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1. 发明申请

US20030162216A1 Nucleic acid ligand diagnostic biochip 有权
标题翻译：核酸配体诊断生物芯片
公开(公告)号：US20030162216A1
公开(公告)日：2003-08-28
申请号：US10375487
申请日：2003-02-27
申请人： SomaLogic, Inc.
发明人： Larry Gold , Dominic A. Zichi
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/542 , C12M001/34
CPC分类号： C12Q1/6839 , C07B2200/11 , C12Q1/6834 , C12Q1/6837 , C40B40/00 , Y10S977/924 , C12Q2565/514 , C12Q2565/101 , C12Q2541/101 , C12Q2525/205
摘要： A nucleic acid ligand nullbiochipnull is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily fluid. The target molecules include, but are not limited to, proteins (cellular, viral, bacterial, etc.) hormones, sugars, metabolic byproducts, cofactor, and intermediates, drugs, and toxins. Contacting the test mixture with the biochip leads to the binding of a target molecule to its cognate nucleic acid ligand. The biochip may then be contacted with a reagent(s) that reacts covalently with proteins and not with nucleic acids. Each protein target in the test mixture may then detected by detecting the presence of the reagent at the appropriate address on the biochip.
摘要翻译：公开了一种核酸配体“生物芯片”，其由以空间限定的方式连接一个或多个特定核酸配体的固体支持物组成。每个核酸配体特异性地并且强烈地结合到测试混合物（例如体液）中所含的特定靶分子。靶分子包括但不限于蛋白质（细胞，病毒，细菌等）激素，糖，代谢副产物，辅因子和中间体，药物和毒素。将测试混合物与生物芯片接触导致靶分子与其同源核酸配体的结合。然后生物芯片可以与与蛋白质共价反应的试剂与不与核酸反应的试剂接触。然后可以通过检测生物芯片上适当地址处的试剂的存在来检测测试混合物中的每个蛋白质靶标。

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