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1. 发明授权

US08044166B2 Process for preparing pentamethylene 1,5-diisocyanate 有权
标题翻译：制备五亚甲基-1,5-二异氰酸酯的方法
公开(公告)号：US08044166B2
公开(公告)日：2011-10-25
申请号：US12373088
申请日：2007-07-25
申请人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
发明人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
IPC分类号： C08G18/00 , C07C263/12 , C07C263/10 , C12P13/00
CPC分类号： C12P13/00 , C07B59/001 , C07C265/14 , C08G18/73 , C08G2101/00 , C09D175/04 , C12P13/001 , C12P13/02
摘要： The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof.
摘要翻译：本发明涉及一种制备五亚甲基-1,5-二异氰酸酯，以这种方式制备的五亚甲基-1,5-二异氰酸酯及其用途的方法。

2. 发明申请

US20090292100A1 PROCESS FOR PREPARING PENTAMETHYLENE 1,5-DIISOCYANATE 有权
标题翻译：制备戊二烯1,5-二异氰酸酯的方法
公开(公告)号：US20090292100A1
公开(公告)日：2009-11-26
申请号：US12373088
申请日：2007-07-25
申请人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
发明人： Martin Fiene , Eckhard Stroefer , Wolfgang Siegel , Stephan Freyer , Oskar Zelder , Gerhard Schulz
IPC分类号： C08G18/00 , C07C263/12 , C12P13/00 , C07C263/10
CPC分类号： C12P13/00 , C07B59/001 , C07C265/14 , C08G18/73 , C08G2101/00 , C09D175/04 , C12P13/001 , C12P13/02
摘要： The present invention relates to a process for preparing pentamethylene 1,5-diisocyanate, to pentamethylene 1,5-diisocyanate prepared in this way and to the use thereof.
摘要翻译：本发明涉及一种制备五亚甲基-1,5-二异氰酸酯，以这种方式制备的五亚甲基-1,5-二异氰酸酯及其用途的方法。

3. 发明授权

US06417353B1 Preparing amines 失效
标题翻译：制备胺
公开(公告)号：US06417353B1
公开(公告)日：2002-07-09
申请号：US09520908
申请日：2000-03-07
申请人： Frank Funke , Joachim Wulff-Döring , Gerhard Schulz , Wolfgang Siegel , Andreas Kramer , Johann-Peter Melder , Arthur Höhn , Philipp Buskens , Wolfgang Reif , Jan Nouwen
发明人： Frank Funke , Joachim Wulff-Döring , Gerhard Schulz , Wolfgang Siegel , Andreas Kramer , Johann-Peter Melder , Arthur Höhn , Philipp Buskens , Wolfgang Reif , Jan Nouwen
IPC分类号： C07B4304
CPC分类号： C07C209/26 , B01J23/885 , B01J37/03 , C07C213/02 , C07C2601/08 , C07C2602/10 , C07C211/06 , C07C211/07 , C07C211/17 , C07C211/27 , C07C211/30 , C07C211/35 , C07C211/38 , C07C217/58
摘要： Amines are prepared by reacting aldehydes or ketones at elevated temperature under elevated pressure with nitrogen compounds selected from the group of ammonia, primary and secondary amines, and with hydrogen in the presence of a catalyst containing copper, wherein the catalytically active mass of the catalyst contains, before the reduction with hydrogen, 20 to 85% by weight of oxygen-containing compounds of zirconium, calculated as ZrO2, 1 to 30% by weight of oxygen-containing compounds of copper, calculated as CuO, 14 to 70% by weight of oxygen-containing compounds of nickel, calculated as NiO, 0 to 5% by weight of oxygen-containing compounds of molybdenum, calculated as MoO3, and 0 to 10% by weight of oxygen-containing compounds of aluminum, calculated as Al2O3.
摘要翻译：胺在升高的温度下在升高的温度下与选自氨，伯胺和仲胺的氮化合物和氢气在含催化剂的聚合物的存在下反应制备，其中催化剂活性物质含有，在用氢还原之前，以ZrO 2计为20〜85重量％的含氧化合物，以30重量％计，氧化铝为14〜70重量％，氧化铝为100重量％以NiO表示的镍化合物，以MoO 3计为0〜5重量％的含氧化合物的钼和0〜10重量％的按Al 2 O 3计算的含氧化合物的铝。

4. 发明授权

US09169193B2 Method for producing O-Alkylated aminoalcohols 有权
标题翻译：制备O-烷基化氨基醇的方法
公开(公告)号：US09169193B2
公开(公告)日：2015-10-27
申请号：US12158517
申请日：2006-12-11
申请人： Wolfgang Siegel , Gerd Haderlein , Tobias Stäb
发明人： Wolfgang Siegel , Gerd Haderlein , Tobias Stäb
IPC分类号： C07C215/00 , C07C213/06
CPC分类号： C07C213/06 , C07C2601/14 , C07C217/52
摘要： A process for preparing O-alkylated amino alcohols by reacting N-unsubstituted or N-monosubstituted amino alkoxide salts with alkyl halides, the amino alkoxide salts being formed by means of alkali metal or alkaline earth metal hydroxides.
摘要翻译：通过使N-未取代或N-单取代的氨基醇盐与烷基卤化物反应制备O-烷基化氨基醇的方法，所述氨基醇盐通过碱金属或碱土金属氢氧化物形成。

5. 发明授权

US08617854B2 Method for producing L-phenylephrine using an alcohol dehydrogenase of Aromatoleum aromaticum EBN1 (Azoarcus sp. EBN1) 有权
标题翻译：使用芳香香草EBN1（Azoarcus sp。EBN1）的醇脱氢酶生产L-苯肾上腺素的方法
公开(公告)号：US08617854B2
公开(公告)日：2013-12-31
申请号：US13063630
申请日：2009-09-15
申请人： Michael Breuer , Andreas Pletsch , Bernhard Hauer , Wolfgang Siegel
发明人： Michael Breuer , Andreas Pletsch , Bernhard Hauer , Wolfgang Siegel
IPC分类号： C12P7/22 , C12P13/00
CPC分类号： C12P13/001 , C12P7/22
摘要： The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
摘要翻译：本发明涉及一种制备取代的光学活性醇的多阶段方法，其包括酶催化的合成步骤，特别是由醇脱氢酶催化的合成步骤。本发明的方法特别适用于生产去氧肾上腺素，即3 - [（1R）-1-羟基-2-甲基氨基 - 乙基] - 苯酚。

6. 发明授权

US08354558B2 Process for diastereoselective conversion of chiral imines 失效
标题翻译：手性亚胺的非对映选择性转化方法
公开(公告)号：US08354558B2
公开(公告)日：2013-01-15
申请号：US12746868
申请日：2008-12-10
申请人： Wolfgang Siegel , Thilo Hahn , Tobias Staeb
发明人： Wolfgang Siegel , Thilo Hahn , Tobias Staeb
IPC分类号： C07C209/52
CPC分类号： C07C209/26 , C07B2200/07 , C07C209/52 , C07C209/62 , C07C211/07 , C07C211/27
摘要： Diastereoselective conversion of chiral imines of the formula I to amines of the formula II where the R1 to R4 radicals are each as defined in the description and R1 and R2 are different than one another, by converting the imine of the formula I in the presence of hydrogen and a heterogeneous copper-containing catalyst.
摘要翻译：通式I的手性亚胺的非对映选择性转化为式II的胺，其中R 1至R 4基团各自如说明书中所定义，并且R 1和R 2彼此不同，通过在存在下转化式I的亚胺氢和异质含铜催化剂。

7. 发明申请

US20120263659A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS 有权
标题翻译：使用生理冷却活性成分，以及含有此类活性成分的试剂
公开(公告)号：US20120263659A1
公开(公告)日：2012-10-18
申请号：US13510454
申请日：2010-11-22
申请人： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
发明人： Thomas Subkowski , Michael Backes , Heiko Oertling , Arnold Machinek , Hubert Loges , Ulrike Simchen , Horst Surburg , Claus Bollschweiler , Jens Wittenberg , Wolfgang Siegel
IPC分类号： A61K31/438 , C07D491/048 , A61K31/4745 , C07D401/04 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D405/12 , A61K31/443 , C07D317/60 , A61K31/36 , C07C233/11 , A61K31/165 , C07D213/74 , A61K31/4402 , C07D277/42 , A61K31/426 , A61Q11/00 , A61P11/14 , A61P11/04 , C12N5/07 , C07D495/10
CPC分类号： C07D495/20 , A23G3/36 , A23G4/06 , A23L2/52 , A23L27/2054 , A23L33/10 , A23V2002/00 , A24B13/00 , A24D1/002 , A61K8/49 , A61K8/4953 , A61K31/165 , A61K31/167 , A61K31/36 , A61K31/426 , A61K31/4375 , A61K31/438 , A61K31/4402 , A61K31/443 , A61K31/4741 , A61K31/4743 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K2800/10 , A61K2800/244 , A61K2800/78 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , C07C233/11 , C07C235/36 , C07C235/38 , C07C2601/14 , C07D213/75 , C07D317/60 , C07D401/04 , C07D405/12 , C07D491/147 , C07D495/22 , C09D5/1625 , D06M15/03 , D06M15/07 , D06M16/00
摘要： The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.
摘要翻译：本发明涉及一种用于实现对皮肤或粘膜的冷却作用的TRPM8调节剂。

8. 发明申请

US20120178958A1 METHOD FOR PRODUCING LINEAR PENTENENITRILE 有权
标题翻译：生产线性胆固醇的方法
公开(公告)号：US20120178958A1
公开(公告)日：2012-07-12
申请号：US13361783
申请日：2012-01-30
申请人： Tim Jungkamp , Robert Baumann , Michael Bartsch , Gerd Haderlein , Hermann Luyken , Jens Scheidel , Tobias Aechtner , Peter Pfab , Petra Deckert , Wolfgang Siegel , Peter Baßler
发明人： Tim Jungkamp , Robert Baumann , Michael Bartsch , Gerd Haderlein , Hermann Luyken , Jens Scheidel , Tobias Aechtner , Peter Pfab , Petra Deckert , Wolfgang Siegel , Peter Baßler
IPC分类号： C07C253/30
CPC分类号： C07C253/30 , C07C253/10 , Y02P20/582 , C07C255/07
摘要： A method for producing 3-pentenenitrile is provided that includes: (a) isomerizing an educt stream containing 2-methyl-3-butenenitrile on at least one dissolved or dispersed isomerisation catalyst to form a stream (1), which contains the isomerisation catalyst(s), 2-methyl-3-butenenitrile, 3-pentenenitrile and (Z)-2-methyl-2-butenenitrile; (b) distilling the stream (1) to obtain a stream (2) as the overhead product, which contains 2-methyl-3-butenenitrile, 3-pentenenitrile and (Z)-2-methyl-2-butenenitrile and a stream (3) as the bottom product, which contains the isomerisation catalyst(s); (c) distilling the stream (2) to obtain a stream (4) as the overhead product, which is enriched with (Z)-2-methyl-2-butenenitrile in comparison to stream (2), and a stream (5) as the bottom product, which is enriched with 3-pentenenitrile and 2-methyl-3-butenenitrile in comparison to stream (2); (d) distilling stream (5) to obtain a stream (6) as the bottom product, which contains 3-pentenenitrile and a stream (7) as the head product containing 2-methyl-3-butenenitrile.
摘要翻译：提供了一种制备3-戊烯腈的方法，其包括：（a）在至少一种溶解或分散的异构化催化剂上异构化含有2-甲基-3-丁烯腈的流出物流以形成含有异构化催化剂（ s），2-甲基-3-丁烯腈，3-戊烯腈和（Z）-2-甲基-2-丁烯腈; （b）蒸馏物流（1）以获得作为塔顶产物的物流（2），其含有2-甲基-3-丁烯腈，3-戊烯腈和（Z）-2-甲基-2-丁烯腈和流（ 3）作为含有异构化催化剂的底部产物; （c）与料流（2）相比，蒸馏物流（2）以获得作为塔顶产物的物流（4），其与（2）相比富含（Z）-2-甲基-2-丁烯腈，作为与料流（2）相比富含3-戊烯腈和2-甲基-3-丁烯腈的底部产物; （d）蒸馏物流（5），得到作为底物的物流（6），其含有3-戊烯腈和作为含有2-甲基-3-丁烯腈的头部产物的物流（7）。

9. 发明申请

US20110004012A1 METAL CARBAMATES FORMED FROM TOLYLENEDIAMINES 失效
标题翻译：由戊烯二胺形成的金属碳酸盐
公开(公告)号：US20110004012A1
公开(公告)日：2011-01-06
申请号：US12920224
申请日：2009-03-18
申请人： Andreas Leitner , Robert Baumann , Wolfgang Siegel
发明人： Andreas Leitner , Robert Baumann , Wolfgang Siegel
IPC分类号： C07C271/28 , C07C269/04
CPC分类号： C07C269/04 , C07C269/06 , C07C271/28
摘要： The invention provides metal carbamates of the general formula (I) where R1 and R2 are the same or different and are each an alkyl group having 1-18 carbon atoms and M is an alkali metal atom.
摘要翻译：本发明提供通式（I）的金属氨基甲酸酯，其中R 1和R 2相同或不同，并且各自为具有1-18个碳原子的烷基，M为碱金属原子。

10. 发明授权

US07498451B2 Obtaining an aliphatic dialdehyde Monoacetal 失效
标题翻译：获得脂族二醛单缩醛
公开(公告)号：US07498451B2
公开(公告)日：2009-03-03
申请号：US10536900
申请日：2003-11-27
申请人： Gerd Haderlein , Hans-Georg Göbbel , Wolfgang Siegel
发明人： Gerd Haderlein , Hans-Georg Göbbel , Wolfgang Siegel
IPC分类号： C07D317/26 , C07C45/64
CPC分类号： C07D317/26 , B01D1/22 , B01D3/141 , B01D3/148 , B01D3/322 , C07C45/60 , C07C45/71 , C07C45/82 , C07C47/198
摘要： The invention relates to a process for obtaining a pure aliphatic dialdehyde monoacetal by reaction of the corresponding aliphatic dialdehyde or a precursor of the corresponding aliphatic dialdehyde with one or more aliphatic mono- or polyhydric alcohols while distillatively removing water to obtain a reaction mixture which is separated distillatively, which comprises carrying out the distillative separation continuously in a dividing wall column to obtain pure aliphatic dialdehyde monoacetal as a sidestream from the dividing wall column, or in two distillation columns to obtain crude aliphatic dialdehyde monoacetal as a sidestream in the first distillation column, feed the crude aliphatic dialdehyde monoacetal to the second distillation column and obtain pure aliphatic dialdehyde monoacetal as the sidestream from the second distillation column.
摘要翻译：本发明涉及通过相应的脂族二醛或相应的脂族二醛的前体与一种或多种脂肪族一元醇或多元醇反应而获得纯的脂族二醛单缩醛的方法，同时蒸馏除去水，得到分离的反应混合物蒸馏，其包括在分隔壁塔中连续进行蒸馏分离以获得作为来自分隔壁塔的侧流的纯脂族二醛单缩醛，或在两个蒸馏塔中，以在第一蒸馏塔中获得作为侧流的粗脂族二醛单缩醛，将粗脂族二醛单缩醛进料至第二蒸馏塔，得到作为来自第二蒸馏塔的侧流的纯脂族二醛单缩醛。

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