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1. 发明申请

US20130022977A1 METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES 审中-公开
标题翻译：用于检测天然核酸的方法和诊断宫颈异常
公开(公告)号：US20130022977A1
公开(公告)日：2013-01-24
申请号：US13619039
申请日：2012-09-14
申请人： Stanley Lapidus , John F. Thompson , Doron Lipson , Patrice Milos , J. William Efcavitch , Stanley Letovsky
发明人： Stanley Lapidus , John F. Thompson , Doron Lipson , Patrice Milos , J. William Efcavitch , Stanley Letovsky
IPC分类号： C12Q1/68 , B82Y15/00
摘要： The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.
摘要翻译：本发明一般涉及用于检测胎儿核酸的方法和用于诊断胎儿异常的方法。在某些实施方案中，本发明提供了用于确定胎儿核酸是否存在于母体样品中的方法，包括获得怀疑包括胎儿核酸的母体样品，并对样品进行测序反应以确定至少部分 Y染色体，从而确定胎儿核酸存在于样品中。在其它实施方案中，本发明提供用于定量或定性分析以检测母体样品中的胎儿核酸的方法，而不管检测Y染色体的能力，特别是对于包括来自雌性胎儿的正常核酸的样品的检测能力。

2. 发明申请

US20130196317A1 METHODS FOR DETECTING FETAL NUCLEIC ACIDS AND DIAGNOSING FETAL ABNORMALITIES 审中-公开
公开(公告)号：US20130196317A1
公开(公告)日：2013-08-01
申请号：US13614391
申请日：2012-09-13
申请人： Stanley N. Lapidus , John F. Thompson , Doron Lipson , Patrice Milos , J. William Efcavitch , Stanley Letovsky
发明人： Stanley N. Lapidus , John F. Thompson , Doron Lipson , Patrice Milos , J. William Efcavitch , Stanley Letovsky
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6869 , C12Q2600/156
摘要： The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a sequencing reaction on the sample to determine presence of at least a portion of a Y chromosome in the sample, thereby determining that fetal nucleic acid is present in the sample. In other embodiments, the invention provides methods for quantitative or qualitative analysis to detect fetal nucleic acid in a maternal sample, regardless of the ability to detect the Y chromosome, particularly for samples including normal nucleic acids from a female fetus.

3. 发明申请

US20100203524A1 POLYMERASES AND METHODS OF USE THEREOF 审中-公开
标题翻译：聚合物及其使用方法
公开(公告)号：US20100203524A1
公开(公告)日：2010-08-12
申请号：US12609543
申请日：2009-10-30
申请人： J. William Efcavitch , Jayson L. Bowers , Philip R. Buzby , John F. Thompson
发明人： J. William Efcavitch , Jayson L. Bowers , Philip R. Buzby , John F. Thompson
IPC分类号： C12Q1/68 , C12N9/10
CPC分类号： C12P19/34 , C12N9/1241 , C12Q1/6869
摘要： The invention generally relates to polymerases for efficient and controlled sequencing-by-synthesis reactions. In certain embodiments, the invention provides a polymerase enzyme including at least one mutation that enhances ability of the polymerase as compared to a wild-type polymerase to incorporate a nucleotide into a nascent strand of DNA or cDNA including at least one modified nucleotide.
摘要翻译：本发明一般涉及用于有效和控制的合成反应的聚合酶。在某些实施方案中，本发明提供了聚合酶，其包括与野生型聚合酶相比增强聚合酶能力的至少一个突变，以将核苷酸掺入包含至少一个修饰的核苷酸的DNA或cDNA的新生链中。

4. 发明申请

US20100233696A1 METHODS, FLOW CELLS AND SYSTEMS FOR SINGLE CELL ANALYSIS 审中-公开
标题翻译：方法，流式细胞和单细胞分析系统
公开(公告)号：US20100233696A1
公开(公告)日：2010-09-16
申请号：US12612520
申请日：2009-11-04
申请人： Richard Joseph , James J. DiMeo , Mirna Jarosz , John F. Thompson , Jayson Bowers , Scott Chouinard , Philipp Kapronov , J. William Efcavitch , Christopher Hart , Fatih Ozsolak
发明人： Richard Joseph , James J. DiMeo , Mirna Jarosz , John F. Thompson , Jayson Bowers , Scott Chouinard , Philipp Kapronov , J. William Efcavitch , Christopher Hart , Fatih Ozsolak
IPC分类号： C12Q1/68 , B01L3/00 , G01N33/53
CPC分类号： B01L3/502715 , B01L3/5025 , B01L2200/028 , B01L2300/0877 , B01L2300/088 , B01L2300/123 , B01L2300/161 , B01L2400/0415 , B01L2400/0445 , B01L2400/0487 , C12Q1/6869 , Y10T436/143333
摘要： A method, flow cell and/or device for increasing the recovery of a limiting analyte in a sample, e.g., for single molecule analysis is disclosed. Methods for preparing a nucleic acid sample from a single cell and capturing nucleic acids on a surface configured for use in or with single molecule analysis are also provided.
摘要翻译：公开了用于增加样品中限制性分析物的回收的方法，流动池和/或装置，例如用于单分子分析。还提供了从单个细胞制备核酸样品并捕获配置用于单分子分析或用于单分子分析的表面上的核酸的方法。

5. 发明申请

US20100159533A1 SIMPLIFIED SAMPLE PREPARATION FOR RNA ANALYSIS 审中-公开
标题翻译： RNA分析的简化样品制备
公开(公告)号：US20100159533A1
公开(公告)日：2010-06-24
申请号：US12625115
申请日：2009-11-24
申请人： Doron Lipson , Tal Raz , John F. Thompson
发明人： Doron Lipson , Tal Raz , John F. Thompson
IPC分类号： C12P19/34 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6806 , C12Q1/6844 , C12Q2525/179 , C12Q2525/204 , C12Q2521/107
摘要： Methods and kits for selective preparing cDNA relatively free of sequences found in rRNA and subcellular RNAs are disclosed. The methods and kits utilize approximately 200 hexamer sequences which target messenger RNA. The methods and kits are useful in preparing samples for sequencing analysis, especially when performing single molecule sequencing by synthesis.
摘要翻译：公开了用于选择性制备相对不含在rRNA和亚细胞RNA中发现的序列的cDNA的方法和试剂盒。该方法和试剂盒利用约200个靶向信使RNA的六聚体序列。方法和试剂盒可用于制备样品进行测序分析，特别是通过合成进行单分子测序时。

6. 发明申请

US20100184045A1 Methods for sequencing degraded or modified nucleic acids 审中-公开
标题翻译：测序降解或修饰的核酸的方法
公开(公告)号：US20100184045A1
公开(公告)日：2010-07-22
申请号：US12586539
申请日：2009-09-23
申请人： John F. Thompson
发明人： John F. Thompson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869
摘要： The invention provides methods and compositions for sequencing DNA or RNA samples that would be impossible to do via standard means. Samples that are part of mixtures or are degraded or modified may be sequenced so that the individual from whom the sample originated can be determined or useful biological information can be associated with the sample. Methods are described that allow high efficiency sequencing of degraded nucleic acid samples such as are typically found with FFPE. Samples from severely degraded sources or that have been treated with preservatives such as formalin may be sequenced. In addition to permitting identification of samples, information about disease or treatment status may also be determined.
摘要翻译：本发明提供了用于测序DNA或RNA样品的方法和组合物，其通过标准方法是不可能的。作为混合物的一部分或被降解或修饰的样品可以被测序，使得来自样品的个体可以被确定或有用的生物信息可以与样品相关联。描述了允许对通常用FFPE发现的降解的核酸样品进行高效测序的方法。来自严重降解来源或已用防腐剂如福尔马林处理的样品可以进行测序。除了允许样品的鉴定之外，还可以确定关于疾病或治疗状态的信息。

7. 发明申请

US20090186347A1 Markers for metabolic syndrome 审中-公开
标题翻译：代谢综合征的标记
公开(公告)号：US20090186347A1
公开(公告)日：2009-07-23
申请号：US12152141
申请日：2008-05-09
申请人： David R. Cox , Kelly A. Frazer , David A. Hinds , Craig L. Hyde , John F. Thompson
发明人： David R. Cox , Kelly A. Frazer , David A. Hinds , Craig L. Hyde , John F. Thompson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided.
摘要翻译：提供多态性与代谢综合征之间的相关性，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗死。提供诊断和治疗代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗死的方法。提供了代谢综合征，胰岛素抵抗，肥胖，高血压，血脂异常，糖尿病和/或心肌梗塞的诊断和治疗的系统和试剂盒。

8. 发明授权

US4172634A Cam follower for variable power scopes 失效
标题翻译：用于可变电源示波器的凸轮跟随器
公开(公告)号：US4172634A
公开(公告)日：1979-10-30
申请号：US837484
申请日：1977-09-28
申请人： John F. Thompson
发明人： John F. Thompson
IPC分类号： F41G1/38 , G02B7/10 , G02B23/14 , G02B15/16
CPC分类号： G02B23/145 , F41G1/38 , G02B7/10
摘要： A mechanism for varying the power of a telescopic gun sight wherein the erector lenses are moved longitudinally of the sight. A cam sleeve is used in combination with plastic cam followers. Screws are passed through the cam followers and threaded into the erector lens cells to bias runners formed on the lens cells against the inside surface of the erector lens tube thereby loosening manufacturing tolerance requirements while providing smoother and more accurate lens movement and power change.
摘要翻译：用于改变伸缩枪瞄准器的功率的机构，其中竖立镜头在视线的纵向移动。凸轮套筒与塑料凸轮从动件结合使用。螺钉穿过凸轮从动件并拧入竖立器透镜单元中，以将形成在透镜单元上的流道偏压在竖立透镜管的内表面上，从而松动制造公差要求，同时提供更平滑和更准确的透镜运动和功率变化。

9. 发明授权

US06927317B2 Modulating ramp activity 失效
标题翻译：调整斜坡活动
公开(公告)号：US06927317B2
公开(公告)日：2005-08-09
申请号：US10006542
申请日：2001-11-30
申请人： John D. McNeish , Walter C. Soeller , John F. Thompson
发明人： John D. McNeish , Walter C. Soeller , John F. Thompson
IPC分类号： A01K67/027 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/16 , A61P3/08 , A61P9/04 , A61P9/10 , A61P9/12 , A61P15/00 , A61P17/00 , A61P21/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07K14/705 , C12N5/08 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , C12N5/00 , C12N5/02
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K38/00 , A61K49/0004 , C07K14/705 , C12N2503/02 , C12N2510/00 , C12N2517/02 , C12N2800/30 , C12N2830/008 , C12N2830/85 , C12N2840/203
摘要： The invention provides genetically-modified non-human mammals and genetically-modified animal cells containing a disrupted RAMP1, RAMP2, or RAMP3 gene. Also provided by the invention are methods of screening for agents that modulate the activity or expression of a RAMP and methods of treating mammals to modulate liver function and/or muscle metabolism.
摘要翻译：本发明提供遗传修饰的非人哺乳动物和含有破坏的RAMP1，RAMP2或RAMP3基因的遗传修饰的动物细胞。本发明还提供筛选调节RAMP的活性或表达的试剂的方法以及治疗哺乳动物调节肝功能和/或肌肉代谢的方法。

10. 发明授权

US4286388A Sight with reduced friction line of sight adjustment 失效
标题翻译：视力减弱，视线调整
公开(公告)号：US4286388A
公开(公告)日：1981-09-01
申请号：US862463
申请日：1977-12-20
申请人： Cecil J. Ross , John F. Thompson
发明人： Cecil J. Ross , John F. Thompson
IPC分类号： F41G1/26 , F41G1/387 , F41G11/00 , F41G1/38 , G02B27/32
CPC分类号： F41G11/001 , F41G1/26
摘要： A line of sight adjustment mechanism for an optical gun sight which includes windage and elevation screws which bear against an internal component of the sight that defines the line of sight of the sight. A spring biases the internal component against the windage and elevation screws. Hardened steel balls are set into the internal component and affixed thereto at approximate positions to provide point contact between the internal component and the windage and elevation screws, and between the internal component and the spring. Adjustment friction is thus reduced with a resultant reduction in tracking error.
摘要翻译：一种用于光学枪瞄准器的视线调节机构，其包括阻挡和升高螺钉，其抵靠限定视线的视线的视线的内部部件。弹簧偏压风挡和升降螺钉的内部部件。硬化的钢球被放置在内部部件中并在其附近固定在近似位置，以提供内部部件与风挡和升降螺钉之间以及内部部件和弹簧之间的点接触。因此减小了调整摩擦，从而减少了跟踪误差。

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