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1. 发明授权

US09610329B2 Stabilized glucagon solutions 有权
公开(公告)号：US09610329B2
公开(公告)日：2017-04-04
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61K9/107 , A61K47/24 , A61K47/26 , A61K9/00 , A61K9/19
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

2. 发明申请

US20110237510A1 STABILIZED GLUCAGON SOLUTIONS 有权
公开(公告)号：US20110237510A1
公开(公告)日：2011-09-29
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61P3/08 , B65D85/00
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

3. 发明申请

US20110097386A1 STABILIZED GLUCAGON SOLUTIONS 审中-公开
标题翻译：稳定的GLUCAGON解决方案
公开(公告)号：US20110097386A1
公开(公告)日：2011-04-28
申请号：US12715203
申请日：2010-03-01
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61K9/127 , A61P3/08
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/19 , A61K47/24
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.
摘要翻译：已经设计了由糖如葡萄糖和表面活性剂如肉豆蔻酰溶血磷脂酰胆碱（LMPC）组成的制剂，以在长时间的生理条件下稳定胰高血糖素分子的亲水部分和疏水部分，其浓度与pH和pH足够相似，血浆的渗透压，以免诱发或最小化部位刺激。单糖和表面活性剂的组合使得胰高血糖素分子在37℃下在水溶液中稳定7天。

4. 发明申请

US20100227795A1 INSULIN FORMULATIONS FOR RAPID UPTAKE 有权
标题翻译：胰岛素制剂用于快速摄取
公开(公告)号：US20100227795A1
公开(公告)日：2010-09-09
申请号：US12397219
申请日：2009-03-03
申请人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
发明人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/28 , A61K47/12 , A61K47/183 , C07K14/62
摘要： Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.
摘要翻译：本文描述了具有改善的稳定性和快速起效的可注射的胰岛素制剂。制剂可用于皮下，皮内或肌内给药。在优选的实施方案中，通过皮下注射施用制剂。制剂含有与螯合剂和溶解剂以及任选的其它赋形剂组合的胰岛素。在优选的实施方案中，制剂含有人胰岛素，锌螯合剂如EDTA和溶解剂如柠檬酸或柠檬酸钠。当通过皮下注射给药时，这些制剂被快速地吸收到血流中。在优选的实施方案中，胰岛素以多用途无菌小瓶中的透明液体中性pH提供。在替代实施方案中，胰岛素以无菌小瓶中的粉末形式提供。将其与包含药学上可接受的载体如水，锌螯合剂如EDTA的稀释剂和不久之前或给药时的溶解剂如柠檬酸混合。在另一个实施方案中，将胰岛素作为冷冻混合物储存，准备在解冻时使用。

5. 发明授权

US09060927B2 Insulin formulations for rapid uptake 有权
标题翻译：胰岛素配方快速吸收
公开(公告)号：US09060927B2
公开(公告)日：2015-06-23
申请号：US12397219
申请日：2009-03-03
申请人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
发明人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
IPC分类号： A61K38/28 , C07K14/62 , A61K9/00 , A61K38/00
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/28 , A61K47/12 , A61K47/183 , C07K14/62
摘要： Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.
摘要翻译：本文描述了具有改善的稳定性和快速起效的可注射的胰岛素制剂。制剂可用于皮下，皮内或肌内给药。在优选的实施方案中，通过皮下注射施用制剂。制剂含有与螯合剂和溶解剂以及任选的其它赋形剂组合的胰岛素。在优选的实施方案中，制剂含有人胰岛素，锌螯合剂如EDTA和溶解剂如柠檬酸或柠檬酸钠。当通过皮下注射给药时，这些制剂被快速地吸收到血流中。在优选的实施方案中，胰岛素以多用途无菌小瓶中的透明液体中性pH提供。在替代实施方案中，胰岛素以无菌小瓶中的粉末形式提供。将其与包含药学上可接受的载体如水，锌螯合剂如EDTA的稀释剂和不久之前或给药时的溶解剂如柠檬酸混合。在另一个实施方案中，将胰岛素作为冷冻混合物储存，准备在解冻时使用。

6. 发明申请

US20120178675A1 Compositions And Methods For Modulating The Pharmacokinetics and Pharmacodynamics of Insulin 审中-公开
标题翻译：用于调节胰岛素的药代动力学和药效学的组合物和方法
公开(公告)号：US20120178675A1
公开(公告)日：2012-07-12
申请号：US13176435
申请日：2011-07-05
申请人： Roderike Pohl , Solomon Steiner , Robert Hauser , Richard Seibert , Ming Li
发明人： Roderike Pohl , Solomon Steiner , Robert Hauser , Richard Seibert , Ming Li
IPC分类号： A61K38/28 , A61P25/00 , A61P3/10
CPC分类号： C07K14/62 , A61K9/0019 , A61K38/28 , A61K47/183
摘要： Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of rapid acting injectable insulin formulations are described herein. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“EDTA”) and a dissolution/stabilization agent, and optionally additional excipients. Calcium disodium EDTA is less likely to remove calcium from the body, and typically has less pain on injection in the subcutaneous tissue. Modulating the type and quantity of EDTA can change the insulin absorption profile. Increasing the quantity of citrate can further enhance absorption and chemically stabilize the formulation. In the preferred embodiment, the formulation contains human insulin, calcium disodium EDTA and a dissolution/stabilization agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection.
摘要翻译：本文描述了用于调节快速作用的可注射胰岛素制剂的药代动力学和药效学的组合物和方法。在优选的实施方案中，通过皮下注射施用制剂。制剂含有与锌螯合剂如乙二胺四乙酸（“EDTA”）和溶解/稳定剂以及任选的其它赋形剂组合的胰岛素。 EDTA二钠不太可能从体内去除钙，并且通常在皮下组织中注射时疼痛较少。调节EDTA的类型和数量可以改变胰岛素吸收特征。增加柠檬酸盐的量可以进一步增强吸收和化学稳定制剂。在优选的实施方案中，制剂含有人胰岛素，EDTA二钠钙和溶解/稳定剂如柠檬酸或柠檬酸钠。当通过皮下注射给药时，这些制剂被快速地吸收到血流中。

7. 发明授权

US12076872B1 Magnetic shaver 有权
公开(公告)号：US12076872B1
公开(公告)日：2024-09-03
申请号：US18416831
申请日：2024-01-18
申请人： Ming Li
发明人： Ming Li
IPC分类号： B26B19/38 , B26B19/14 , B26B19/32
CPC分类号： B26B19/386 , B26B19/14 , B26B19/32 , B26B19/3846
摘要： A magnetic shaver, comprising a connecting part, wherein the connecting part is detachably connected to the device host, and the device host is provided with a control mainboard and a power supply; a bottom shell, wherein the bottom shell is installed on the connecting part; the connecting part and the bottom shell are provided with a gear driving mechanism, and the gear driving mechanism is powered and controlled by the device host; a cutter head assembly, wherein the cutter head assembly is magnetically connected and assembled with the bottom shell through a magnetic structure; when the cutter head assembly is installed on the bottom shell, the gear driving mechanism drives the cutter head assembly. The cutter head assembly and the bottom shell are disassembled and assembled through magnetic attraction, so the cutter head assembly can be easily disassembled and replaced, making the operation more convenient.

8. 发明公开

US20240142071A1 COMBINATION LIGHT STRING 审中-公开
公开(公告)号：US20240142071A1
公开(公告)日：2024-05-02
申请号：US17983542
申请日：2022-11-09
申请人： Ming Li
发明人： Ming Li
IPC分类号： F21S4/10 , F21V33/00 , H05B47/155
CPC分类号： F21S4/10 , F21V33/0056 , H05B47/155 , F21Y2115/10
摘要： The invention discloses a combination light string, comprising: line lamps, wherein a plurality of the line lamps are respectively connected in parallel on an electric wire; bulb lamps, wherein a plurality of the bulb lamps are respectively connected in parallel on the electric wire, and the bulb lamps are connected in series with the line lamps; control units, which are respectively connected to each of the line lamps and each of the bulb lamps; at least one bulb lamp is provided between any adjacent two line lamps; the control unit can individually control the working states of all the line lamps, and the control unit can individually control the working states of the bulb lamps, so as to realize the control of each of the line lamps and each of the bulb lamps.

9. 外观设计

USD982559S1 Remote controller 有权
公开(公告)号：USD982559S1
公开(公告)日：2023-04-04
申请号：US29767611
申请日：2021-01-25
申请人： Ming Li
设计人： Ming Li

10. 外观设计

USD968843S1 Soap dispenser 有权
公开(公告)号：USD968843S1
公开(公告)日：2022-11-08
申请号：US29844818
申请日：2022-07-01
申请人： Pan Liao , Ming Li
设计人： Ming Li , Xiaoyan Jiang

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