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1. 发明申请

US20120228802A1 DEVICE AND METHOD FOR FOCUSING A BEAM OF LIGHT WITH REDUCED FOCAL PLANE DISTORTION 审中-公开
标题翻译：用减轻焦点平面失真聚焦光束的装置和方法
公开(公告)号：US20120228802A1
公开(公告)日：2012-09-13
申请号：US12669466
申请日：2008-07-21
申请人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
发明人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
IPC分类号： B29C35/08 , G02B27/30
CPC分类号： B29C64/135
摘要： A system for focusing a light beam may be used for multi-photon stereolithography. It comprises a collimator or expander for adjusting the beam divergence and a scanner for directing the beam onto a focusing device to focus the beam to a focal point or beam waist and to scan the focused beam. A controller controls adjustment of the beam divergence so that the focal point or beam waist is scanned substantially in a plane. A light source may be provided to generate the light beam. The expander may comprise a diverging lens and a converging lens for expanding the beam to produce a collimated beam. The divergence of the collimated beam is dependent on the distance between the diverging lens and the converging lens, which may be adjusted to adjust the beam divergence. The focusing device may comprise a dry objective lens to focus the collimated beam onto the target material to induce multi-photon absorption in the target material at the beam waist of the focused beam.
摘要翻译：用于聚焦光束的系统可以用于多光子立体光刻。它包括用于调整光束发散的准直器或扩展器和用于将光束引导到聚焦装置上以将光束聚焦到焦点或光束腰部并扫描聚焦光束的扫描器。控制器控制光束发散的调节，使得焦点或光束腰部基本上在平面中扫描。可以提供光源以产生光束。扩展器可以包括发散透镜和用于展开光束以产生准直光束的会聚透镜。准直光束的发散度取决于发散透镜和会聚透镜之间的距离，其可以被调整以调节光束发散。聚焦装置可以包括干物镜，以将准直光束聚焦到目标材料上，以在聚焦光束的束腰处的目标材料中引起多光子吸收。

2. 发明授权

US07718351B2 Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement 失效
标题翻译：用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
公开(公告)号：US07718351B2
公开(公告)日：2010-05-18
申请号：US11375375
申请日：2006-03-14
申请人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
IPC分类号： G03F1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

3. 发明申请

US20120098164A1 TWO-PHOTON STEREOLITHOGRAPHY USING PHOTOCURABLE COMPOSITIONS 审中-公开
标题翻译：使用光电组合物的双光子立体成像
公开(公告)号：US20120098164A1
公开(公告)日：2012-04-26
申请号：US12669461
申请日：2008-07-21
申请人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
发明人： Shyi-Herng Kan , Tseng-Ming Hsieh , Jackie Y. Ying
IPC分类号： H01J37/30
CPC分类号： B29C64/135
摘要： Two-photon stereolithography can be performed using a photocurable material comprising a poly(meth)acrylate having a (meth)acrylate functionality of at least 3 and a molecular weight (MW) of at least 650, a urethane(meth)acrylate having a (meth)acrylate functionality of 2 to 4 and a MW of 400 to 10,000, a di(meth)acrylate made from bisphenol A or bisphenol F; and a photoinitiator. A beam of light is focused to a focus region of the material to induce two-photon absorption in the focus region, and thus polymerization of the material in the focus region. The beam is scanned across said material according to a pre-selected pattern so that the beam is focused to different pre-selected regions, to induce polymerization of the material at the pre-selected regions.
摘要翻译：双光子立体光刻可以使用包含（甲基）丙烯酸酯官能度为至少3，分子量（MW）至少为650的聚（甲基）丙烯酸酯的光固化材料，具有（（甲基）丙烯酸酯官能度为2〜4，MW为400〜10,000，由双酚A或双酚F制成的二（甲基）丙烯酸酯; 和光引发剂。光束被聚焦到材料的焦点区域，以在聚焦区域中引起双光子吸收，从而聚焦在聚焦区域中的材料。根据预先选择的图案将光束扫描穿过所述材料，使得光束被聚焦到不同的预选区域，以在预选区域处诱导材料的聚合。

4. 发明申请

US20070218544A1 Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement 失效
标题翻译：用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
公开(公告)号：US20070218544A1
公开(公告)日：2007-09-20
申请号：US11375375
申请日：2006-03-14
申请人： Jackie Ying , Shyi-Herng Kan , Jeremy Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Ying , Shyi-Herng Kan , Jeremy Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M1/34 , H01L21/00 , C12M3/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. In some cases, a structure formed by three-dimensional fabrication comprises a wall defining a cavity and a plurality of pores in at least a portion of the wall. The pores may permeate the wall and enable exchange of a component (e.g., a molecule and/or a cell) between a portion interior to the cavity and a portion exterior to the cavity. For instance, pores may allow delivery of molecules, cell migration, and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal, or alternatively and/or additionally, can be used ex vivo as bioartificial assist devices.
摘要翻译：本发明涉及包括用于组织工程和器官置换的生物相容结构的方法和装置，更具体地涉及涉及通过用于组织工程和器官置换的三维制造形成的生物相容性结构的方法和装置。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。在一些情况下，通过三维制造形成的结构包括在壁的至少一部分中限定空腔和多个孔的壁。孔可以渗透到壁上并且使得能够在空腔内部的部分和腔外部的部分（例如，分子和/或细胞）之间进行交换。例如，孔可以允许在结构和其宿主环境之间传递分子，细胞迁移和/或结缔组织的产生。本发明的结构可以植入哺乳动物，或者另外地和/或另外可以作为生物人造辅助装置离体使用。

5. 发明授权

US09358737B2 3D mold for manufacturing of sub-micron 3D structures using 2-D photon lithography and nanoimprinting and process thereof 有权
标题翻译：用于使用2-D光子光刻和纳米压印及其工艺制造亚微米3D结构的3D模具
公开(公告)号：US09358737B2
公开(公告)日：2016-06-07
申请号：US12933803
申请日：2009-11-23
申请人： Shyi-Herng Kan
发明人： Shyi-Herng Kan
IPC分类号： G06F17/50 , B29D11/00 , B82Y10/00 , B82Y40/00 , G03F7/00 , G03F7/20 , G02B3/04 , G02B3/12
CPC分类号： B29D11/00365 , B82Y10/00 , B82Y40/00 , G02B3/04 , G02B3/12 , G03F7/0002 , G03F7/2053 , G03F7/70375
摘要： A process to manufacture a 3D mold to fabricate a high-throughput and low cost sub-micron 3D structure product is disclosed. The process integrates use of 2-photon laser lithography and 3D write technology to make a 3D mold of each layer of the 3D structure product, and then use nanoimprinting to form a sheet of polymer film of each layer of the 3D structure from the said 3D mold of that layer. Each layer of the sheet of polymer film is then fabricated into the sub-micron 3D structure product. The 3D mold of each layer of a high-throughput and low cost sub-micron 3D structure product, is further used to make master molds which is then used to form a sheet of polymer film of each layer of the 3D structure to fabricate the sub-micron 3D structure product. Applications using this process are also disclosed.
摘要翻译：公开了一种制造3D模具以制造高通量和低成本亚微米3D结构产品的工艺。该过程集成了使用双光子激光平版印刷和3D写入技术来制作3D结构产品的每一层的3D模具，然后使用纳米压印形成来自所述3D的3D结构的每层的聚合物膜片该层的模具。然后将各层聚合物薄膜制成亚微米3D结构产品。高通量和低成本亚微米3D结构产品的每一层的3D模具进一步用于制造主模具，然后将其用于形成3D结构的每层的聚合物膜片，以制造子 -micron 3D结构产品。还公开了使用该方法的应用。

6. 发明申请

US20110046764A1 3D Mold For Manufacturing Of Sub-Micron 3D Structures Using 2-D Photon Lithography And Nanoimprinting And Process Thereof 有权
标题翻译：用于制造使用2-D光子光刻和纳米印刷及其工艺的亚微米3D结构的3D模具
公开(公告)号：US20110046764A1
公开(公告)日：2011-02-24
申请号：US12933803
申请日：2009-11-23
申请人： Shyi-Herng Kan
发明人： Shyi-Herng Kan
IPC分类号： G06F17/50 , B28B7/36 , B29C35/08
CPC分类号： B29D11/00365 , B82Y10/00 , B82Y40/00 , G02B3/04 , G02B3/12 , G03F7/0002 , G03F7/2053 , G03F7/70375
摘要： A process to manufacture a 3D mold to fabricate a high-throughput and low cost sub-micron 3D structure product is disclosed. The process integrates use of 2-photon laser lithography and 3D write technology to make a 3D mold of each layer of the 3D structure product, and then use nanoimprinting to form a sheet of polymer film of each layer of the 3D structure from the said 3D mold of that layer. Each layer of the sheet of polymer film is then fabricated into the sub-micron 3D structure product. The 3D mold of each layer of a high-throughput and low cost sub-micron 3D structure product, is further used to make master molds which is then used to form a sheet of polymer film of each layer of the 3D structure to fabricate the sub-micron 3D structure product. Applications using this process are also disclosed.
摘要翻译：公开了一种制造3D模具以制造高通量和低成本亚微米3D结构产品的工艺。该过程集成了使用双光子激光平版印刷和3D写入技术来制作3D结构产品的每一层的3D模具，然后使用纳米压印形成来自所述3D的3D结构的每层的聚合物膜片该层的模具。然后将各层聚合物薄膜制成亚微米3D结构产品。高通量和低成本亚微米3D结构产品的每一层的3D模具进一步用于制造主模具，然后将其用于形成3D结构的每层的聚合物膜片，以制造子 -micron 3D结构产品。还公开了使用该方法的应用。

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