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1. 发明授权

US08394414B2 Method for drug delivery to the pulmonary system 失效
公开(公告)号：US08394414B2
公开(公告)日：2013-03-12
申请号：US10706243
申请日：2003-11-12
申请人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
发明人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
IPC分类号： A61K9/16
CPC分类号： A61K9/5146 , A61K9/0073 , A61K9/0075 , A61K9/1617
摘要： Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6.4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6.4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

2. 发明授权

US06428771B1 Method for drug delivery to the pulmonary system 失效
标题翻译：向肺系统输送药物的方法
公开(公告)号：US06428771B1
公开(公告)日：2002-08-06
申请号：US08441378
申请日：1995-05-15
申请人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
发明人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
IPC分类号： A61K912
CPC分类号： A61K9/5146 , A61K9/0073 , A61K9/0075 , A61K9/1617
摘要： Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6.4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6.4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.
摘要翻译：药物递送到肺部系统已经通过将待递送的药物封装在尺寸范围在0.5至10微米之间的微粒中，优选在2至5微米的范围内，通过在pH较大的材料释放药物形成超过6.4。在优选的实施方案中，药物递送系统基于在pH6.4或更低的pH下稳定的二酮哌嗪微粒的形成，并且在pH大于6.4时不稳定，或者在酸性和碱性pH两者下都是稳定的还可以使用其他类型的材料，包括可生物降解的天然和合成聚合物，如蛋白质，混合氨基酸（蛋白质类），藻酸盐和聚（羟基酸）的聚合物。在另一个实施方案中，微粒已经被修饰以实现靶向特定细胞类型，并且仅在达到靶细胞后才能实现释放。

3. 发明授权

US6071497A Microparticles for lung delivery comprising diketopiperazine 失效
公开(公告)号：US6071497A
公开(公告)日：2000-06-06
申请号：US847352
申请日：1997-04-24
申请人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
发明人： Solomon S. Steiner , Robert Feldstein , Huiling Lian , Christopher A. Rhodes , Gregory S. Shen
IPC分类号： A61K9/00 , A61K9/12 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/51 , A61K9/72 , A61K31/727 , A61K38/28 , A61K48/00
CPC分类号： A61K9/5146 , A61K9/0073 , A61K9/0075 , A61K9/1617
摘要： Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6.4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6.4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

4. 发明申请

US20120174923A1 Unit Dose Capsules and Dry Powder Inhaler 有权
公开(公告)号：US20120174923A1
公开(公告)日：2012-07-12
申请号：US13421529
申请日：2012-03-15
申请人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
发明人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
IPC分类号： A61M15/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.

5. 发明申请

US20110237510A1 STABILIZED GLUCAGON SOLUTIONS 有权
公开(公告)号：US20110237510A1
公开(公告)日：2011-09-29
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61P3/08 , B65D85/00
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

6. 发明申请

US20080190425A1 UNIT DOSE CARTRIDGE AND DRY POWDER INHALER 有权
标题翻译：单位剂量桶和干粉吸入器
公开(公告)号：US20080190425A1
公开(公告)日：2008-08-14
申请号：US12102625
申请日：2008-04-14
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M15/00 , A61M16/10
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

7. 发明授权

US5197490A Information processing system for counting coughs or evaluating other activities of a patient 失效
标题翻译：信息处理系统用于计数或评估患者的其他活动
公开(公告)号：US5197490A
公开(公告)日：1993-03-30
申请号：US510936
申请日：1990-04-19
申请人： Solomon S. Steiner , Bruce J. Albala , Robert Feldstein
发明人： Solomon S. Steiner , Bruce J. Albala , Robert Feldstein
IPC分类号： A61B5/00 , A61B5/11
CPC分类号： A61B5/0017 , A61B5/11 , A61B5/1123 , A61B5/1128 , A61B5/6892
摘要： A system using audio and visual information to count coughs or evaluate other discrete information, including respiration and heart rate, relating to a patient in a fixed location such as a bed is disclosed. The system provides movement- and sound-based information derived from the patient's activities to a storage device and subsequently to a signal processing apparatus. One embodiment of the invention includes a pressure transducer, a video camera, a directional microphone, and a videocassette recorder (VCR) having two audio channels. Signals obtained from the transducer and microphone are transmitted to the two audio channel inputs of the VCR, while movement of the patient is recorded using the video camera connected to the video channel input of the VCR. Part or all of the information stored using the VCR may be transmitted to signal processing equipment and frequency filtered to determine the presence and number of coughs, and any remaining information (e.g. the video data) may be used to confirm the count. Because various conditions manifest themselves in movements having different frequency characteristics, the present system, as appropriately modified, also can be used to determine the presence of symptoms such as restlessness and thereby evaluate the effectiveness of medicines such as sedatives and hypnotics.
摘要翻译：公开了一种使用音频和视觉信息计算咳嗽或评估与固定位置（例如床）中的患者有关的其它离散信息（包括呼吸和心率）的系统。该系统将从患者活动得到的基于运动和声音的信息提供给存储装置，随后提供给信号处理装置。本发明的一个实施例包括压力换能器，摄像机，定向麦克风和具有两个音频通道的录像机（VCR）。从传感器和麦克风获得的信号被传送到VCR的两个音频通道输入端，同时使用连接到VCR的视频通道输入的摄像机记录病人的移动。使用VCR存储的信息的部分或全部可以被发送到信号处理设备并经频率滤波以确定咳嗽的存在和数量，并且可以使用任何剩余信息（例如，视频数据）来确认计数。由于各种条件表现为具有不同频率特征的运动，所以适当修改的本系统也可用于确定诸如不安的症状的存在，从而评估诸如镇静剂和催眠药之类的药物的有效性。

8. 发明申请

US20080127970A1 Unit Dose Capsules and Dry Powder Inhaler 有权
标题翻译：单位剂量胶囊和干粉吸入器
公开(公告)号：US20080127970A1
公开(公告)日：2008-06-05
申请号：US11949707
申请日：2007-12-03
申请人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
发明人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
IPC分类号： A61M15/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece. The mouthpiece is connected by a swivel joint to the mixing section, and may swivel back onto the intake section and be enclosed by a cover. The intake chamber comprises a special piston with a tapered piston rod and spring, and one or more bleed-through orifices to modulate the flow of air through the device. The intake chamber further optionally comprises a feedback module to generate a tone indicating to the user when the proper rate of airflow has been achieved. The mixing section holds a capsule with holes containing a dry powder medicament, and the cover only can open when the mouthpiece is at a certain angle to the intake section. The mixing section further opens and closes the capsule when the intake section is at a certain angle to the mouthpiece. The mixing section is a Venturi chamber configured by protrusions or spirals to impart a cyclonic flow to air passing through the mixing chamber. The mouthpiece includes a tongue depressor, and a protrusion to contact the lips of the user to tell the user that the DPI is in the correct position. An optional storage section, with a cover, holds additional capsules. The cover for the mouthpiece, and the cover for the storage section may both be transparent, magnifying lenses. The capsules may be two-part capsules where each portion has apertures which correspond to apertures in the other half when each half is partially fitted to the other half, and fully fitted to the other half. All the apertures may be closed when the two halves are rotated around their longitudinal axes with respect to each other. Each capsule may have a unique key on each half that only fits with a particular inhaler.
摘要翻译：描述了一种干粉吸入器，其包括进气段; 混合部分和喉舌。接口通过旋转接头连接到混合部分，并且可以旋转回到进气部分并被盖封闭。进气室包括具有锥形活塞杆和弹簧的特殊活塞，以及一个或多个渗流孔口，用于调节通过该装置的空气流。进气室还可选地包括反馈模块，以产生当达到适当的气流速率时向用户指示的音调。混合部分容纳具有含有干粉药物的孔的胶囊，并且仅当吸嘴与进气部分成一定角度时，盖子才能打开。当进气部分与嘴件成一定角度时，混合部分进一步打开和关闭胶囊。混合部分是由突起或螺旋构成的文丘里室，以使气流通过混合室。接口管包括舌形按压器和用于接触用户嘴唇的突起，以告诉用户DPI处于正确的位置。带有盖子的可选存储部分可容纳另外的胶囊。用于接口管的盖和用于存储部的盖可以都是透明的放大镜。胶囊可以是两部分胶囊，其中每个部分具有对应于另一半中的孔的孔，当每个半部分部分地配合到另一半时，并且完全配合到另一半。当两个半部相对于彼此的纵向轴线旋转时，所有的孔可以被关闭。每个胶囊可以在每一半上具有仅与特定吸入器配合的唯一键。

9. 发明授权

US07305986B1 Unit dose capsules for use in a dry powder inhaler 有权
标题翻译：用于干粉吸入器的单位剂量胶囊
公开(公告)号：US07305986B1
公开(公告)日：2007-12-11
申请号：US09621092
申请日：2000-07-21
申请人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
发明人： Solomon S. Steiner , Robert Feldstein , Per B. Fog , Trent Poole
IPC分类号： A61M15/00
CPC分类号： A61M15/003 , A61M13/00 , A61M15/002 , A61M15/0021 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0043 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43 , F16L37/252
摘要： Described are capsules to contain a drug for use in an inhaler. The capsules may be two-part capsules where each half has apertures which may correspond to apertures in the other half. The first half fits snugly within the second half and the two halves may be rotated around their longitudinal axes with respect to each other to produce unlocked and locked positions. In the unlocked position, at least one aperture in the first half aligns with at least one aperture in the second half, which permits introduction of a medicament. In the locked position, at least two apertures in the first half align with at least two apertures in the second half, allowing air to pass through the capsule, releasing the medicament contained therein. Each capsule may have a unique key on each half that only fits with a particular inhaler or identifies the medicament contained therein.
摘要翻译：描述了容纳用于吸入器的药物的胶囊。胶囊可以是两部分胶囊，其中每一半具有可对应于另一半中的孔的孔。前半部分紧密地配合在第二半部分内，并且两个半部可以相对于彼此绕其纵向轴线旋转以产生解锁和锁定位置。在解锁位置，前半部中的至少一个孔与第二半中的至少一个孔对准，这允许引入药物。在锁定位置，第一半部中的至少两个孔与第二半部中的至少两个孔对准，允许空气通过胶囊，释放其中所含的药物。每个胶囊可以在每一半上具有仅与特定吸入器匹配的识别钥匙，或识别其中包含的药物。

10. 发明授权

US09610329B2 Stabilized glucagon solutions 有权
公开(公告)号：US09610329B2
公开(公告)日：2017-04-04
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61K9/107 , A61K47/24 , A61K47/26 , A61K9/00 , A61K9/19
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

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