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1. 发明授权

US07704728B2 Microfluidic gravity pump with constant flow rate 有权
标题翻译：微流量重力泵具有恒定流量
公开(公告)号：US07704728B2
公开(公告)日：2010-04-27
申请号：US10198477
申请日：2002-07-18
申请人： Shuichi Takayama , Joseph Chang , Dongeun Huh , Xiaoyue Zhu , Brenda Cho , Gary D. Smith
发明人： Shuichi Takayama , Joseph Chang , Dongeun Huh , Xiaoyue Zhu , Brenda Cho , Gary D. Smith
IPC分类号： C12M1/36
CPC分类号： B01L3/50273 , B01L3/502776 , B01L2200/0647 , B01L2300/163 , B01L2400/0457 , C12M23/16 , F04B19/006 , Y10T137/0318 , Y10T137/0357 , Y10T137/4449 , Y10T436/117497
摘要： A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.
摘要翻译：微流体系统采用微通道和重力驱动泵，其包括以基本恒定的速率向微通道供应流体的水平取向的流体供应储存器。该装置对于许多微流体应用是有用的，例如在恒定流动诱导应激，细胞大小分选，活动精子分选或胚胎培养的生物系统的培养和/或治疗中。

2. 发明申请

US20060166357A1 Integrated microfludic control employing programmable tactile actuators 有权
标题翻译：采用可编程触觉执行器的集成微电极控制
公开(公告)号：US20060166357A1
公开(公告)日：2006-07-27
申请号：US10548692
申请日：2004-03-10
申请人： Shuichi Takayama , Xiaoyue Zhu , Wei Gu , Gary Smith , Yunseok Heo , Brenda Cho , Nobuyuki Futai
发明人： Shuichi Takayama , Xiaoyue Zhu , Wei Gu , Gary Smith , Yunseok Heo , Brenda Cho , Nobuyuki Futai
IPC分类号： C12M3/00
CPC分类号： B01L3/50273 , B01J2219/00396 , B01J2219/00891 , B01L3/502738 , B01L2200/10 , B01L2200/12 , B01L2200/143 , B01L2300/025 , B01L2300/044 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12M23/16 , F16K99/0001 , F16K99/0026 , F16K99/0048 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , G09B23/12
摘要： Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane, for example, a commercial Braille display. The display may be computer controlled, for example by simple text editor software, to activate individual Braille protrusions or a plurality of protrusions to actuate the active portions of the microfluidic device. Integral devices can incorporate the tactile actuators in a single device, but still external to the membrane.
摘要翻译：具有诸如阀，蠕动泵和混合部分的主动特征的微流体装置被制造成在活性特征上具有薄的弹性膜。主动特征由膜外部的触觉致动器激活，例如商业盲文显示器。显示器可以是计算机控制的，例如通过简单的文本编辑器软件来激活单个盲文突起或多个突起来致动微流体装置的有效部分。整体设备可以将触觉致动器结合在单个设备中，但仍然在膜的外部。

3. 发明授权

US06749628B1 Stent and catheter assembly and method for treating bifurcations 有权
标题翻译：支架和导管组装及治疗分叉的方法
公开(公告)号：US06749628B1
公开(公告)日：2004-06-15
申请号：US09861473
申请日：2001-05-17
申请人： Joseph R. Callol , Brian D. Brandt , Nazanine Matin , Hans F. Valencia , W. Stan Wilson , Steve Bigus , David Chi , Brenda Cho
发明人： Joseph R. Callol , Brian D. Brandt , Nazanine Matin , Hans F. Valencia , W. Stan Wilson , Steve Bigus , David Chi , Brenda Cho
IPC分类号： A61F206
CPC分类号： A61F2/856 , A61F2/852 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91591 , A61F2250/0039 , A61F2250/006
摘要： The present invention provides for an improved stent design and stent delivery catheter assembly for repairing a main vessel and a side branch vessel forming a bifurcation. The present invention includes a trap door stent design, a stent delivery catheter assembly, an apparatus for crimping the stent and the method for crimping the stent onto the catheter assembly, and the method for delivering and implanting the stent in a bifurcated vessel. More particularly, the invention relates to a stent having rings aligned along a common longitudinal axis and connected by links, where the stent has a proximal section, a distal section and a central section. The number of rings and the expanded diameter of the sections is varied to create a “trap door” capable of expanding to a slightly larger diameter than the proximal section and distal section of the stent. The stent is implanted at a bifurcation so that the proximal section and distal section are in the main vessel, and the central section covers at least a portion of the opening to the side branch vessel. A second stent can be implanted in the side branch vessel and abut the expanded central section to provide full coverage of the bifurcated area in the main vessel and the side branch vessel.
摘要翻译：本发明提供了用于修复形成分叉的主血管和侧分支血管的改进的支架设计和支架输送导管组件。本发明包括捕获门支架设计，支架输送导管组件，用于卷曲支架的装置和用于将支架卷曲到导管组件上的方法，以及用于将支架输送和植入分叉容器中的方法。更具体地说，本发明涉及一种支架，其具有沿着共同的纵向轴线对齐并通过连接件连接的环，其中支架具有近端部分，远侧部分和中心部分。改变环的数量和扩大的直径以产生能够扩展到比支架的近端部分和远端部分稍大的直径的“诱捕门”。支架以分叉植入，使得近端部分和远端部分在主血管中，并且中心部分覆盖至侧支血管的开口的至少一部分。第二支架可以植入侧支血管并且邻接扩张的中心部分以提供主血管和侧支血管中的分叉区域的全面覆盖。

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