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1. 发明授权

US08277809B2 CXCL13 antagonists and their use for the treatment of inflammatory diseases 有权
标题翻译： CXCL13拮抗剂及其用于治疗炎性疾病的用途
公开(公告)号：US08277809B2
公开(公告)日：2012-10-02
申请号：US11738019
申请日：2007-04-20
申请人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
发明人： Peter Bugelski , Anuk Das , Donald E. Griswold , Bailin Liang , Li Li , Robert T. Sarisky , Xiaozhou Shang
IPC分类号： A61K39/395
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
摘要翻译：治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。

2. 发明授权

US07833755B2 Anti-IL-6 antibody nucleic acid molecules and methods 有权
标题翻译：抗IL-6抗体核酸分子及方法
公开(公告)号：US07833755B2
公开(公告)日：2010-11-16
申请号：US12470753
申请日：2009-05-22
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： C12N5/10 , C12N15/13 , C12N15/63
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。

3. 发明申请

US20090239258A1 Anti-IL-6 Antibody Nucleic Acid Molecules and Methods 有权
标题翻译：抗IL-6抗体核酸分子和方法
公开(公告)号：US20090239258A1
公开(公告)日：2009-09-24
申请号：US12470753
申请日：2009-05-22
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： C12P21/02 , C07H21/00 , C12N15/63 , C12N5/10
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体核酸，载体，宿主细胞，转基因动物或植物及其制备和使用方法在诊断和/或治疗组合物，方法和装置中具有应用。

4. 发明授权

US07479479B2 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
标题翻译： CNGH0010特异性多核苷酸，多肽，抗体，组合物，方法和用途
公开(公告)号：US07479479B2
公开(公告)日：2009-01-20
申请号：US11680113
申请日：2007-02-28
申请人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-yu R. Song , Chong Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/92 , C12Q1/6883 , C12Q2600/158
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.
摘要翻译：对于至少一个这样的CNGH0010多肽，其变体或片段，以及编码这样的CNGH0010多肽和抗体，互补核酸，载体，宿主细胞的核酸，对于至少一个这样的CNGH0010多肽，变体或其片段特异的新型多肽（CNGH0010）和抗体，包括特定部分或变体，其制备和使用方法可用于治疗和诊断制剂，给药和装置。上述多肽可用于产生人，灵长类动物，啮齿动物，哺乳动物，嵌合，人源化和/或CDR移植抗CNGH0010抗体。 CNGH0010多肽和抗体用于调节或治疗细胞，组织，器官，动物或患者中的至少一种CNGH0010相关疾病。这些疾病可以包括但不限于牛皮癣，类风湿性关节炎，肺气肿，哮喘，糖尿病，自身免疫性甲状腺炎，包括克罗恩病和溃疡性结肠炎在内的炎性肠病，不同类型的皮炎，包括过敏性皮炎，接触性皮炎，光化性角化病，伤口愈合，瘢痕形成，各种肾脏疾病，各种呼吸道疾病，生殖器官的各种疾病，如子宫内膜异位症，黑素瘤，鳞状细胞癌，卵巢癌，乳腺癌，肺癌，结肠癌，前列腺癌，肾细胞癌，Grave's 疾病等炎症和过度增生性疾病。

5. 发明申请

US20060257407A1 Anti-IL-6 antibodies, compositions, methods and uses 有权
标题翻译：抗IL-6抗体，组合物，方法和用途
公开(公告)号：US20060257407A1
公开(公告)日：2006-11-16
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
发明人： Yan Chen , Debra Gardner , David Knight , Michael Lark , Bailin Liang , David Shealy , Xiao-Yu Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Sheng-Jiun Wu , Jing Yang , David Marquis , Eric Smith , Alain Vasserot
IPC分类号： A61K39/395 , C07H21/04 , C07K16/24
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

6. 发明申请

US20110081355A1 Methods of Diagnosing and Treating Conditions Using Anti-IL-6 Antibodies 有权
标题翻译：使用抗IL-6抗体诊断和治疗病症的方法
公开(公告)号：US20110081355A1
公开(公告)日：2011-04-07
申请号：US12901200
申请日：2010-10-08
申请人： YAN CHEN , DEBRA GARDNER , DAVID M. KNIGHT , MICHAEL W. LARK , BAILIN LIANG , DAVID J. SHEALY , XIAO-YU R. SONG , VEDRANA STOJANOVIC-SUSULIC , RAYMOND W. SWEET , SUSAN H. TAM , SHENG-JIUN WU , JING YANG , DAVID MATTHEW MARQUIS , ERIC MICHAEL SMITH , ALAIN PHILIPPE VASSEROT
发明人： YAN CHEN , DEBRA GARDNER , DAVID M. KNIGHT , MICHAEL W. LARK , BAILIN LIANG , DAVID J. SHEALY , XIAO-YU R. SONG , VEDRANA STOJANOVIC-SUSULIC , RAYMOND W. SWEET , SUSAN H. TAM , SHENG-JIUN WU , JING YANG , DAVID MATTHEW MARQUIS , ERIC MICHAEL SMITH , ALAIN PHILIPPE VASSEROT
IPC分类号： A61K39/395 , A61P19/02 , A61P9/10 , A61P25/00 , A61P11/00 , A61P37/00 , A61P35/00 , A61P31/00 , C12N5/00 , G01N33/53
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma.
摘要翻译：抗IL-6抗体用于治疗IL-6相关病症，如类风湿性关节炎，骨关节炎，骨质溶解，骨科植入物无菌松动，系统性红斑狼疮，皮肤红斑狼疮，狼疮肾炎，2型糖尿病，慢性阻塞性肺炎疾病和肾细胞癌。

7. 发明授权

US07560112B2 Anti-il-6 antibodies, compositions, methods and uses 有权
标题翻译：抗il-6抗体，组合物，方法和用途
公开(公告)号：US07560112B2
公开(公告)日：2009-07-14
申请号：US11413561
申请日：2006-04-28
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395 , C07K16/24 , C12N5/12
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

8. 发明申请

US20080014201A1 CXCL13 Antagonists and Their Use for the Treatment of Inflammatory Diseases 有权
标题翻译： CXCL13拮抗剂及其用于治疗炎症疾病的用途
公开(公告)号：US20080014201A1
公开(公告)日：2008-01-17
申请号：US11738019
申请日：2007-04-20
申请人： Peter Bugelski , Anuk Das , Donald Griswold , Bailin Liang , Li Li , Robert Sarisky , Xiaozhou Shang
发明人： Peter Bugelski , Anuk Das , Donald Griswold , Bailin Liang , Li Li , Robert Sarisky , Xiaozhou Shang
IPC分类号： A61K39/395 , A61K31/7052 , A61P11/00 , A61P29/00 , A61K38/02
CPC分类号： C07K16/241 , A61K2039/507 , C07K16/24 , C07K2317/76
摘要： Methods of treating disorders related to CXCL13 activity utilize CXCL13 antagonists and, optionally, TNFα antagonists, such as antibodies, including specified portions or variants, polypeptides, polynucleotides, siRNA, shRNA, ribozymes, and DNAzymes. Disorders related to CXCL13 activity include inflammatory disorders, such as pulmonary disorders, for example, asthma, emphysema, and COPD, and systemic lupus erythematosus.
摘要翻译：治疗与CXCL13活性相关的疾病的方法利用CXCL13拮抗剂和任选的TNFα拮抗剂，例如包括特定部分或变体，多肽，多核苷酸，siRNA，shRNA，核酶和DNA酶的抗体。与CXCL13活性相关的疾病包括炎症性疾病，例如肺部疾病，例如哮喘，肺气肿和COPD，以及系统性红斑狼疮。

9. 发明申请

US20060141479A1 CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses 有权
公开(公告)号：US20060141479A1
公开(公告)日：2006-06-29
申请号：US10835904
申请日：2004-04-30
申请人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
发明人： Xiao-Yu Song , Chris Huang , Keying Ma , Bailin Liang , Michael Naso
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47 , C07K16/18
CPC分类号： C07K14/47 , A61K45/06
摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

10. 发明授权

US08623362B2 Anti-IL-6 antibodies 有权
标题翻译：抗IL-6抗体
公开(公告)号：US08623362B2
公开(公告)日：2014-01-07
申请号：US13524684
申请日：2012-06-15
申请人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David J. Shealy , Xiao-Yu R. Song , Vedrana Stojanovic-Susulic , Raymond W. Sweet , Susan H. Tam , Sheng-Jiun Wu , Jing Yang , David Matthew Marquis , Eric Michael Smith , Alain Philippe Vasserot
IPC分类号： A61K39/395
CPC分类号： C07K16/248 , A61K2039/505 , A61K2039/54 , C07K2316/96 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：抗IL-6抗体，包括编码至少一种抗IL-6抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有在诊断和/或治疗组合物中的应用，方法和设备。

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