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1. 发明申请

US20120035464A1 CONTROL APPARATUS FOR CONTROLLING A THERAPEUTIC APPARATUS 审中-公开
标题翻译：用于控制治疗设备的控制装置
公开(公告)号：US20120035464A1
公开(公告)日：2012-02-09
申请号：US13265142
申请日：2010-04-13
申请人： Balasundara Raju , Shunmugavelu Sokka
发明人： Balasundara Raju , Shunmugavelu Sokka
IPC分类号： A61B5/055 , A61B8/00
CPC分类号： A61N7/02 , A61B34/10 , A61B2017/00084 , A61B2090/374 , G01R33/4814 , G01R33/485
摘要： A control apparatus (106) for controlling a therapeutic apparatus (100), wherein the control apparatus comprises: —an ultrasound control interface (110) for controlling a therapeutic ultrasound system (102), —a magnetic resonance control interface (112) for controlling a magnetic resonance apparatus (104) adapted for acquiring magnetic resonance imaging data from a subject and for acquiring magnetic resonance spectroscopy data from a subject (244), —an image processing module (124, 126, 128) for generating at least one magnetic resonance imaging image (500) from the magnetic resonance imaging data and for generating at least one magnetic resonance spectroscopy map (502, 514, 516, 518, 520) from the magnetic resonance spectroscopy data, —a planning module (120) adapted for receiving the magnetic resonance imaging image and the magnetic resonance spectroscopy map and for outputting planning data (732), —a control module (122) adapted for controlling the therapeutic ultrasound system using the ultrasound control apparatus using the planning data, wherein the control module is further adapted for controlling the acquisition of the acquiring magnetic resonance imaging data and magnetic resonance spectroscopy data using the magnetic resonance control interface.
摘要翻译：一种用于控制治疗装置（100）的控制装置（106），其中所述控制装置包括： - 用于控制治疗性超声系统（102）的超声控制接口（110）， - 用于控制的磁共振控制接口（112）一种适于从受检者获取磁共振成像数据并用于从受检者（244）获取磁共振波谱数据的磁共振设备（104）， - 一个图像处理模块（124,126,128），用于产生至少一个磁共振来自磁共振成像数据的成像图像（500）和用于从磁共振波谱数据产生至少一个磁共振谱图（502,514,516,518,520）， - 规划模块（120），适于接收磁共振成像图像和磁共振谱图，并用于输出规划数据（732）， - 适于控制治疗性超声波的控制模块（122）使用所述规划数据使用所述超声波控制装置，其中所述控制模块还适于使用所述磁共振控制接口来控制获取磁共振成像数据和磁共振波谱数据的采集。

2. 发明授权

US09486651B2 MRI-guided HIFU marking to guide radiotherapy and other procedures 有权
标题翻译： MRI指导HIFU标记指导放疗等手术
公开(公告)号：US09486651B2
公开(公告)日：2016-11-08
申请号：US12531495
申请日：2008-03-07
申请人： Gregory Karczmar , Shunmugavelu Sokka , Charles A. Pelizzari
发明人： Gregory Karczmar , Shunmugavelu Sokka , Charles A. Pelizzari
IPC分类号： A61N7/00 , A61B5/00 , A61B5/055 , A61N7/02 , A61N5/10
CPC分类号： A61N7/02 , A61B90/39 , A61B2090/374 , A61B2090/376 , A61N5/1049 , A61N2005/1061
摘要： The present disclosure provides for effective systems and methods for increasing target tissue conspicuity within a particular anatomy of a particular patient. In an exemplary embodiment, a system associated with the present disclosure includes: (a) a MRI-guided HIFU system for generating ablation markings on a target tissue region, the MRI-guided HIFU system including a transducer for delivering HIFU to the target tissue region, the delivered HIFU generating the ablation markings on the target tissue and an MRI imaging system adapted to generate a three dimensional image of the target tissue region during HIFU delivery for guiding the delivery of the HIFU to the target tissue region; (b) a radiotherapy delivery system for delivering radiotherapy treatment to the target tissue region; and (c) a CT imaging system operable within the radiotherapy delivery system for generating a three dimensional image of the target tissue region. The markings generated on the target tissue region by the MRI-guided HIFU are visible in the image generated by the CT imaging system. The image generated by the CT imaging system guides the location of the radiotherapy treatment delivered to the target tissue region.
摘要翻译：本公开提供了用于增加特定患者的特定解剖结构内的目标组织显着性的有效系统和方法。在示例性实施例中，与本公开相关联的系统包括：（a）用于在目标组织区域上产生消融标记的MRI引导的HIFU系统，所述MRI引导的HIFU系统包括用于将HIFU传送到目标组织区域的换能器所传送的HIFU在靶组织上产生消融标记，以及MRI成像系统，其适于在HIFU递送期间产生目标组织区域的三维图像，用于将HIFU传送到目标组织区域; （b）放射治疗递送系统，用于向目标组织区域递送放射治疗; 和（c）可在放射治疗递送系统内操作的用于产生目标组织区域的三维图像的CT成像系统。通过MRI引导的HIFU在靶组织区域上产生的标记在CT成像系统产生的图像中是可见的。由CT成像系统产生的图像引导放射治疗治疗传送到目标组织区域的位置。

3. 发明申请

US20100312117A1 ULTRASONIC VISUALIZATION OF PERCUTANEOUS NEEDLES, INTRAVASCULAR CATHETERS AND OTHER INVASIVE DEVICES 审中-公开
标题翻译：超声心动图可视化，血管内镜和其他入侵装置
公开(公告)号：US20100312117A1
公开(公告)日：2010-12-09
申请号：US12745374
申请日：2008-11-18
申请人： Anna Fernandez , Hua Xie , Christopher Hall , Shunmugavelu Sokka , Thomas Gauthier
发明人： Anna Fernandez , Hua Xie , Christopher Hall , Shunmugavelu Sokka , Thomas Gauthier
IPC分类号： A61B8/14
CPC分类号： A61B8/0841 , A61B8/0833 , A61B8/463 , A61B8/481 , A61B8/483 , A61B18/1477 , A61B18/1492 , A61B2017/3413 , A61B2018/00011 , A61B2018/1425 , A61B2090/3925 , A61B2090/3933
摘要： An invasive medical device includes a fluid path of microbubbles which is imaged by ultrasound during use of the device. The fluid path extends through the device, preferably to the distal end of the device, so that the diffuse reflection of ultrasound from the microbubbles can be received to image the location of the device. The fluid path can be open, terminating at the tip of the device, or can be a closed path of a circulating microbubble fluid used for imaging and/or cooling.
摘要翻译：侵入式医疗装置包括在使用装置期间通过超声波成像的微泡的流体路径。流体路径延伸穿过装置，优选地延伸到装置的远端，使得可以接收来自微泡的超声波的漫反射以对装置的位置成像。流体路径可以打开，终止于装置的尖端，或者可以是用于成像和/或冷却的循环微泡流体的封闭路径。

4. 发明授权

US09986916B2 Catheter comprising capacitive micromachined ultrasonic transducers with an adjustable focus 有权
公开(公告)号：US09986916B2
公开(公告)日：2018-06-05
申请号：US13885791
申请日：2011-11-15
申请人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
发明人： Max Oskar Köhler , Peter Dirksen , Shunmugavelu Sokka , Ronald Dekker
IPC分类号： A61B8/08 , A61B8/12 , A61B5/01 , A61N7/02 , B06B1/02 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00 , A61B5/06 , A61B6/12 , A61B8/00 , A61B18/00 , A61N7/00 , A61B90/00
CPC分类号： A61B5/015 , A61B5/055 , A61B5/064 , A61B5/4836 , A61B6/03 , A61B6/12 , A61B6/4057 , A61B8/0841 , A61B8/12 , A61B8/445 , A61B8/4488 , A61B8/54 , A61B8/58 , A61B2018/00023 , A61B2090/064 , A61B2090/374 , A61B2562/028 , A61N7/022 , A61N2007/0095 , B06B1/0292 , G06F19/00
摘要： A catheter (700, 800, 1206) includes a shaft with distal (808, 906, 1004, 208) and proximal ends (1006). The distal end comprises at least one array of capacitive micromachined ultrasound transducers (308, 402, 404, 500, 512, 600, 604, 802, 008) with an adjustable focus for controllably heating a target zone (806, 1014, 1210). A connector (1012) at the proximal end supplies the at least one array of capacitive micromachined ultrasound transducers with electrical power and controls the adjustable focus.

5. 发明授权

US08932239B2 Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids 有权
标题翻译：用于超声药物输送和具有相变流体的热疗法的方法和装置
公开(公告)号：US08932239B2
公开(公告)日：2015-01-13
申请号：US11914777
申请日：2006-05-25
申请人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
发明人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
IPC分类号： A61B8/00 , A61M37/00 , A61K41/00 , A61K49/22 , A61B8/12 , A61N7/00 , A61N7/02 , A61B17/22
CPC分类号： A61M37/0092 , A61B8/12 , A61B8/546 , A61B2017/22008 , A61K41/0033 , A61K49/223 , A61N7/00 , A61N7/02
摘要： An ultrasound treatment includes applying ultrasound at a first energy level to a region of interest in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle. Ultrasound at a second energy level is applied to the region of interest during a second portion of the treatment cycle for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.
摘要翻译：超声处理包括在处理周期的第一部分期间将超声波以第一能级应用于受试者中感兴趣的区域，以激活空化成核剂。在治疗周期的第二部分期间，将第二能量级的超声波施加到感兴趣区域，以在存在在治疗周期的第一部分期间激活的空化成核剂的情况下实施期望的热疗法。第二能级处于与第一能级不同的能级。

6. 发明申请

US20100280356A1 THERAPY SYSTEM WITH TEMPERATURE CONTROL 有权
标题翻译：具有温度控制的治疗系统
公开(公告)号：US20100280356A1
公开(公告)日：2010-11-04
申请号：US12812240
申请日：2009-01-09
申请人： Max Oskar Kohler , Shunmugavelu Sokka
发明人： Max Oskar Kohler , Shunmugavelu Sokka
IPC分类号： A61N7/02 , A61B5/055
CPC分类号： A61N7/02 , A61B5/015 , A61B5/055 , A61B2017/00084 , A61B2090/374
摘要： A therapy system comprises a therapy module to direct a therapeutic action to a target along successive trajectories in a target region that includes the target. A thermometry module is provided to measure temperature a measurement field and in particular to compute a thermal dose. A control module to controls the therapy module to apply the therapeutic action along the respective trajectories on the basis of the measured temperature and/or thermal dose. The successive trajectories are located in the target zone outward or inward relative to one another within the target zone. In particular the therapeutic action subsists in application a focused ultrasound beam to the target. Temperature measurement is done on the basis of magnetic resonance signals.
摘要翻译：治疗系统包括治疗模块，用于在包括目标的目标区域中沿着连续轨迹将治疗作用指向靶。提供测温模块以测量测量场的温度，特别是计算热剂量。控制模块，用于控制治疗模块，基于测量的温度和/或热剂量，沿着相应的轨迹施加治疗作用。连续轨迹在目标区域内相对于彼此向外或向内位于目标区域中。特别地，治疗作用在应用中存在聚焦超声波束到目标。温度测量是基于磁共振信号进行的。

7. 发明申请

US20080200845A1 Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids 有权
标题翻译：用于超声药物递送和相可转换液体治疗的方法和装置
公开(公告)号：US20080200845A1
公开(公告)日：2008-08-21
申请号：US11914777
申请日：2006-05-25
申请人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
发明人： Shunmugavelu Sokka , Christopher Stephen Hall , Marcel Rene Bohmer
IPC分类号： A61N7/02 , A61M37/00
CPC分类号： A61M37/0092 , A61B8/12 , A61B8/546 , A61B2017/22008 , A61K41/0033 , A61K49/223 , A61N7/00 , A61N7/02
摘要： An ultrasound treatment comprises applying ultrasound at a first energy level (32) to a region of interest (20) in a subject for activating a cavitation nucleation agent during a first portion of a treatment cycle (t1-t2). Ultrasound at a second energy level (34) is applied to the region of interest (20) during a second portion of the treatment cycle (t2-t3) for implementing a desired thermal therapy in the presence of the cavitation nucleation agent activated during the first portion of the treatment cycle. The second energy level is at an energy level different from the first energy level.
摘要翻译：超声处理包括将第一能级（32）的超声波施用于受试者的感兴趣区域（20），以在治疗周期（t 1 -t 2）的第一部分期间激活空化成核剂。在治疗周期（t 2 -t 3）的第二部分期间，在第二能量水平（34）处的超声被施加到感兴趣区域（20），以在存在激活的空化成核剂的情况下实现期望的热疗法治疗周期的第一部分。第二能级处于与第一能级不同的能级。

8. 发明授权

US09687681B2 Therapy system with temperature control 有权
公开(公告)号：US09687681B2
公开(公告)日：2017-06-27
申请号：US12812240
申请日：2009-01-09
申请人： Max Oskar Kohler , Shunmugavelu Sokka
发明人： Max Oskar Kohler , Shunmugavelu Sokka
IPC分类号： A61N7/02 , A61B5/01 , A61B5/055 , A61B17/00 , A61B90/00
CPC分类号： A61N7/02 , A61B5/015 , A61B5/055 , A61B2017/00084 , A61B2090/374
摘要： A therapy system comprises a therapy module to direct a therapeutic action to a target along successive trajectories in a target zone that includes the target. A thermometry module is provided to measure temperature in a measurement field and to compute a thermal dose. The measurement field at least partially covers the target zone. A control module controls the therapy module to switch the therapeutic action to a next successive trajectory on the basis of the measured temperature or thermal dose. The successive trajectories are located inside of or outside of one another within the target zone. The therapeutic action comprises application of a focused ultrasound beam to the target. Temperature measurement is done on the basis of magnetic resonance signals.

9. 发明授权

US08725232B2 Therapeutic apparatus 失效
标题翻译：治疗仪器
公开(公告)号：US08725232B2
公开(公告)日：2014-05-13
申请号：US13519145
申请日：2010-12-21
申请人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
发明人： Erkki Tapani Vahala , Shunmugavelu Sokka , Julius Koskela , Max Oskar Kohler
IPC分类号： A61B5/055 , A61B8/00 , A61H1/00 , A61B18/04 , A61F7/00
CPC分类号： A61N7/02 , A61B2017/00084 , A61B2018/00642 , A61B2090/374 , G01R33/4804 , G01R33/4814
摘要： A therapeutic apparatus comprising a high intensity focused ultrasound system (302) for sonicating a sonication volume (324) of a subject (320). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (350) within an imaging volume (316). The sonication volume is within the imaging volume. The therapeutic apparatus further comprises a controller (304) for controlling the therapeutic apparatus. The treatment plan comprises instructions for controlling the operation of the high intensity focused ultrasound system. The controller is adapted for sonicating (100) the target volume using the high intensity focused ultrasound system. The controller is adapted for repeatedly acquiring (102) magnetic resonance thermometry data using the magnetic resonance imaging system during execution of the treatment plan. The controller is adapted for modifying (104) the treatment plan during execution of the treatment plan using the magnetic resonance thermometry data.
摘要翻译：一种治疗装置，包括用于超声处理受试者（320）的超声处理体积（324）的高强度聚焦超声系统（302）。治疗装置还包括用于在成像体积（316）内获取磁共振测温数据（350）的磁共振成像系统（300）。超声处理体积在成像体积内。治疗装置还包括用于控制治疗装置的控制器（304）。治疗方案包括用于控制高强度聚焦超声系统的操作的指令。控制器适用于使用高强度聚焦超声系统超声处理（100）目标体积。控制器适于在执行治疗计划期间使用磁共振成像系统反复获取（102）磁共振测温数据。控制器适用于使用磁共振测温数据修改（104）处理计划执行期间的治疗计划。

10. 发明授权

US08496587B2 Therapy system for depositing energy 有权
标题翻译：放电能量治疗系统
公开(公告)号：US08496587B2
公开(公告)日：2013-07-30
申请号：US13061566
申请日：2009-09-03
申请人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
发明人： Max Oskar Kohler , Teuvo Vaara , Shunmugavelu Sokka , Gosta Jakob Ehnholm
IPC分类号： A61B8/00
CPC分类号： A61N7/02 , A61B18/18 , A61B2017/00084 , A61B2090/374
摘要： A therapy system includes a therapy module, e.g., a high-intensity-focused ultrasound transmitter, to perform successive deposits of energy in a target zone. The successive deposits being separated by a cool down period. The therapy system further includes a thermometry module, e.g. by a magnetic resonance examination system, configured for thermometry to measure temperature in a measurement field. A control module regulates the cool down period in dependence of the measured off-focus maximum temperature during the energy deposit preceding the cool down period.
摘要翻译：治疗系统包括治疗模块，例如高强度聚焦超声波发射器，以在目标区域中执行能量的连续沉积。连续的沉积物被冷却时间隔开。治疗系统还包括温度测量模块，例如，通过磁共振检查系统，被配置为用于在测量场中测量温度的温度测量。控制模块根据在冷却时段之前的能量存储期间测量的离焦最大温度来调节冷却时间。

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