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1. 发明申请

US20050186233A1 Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US20050186233A1
公开(公告)日：2005-08-25
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/19 , A61Q5/00 , A61Q5/10 , C12Q1/00 , C12Q1/533 , A61K7/135
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

2. 发明授权

US07585514B2 Administration of agents mimicking DOPAchrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿DOPAchrome互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US07585514B2
公开(公告)日：2009-09-08
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

3. 发明申请

US20100074929A1 ADMINISTRATION OF AGENTS MIMICKING DOPACHROME TAUTOMERASE (TRP-2) ACTIVITY FOR PROTECTING HAIR FOLLICLE MELANOCYTES 有权
标题翻译：用于保护头发微生物蛋白的药剂的治疗药物DOPACHROME TAUTOMERASE（TRP-2）活性
公开(公告)号：US20100074929A1
公开(公告)日：2010-03-25
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , C12Q1/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

4. 发明授权

US6113889A Screening of candidates for biological hair care activity 失效
标题翻译：筛选候选人的生物护发活动
公开(公告)号：US6113889A
公开(公告)日：2000-09-05
申请号：US233062
申请日：1999-01-20
申请人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , A61Q7/00 , G01N33/50 , A61K7/06
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.
摘要翻译：本发明涉及一种用于测试头发护理领域中使用的潜在活性物质的方法，该方法的特征在于，至少一种没有真皮乳头的毛囊的片段被分离，该片段从点下面皮脂腺附着并排除位于皮脂腺附着点之上的毛发部分; 将该片段在合适的培养基中培养足够的时间; 该片段与潜在活性的护发物质接触; 定量测定所述被测物质的活性的标记物; 并且与其对照相比，评估该测定的结果。

5. 发明授权

US08445004B2 Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US08445004B2
公开(公告)日：2013-05-21
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

6. 发明授权

US5891426A Screening of candidates for biological hair care activity 失效
公开(公告)号：US5891426A
公开(公告)日：1999-04-06
申请号：US800457
申请日：1997-02-18
申请人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , A61Q7/00 , G01N33/50 , A61K7/06
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.

7. 发明授权

US06184252B2 2-amino-1,3-alkanediol compositions for inducing/stimulating hair growth and/or retarding hair loss 失效
标题翻译：用于诱导/刺激毛发生长和/或减缓脱发的2-氨基-1,3-链烷二醇组合物
公开(公告)号：US06184252B2
公开(公告)日：2001-02-06
申请号：US08801315
申请日：1997-02-18
申请人： Dominique Fagot , Olivier Gaillard , Michel Philippe , Bruno Bernard
发明人： Dominique Fagot , Olivier Gaillard , Michel Philippe , Bruno Bernard
IPC分类号： A61K3116
CPC分类号： A61Q7/00 , A61K8/41 , A61K8/68 , Y10S514/88
摘要： Topically applicable hair growth-/hair loss-affecting cosmetic/pharmaceutical compositions for treating mammalian subjects with hair or scalp disorders, comprise an effective amount of at least one 2-amino-1,3-alkanediol compound having the structural formula (I): formulated into a physiologically topically acceptable carrier medium therefor.
摘要翻译：包含有效量的具有结构式（I）的有效量的至少一种2-氨基-1,3-烷二醇化合物：用于治疗哺乳动物受毛发或头皮疾病的受试者的局部适用的头发生长/ 配制成生理局部可接受的载体介质。

8. 发明授权

US5712169A Screening of candidates for biological hair care activity 失效
标题翻译：筛选候选人的生物护发活动
公开(公告)号：US5712169A
公开(公告)日：1998-01-27
申请号：US678979
申请日：1996-07-12
申请人： Bruno Bernard , Olivier Gaillard
发明人： Bruno Bernard , Olivier Gaillard
IPC分类号： G01N33/50 , G01N33/567 , A61K7/06 , A61K49/00 , C12N5/00
CPC分类号： G01N33/5088
摘要： A procedure for screening a candidate substance for biological hair care activity comprises (i) microdissecting and isolating at least one viable hair follicle and the epidermal surroundings thereof, while preserving the continuity of such at least one hair follicle and the epidermal environment thereof, but removing the adipose tissue therefrom, (ii) incubating the at least one hair follicle in a nutrient medium for a given period of time, (iii) contacting the at least one incubated hair follicle with the candidate substance for biological hair care activity, and (iv) measuring a marker of the hair care activity of the candidate substance and thence evaluating the results of such measurement in comparison with a control.
摘要翻译：用于筛选用于生物毛发护理活动的候选物质的方法包括（i）显微解剖和分离至少一个存活的毛囊及其表皮环境，同时保持这种至少一个毛囊及其表皮环境的连续性，但除去（ii）将营养培养基中的至少一个毛囊孵育给定时间段，（iii）使至少一个孵化的毛囊与用于生物毛发护理活动的候选物质接触，和（iv ）测量候选物质的毛发护理活动的标记，并且从而与对照相比较，评估这种测量的结果。

9. 发明申请

US20140346011A1 BATCH CONVEYING UNIT FOR A UNIT FOR CONVERTING PLATE-LIKE ELEMENTS IN A PACKAGING PRODUCTION LINE 有权
标题翻译：批量输送单元，用于在包装生产线中转换板状元件
公开(公告)号：US20140346011A1
公开(公告)日：2014-11-27
申请号：US14362170
申请日：2012-11-01
申请人： Olivier Gaillard , Jean-Jacques Lucas
发明人： Olivier Gaillard , Jean-Jacques Lucas
IPC分类号： B65G47/30 , B65G47/34
CPC分类号： B65G47/30 , B26D7/32 , B65G15/105 , B65G23/26 , B65G47/34 , B65G47/682
摘要： A batch conveying unit for a unit for conveying plate-like elements has at least two transport devices adjacent and parallel to one another (13, 14, 16) which are capable of transporting (L) the batches (3, 6) in a longitudinal direction, drive means for the transport devices (13), and an actuating device for coupling and decoupling a second transport device (14, 28) relative to a first transport device (14, 27), so as to transport (L) a first batch (6) of elements with the first transport device (14, 27) in the longitudinal direction and to leave a second batch (7) of plate-like elements with the second transport device (14, 28) substantially immobile longitudinally when the second transport device (14, 28) is decoupled from the first transport device (14, 27).
摘要翻译：用于输送板状元件的单元的分批输送单元具有彼此相邻并且彼此平行的至少两个运输装置（13,14,16），其能够以纵向方式运送（L）批料（3）方向，用于运输装置（13）的驱动装置，以及用于相对于第一输送装置（14,27）联接和分离第二输送装置（14,28）的致动装置，以便输送（L）第一批量（6）的元件与第一输送装置（14,27）在纵向方向上并且留下第二批（7）的板状元件，其中第二输送装置（14,28）在第二输送装置运输装置（14,28）与第一输送装置（14,27）分离。

10. 发明授权

US09315339B2 Batch conveying unit for a unit for converting plate-like elements in a packaging production line 有权
标题翻译：用于在包装生产线中转换板状元件的单元的批量输送单元
公开(公告)号：US09315339B2
公开(公告)日：2016-04-19
申请号：US14362170
申请日：2012-11-01
申请人： Olivier Gaillard , Jean-Jacques Lucas
发明人： Olivier Gaillard , Jean-Jacques Lucas
IPC分类号： B65G47/46 , B65G47/30 , B65G23/26 , B65G47/68 , B65G15/10 , B26D7/32 , B65G47/34
CPC分类号： B65G47/30 , B26D7/32 , B65G15/105 , B65G23/26 , B65G47/34 , B65G47/682
摘要： A batch conveying unit for a unit for conveying plate-like elements has at least two transport devices adjacent and parallel to one another (13, 14, 16) which are capable of transporting (L) the batches (3, 6) in a longitudinal direction, drive devices for the transport devices (13), and an actuating device for coupling and decoupling a second transport device (14, 28) relative to a first transport device (14, 27), so as to transport (L) a first batch (6) of elements with the first transport device (14, 27) in the longitudinal direction and to leave a second batch (7) of plate-like elements with the second transport device (14, 28) substantially immobile longitudinally when the second transport device (14, 28) is decoupled from the first transport device (14, 27).
摘要翻译：用于输送板状元件的单元的分批输送单元具有彼此相邻并且彼此平行的至少两个运输装置（13,14,16），其能够以纵向方式运送（L）批料（3）方向，用于运输装置（13）的驱动装置，以及用于相对于第一输送装置（14,27）联接和分离第二输送装置（14,28）的致动装置，以便运送（L）第一批量（6）的元件与第一输送装置（14,27）在纵向方向上并且留下第二批（7）的板状元件，其中第二输送装置（14,28）在第二输送装置运输装置（14,28）与第一输送装置（14,27）分离。

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