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1. 发明申请

US20090118670A1 Cannula inserting system 审中-公开
标题翻译：插管系统
公开(公告)号：US20090118670A1
公开(公告)日：2009-05-07
申请号：US11911670
申请日：2006-04-21
申请人： Sieglinde Neerken , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Gerhardus Wilhelmus Lucassen , Eric Cohen-Solal , Claude Cohen-Bacrie , Balasundara Raju , Marion Geerligs , Nicole Leonarda Wilhelmina Eikelenberg , Carole Schwach
发明人： Sieglinde Neerken , Frederikus Johannes Maria De Vreede , Robertus Hekkenberg , Gerhardus Wilhelmus Lucassen , Eric Cohen-Solal , Claude Cohen-Bacrie , Balasundara Raju , Marion Geerligs , Nicole Leonarda Wilhelmina Eikelenberg , Carole Schwach
IPC分类号： A61M5/42 , A61B5/103
CPC分类号： A61M5/427 , A61B5/0059 , A61B5/0066 , A61B5/0095 , A61B5/15003 , A61B5/150175 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150748 , A61B5/1535 , A61B5/155 , A61B5/489 , A61B8/06 , A61B8/0833
摘要： The invention relates to a highly automated puncture system for inserting a cannula or a needle into a blood vessel of a person or an animal. The puncture system has an acquisition module that allows for determining at least a location of a blood vessel underneath of the surface of a skin and is further enabled to determine an optimal puncture location that is potentially suitable for inserting a cannula into the blood vessel. Further, the puncture system has tissue analysis means to analyse the skin surface in the proximity of the puncture location to check whether the skin is suitable for punctuation. This prevents puncturing the skin at locations where scars, wound and the like can be found.
摘要翻译：本发明涉及一种用于将插管或针插入人或动物的血管中的高度自动化的穿刺系统。穿刺系统具有采集模块，其允许确定皮肤表面下方的血管的至少位置，并且还能够确定潜在地适合于将插管插入血管中的最佳穿刺位置。此外，穿刺系统具有组织分析装置，用于分析穿刺位置附近的皮肤表面，以检查皮肤是否适于标点符号。这可以防止在可以发现疤痕，伤口等的位置刺穿皮肤。

2. 发明申请

US20080015439A1 Method and Apparatus for Measuring and/or Detecting Flow Behavior of a Body Fluid Using Ultrasound 审中-公开
标题翻译：用于使用超声测量和/或检测体液流动特性的方法和装置
公开(公告)号：US20080015439A1
公开(公告)日：2008-01-17
申请号：US11574885
申请日：2005-09-08
申请人： Balasundara Raju , Eric Cohen-Solal , Shervin Ayati
发明人： Balasundara Raju , Eric Cohen-Solal , Shervin Ayati
IPC分类号： A61B8/14
CPC分类号： A61N1/3925 , A61B5/021 , A61B8/02 , A61B8/06 , A61B8/488 , A61N1/39 , G01S15/025 , G01S15/58 , G01S15/582 , G01S15/586
摘要： An ultrasound method and apparatus for detecting and/or measuring the pulse and/or blood flow of a subject calculates a Doppler signal spectrum from an ultrasound signal backscattered from the blood in an artery of the subject. Indicia of flow behavior are calculated for several frequency slices within the Doppler signal spectrum and these indicia may be used to determine pulsatility and/or blood flow, as well as other parameters of flow behavior. Because of the robust nature of the calculated indicia, the ultrasound method and apparatus has particular use in an Automated or Semi-Automated External Defibrillator (AED) for determining whether to defibrillate a patient.
摘要翻译：用于检测和/或测量受试者的脉搏和/或血流量的超声方法和装置从从受试者的动脉中的血液反向散射的超声信号计算多普勒信号频谱。针对多普勒信号频谱内的几个频率片段计算流行为的指标，并且这些标记可用于确定脉动和/或血液流量以及流动行为的其他参数。由于计算标记的鲁棒性，超声方法和装置在自动或半自动外部除颤器（AED）中特别有用，用于确定是否对患者进行去纤颤。

3. 发明申请

US20120184854A1 ULTRASONIC VASCULAR FLOW SENSOR WITH TRIANGULAR SENSOR GEOMETRY 审中-公开
标题翻译：超声波流量传感器，具有三角形传感器几何
公开(公告)号：US20120184854A1
公开(公告)日：2012-07-19
申请号：US13203065
申请日：2010-02-10
申请人： Balasundara Raju , Eric Cohen-Solal , Ramon Erkamp , John Fraser
发明人： Balasundara Raju , Eric Cohen-Solal , Ramon Erkamp , John Fraser
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B8/4236 , A61B8/4483 , A61B8/4494 , B06B1/0629
摘要： An ultrasonic blood flow sensor includes a plurality of adjacent triangular shaped transducer elements which transmit ultrasound waves into a blood vessel and receive reflected ultrasound waves from the blood flow in the vessel. Preferably the transducer elements are paired in pairs of transmit and receive elements. The elements are fixed in a matrix which may be attached in acoustic coupling contact with the skin The matrix retains adjacent transducer elements slightly spaced apart so that the matrix of transducer elements may bend and conform to the shape of the skin surface. The spacing between the triangular elements is neither parallel nor orthogonal to the length dimension of the matrix so that a blood vessel will not be aligned with a space between transducer elements when the matrix is affixed across the location of a blood vessel. In addition the geometry of the elements creates a beam pattern that provide more overlap between transmit and receive beam profiles, thereby increasing the area of sensor coverage.
摘要翻译：超声波血流传感器包括多个相邻的三角形换能器元件，其将超声波传输到血管中并从血管中的血流接收反射的超声波。优选地，换能器元件成对地配对成对的发射和接收元件。这些元件被固定在可以与皮肤的声学耦合接触附接的矩阵中。矩阵保持相邻的换能器元件稍微间隔开，使得换能器元件的矩阵可以弯曲并符合皮肤表面的形状。三角形元件之间的间距既不平行也不垂直于矩阵的长度尺寸，使得当基体固定在血管的位置时，血管将不会与换能器元件之间的空间对齐。此外，元件的几何形状产生了在发射和接收波束轮廓之间提供更多重叠的波束图案，从而增加了传感器覆盖面积。

4. 发明申请

US20090209862A1 METHOD AND APPARATUS FOR MEDICAL ULTRASOUND DIAGNOSTICS 审中-公开
标题翻译：医学超声诊断方法与装置
公开(公告)号：US20090209862A1
公开(公告)日：2009-08-20
申请号：US11571196
申请日：2005-06-27
申请人： Balasundara Raju , Eric Cohen-Solal , Shervin Ayati
发明人： Balasundara Raju , Eric Cohen-Solal , Shervin Ayati
IPC分类号： A61B8/14
CPC分类号： G01S7/52085 , A61B8/06 , A61B8/08 , G01S15/8909 , G01S15/8927
摘要： A method and apparatus for medical ultrasound diagnostics use time multiplexing of ultrasonic transducers of a multi-transducer array (108) disposed upon or in an application pad. Embodiments of the invention facilitate low excitation power and low wire count electrical interfaces (106, 306, 406) to the transducers and reduce electromagnetic interference between the transducers, as well as increase reliability and accuracy of positioning the application pad on the body of a patient. In one exemplary application, the invention facilitates assessment of blood perfusion.
摘要翻译：用于医疗超声诊断的方法和装置使用设置在应用垫上或其中的多换能器阵列（108）的超声换能器的时间复用。本发明的实施例便于对换能器的低激励功率和低线数电接口（106,306,406），并减少换能器之间的电磁干扰，并且增加将应用垫定位在患者身上的可靠性和准确性。在一个示例性应用中，本发明便于评估血液灌注。

5. 发明申请

US20110178391A1 SYSTEM AND METHOD FOR ULTRASOUND THERAPY TREATMENT 有权
标题翻译：超声治疗系统与方法
公开(公告)号：US20110178391A1
公开(公告)日：2011-07-21
申请号：US13119810
申请日：2009-09-14
申请人： Anna Theresa Fernandez , Balasundara Raju
发明人： Anna Theresa Fernandez , Balasundara Raju
IPC分类号： A61B5/055 , A61N7/00
CPC分类号： A61N7/022 , A61B2090/3782 , A61N2007/0056
摘要： A system and method for treating tissue, such as treating prostate diseases, using an ultrasound therapy system. An ultrasonic applicator (100) has at least one transducer element (102). The steering and focusing of ultrasound beams uses at least one variable focus lens, which may be a fluid focus lens (10), attached to each transducer element so that focus of the variable focus lens is controlled by a voltage signal. A treatment controller (122) receives input from an imaging means (124) and controls the voltage applied to the variable focus lens (10). The treatment controller controls the lens voltage signals, at least partially determined by the input from the imaging means, and directs an ultrasonic treatment beam (26) emitted by the transducer element. Fine adjustment of the therapy beam is achieved to deliver therapy for various prostate sizes and shapes while avoiding damage to critical structures such as the rectal wall and nerve bundles.
摘要翻译：使用超声治疗系统治疗组织的系统和方法，例如治疗前列腺疾病。超声波施加器（100）具有至少一个换能器元件（102）。超声波束的转向和聚焦使用至少一个可变焦距透镜，其可以是连接到每个换能器元件的流体聚焦透镜（10），使得可变焦距透镜的焦点由电压信号控制。处理控制器（122）从成像装置（124）接收输入并控制施加到可变焦距透镜（10）的电压。处理控制器至少部分地由来自成像装置的输入确定的镜片电压信号控制，并且引导由换能器元件发射的超声处理束（26）。实现治疗束的精细调整以递送针对各种前列腺大小和形状的治疗，同时避免对诸如直肠壁和神经束的关键结构的损伤。

6. 发明申请

US20110130663A1 SYMMETRIC AND PREFERIENTIALLY STEERED RANDOM ARRAYS FOR ULTRASOUND THERAPY 审中-公开
标题翻译：用于超声治疗的对称和优选的随机阵列
公开(公告)号：US20110130663A1
公开(公告)日：2011-06-02
申请号：US12446466
申请日：2007-10-19
申请人： Balasundara Raju , Christopher S. Hall
发明人： Balasundara Raju , Christopher S. Hall
IPC分类号： A61B8/00
CPC分类号： A61N7/00 , A61B2017/22028 , A61N7/02 , A61N2007/0078 , B06B1/0622
摘要： A phased ultrasound array for an ultrasound generating device. In one embodiment, the array includes a plurality of ultrasound elements arranged symmetrically about a point or dividing line in the array with respect to element size, shape and/or element location. In another embodiment, a majority of larger elements of the ultrasound array are arranged on a first portion of the array and a majority of smaller ultrasound elements are arranged on a second portion of the array. The first portion is closer to a preferred direction of steering than the second portion. Another method includes selecting randomly sized ultrasound elements and arranging the ultrasound elements symmetrically on the array. An additional method includes selecting randomly sized ultrasound elements and arranging the ultrasound elements wherein the larger ultrasound elements are arranged on a first portion of the array and smaller ultrasound elements are arranged on a second portion of the array.
摘要翻译：用于超声波产生装置的相位超声阵列。在一个实施例中，阵列包括相对于元件尺寸，形状和/或元件位置围绕阵列中的点或分界线对称布置的多个超声元件。在另一个实施例中，超声阵列的大部分较大的元件布置在阵列的第一部分上，并且大部分较小的超声波元件布置在阵列的第二部分上。第一部分比第二部分更接近转向的优选方向。另一种方法包括选择随机大小的超声元件并将超声元件对称地布置在阵列上。附加方法包括选择随机大小的超声元件并布置超声波元件，其中较大的超声波元件布置在阵列的第一部分上，较小的超声波元件布置在阵列的第二部分上。

7. 发明申请

US20100069754A1 APPARATUS FOR 3D ULTRASOUND IMAGING AND THERAPY 有权
标题翻译： 3D超声成像和治疗设备
公开(公告)号：US20100069754A1
公开(公告)日：2010-03-18
申请号：US12516598
申请日：2007-11-06
申请人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
发明人： Balasundara Raju , Christopher Hall , Chien Ting Chin , William T. Shi
IPC分类号： A61B8/14 , A61N7/00
CPC分类号： A61B8/08 , A61B8/0808 , A61B8/0833 , A61B8/4483 , A61B8/463 , A61B8/483 , A61B2090/378 , A61M37/0092 , A61N7/02 , B06B1/0625 , B06B1/0637
摘要： An apparatus for application of three-dimensional ultrasound imaging and therapy comprising a two-dimensional ultrasound imaging array of transducer elements having an image signal transmitter and receiver that forms, steers and selectively focuses ultrasound beams to a three-dimensional moving or stationary spatial volume; one or more two-dimensional ultrasound therapy arrays of transducer elements, each array having a therapy signal transmitter that forms, steers and selectively focuses and delivers ultrasound therapy to the volume; wherein the location of the array of imaging and therapy transducer elements are known relative to one another; and a controller that controls the image transmitter and receiver to provide three-dimensional images of the volume and simultaneously independently controls each of the one or more therapy transmitters to deliver therapy to the volume. Also disclosed is a method of delivering ultrasound therapy to a biological tissue in a three-dimensional moving or stationary spatial volume utilizing the apparatus.
摘要翻译：一种用于应用三维超声成像和治疗的装置，包括具有图像信号发射器和接收器的换能器元件的二维超声成像阵列，所述图像信号发射器和接收器形成，控制和选择性地将超声波束聚焦到三维移动或固定空间体积; 换能器元件的一个或多个二维超声治疗阵列，每个阵列具有治疗信号发射器，其形成，转向和选择性地聚焦并将超声治疗递送到所述体积; 其中成像和治疗换能器元件阵列的位置相对于彼此是已知的; 以及控制器，其控制所述图像发射器和接收器以提供所述体积的三维图像，并且同时独立地控制所述一个或多个治疗发射器中的每一个以向所述体积传递治疗。还公开了利用该装置在三维移动或静止空间体积中向生物组织递送超声治疗的方法。

8. 发明授权

US08867811B2 MR imaging guided therapy 有权
标题翻译： MR成像指导治疗
公开(公告)号：US08867811B2
公开(公告)日：2014-10-21
申请号：US13321557
申请日：2010-05-27
申请人： Balasundara Raju , Ajay Anand , Gosta Jakob Ehnholm
发明人： Balasundara Raju , Ajay Anand , Gosta Jakob Ehnholm
IPC分类号： G06K9/00 , A61B6/00 , A61N7/02 , A61B17/00 , A61B19/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2090/374
摘要： A therapeutic system, comprising: a MR imaging unit arranged to acquire MR signals from a patient in an examination volume, and a thermal treatment unit for depositing thermal energy within tissue of the patient. The system is arranged for: initiating a thermal treatment by heating the tissue at a focus within the examination volume selectively acquiring MR signals from a first image plane, including the focus, reconstructing a thermographic MR image from the MR signals acquired from the first image plane, computing a baseline thermographic MR image from a temperature distribution within at least one second image plane, moving the focus to a new position within the examination volume, changing the position and/or orientation of the first image plane corresponding to the new position of the focus, repeating the acquiring and reconstructing steps, wherein the baseline thermographic MR image is used for thermographic image reconstruction in a subsequent reconstructing step.
摘要翻译：一种治疗系统，包括：MR成像单元，其布置成在检查体积中从患者获取MR信号;以及热治疗单元，用于在患者的组织内沉积热能。该系统被布置为：通过在检查体积内的焦点处加热组织来开始热处理，其选择性地从包括焦点的第一图像平面获取MR信号，从从第一图像平面获取的MR信号重构热成像MR图像从至少一个第二图像平面内的温度分布计算基线热成像MR图像，将焦点移动到检查体积内的新位置，改变对应于第一图像的新位置的第一图像平面的位置和/或取向聚焦，重复获取和重建步骤，其中基线热成像MR图像用于随后重建步骤中的热成像图像重建。

9. 发明申请

US20120035464A1 CONTROL APPARATUS FOR CONTROLLING A THERAPEUTIC APPARATUS 审中-公开
标题翻译：用于控制治疗设备的控制装置
公开(公告)号：US20120035464A1
公开(公告)日：2012-02-09
申请号：US13265142
申请日：2010-04-13
申请人： Balasundara Raju , Shunmugavelu Sokka
发明人： Balasundara Raju , Shunmugavelu Sokka
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61N7/02 , A61B34/10 , A61B2017/00084 , A61B2090/374 , G01R33/4814 , G01R33/485
摘要： A control apparatus (106) for controlling a therapeutic apparatus (100), wherein the control apparatus comprises: —an ultrasound control interface (110) for controlling a therapeutic ultrasound system (102), —a magnetic resonance control interface (112) for controlling a magnetic resonance apparatus (104) adapted for acquiring magnetic resonance imaging data from a subject and for acquiring magnetic resonance spectroscopy data from a subject (244), —an image processing module (124, 126, 128) for generating at least one magnetic resonance imaging image (500) from the magnetic resonance imaging data and for generating at least one magnetic resonance spectroscopy map (502, 514, 516, 518, 520) from the magnetic resonance spectroscopy data, —a planning module (120) adapted for receiving the magnetic resonance imaging image and the magnetic resonance spectroscopy map and for outputting planning data (732), —a control module (122) adapted for controlling the therapeutic ultrasound system using the ultrasound control apparatus using the planning data, wherein the control module is further adapted for controlling the acquisition of the acquiring magnetic resonance imaging data and magnetic resonance spectroscopy data using the magnetic resonance control interface.
摘要翻译：一种用于控制治疗装置（100）的控制装置（106），其中所述控制装置包括： - 用于控制治疗性超声系统（102）的超声控制接口（110）， - 用于控制的磁共振控制接口（112）一种适于从受检者获取磁共振成像数据并用于从受检者（244）获取磁共振波谱数据的磁共振设备（104）， - 一个图像处理模块（124,126,128），用于产生至少一个磁共振来自磁共振成像数据的成像图像（500）和用于从磁共振波谱数据产生至少一个磁共振谱图（502,514,516,518,520）， - 规划模块（120），适于接收磁共振成像图像和磁共振谱图，并用于输出规划数据（732）， - 适于控制治疗性超声波的控制模块（122）使用所述规划数据使用所述超声波控制装置，其中所述控制模块还适于使用所述磁共振控制接口来控制获取磁共振成像数据和磁共振波谱数据的采集。

10. 发明授权

US08801615B2 System and method for ultrasound therapy treatment 有权
标题翻译：超声治疗的系统和方法
公开(公告)号：US08801615B2
公开(公告)日：2014-08-12
申请号：US13119810
申请日：2009-09-14
申请人： Anna Theresa Fernandez , Balasundara Raju
发明人： Anna Theresa Fernandez , Balasundara Raju
IPC分类号： A61N7/00
CPC分类号： A61N7/022 , A61B2090/3782 , A61N2007/0056
摘要： A system and method for treating tissue uses an ultrasound therapy system including an ultrasonic applicator having has at least one transducer element. Steering and focusing of ultrasound beams uses at least one variable focus lens, which may be a fluid focus lens, attached to each transducer element so that focus of the variable focus lens is controlled by a voltage signal. A treatment controller receives input from an imager and controls the voltage applied to the variable focus lens. The treatment controller controls the lens voltage signals, at least partially determined by the input from the imager, and directs an ultrasonic treatment beam emitted by the transducer element. Fine adjustment of the therapy beam is achieved to deliver therapy for various prostate sizes and shapes while avoiding damage to critical structures such as the rectal wall and nerve bundles.
摘要翻译：用于治疗组织的系统和方法使用包括具有至少一个换能器元件的超声波施加器的超声治疗系统。超声波束的转向和聚焦使用至少一个连接到每个换能器元件的可变焦距透镜，其可以是流体聚焦透镜，使得可变焦距透镜的焦点由电压信号控制。处理控制器从成像器接收输入并控制施加到可变焦距透镜的电压。处理控制器至少部分地由来自成像器的输入确定的透镜电压信号控制，并且引导由换能器元件发射的超声处理光束。实现治疗束的精细调整以递送针对各种前列腺大小和形状的治疗，同时避免对诸如直肠壁和神经束的关键结构的损伤。

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