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1. 发明申请

US20100240117A1 THREE DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸中生物化学结构的三维制造
公开(公告)号：US20100240117A1
公开(公告)日：2010-09-23
申请号：US12749831
申请日：2010-03-30
申请人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

2. 发明申请

US20120228802A1 DEVICE AND METHOD FOR FOCUSING A BEAM OF LIGHT WITH REDUCED FOCAL PLANE DISTORTION 审中-公开
标题翻译：用减轻焦点平面失真聚焦光束的装置和方法
公开(公告)号：US20120228802A1
公开(公告)日：2012-09-13
申请号：US12669466
申请日：2008-07-21
申请人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
发明人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
IPC分类号： B29C35/08 , G02B27/30
CPC分类号： B29C64/135
摘要： A system for focusing a light beam may be used for multi-photon stereolithography. It comprises a collimator or expander for adjusting the beam divergence and a scanner for directing the beam onto a focusing device to focus the beam to a focal point or beam waist and to scan the focused beam. A controller controls adjustment of the beam divergence so that the focal point or beam waist is scanned substantially in a plane. A light source may be provided to generate the light beam. The expander may comprise a diverging lens and a converging lens for expanding the beam to produce a collimated beam. The divergence of the collimated beam is dependent on the distance between the diverging lens and the converging lens, which may be adjusted to adjust the beam divergence. The focusing device may comprise a dry objective lens to focus the collimated beam onto the target material to induce multi-photon absorption in the target material at the beam waist of the focused beam.
摘要翻译：用于聚焦光束的系统可以用于多光子立体光刻。它包括用于调整光束发散的准直器或扩展器和用于将光束引导到聚焦装置上以将光束聚焦到焦点或光束腰部并扫描聚焦光束的扫描器。控制器控制光束发散的调节，使得焦点或光束腰部基本上在平面中扫描。可以提供光源以产生光束。扩展器可以包括发散透镜和用于展开光束以产生准直光束的会聚透镜。准直光束的发散度取决于发散透镜和会聚透镜之间的距离，其可以被调整以调节光束发散。聚焦装置可以包括干物镜，以将准直光束聚焦到目标材料上，以在聚焦光束的束腰处的目标材料中引起多光子吸收。

3. 发明授权

US07718351B2 Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement 失效
标题翻译：用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
公开(公告)号：US07718351B2
公开(公告)日：2010-05-18
申请号：US11375375
申请日：2006-03-14
申请人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
IPC分类号： G03F1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

4. 发明申请

US20120098164A1 TWO-PHOTON STEREOLITHOGRAPHY USING PHOTOCURABLE COMPOSITIONS 审中-公开
标题翻译：使用光电组合物的双光子立体成像
公开(公告)号：US20120098164A1
公开(公告)日：2012-04-26
申请号：US12669461
申请日：2008-07-21
申请人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
发明人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
IPC分类号： H01J37/30
CPC分类号： B29C64/135
摘要： Two-photon stereolithography can be performed using a photocurable material comprising a poly(meth)acrylate having a (meth)acrylate functionality of at least 3 and a molecular weight (MW) of at least 650, a urethane(meth)acrylate having a (meth)acrylate functionality of 2 to 4 and a MW of 400 to 10,000, a di(meth)acrylate made from bisphenol A or bisphenol F; and a photoinitiator. A beam of light is focused to a focus region of the material to induce two-photon absorption in the focus region, and thus polymerization of the material in the focus region. The beam is scanned across said material according to a pre-selected pattern so that the beam is focused to different pre-selected regions, to induce polymerization of the material at the pre-selected regions.
摘要翻译：双光子立体光刻可以使用包含（甲基）丙烯酸酯官能度为至少3，分子量（MW）至少为650的聚（甲基）丙烯酸酯的光固化材料，具有（（甲基）丙烯酸酯官能度为2〜4，MW为400〜10,000，由双酚A或双酚F制成的二（甲基）丙烯酸酯; 和光引发剂。光束被聚焦到材料的焦点区域，以在聚焦区域中引起双光子吸收，从而聚焦在聚焦区域中的材料。根据预先选择的图案将光束扫描穿过所述材料，使得光束被聚焦到不同的预选区域，以在预选区域处诱导材料的聚合。

5. 发明授权

US08003380B2 High throughput cell-based assays fabricated with integrated silicon and cell culture technologies 有权
标题翻译：采用集成硅和细胞培养技术制造的高通量基于细胞的测定
公开(公告)号：US08003380B2
公开(公告)日：2011-08-23
申请号：US11325609
申请日：2006-01-04
申请人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
发明人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
IPC分类号： C12M1/12
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
摘要翻译：本发明涉及涉及可与物种如生物分子，细胞等相互作用的多孔材料（例如膜）的制品和方法，由此该物质可能相对于多孔材料的表面粘附或变得固定或涂覆多孔表面的粘附层。多孔材料可以能够附着物质以控制物质在材料表面上的定位和空间分布。这样的制品和方法可用于例如生物测定，生物传感器或生物细胞的培养。

6. 发明申请

US20100248245A1 INTEGRATED APPARATUS FOR CONDUCTING AND MONITORING CHEMICAL REACTIONS 有权
标题翻译：用于导电和监测化学反应的综合装置
公开(公告)号：US20100248245A1
公开(公告)日：2010-09-30
申请号：US12746510
申请日：2008-11-06
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/38
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

7. 发明授权

US09707563B2 Reagent fluid dispensing device, and method of dispensing a reagent fluid 有权
公开(公告)号：US09707563B2
公开(公告)日：2017-07-18
申请号：US13696063
申请日：2011-05-04
申请人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
发明人： Mo-Huang Li , Jackie Y. Ying , Guolin Xu , Yoke San Daniel Lee , Emril Mohamed Ali , Tseng-Ming Hsieh
IPC分类号： B01L3/00 , B01L3/02 , F04F1/18
CPC分类号： B01L3/52 , F04F1/18
摘要： According to various embodiments, a reagent fluid dispensing device may be provided. The reagent fluid dispensing device may include a chamber for receiving a reagent fluid, the chamber having a first opening and a second opening; a first fluid conduit connected to the first opening of the chamber; a reservoir connected to the first fluid conduit, the reservoir having a first opening, wherein the first opening of the reservoir is connected to the first fluid conduit to form a passive valve, wherein the reservoir is dimensionalized for storing a predetermined volume of the reagent fluid; and a pneumatic conduit connected to the second opening of the chamber, wherein selective application of pneumatic pressure to the chamber through the pneumatic conduit transfers the reagent fluid from the reservoir to the chamber through the first fluid conduit. According to various embodiments, a microfluidic device including the reagent fluid dispensing device, and a method of dispensing a reagent fluid may be provided.

8. 发明申请

US20130203146A1 MICROFABRICATED SCAFFOLD STRUCTURES 审中-公开
标题翻译：微结构SCAFFOLD结构
公开(公告)号：US20130203146A1
公开(公告)日：2013-08-08
申请号：US13813936
申请日：2011-08-03
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Andrew Chwee Aun Wan
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Andrew Chwee Aun Wan
IPC分类号： C12N5/00
CPC分类号： C12N5/0062 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/62 , B33Y80/00
摘要： The present invention relates to a method for producing a three-dimensional scaffold construct comprising encapsulated cells, the method comprising: (a) providing a solution comprising cells, a photoinitiator, and a plurality of units capable of forming polymer chains; (b) providing a photolithography instrument comprising a two-photon laser; and (c) using the instrument to apply the laser to the solution to activate the photoinitiator thereby facilitating polymerisation of said units to form polymer chains, and, cross-linking of the polymer chains; wherein the laser is applied to the solution in three-dimensions in a pre-defined pattern to assemble said construct, and said cells are encapsulated within the assembled construct.
摘要翻译：本发明涉及一种生产包含胶囊细胞的三维支架结构的方法，该方法包括：（a）提供包含细胞，光引发剂和能够形成聚合物链的多个单元的溶液; （b）提供包括双光子激光器的光刻仪器; 和（c）使用该仪器将激光施加到溶液中以激活光引发剂，从而促进所述单元的聚合以形成聚合物链，以及聚合物链的交联; 其中激光以预定图案以三维施加到溶液以组装所述构建体，并且所述细胞被包封在组装的构建体内。

9. 发明授权

US08658099B2 Integrated apparatus for conducting and monitoring chemical reactions 有权
标题翻译：用于进行和监测化学反应的综合设备
公开(公告)号：US08658099B2
公开(公告)日：2014-02-25
申请号：US12746510
申请日：2008-11-06
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
IPC分类号： G05D23/00
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

10. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

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