着离子电渗在常规离子电渗系统中进行，水的电解发生在电极和药物介质的界面处产生氢或羟基离子。由于这些离子是高度移动的，所以它们优先于较大的药物离子直接转运到患者的皮肤中。因此，经历了pH的极端变化，其由于药物介质的酸化或碱化以及电流通过皮肤而导致燃烧。本发明还通过使用反应性电极避免生产其它竞争离子。选择电极和药物使得电极将与互补离子（溶液中的药物解离时形成的离子）反应以形成不溶性材料。

9. 发明申请

US20110162451A1 DIGITAL WOUND DETECTION SYSTEM 有权
标题翻译：数字检测系统
公开(公告)号：US20110162451A1
公开(公告)日：2011-07-07
申请号：US12116605
申请日：2008-05-07
申请人： Tomasz J. Petelenz , Stephen C. Jacobsen
发明人： Tomasz J. Petelenz , Stephen C. Jacobsen
IPC分类号： G01L5/14 , G01P15/093
CPC分类号： G01P1/127 , A42B3/046 , F41H1/02 , F41H1/04 , F41J5/056 , G01L5/0052 , G01P15/04 , G01P15/0891 , G01P15/0922
摘要： Methods and devices for a miniature, ultra-low power impact recorder for detecting, quantifying and recording the energy of an explosive blast or ballistic projectile impact. In one embodiment, the impact recorder can included a sensor comprised of an array of electromechanical resonators that is sensitive to the vibrations produced in selected, discrete frequency ranges that approximate the spectral signature characteristics of the shockwave resulting from the ballistic impact event, even after traveling through impacted material or body tissues.
摘要翻译：用于检测，量化和记录爆炸性爆炸或弹道射弹冲击能量的微型超低功率冲击记录仪的方法和装置。在一个实施例中，冲击记录器可以包括传感器，其包括机电谐振器的阵列，其对于在选定的离散频率范围内产生的振动敏感，所述离散频率范围近似于由弹道撞击事件引起的冲击波的频谱特征特征，即使在旅行通过冲击材料或身体组织。

10. 发明申请

US20100022900A1 Non-Invasive Method And Device For Measuring Cardiac Output 有权
标题翻译：非侵入性方法和测量心输出量的装置
公开(公告)号：US20100022900A1
公开(公告)日：2010-01-28
申请号：US12348842
申请日：2009-01-05
申请人： Stephen C. Peterson , Tomasz J. Petelenz , Stephen C. Jacobsen
发明人： Stephen C. Peterson , Tomasz J. Petelenz , Stephen C. Jacobsen
IPC分类号： A61B5/02
CPC分类号： A61B5/05 , A61B5/02028 , A61B5/029 , A61B5/0507
摘要： A system comprising a housing containing a signal generator coupled to an antenna and a dielectric material disposed about the antenna. The device is adapted to generate and direct a plurality of signals towards the heart of the person and measure a magnitude of a signal returned from the heart. The device further comprises a processor to compare differences between a magnitude of a signal propagated and the magnitude of the signal returned off the heart and determine a signal frequency having a maximum return loss value based on those differences. The processor also estimates a change in the amplitude of motion of a portion of a wall of the heart based on the differences between the magnitude of the signal propagated by the device and the magnitude of the signal returned off of the portion of the heart.
摘要翻译：一种系统，包括壳体，其容纳耦合到天线的信号发生器和围绕天线设置的电介质材料。该装置适于产生并引导人的心脏的多个信号并且测量从心脏返回的信号的幅度。该装置还包括处理器，用于比较传播的信号的幅度与从心脏返回的信号的大小之间的差异，并基于这些差异确定具有最大回波损耗值的信号频率。处理器还基于由器件传播的信号的幅度与从心脏部分返回的信号的大小之间的差异来估计心脏壁的一部分的运动幅度的变化。

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