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1. 发明授权

US09610329B2 Stabilized glucagon solutions 有权
公开(公告)号：US09610329B2
公开(公告)日：2017-04-04
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61K9/107 , A61K47/24 , A61K47/26 , A61K9/00 , A61K9/19
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

2. 发明申请

US20110237510A1 STABILIZED GLUCAGON SOLUTIONS 有权
公开(公告)号：US20110237510A1
公开(公告)日：2011-09-29
申请号：US12891240
申请日：2010-09-27
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61P3/08 , B65D85/00
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/19 , A61K47/26
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.

3. 发明申请

US20110097386A1 STABILIZED GLUCAGON SOLUTIONS 审中-公开
标题翻译：稳定的GLUCAGON解决方案
公开(公告)号：US20110097386A1
公开(公告)日：2011-04-28
申请号：US12715203
申请日：2010-03-01
申请人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
发明人： Solomon S. Steiner , Robert Hauser , Ming Li , Robert Feldstein , Roderike Pohl
IPC分类号： A61K38/26 , A61K9/127 , A61P3/08
CPC分类号： A61K38/26 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/19 , A61K47/24
摘要： A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.
摘要翻译：已经设计了由糖如葡萄糖和表面活性剂如肉豆蔻酰溶血磷脂酰胆碱（LMPC）组成的制剂，以在长时间的生理条件下稳定胰高血糖素分子的亲水部分和疏水部分，其浓度与pH和pH足够相似，血浆的渗透压，以免诱发或最小化部位刺激。单糖和表面活性剂的组合使得胰高血糖素分子在37℃下在水溶液中稳定7天。

4. 发明申请

US20100227795A1 INSULIN FORMULATIONS FOR RAPID UPTAKE 有权
标题翻译：胰岛素制剂用于快速摄取
公开(公告)号：US20100227795A1
公开(公告)日：2010-09-09
申请号：US12397219
申请日：2009-03-03
申请人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
发明人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
IPC分类号： A61K38/28 , A61P3/10
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/28 , A61K47/12 , A61K47/183 , C07K14/62
摘要： Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.
摘要翻译：本文描述了具有改善的稳定性和快速起效的可注射的胰岛素制剂。制剂可用于皮下，皮内或肌内给药。在优选的实施方案中，通过皮下注射施用制剂。制剂含有与螯合剂和溶解剂以及任选的其它赋形剂组合的胰岛素。在优选的实施方案中，制剂含有人胰岛素，锌螯合剂如EDTA和溶解剂如柠檬酸或柠檬酸钠。当通过皮下注射给药时，这些制剂被快速地吸收到血流中。在优选的实施方案中，胰岛素以多用途无菌小瓶中的透明液体中性pH提供。在替代实施方案中，胰岛素以无菌小瓶中的粉末形式提供。将其与包含药学上可接受的载体如水，锌螯合剂如EDTA的稀释剂和不久之前或给药时的溶解剂如柠檬酸混合。在另一个实施方案中，将胰岛素作为冷冻混合物储存，准备在解冻时使用。

5. 发明授权

US09060927B2 Insulin formulations for rapid uptake 有权
标题翻译：胰岛素配方快速吸收
公开(公告)号：US09060927B2
公开(公告)日：2015-06-23
申请号：US12397219
申请日：2009-03-03
申请人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
发明人： Solomon S. Steiner , Roderike Pohl , Ming Li , Robert Hauser
IPC分类号： A61K38/28 , C07K14/62 , A61K9/00 , A61K38/00
CPC分类号： A61K9/0019 , A61K38/00 , A61K38/28 , A61K47/12 , A61K47/183 , C07K14/62
摘要： Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In the preferred embodiment, the formulations are administered via subcutaneous injection. The formulations contain insulin in combination with a chelator and dissolution agent, and optionally additional excipients. In the preferred embodiment, the formulation contains human insulin, a zinc chelator such as EDTA and a dissolution agent such as citric acid or sodium citrate. These formulations are rapidly absorbed into the blood stream when administered by subcutaneous injection. In the preferred embodiment, the insulin is provided as a clear liquid, neutral pH, in a multi-use sterile vial. In an alternative embodiment, the insulin is provided as a powder in a sterile vial. This is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water, a zinc chelator such as EDTA and a dissolution agent such as citric acid shortly before or at the time of administration. In another embodiment, the insulin is stored as a frozen mixture, ready for use upon thawing.
摘要翻译：本文描述了具有改善的稳定性和快速起效的可注射的胰岛素制剂。制剂可用于皮下，皮内或肌内给药。在优选的实施方案中，通过皮下注射施用制剂。制剂含有与螯合剂和溶解剂以及任选的其它赋形剂组合的胰岛素。在优选的实施方案中，制剂含有人胰岛素，锌螯合剂如EDTA和溶解剂如柠檬酸或柠檬酸钠。当通过皮下注射给药时，这些制剂被快速地吸收到血流中。在优选的实施方案中，胰岛素以多用途无菌小瓶中的透明液体中性pH提供。在替代实施方案中，胰岛素以无菌小瓶中的粉末形式提供。将其与包含药学上可接受的载体如水，锌螯合剂如EDTA的稀释剂和不久之前或给药时的溶解剂如柠檬酸混合。在另一个实施方案中，将胰岛素作为冷冻混合物储存，准备在解冻时使用。

6. 发明申请

US20120240929A1 UNIT DOSE CARTRIDGE AND DRY POWDER INHALER 有权
标题翻译：单位剂量桶和干粉吸入器
公开(公告)号：US20120240929A1
公开(公告)日：2012-09-27
申请号：US13490292
申请日：2012-06-06
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M15/00
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

7. 发明授权

US08950397B2 Unit dose cartridge and dry powder inhaler 有权
标题翻译：单位剂量筒和干粉吸入器
公开(公告)号：US08950397B2
公开(公告)日：2015-02-10
申请号：US13490292
申请日：2012-06-06
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M11/00 , A61M15/00 , A61M16/04
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

8. 发明申请

US20080190425A1 UNIT DOSE CARTRIDGE AND DRY POWDER INHALER 有权
标题翻译：单位剂量桶和干粉吸入器
公开(公告)号：US20080190425A1
公开(公告)日：2008-08-14
申请号：US12102625
申请日：2008-04-14
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M15/00 , A61M16/10
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

9. 发明授权

US08215300B2 Unit dose cartridge and dry powder inhaler 有权
标题翻译：单位剂量筒和干粉吸入器
公开(公告)号：US08215300B2
公开(公告)日：2012-07-10
申请号：US12102625
申请日：2008-04-14
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M11/00
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

10. 发明授权

US07464706B2 Unit dose cartridge and dry powder inhaler 有权
标题翻译：单位剂量筒和干粉吸入器
公开(公告)号：US07464706B2
公开(公告)日：2008-12-16
申请号：US10655153
申请日：2003-09-04
申请人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
发明人： Solomon S. Steiner , Trent A. Poole , Per B. Fog , Roderike Pohl , Michael Crick , Robert Feldstein
IPC分类号： A61M11/00
CPC分类号： A61M15/0015 , A61M15/002 , A61M15/0023 , A61M15/0025 , A61M15/0028 , A61M15/0086 , A61M16/0495 , A61M16/0825 , A61M2202/064 , A61M2205/43
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要翻译：描述了具有改善的空气动力学特性以用于稀释，分散和计量药物颗粒以提高肺部药物递送给患者的效率的干粉吸入器。吸入器通常包括具有进气口的壳体，空气流量控制/止回阀，混合部分和吹嘴。装有单剂量药物的药筒可以安装在混合部分中。

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