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    • 5. 发明授权
    • Optical fiber scanner for performing multimodal optical imaging
    • 用于执行多模光学成像的光纤扫描器
    • US07616986B2
    • 2009-11-10
    • US10880008
    • 2004-06-28
    • Eric SeibelXingde LiXiumei Liu
    • Eric SeibelXingde LiXiumei Liu
    • A61B6/00
    • A61B5/6852A61B3/102A61B5/0062A61B5/0066A61B5/0068B31B2105/001G02B6/262G02B6/32G02B6/3502G02B7/08G02B21/0028G02B21/0036G02B21/006G02B21/0076G02B23/2423G02B26/103
    • An optical fiber scanner is used for multiphoton excitation imaging, optical coherence tomography, or for confocal imaging in which transverse scans are carried out at a plurality of successively different depths within tissue. The optical fiber scanner is implemented as a scanning endoscope using a cantilevered optical fiber that is driven into resonance or near resonance by an actuator. The actuator is energized with drive signals that cause the optical fiber to scan in a desired pattern at successively different depths as the depth of the focal point is changed. Various techniques can be employed for depth focus tracking at a rate that is much slower than the transverse scanning carried out by the vibrating optical fiber. The optical fiber scanner can be used for confocal imaging, multiphoton fluorescence imaging, nonlinear harmonic generation imaging, or in an OCT system that includes a phase or frequency modulator and delay line.
    • 光纤扫描器用于多光子激发成像,光学相干断层扫描或用于共焦成像,其中横向扫描在组织内的多个连续不同的深度进行。 光纤扫描器被实现为使用由致动器驱动到共振或接近谐振的悬臂光纤的扫描内窥镜。 致动器通过驱动信号通电,当驱动信号使焦点的深度改变时,光纤以连续不同的深度以所需的图案扫描。 可以采用比由振动光纤执行的横向扫描慢得多的速度进行深度聚焦跟踪的各种技术。 光纤扫描器可用于共焦成像,多光子荧光成像,非线性谐波生成成像,或在包括相位或频率调制器和延迟线的OCT系统中。
    • 6. 发明授权
    • High resolution optical coherence tomography based imaging for intraluminal and interstitial use implemented with a reduced form factor
    • 高分辨率光学相干断层扫描成像用于腔内和间质用途,实现减小的形状因子
    • US07952718B2
    • 2011-05-31
    • US12114281
    • 2008-05-02
    • Xingde LiXiumei LiuJoo Ha Hwang
    • Xingde LiXiumei LiuJoo Ha Hwang
    • G01B9/02
    • G01B9/0205A61B5/0066A61B5/6852G01B9/02063G01B9/02091G01B2290/65G01N21/4795
    • Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments, the optical assembly is encapsulated in a glass housing or metal-like housing with a glass window, which is then selectively passed through a hollow needle. Esophageal imaging embodiments are combined with a balloon catheter. Circumferential and three-dimensional spiral scanning can be achieved in each embodiment.
    • 适用于医疗应用如针刺活检,腔内和血管内成像的机械稳健的最小形状因子部分通过采用复合透镜来实现,其中部分或全部光学元件(包括光纤)被串联热熔合。 为了在不增加光学组件的直径的情况下实现期望的工作距离,可以在光纤和聚焦光学器件之间设置隔离物。 复合透镜配置可以在不增加探针直径的情况下,在单个透镜的期望工作距离下实现更高的横向分辨率。 在示例性针活检实施例中,光学组件被封装在具有玻璃窗的玻璃外壳或金属状外壳中,然后玻璃窗选择性地穿过中空针。 食管成像实施例与气囊导管组合。 在各实施例中可以实现圆周和三维螺旋扫描。
    • 8. 发明申请
    • HIGH RESOLUTION OPTICAL COHERENCE TOMOGRAPHY BASED IMAGING FOR INTRALUMINAL AND INTERSTITIAL USE IMPLEMENTED WITH A REDUCED FORM FACTOR
    • 高分辨光学相干基于图像的成像,用于减少形式因子实现的内脏和间质使用
    • US20090323076A1
    • 2009-12-31
    • US12114281
    • 2008-05-02
    • Xingde LiXiumei LiuJoo Ha Hwang
    • Xingde LiXiumei LiuJoo Ha Hwang
    • G01B9/02
    • G01B9/0205A61B5/0066A61B5/6852G01B9/02063G01B9/02091G01B2290/65G01N21/4795
    • Mechanically robust minimal form factor OCT probes suitable for medical applications such as needle biopsy, intraluminal and intravascular imaging are achieved in part by employing compound lenses with some or all of the optical elements, including an optical fiber, to be thermally fused in tandem. To achieve a desired working distance without increasing a diameter of the optics assembly, a spacer can be disposed between the optical fiber and focusing optics. The compound lens configuration can achieve higher transverse resolution compared to a single lens at a desired working distance without increasing the probe diameter. In exemplary needle biopsy embodiments, the optical assembly is encapsulated in a glass housing or metal-like housing with a glass window, which is then selectively passed through a hollow needle. Esophageal imaging embodiments are combined with a balloon catheter. Circumferential and three-dimensional spiral scanning can be achieved in each embodiment.
    • 适用于医疗应用如针刺活检,腔内和血管内成像的机械稳健的最小形状因子部分通过采用复合透镜来实现,其中部分或全部光学元件(包括光纤)被串联热熔合。 为了在不增加光学组件的直径的情况下实现期望的工作距离,可以在光纤和聚焦光学器件之间设置隔离物。 复合透镜配置可以在不增加探针直径的情况下,在单个透镜的期望工作距离下实现更高的横向分辨率。 在示例性针活检实施例中,光学组件被封装在具有玻璃窗的玻璃外壳或金属状外壳中,然后玻璃窗选择性地穿过中空针。 食管成像实施例与气囊导管组合。 在各实施例中可以实现圆周和三维螺旋扫描。