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1. 发明申请

US20090226571A1 Fermentative Production of Non-Volatile Microbial Metabolism Products in Solid Form 审中-公开
标题翻译：固体形式的非挥发性微生物代谢产物的发酵生产
公开(公告)号：US20090226571A1
公开(公告)日：2009-09-10
申请号：US11991515
申请日：2006-09-06
申请人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
发明人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
IPC分类号： A23K1/16 , C12P1/00 , C12P7/46 , C12P7/48 , C12P13/04 , C12P19/38 , C12P19/30 , C12P7/64 , C12P7/02 , C12P19/00 , C12P21/04 , C12P7/26 , C12P19/04 , C12P19/12 , C12P7/42 , C12P7/18 , C07C53/00 , C07C205/00 , C07H19/00 , C07C35/00 , C07H1/00 , C07K2/00 , C07C49/00 , C08B37/16 , C13K13/00 , C07C31/18 , D06M13/224 , D06M13/00 , A23L1/48 , D21H23/22
CPC分类号： C12P13/08 , A23K10/12 , A23L7/104 , C12P7/46 , C12P13/02 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/14
摘要： The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.
摘要翻译：本发明涉及一种通过糖基微生物发酵生产固体形式的至少一种非挥发性微生物代谢物的方法，其中使用含糖单体的含糖液体培养基生产所需代谢物的微生物菌株含量超过基于液体介质总重量的20重量％，随后大量除去发酵液的挥发性成分，所述含糖液体介质通过以下步骤制备：a1）从谷物中研磨选定的淀粉原料 ; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中为了液化目的，至少部分所述研磨料液体通过连续或分批加入水性液体。此外，本发明涉及通过本发明的方法获得的非挥发性微生物代谢物的固体制剂; 以及使用这种固体制剂作为人或动物营养的添加剂或补充剂或用于处理纺织品，皮革，纤维素，纸或表面的固体制剂。

2. 发明申请

US20090162892A1 Fermentative production of fine chemicals 有权
标题翻译：发酵精细化学品生产
公开(公告)号：US20090162892A1
公开(公告)日：2009-06-25
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/00 , C12P19/38 , C12P19/30 , C12P19/12 , C12P19/04 , C12P13/04 , C12P17/18 , C12P17/12 , C12P7/64 , C12P7/40 , C12P7/48 , C12P7/46 , C12P7/42 , C12P7/26 , C12P7/02
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.
摘要翻译：本发明涉及通过糖基微生物发酵生产具有至少3个碳原子或至少2个碳原子和至少1个氮原子的至少一种微生物代谢物的方法，包括：a）制备含糖液体介质，其单糖含量大于淀粉原料的20重量％以上，所述含糖液体介质还包含淀粉原料的非淀粉状固体成分; b）用于生产代谢物的含糖液体培养基的发酵; 和c）从所述发酵液中消耗或分离至少一种代谢物，其中产生所需代谢物的微生物菌株与所述含糖液体培养基一起培养，所述液体培养基通过以下步骤获得：a1）研磨所述淀粉原料; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中至少一些所述絮凝液通过连续或分批添加至所述水性液体而液化。

3. 发明申请

US20080299606A1 Fermentative Production of Organic Compounds 失效
标题翻译：有机化合物的发酵生产
公开(公告)号：US20080299606A1
公开(公告)日：2008-12-04
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/04 , C12P13/00 , C12P7/64 , C12P7/18 , C12P7/40 , C12P19/38 , C12P19/40 , C12P19/30
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

4. 发明授权

US09109244B2 Fermentative production of fine chemicals 有权
公开(公告)号：US09109244B2
公开(公告)日：2015-08-18
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P25/00 , C12P7/46 , C12P13/12 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

5. 发明授权

US08741599B2 Fermentative production of organic compounds 失效
标题翻译：发酵生产有机化合物
公开(公告)号：US08741599B2
公开(公告)日：2014-06-03
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P19/14 , C12P19/02 , C12P13/04 , C12P13/08 , C12P13/00 , C12P7/66 , C12P1/00 , C12P19/38 , C12P7/14 , C12N1/00 , C12N1/20
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

6. 发明授权

US08044166B2 Process for preparing pentamethylene 1,5-diisocyanate 有权
标题翻译：制备五亚甲基-1,5-二异氰酸酯的方法
公开(公告)号：US08044166B2
公开(公告)日：2011-10-25
申请号：US12373088
申请日：2007-07-25
申请人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
发明人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
IPC分类号： C08G18/00 , C07C263/12 , C07C263/10 , C12P13/00
CPC分类号： C12P13/00 , C07B59/001 , C07C265/14 , C08G18/73 , C08G2101/00 , C09D175/04 , C12P13/001 , C12P13/02
摘要： The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof.
摘要翻译：本发明涉及一种制备五亚甲基-1,5-二异氰酸酯，以这种方式制备的五亚甲基-1,5-二异氰酸酯及其用途的方法。

7. 发明申请

US20090292100A1 PROCESS FOR PREPARING PENTAMETHYLENE 1,5-DIISOCYANATE 有权
标题翻译：制备戊二烯1,5-二异氰酸酯的方法
公开(公告)号：US20090292100A1
公开(公告)日：2009-11-26
申请号：US12373088
申请日：2007-07-25
申请人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
发明人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
IPC分类号： C08G18/00 , C07C263/12 , C12P13/00 , C07C263/10
CPC分类号： C12P13/00 , C07B59/001 , C07C265/14 , C08G18/73 , C08G2101/00 , C09D175/04 , C12P13/001 , C12P13/02
摘要： The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof.
摘要翻译：本发明涉及一种制备五亚甲基-1,5-二异氰酸酯，以这种方式制备的五亚甲基-1,5-二异氰酸酯及其用途的方法。

8. 发明授权

US08728762B2 Fermentative production of organic compounds 有权
标题翻译：发酵生产有机化合物
公开(公告)号：US08728762B2
公开(公告)日：2014-05-20
申请号：US12095130
申请日：2006-11-27
申请人： Matthias Boy , Stephan Freyer
发明人： Matthias Boy , Stephan Freyer
IPC分类号： C12P21/04 , C12P19/14 , C12P19/02 , C12P13/04 , C12P13/08 , C12P13/00 , C12P7/64 , C12P7/56 , C12P7/48 , C12P7/14 , C12N1/00 , C12N1/20
CPC分类号： C12P19/14 , C12P13/08 , C12P13/14
摘要： The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the following steps: i) a starch source is ground in order to obtain a grinding material which contains at least one part of the non-starch containing solid components of the starch source; ii) the grinding material is suspended in an aqueous liquid in an amount such that the dry mass content in the suspension is at least 45 wt. %, iii) the starch component is hydrolysed in the grinding material by liquefying and optionally, subsequently, sweetening, in order to obtain an aqueous medium M, which contains the hydrolysed starch components and at least one part of the non-starch containing solid components of the starch source, is obtained; and iv) the aqueous substance M obtained in step iii) is used for fermentation in order to cultivate a micro-organism which is capable of over-producing the organic compound; the suspension obtained in step ii) is heated in step iii) by introducing vapor into the suspension, in order to obtain temperatures greater than the pasting temperature of the starch obtained in the grinding materials.
摘要翻译：本发明涉及通过发酵生产至少一种含有至少3个C原子，至少2个C原子和至少1个N原子的有机化合物的方法。所述方法包括以下步骤：i）研磨淀粉源以获得含有至少一部分淀粉源的非淀粉固体组分的研磨材料; ii）研磨材料悬浮在水性液体中，其量使得悬浮液中的干质量含量至少为45重量％。％，iii）淀粉组分在研磨材料中通过液化和任选地随后进行甜化而水解，以获得含有水解淀粉组分的水性介质M和至少一部分含淀粉的固体组分的淀粉来源; 和iv）将步骤iii）中获得的水性物质M用于发酵，以培养能够过度生产有机化合物的微生物; 将步骤ii）中获得的悬浮液在步骤iii）中通过将蒸气引入悬浮液中来加热，以获得大于在研磨材料中获得的淀粉的糊化温度的温度。

9. 发明授权

US08785154B2 Method for manufacturing an aqueous glucose solution from plants of the Triticeae species 失效
标题翻译：从Triticeae种植物制造葡萄糖水溶液的方法
公开(公告)号：US08785154B2
公开(公告)日：2014-07-22
申请号：US12937554
申请日：2009-04-09
申请人： Matthias Boy , Stephan Freyer , Julia Brodersen
发明人： Matthias Boy , Stephan Freyer , Julia Brodersen
IPC分类号： C12P21/02
CPC分类号： C12P19/02 , A23K10/12 , A23K20/147 , C12P21/00 , C13K1/06
摘要： The present invention relates to a method for manufacturing an aqueous glucose solution from the starch components of Triticeae grains, for example from rye, triticale or in particular wheat grains. The invention also relates to a glucose-based fermentation method for manufacturing organic compounds in which the glucose manufactured for fermentation is produced from the starch components of Triticeae grains by way of a method according to the invention.
摘要翻译：本发明涉及一种由Triticeae颗粒的淀粉组分制备葡萄糖水溶液的方法，例如来自黑麦，黑小麦或特别是小麦籽粒。本发明还涉及一种用于制造有机化合物的葡萄糖基发酵方法，其中通过根据本发明的方法由Triticeae颗粒的淀粉组分制备用于发酵的葡萄糖。

10. 发明申请

US20080318287A1 Fermentative Production of Organic Compounds Using Substances Containing Dextrin 有权
标题翻译：使用含有糊精的物质发酵生产有机化合物
公开(公告)号：US20080318287A1
公开(公告)日：2008-12-25
申请号：US12094646
申请日：2006-11-27
申请人： Matthias Boy , Stephan Freyer
发明人： Matthias Boy , Stephan Freyer
IPC分类号： C12P13/08
CPC分类号： C12P7/26 , C12P7/42 , C12P7/62 , C12P7/6418 , C12P7/6427 , C12P7/6463 , C12P13/00 , C12P13/005 , C12P13/04 , C12P19/14 , C12P19/30 , C12P19/38
摘要： A process for the production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least 1N atom by means of fermentation, comprises the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and liquefying the millbase present in the aqueous liquid in the presence of at least one starch-liquefying enzyme, obtaining an aqueous dextrin-containing medium (1) which comprises at least a part of the nonstarchy solid constituents of the starch feedstock; and b) using the aqueous dextrin-containing medium (1) in a fermentation for culturing a microorganism which is capable of overproducing the organic compound; enzymes which hydrolyze the dextrins to monosaccharides being added in an amount of less than 0.001% by weight based on the total weight of the starch feedstock employed, or not at all.
摘要翻译：通过发酵生产具有至少3个C原子或具有至少2个C原子和至少1N原子的至少一种有机化合物的方法包括以下步骤：a1）研磨淀粉原料，从而得到碾磨基其包括淀粉原料的至少部分非淀粉样固体成分; a2）在至少一种淀粉 - 液化酶的存在下，将磨粒悬浮在水性液体中并液化存在于水性液体中的研磨液，得到含有糊精的培养基（1），其含有至少一部分非淀粉样固体淀粉原料成分; 和b）在含有糊精的培养基（1）中用于培养能够过量产生有机化合物的微生物的发酵中; 基于所使用的淀粉原料的总重量，或者根本不加入将糊精水解成单糖的酶的加入量小于0.001重量％。

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