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1. 发明授权

US5891426A Screening of candidates for biological hair care activity 失效
公开(公告)号：US5891426A
公开(公告)日：1999-04-06
申请号：US800457
申请日：1997-02-18
申请人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , A61Q7/00 , G01N33/50 , A61K7/06
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.

2. 发明授权

US6113889A Screening of candidates for biological hair care activity 失效
标题翻译：筛选候选人的生物护发活动
公开(公告)号：US6113889A
公开(公告)日：2000-09-05
申请号：US233062
申请日：1999-01-20
申请人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Fran.cedilla.oise Jarrousse , Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , A61Q7/00 , G01N33/50 , A61K7/06
CPC分类号： G01N33/5088 , Y10S514/88
摘要： The invention concerns a procedure for testing a potentially-active substance used in the hair-care field, this procedure being characterized by the fact that a fragment of at least one hair follicle without dermal papilla is isolated, this fragment being taken from beneath the point of attachment of the sebaceous gland and excluding the portion of the hair shaft located above the point of attachment of the sebaceous gland; that this fragment is incubated in a suitable culture medium for a sufficient period; that this fragment is placed in contact with a potentially-active hair-care substance; that a marker of the activity of said tested substance is quantitatively determined; and that the results of this determination are assessed as they compare to a control.
摘要翻译：本发明涉及一种用于测试头发护理领域中使用的潜在活性物质的方法，该方法的特征在于，至少一种没有真皮乳头的毛囊的片段被分离，该片段从点下面皮脂腺附着并排除位于皮脂腺附着点之上的毛发部分; 将该片段在合适的培养基中培养足够的时间; 该片段与潜在活性的护发物质接触; 定量测定所述被测物质的活性的标记物; 并且与其对照相比，评估该测定的结果。

3. 发明申请

US20050186233A1 Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US20050186233A1
公开(公告)日：2005-08-25
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/19 , A61Q5/00 , A61Q5/10 , C12Q1/00 , C12Q1/533 , A61K7/135
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

4. 发明授权

US07585514B2 Administration of agents mimicking DOPAchrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿DOPAchrome互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US07585514B2
公开(公告)日：2009-09-08
申请号：US11009153
申请日：2004-12-13
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

5. 发明授权

US08445004B2 Administration of agents mimicking dopachrome tautomerase (TRP-2) activity for protecting hair follicle melanocytes 有权
标题翻译：给予模仿多巴肼互变异构酶（TRP-2）活性以保护毛囊黑素细胞的药剂
公开(公告)号：US08445004B2
公开(公告)日：2013-05-21
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

6. 发明申请

US20100074929A1 ADMINISTRATION OF AGENTS MIMICKING DOPACHROME TAUTOMERASE (TRP-2) ACTIVITY FOR PROTECTING HAIR FOLLICLE MELANOCYTES 有权
标题翻译：用于保护头发微生物蛋白的药剂的治疗药物DOPACHROME TAUTOMERASE（TRP-2）活性
公开(公告)号：US20100074929A1
公开(公告)日：2010-03-25
申请号：US12541398
申请日：2009-08-14
申请人： Stephane Commo , Olivier Gaillard , Bruno Bernard
发明人： Stephane Commo , Olivier Gaillard , Bruno Bernard
IPC分类号： A61K8/02 , C12Q1/02
CPC分类号： C12Q1/533 , A61K8/19 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/10
摘要： Agents mimicking DOPAchrome tautomerase activity are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：施用模仿DOPAchrome互变异构酶活性的试剂，特别是局部应用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止囊泡的发育，并保持灰色或白色头发和/或身体毛发的天然色素沉着。

7. 发明申请

US20050208086A1 Administration of agents inducing DOPAchrome tautomerase (TRP-2) expression for protecting hair follicle melanocytes 审中-公开
标题翻译：诱导诱导DOPAchrome互变异构酶（TRP-2）表达以保护毛囊黑素细胞的药剂的给药
公开(公告)号：US20050208086A1
公开(公告)日：2005-09-22
申请号：US11009364
申请日：2004-12-13
申请人： Stephane Commo , Bruno Bernard
发明人： Stephane Commo , Bruno Bernard
IPC分类号： A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61Q5/00 , A61Q5/06 , A61Q5/10 , A61Q7/00 , A61K7/135
CPC分类号： A61Q5/065 , A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61K2800/70 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：诱导诱导DOPAchrome互变异构酶表达的药剂，特别是局部施用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止并保持灰色或白色头发和/或身体毛发的天然色素沉着。

8. 发明申请

US20090275033A1 Uses of BNIPXL-Beta in premature canities 失效
标题翻译： BNIPXL-Beta在早产儿中的应用
公开(公告)号：US20090275033A1
公开(公告)日：2009-11-05
申请号：US12387138
申请日：2009-04-28
申请人： Bruno Bernard , Stephane Commo , Olivier De Lacharriere
发明人： Bruno Bernard , Stephane Commo , Olivier De Lacharriere
IPC分类号： C12Q1/68 , C07K14/00 , C07H21/02 , C12Q1/00 , G01N33/68 , G01N33/566
CPC分类号： C07K14/4747 , A61K8/64 , A61Q5/00
摘要： The present invention concerns the use of a polypeptide comprising a sequence having at least 90% identity with all or part of BNIPXLβ, for cosmetic or therapeutic applications, in the treatment or prevention of premature canities in humans, said portion comprising at least 30 amino acids, as well as the use, for the same purpose, of a molecule comprising a RNAi sequence having at least 90% identity with all or part of the cDNA sequence of BNIPXLβ, said part comprising at least 18 nucleotides.The invention also concerns methods for screening molecules modulating the expression of a gene coding for BNIPXL-beta and molecules modulating the activity of the BNIPXL-beta polypeptide, in order to identify an agent for use for cosmetic or therapeutic purposes in the field of pigmentation. The invention also encompasses various uses of molecules which may be identified by these methods.
摘要翻译：本发明涉及包含与全部或部分BNIPXLβ具有至少90％同一性的序列用于化妆品或治疗应用的多肽在治疗或预防人类早衰症中的用途，所述部分包含至少30个氨基酸以及用于相同目的的包含与BNIPXLβ的全部或部分cDNA序列具有至少90％同一性的RNAi序列的分子，所述部分包含至少18个核苷酸。本发明还涉及用于筛选调节编码BNIPXL-β的基因的表达的调节分子和调节BNIPXL-β多肽的活性的分子的方法，以鉴定在色素沉着领域中用于化妆品或治疗目的的药剂。本发明还包括可以通过这些方法鉴定的分子的各种用途。

9. 发明申请

US20090118203A1 Administration of agents inducing dopachrome tautomerase (TRP-2) expression for protecting hair follicle melanocytes 审中-公开
标题翻译：施用诱导多巴肼互变异构酶（TRP-2）表达以保护毛囊黑素细胞的药剂
公开(公告)号：US20090118203A1
公开(公告)日：2009-05-07
申请号：US12076753
申请日：2008-03-21
申请人： Stephane Commo , Bruno Bernard
发明人： Stephane Commo , Bruno Bernard
IPC分类号： A61K31/704 , A61K31/7088 , A61K31/352 , C12Q1/48
CPC分类号： A61Q5/065 , A61K8/34 , A61K8/42 , A61K8/63 , A61K8/64 , A61K31/7048 , A61K2800/70 , A61Q5/00 , A61Q5/10 , A61Q7/00
摘要： Agents inducing the expression of DOPAchrome tautomerase are administered, notably topically applied, to protect and/or regenerate the melanocytes of hair follicles, to promote the cyclic renewal of the follicular pigmentation unit, to prevent and/or limit and/or arrest the development of canities, and to maintain the natural pigmentation of gray or white head hair and/or body hair.
摘要翻译：诱导诱导DOPAchrome互变异构酶表达的药剂，特别是局部施用，以保护和/或再生毛囊的黑素细胞，促进滤泡色素沉着单位的循环更新，以预防和/或限制和/或阻止并保持灰色或白色头发和/或身体毛发的天然色素沉着。

10. 发明授权

US5712169A Screening of candidates for biological hair care activity 失效
标题翻译：筛选候选人的生物护发活动
公开(公告)号：US5712169A
公开(公告)日：1998-01-27
申请号：US678979
申请日：1996-07-12
申请人： Bruno Bernard , Olivier Gaillard
发明人： Bruno Bernard , Olivier Gaillard
IPC分类号： G01N33/50 , G01N33/567 , A61K7/06 , A61K49/00 , C12N5/00
CPC分类号： G01N33/5088
摘要： A procedure for screening a candidate substance for biological hair care activity comprises (i) microdissecting and isolating at least one viable hair follicle and the epidermal surroundings thereof, while preserving the continuity of such at least one hair follicle and the epidermal environment thereof, but removing the adipose tissue therefrom, (ii) incubating the at least one hair follicle in a nutrient medium for a given period of time, (iii) contacting the at least one incubated hair follicle with the candidate substance for biological hair care activity, and (iv) measuring a marker of the hair care activity of the candidate substance and thence evaluating the results of such measurement in comparison with a control.
摘要翻译：用于筛选用于生物毛发护理活动的候选物质的方法包括（i）显微解剖和分离至少一个存活的毛囊及其表皮环境，同时保持这种至少一个毛囊及其表皮环境的连续性，但除去（ii）将营养培养基中的至少一个毛囊孵育给定时间段，（iii）使至少一个孵化的毛囊与用于生物毛发护理活动的候选物质接触，和（iv ）测量候选物质的毛发护理活动的标记，并且从而与对照相比较，评估这种测量的结果。

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