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1. 发明申请

US20080312268A1 Substituted tricyclic piperidone compounds 审中-公开
标题翻译：取代三环哌啶酮化合物
公开(公告)号：US20080312268A1
公开(公告)日：2008-12-18
申请号：US12143614
申请日：2008-06-20
申请人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
发明人： Stefan Schunk , Stefan Oberboersch , Hagen-Heinrich Hennies , Martin Maier , Anton Khartulyari
IPC分类号： A61K31/439 , C07D221/22 , A61P25/32 , A61P25/30 , A61P25/00
CPC分类号： C07D471/08
摘要： Substituted tricyclic piperidone derivatives corresponding to Formula I: a method for producing such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug abuse, drug dependency, lethargy and/or anxiety.
摘要翻译：对应于式I的取代的三环哌啶酮衍生物：这种化合物的制备方法; 含有这些化合物的药物组合物，以及这些化合物用于治疗疼痛，抑郁症，尿失禁，腹泻，瘙痒，酒精和药物滥用，药物依赖性，嗜睡和/或焦虑症的用途。

2. 发明授权

US09999673B2 PEGylated lipids and their use for drug delivery 有权
公开(公告)号：US09999673B2
公开(公告)日：2018-06-19
申请号：US13979336
申请日：2012-01-11
申请人： Kallanthottathil G. Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
发明人： Kallanthottathil G. Rajeev , Muthiah Manoharan , Muthusamy Jayaraman , Martin Maier , Jayaprakash K. Nair , David Butler
IPC分类号： A61K47/18 , C07C235/06 , C07C271/16 , C07D207/12 , C07D307/20 , C07D207/14 , C07D307/12 , C08G65/329 , A61K47/48
CPC分类号： A61K47/18 , A61K47/6911 , C07C235/06 , C07C271/16 , C07D207/12 , C07D207/14 , C07D307/12 , C07D307/20 , C08G65/329 , C08L2203/02
摘要： The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

3. 发明授权

US09810189B2 Fuel distributor 有权
公开(公告)号：US09810189B2
公开(公告)日：2017-11-07
申请号：US13609694
申请日：2012-09-11
申请人： Martin Maier , Martin Goehner , Markus Feigl , Helmut Schneider , Nikolaus Hautmann , Dietmar Uhlenbrock , Holger Uhrig
发明人： Martin Maier , Martin Goehner , Markus Feigl , Helmut Schneider , Nikolaus Hautmann , Dietmar Uhlenbrock , Holger Uhrig
IPC分类号： F02M69/50 , F02M55/02
CPC分类号： F02M69/50 , F02M55/025 , F02M2200/25 , F02M2200/26 , F02M2200/315 , F02M2200/857
摘要： A fuel distributor, which is used, in particular, for fuel injection systems of mixture-compressing, internal combustion engines having externally supplied ignition, includes a distributor pipe, a first holder and at least one second holder. The distributor pipe has a longitudinal axis. In this connection, the first holder and the second holder are situated at the distributor pipe so as to be axially set apart from one another with respect to the longitudinal axis. The distributor pipe is designed to allow axial length compensation. It is also possible for at least one holder to be designed to allow axial length compensation.

4. 发明授权

US09325165B2 Device and method for protecting a consumer 有权
标题翻译：用于保护消费者的设备和方法
公开(公告)号：US09325165B2
公开(公告)日：2016-04-26
申请号：US14344985
申请日：2011-09-16
申请人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
发明人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
IPC分类号： H02H5/04 , H02P29/00 , H02P29/02 , G01K7/01 , G01R19/165 , H02H7/085 , H02H3/08
CPC分类号： H02H5/047 , G01K7/01 , G01R19/16571 , H02H3/085 , H02H7/0852 , H02P29/027 , H02P29/68
摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.
摘要翻译：公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接当前路径。第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

5. 发明授权

US08999351B2 Lipids and compositions for the delivery of therapeutics 有权
标题翻译：用于递送治疗剂的脂质和组合物
公开(公告)号：US08999351B2
公开(公告)日：2015-04-07
申请号：US13128287
申请日：2009-11-10
申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu
IPC分类号： A61K39/12 , A61K9/127 , A61K39/00 , C12N15/11
CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464
摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.
摘要翻译：本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3为H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代烷基磷酸酯，烷基硫代磷酸酯，烷基二硫代磷酸酯，烷基膦酸酯，烷基胺，羟基烷基，ω-氨基烷基，ω-（取代的）氨基烷基， ω-磷酸烷基酯，ω-硫代磷酰基烷基酯，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q）），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，ω-氨基烷基，ω-（取代）氨基烷基，ω-磷酸烷基或ω-硫代磷酰基烷基。

6. 发明申请

US20140375301A1 DEVICE AND METHOD FOR PROTECTING A CONSUMER 有权
标题翻译：用于保护消费者的装置和方法
公开(公告)号：US20140375301A1
公开(公告)日：2014-12-25
申请号：US14344985
申请日：2011-09-16
申请人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
发明人： Klaus Behringer , Martin Maier , Klaus Pfitzner , Bernhard Rösch
IPC分类号： H02H5/04 , G01K7/01 , G01R19/165
CPC分类号： H02H5/047 , G01K7/01 , G01R19/16571 , H02H3/085 , H02H7/0852 , H02P29/027 , H02P29/68
摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.
摘要翻译：公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接当前路径。第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

7. 发明申请

US20130017223A1 METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS 审中-公开
标题翻译：用于递送核酸的方法和组合物
公开(公告)号：US20130017223A1
公开(公告)日：2013-01-17
申请号：US13516335
申请日：2010-12-17
申请人： Michael J Hope , Thomas D. Madden , Pieter R. Cullis , Martin Maier , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , Akin Akinc , Muthiah Manoharan
发明人： Michael J Hope , Thomas D. Madden , Pieter R. Cullis , Martin Maier , Muthusamy Jayaraman , Kallanthottathil G. Rajeev , Akin Akinc , Muthiah Manoharan
IPC分类号： A61K47/24 , A61K47/28 , A61P37/04 , A61K31/713 , C12N5/071 , C12N15/85 , A61K31/7088 , A61K31/7105
CPC分类号： A61K47/543 , A61K9/1272 , A61K47/6911 , C12N15/88
摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
摘要翻译：脂质颗粒可以包括多个阳离子脂质，例如第一阳离子脂质和第二阳离子脂质。可以基于第一性质选择第一阳离子脂质，并且可以基于第二性质选择第二阳离子脂质。第一和第二属性是互补的。脂质颗粒的属性可以反映阳离子脂质的选择性质，以及这些性质的互补性质。

8. 发明申请

US20120325939A1 POLE BODY FOR SOLENOID VALVES PRODUCED BY MULTI-COMPONENT MIM 有权
标题翻译：用于多组分MIM生产的电磁阀的阀体
公开(公告)号：US20120325939A1
公开(公告)日：2012-12-27
申请号：US13517447
申请日：2010-12-01
申请人： Juergen Graner , Martin Maier , Juergen Lander , Jochen Rager
发明人： Juergen Graner , Martin Maier , Juergen Lander , Jochen Rager
IPC分类号： F02M51/06 , B21D51/16 , B21K1/20 , F02M61/16
CPC分类号： F02M51/0682 , B22F3/225 , B22F5/10 , B22F7/06 , B29C45/14 , F02M61/166 , F02M61/168 , Y10T29/49412
摘要： An injector having a valve opening, a cylindrical pipe, a valve opening, a valve needle situated inside the pipe in the radial direction and guided to allow axial displacement; a solenoid coil situated outside the pipe in the radial direction; a solenoid core disposed inside the pipe in the radial direction; and a magnetic armature situated inside the pipe, opposite the solenoid core in the radial direction, the magnetic armature being disposed on the valve needle. The pipe is a magnetic first material in a first pipe region and a third pipe region, the first region facing the valve opening in the axial direction, and the third pipe region facing away from the valve opening in the axial direction. The pipe is a non-magnetic second material in a second pipe region, the second pipe region being between the first pipe region and the third pipe region in the axial direction.
摘要翻译：一种具有阀开口的喷射器，一个圆柱形管，一个阀开口，一个阀芯，位于该管内径向并被引导以允许轴向位移; 位于管径向外的螺线管线圈; 在径向上配置在管内的电磁铁芯; 以及位于所述管内的磁性衔铁，所述磁性衔铁位于所述螺线管芯的径向方向上，所述磁性衔铁设置在所述阀针上。管是在第一管区域和第三管区域中的磁性第一材料，第一区域在轴向方向上面对阀开口，第三管区域在轴向方向上背离阀开口。管是第二管区中的非磁性第二材料，第二管区在轴向上位于第一管区和第三管区之间。

9. 发明申请

US20120207974A1 COMPONENT COMPOSITE AND METHOD FOR MANUFACTURING A COMPONENT COMPOSITE 审中-公开
标题翻译：组分复合材料和制造组分复合材料的方法
公开(公告)号：US20120207974A1
公开(公告)日：2012-08-16
申请号：US13391218
申请日：2010-07-02
申请人： Martin Maier , Kai von Garnier , Wilfried Aichele , Juergen Lander , Nikolaus Hautmann , Michael Honer , Jens Koenig
发明人： Martin Maier , Kai von Garnier , Wilfried Aichele , Juergen Lander , Nikolaus Hautmann , Michael Honer , Jens Koenig
IPC分类号： B32B7/12 , B32B38/00 , B05D1/36 , B32B37/12
CPC分类号： B32B7/12 , B23K26/0006 , B23K26/0624 , B23K26/123 , B23K26/355 , B23K26/389 , B23K26/40 , B23K2103/16 , B23K2103/42 , B29C45/14311 , B29C70/683 , B32B5/147 , B32B9/005 , B32B9/041 , B32B9/045 , B32B15/08 , B32B15/18 , B32B27/08 , B32B27/16 , B32B2307/30 , B32B2307/72 , B32B2307/7242 , B32B2605/00 , F16B11/006 , Y10T156/10 , Y10T428/24355
摘要： A component composite, in particular for motor vehicle applications, including a first component having a first contact surface, the first contact surface having a surface structure which has a microstructure overlaid by a nanostructure, and including at least one second component having a second contact surface. A medium, in particular an adhesive layer, is situated for integral connection between the two contact surfaces of the two components.
摘要翻译：一种组分复合材料，特别是用于机动车辆应用，包括具有第一接触表面的第一部件，所述第一接触表面具有具有由纳米结构覆盖的微结构的表面结构，并且包括具有第二接触表面的至少一个第二部件。介质，特别是粘合剂层，被设置为用于两个部件的两个接触表面之间的整体连接。

10. 发明授权

US08090256B2 Optical network architectures and optical communication schemes 有权
标题翻译：光网络架构和光通信方案
公开(公告)号：US08090256B2
公开(公告)日：2012-01-03
申请号：US11867470
申请日：2007-10-04
申请人： Martin Reisslein , Martin Maier , Martin Herzog
发明人： Martin Reisslein , Martin Maier , Martin Herzog
IPC分类号： G02F1/00
CPC分类号： H04J14/0284 , H04J14/0227 , H04J14/0232 , H04J14/0238 , H04J14/0245 , H04J14/025 , H04J14/0282
摘要： The present invention provides optical network methods and systems. In one example, a method for handling packets in a node coupled to a ring and star subnetwork may include (a) receiving in the given node a data packet on the ring subnetwork, (b) detecting a failure on the ring subnetwork, (c) determining a new transmission path to the destination node, and (d) sending the data packet along the new transmission path. In another example, an EPON may include (a) a root coupled to a ring and star subnetwork, (b) ONUs coupled to the root via a splitter/combiner and a first fiber link, (c) a second fiber link coupled to a subset of ONUs and the star subnetwork, and (d) a WDM coupler on the first fiber link that separates a first waveband of wavelengths from a second waveband of wavelengths and guides the first waveband to the star.
摘要翻译：本发明提供光网络方法和系统。在一个示例中，用于处理耦合到环形和星形子网络的节点中的分组的方法可以包括（a）在给定节点中接收环形子网络上的数据分组，（b）检测环形子网络上的故障，（c 确定到目的地节点的新传输路径，以及（d）沿新的传输路径发送数据分组。在另一示例中，EPON可以包括（a）耦合到环和星形子网络的根，（b）经由分路器/组合器和第一光纤链路耦合到根的ONU，（c）耦合到第二光纤链路的第二光纤链路 ONU和星形子网络的子集，以及（d）第一光纤链路上的WDM耦合器，其将第一波长波长与第二波长波段分离，并将第一波段引导到星形。

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