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    • 4. 发明授权
    • Composite wire guide construction
    • 复合导线结构
    • US5213111A
    • 1993-05-25
    • US728233
    • 1991-07-10
    • William A. CookScott E. Eells
    • William A. CookScott E. Eells
    • A61M25/01A61B5/00A61M25/00
    • A61M25/09A61M2025/09091A61M2025/09141A61M2025/09175
    • A wire guide construction for medical procedures that involve accessing specific inner body areas without major surgery. The wire guide comprises a mandrel which is a coaxial composite of a thin stainless steel wire radially surrounded by a shape memory alloy, such as a nickel titanium alloy. The mandrel is of a constant diameter over the majority of its length except it is tapered at its distal end to reveal the inner stainless steel wire. A flexible coil of platinum is attached near the distal end of the mandrel and is secured in place when a smoothly rounded tip is welded to the distal tip of the mandrel. The complete wire guide can be coated with a polymer layer, and 70 to 80% of the distal portion of the wire guide can be coated with a hydrophilic polymer to increase lubricity.
    • 用于医疗程序的导线结构,其涉及在没有大手术的情况下进入特定的内部身体区域 线引导件包括心轴,其是由诸如镍钛合金的形状记忆合金径向包围的薄不锈钢丝的同轴复合材料。 心轴在其长度大部分上具有恒定的直径,除了在其远端处是锥形以露出内部不锈钢丝。 铂金的柔性线圈附着在心轴的远端附近,并且当平滑的圆形尖端焊接到心轴的远端时被固定就位。 整个导丝器可以涂覆聚合物层,并且导线引导件的远端部分的70-80%可以用亲水性聚合物涂覆以增加润滑性。
    • 6. 发明申请
    • DRUG ELUTING OCULAR CONFORMER
    • 药物治疗OCOLAR CONFORMER
    • US20090162417A1
    • 2009-06-25
    • US12337369
    • 2008-12-17
    • Scott E. Eells
    • Scott E. Eells
    • A61F2/16
    • A61F9/00A61F2/14A61F9/0017
    • A coated, drug eluting ocular conformer includes an ocular conformer and at least one substantially purified anti-fibrosis agent. The ocular conformer is formed from a base material having inner and outer sides, including apical and basal portions configured to contact one or more conjunctival tissues in an eye of a patient. The anti-fibrosis agent is formulated into at least one ophthalmic medicament layer over at least one side of the ocular conformer or is impregnated within the base material of the ocular conformer. The device may be configured to release the anti-fibrosis agent from one or both sides of the ocular conformer. An elution control layer may be included to facilitate controlled release of the anti-fibrosis agent. In addition, an adhesion promoting layer may be included in the device to promote adhesion of polymeric layers to the base material or to ocular tissues during delivery. The coated, drug eluting ocular conformer may be used to reduce scarring in the eye, typically by applying the device to the eye following eye surgery, an eye injury caused by chemical, thermal or mechanical trauma, or an eye disease or condition associated with scarring.
    • 包被的药物洗脱眼睛构象异构体包括眼部构象异构体和至少一种基本上纯化的抗纤维化剂。 眼睛构象异构体由具有内侧和外侧的基底材料形成,其包括被构造为接触患者眼睛中的一个或多个结膜组织的顶端部分和基部部分。 将抗纤维化剂配制成至少一个眼用药物层,至少在眼睛构象异构体的一侧上,或者被浸渍在眼睛构象异构体的基底材料内。 该装置可以被配置为从眼睛构象异构体的一侧或两侧释放抗纤维化剂。 可以包括洗脱控制层以促进抗纤维化剂的受控释放。 此外,可以在该装置中包含粘附促进层,以促进聚合物层在输送过程中与基材或眼组织的粘附。 涂覆的药物洗脱性眼部构象异构体可以用于减少眼睛中的瘢痕形成,通常通过在眼科手术后将装置应用于眼睛,由化学,热或机械创伤引起的眼睛损伤或与瘢痕形成相关的眼部疾病或病症 。
    • 10. 发明授权
    • Cast bioremodelable graft
    • 铸造生物可重复移植
    • US08808352B2
    • 2014-08-19
    • US11054043
    • 2005-02-09
    • Scott E. EellsMichael C. HilesThomas A. Osborne
    • Scott E. EellsMichael C. HilesThomas A. Osborne
    • A61F2/06
    • A61L27/507A61L27/3629A61L27/3633A61L27/58
    • A cast bioremodelable graft (22) including a cast tubular construct (33) of a bioremodelable substance (34). The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released from an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23-25) in the graft, which is then loaded on an endoluminal delivery system.
    • 包括生物可重塑物质(34)的铸造管状构造物(33)的铸塑生物可重塑移植物(22)。 将生物可重塑物质浇铸或施加到形式上,然后真空压制以干燥或硬化物质。 可膨胀构件(18)设置在铸造管状结构的内部,下面或周围,以在从内腔输送系统释放时膨胀移植物。 第二层(39)可以施加在第一层(38)上,并且可扩展支架在其间包含支架,而不需要任何单独的附接。 将移植物脱水并优选真空压制以使生物可重塑物质硬化。 去除形式以在移植物中形成一个或多个腔(23-25),然后将其装载在腔内递送系统上。