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1. 发明申请

US20110071277A1 RESISTIN ANTAGONISTS AND THEIR USE 审中-公开
标题翻译：电阻拮抗剂及其使用
公开(公告)号：US20110071277A1
公开(公告)日：2011-03-24
申请号：US12722950
申请日：2010-03-12
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： C07K16/00
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译：公开了抵抗素拮抗剂，包括与限定的表位反应的抗体。还公开了可用于提高抗人抵抗素抗体的抗原。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

2. 发明申请

US20090162375A1 RESISTIN ANTAGONISTS AND THEIR USE 审中-公开
标题翻译：电阻拮抗剂及其使用
公开(公告)号：US20090162375A1
公开(公告)日：2009-06-25
申请号：US11924108
申请日：2007-10-25
申请人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
发明人： Simon Blake , Jill Carton , Jennifer Henrica Lee , Keying Ma , Paul Marsters , Kristen Picha , Xiao-Yu R. Song , Francis Farrell , Lynne Murray , Alexey Teplyakov , Tatiana Ort
IPC分类号： A61K39/395 , C07K16/26 , C07K7/08 , C07H21/00 , C12Q1/02
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： Resistin antagonists, including antibodies reactive with defined epitopes, are disclosed. Antigens useful for raising antibodies against human resistin are also disclosed. Methods of utilizing resistin antagonists to treat or alleviate the symptoms of the diseases with aberrant fibroblast activity including interstitial lung diseases, hypertrophic scarring, keloid scarring and scleroderma are also disclosed. Methods of utilizing resistin as a biomarker to diagnose the risk and/or progression of osteoarthritis are also disclosed. Further disclosed are methods of utilizing the antagonists to treat or alleviate the symptoms of osteoarthritis.
摘要翻译：公开了抗性拮抗剂，包括与限定的表位反应的抗体。还公开了可用于提高抗人抵抗素抗体的抗原。还公开了利用抵抗素拮抗剂治疗或缓解具有异常成纤维细胞活性（包括间质性肺病，肥大性瘢痕形成，瘢痕疙瘩瘢痕形成和硬皮病）的疾病症状的方法。还公开了利用抗性蛋白作为生物标志物来诊断骨关节炎的风险和/或进展的方法。进一步公开的是利用拮抗剂治疗或减轻骨关节炎症状的方法。

3. 发明授权

US07479479B2 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途
公开(公告)号：US07479479B2
公开(公告)日：2009-01-20
申请号：US11680113
申请日：2007-02-28
申请人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/92 , C12Q1/6883 , C12Q2600/158
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

4. 发明申请

US20090137783A1 CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses 审中-公开
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途
公开(公告)号：US20090137783A1
公开(公告)日：2009-05-28
申请号：US12352881
申请日：2009-01-13
申请人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： C07K16/18 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/92 , C12Q1/6883 , C12Q2600/158
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

5. 发明申请

US20060141479A1 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
公开(公告)号：US20060141479A1
公开(公告)日：2006-06-29
申请号：US10835904
申请日：2004-04-30
申请人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47 , C07K16/18
CPC分类号： C07K14/47 , A61K45/06
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

6. 发明申请

US20090186772A1 Markers and Methods for Assessing and Treating Ulcerative Colitis and Related Disorders Using a 19 Gene Panel 审中-公开
标题翻译：使用19基因面板评估和治疗溃疡性结肠炎和相关疾病的标记和方法
公开(公告)号：US20090186772A1
公开(公告)日：2009-07-23
申请号：US12110687
申请日：2008-04-28
申请人： Frederic Baribaud , Xilin Li , Keying Ma , Xiao-Yu Song
发明人： Frederic Baribaud , Xilin Li , Keying Ma , Xiao-Yu Song
IPC分类号： C40B30/04 , C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： A method for assessment of the suitability of a target therapy for a gastrointestinal-related disorder, such as ulcerative colitis, in a subject evaluates the presence, absence, and/or magnitude of expression of one or more genes in a 19- or 5-member gene panel in a sample. The method enables identification of the effectiveness of target therapies prior to starting a patient on such therapies.
摘要翻译：用于评估受试者胃肠道相关疾病（例如溃疡性结肠炎）的目标治疗适用性的方法评价19-或5-位中一个或多个基因的表达的存在，不存在和/或大小，成员基因组在样品中。该方法能够在开始患者之前鉴定目标疗法的有效性。

7. 发明申请

US20080044422A1 CNGH0010 Specific Polynucleotides, Polypeptides, Antibodies, Compositions, Methods and Uses 有权
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途
公开(公告)号：US20080044422A1
公开(公告)日：2008-02-21
申请号：US11680113
申请日：2007-02-28
申请人： Xiao-yu Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-yu Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： A61K31/70 , A01K67/00 , A61K38/00 , A61K39/395 , A61P43/00 , C07K14/00 , C07K16/18 , C12N1/00 , C12N1/20 , C12N15/00 , C12N15/11 , C12N15/82 , C12N5/06 , C12P21/04 , C12Q1/68 , G01N33/00
CPC分类号： C07K14/47 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/92 , C12Q1/6883 , C12Q2600/158
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

8. 发明授权

US07326687B2 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途
公开(公告)号：US07326687B2
公开(公告)日：2008-02-05
申请号：US10835904
申请日：2004-04-30
申请人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/47 , A61K45/06
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

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