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    • 4. 发明授权
    • Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds
    • 苯基黑曲霉素和亚硫酸钠类似物,一类新的抗肿瘤化合物
    • US06358957B1
    • 2002-03-19
    • US09440316
    • 1999-11-12
    • Kenji FukumotoShinkichi KohnoKaneo KanohTohru AsariHiroshi KawashimaHirokatsu SekiyaKazunori OhmizoTakeo Harada
    • Kenji FukumotoShinkichi KohnoKaneo KanohTohru AsariHiroshi KawashimaHirokatsu SekiyaKazunori OhmizoTakeo Harada
    • C07D24106
    • C07D403/06A61K31/496
    • A compound, its pharmaceutically acceptable salts, and/or its pro-drug esters, in isolated form, and methods for isolating, for formulating, and for administering the compound, salt, and/or pro-drug ester as an antitumor agent, wherein the compound, salt, or pro-drug ester has the following structure: wherein: R1, R2, R5, R7,and R8 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C24 alkyl, unsaturated C1-C24 alkenyl, cycloalkyl, cycloalkenyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, substituted nitro, phenyl, and substituted phenyl groups, R3, R4, and R6 are each separately selected from the group consisting of a hydrogen atom, a halogen atom, and saturated C1-C12 alkyl, unsaturated C1-C12 alkenyl, cycloalkyl, alkoxy, cycloalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, substituted amino, nitro, and substituted nitro groups, X1 and X2 are separately selected from the group consisting of an oxygen atom, and a sulfur atom, and the dashed bond represents a bond selected from the group consisting of a carbon-carbon single bond and a carbon-carbon double bond. Most preferably, R3 and R4 are hydrogen, and each are involved in hydrogen bonds, and/or the dashed bond is a double bond, such that the chemical backbone of the compound substantially retains a substantially planar conformation.
    • 分离形式的化合物,其药学上可接受的盐和/或其前药酯,以及用于分配,配制和施用作为抗肿瘤剂的化合物,盐和/或前药酯的方法,其中 化合物,盐或前药酯具有以下结构:其中:R 1,R 2,R 5,R 7和R 8各自独立地选自氢原子,卤素原子和饱和C 1 -C 24烷基 ,不饱和C 1 -C 24烯基,环烷基,环烯基,烷氧基,环烷氧基,芳基,取代的芳基,杂芳基,取代的杂芳基,氨基,取代的氨基,硝基,取代的硝基,苯基和取代的苯基,R 3,R 4和R 6 分别选自氢原子,卤素原子和饱和C 1 -C 12烷基,不饱和C 1 -C 12烯基,环烷基,烷氧基,环烷氧基,芳基,取代的芳基,杂芳基,取代的杂芳基,氨基,取代的氨基,硝基 和取代的硝基,X1和 X2分别选自氧原子和硫原子,虚键表示选自碳 - 碳单键和碳 - 碳双键的键。 最优选地,R 3和R 4是氢,并且各自参与氢键,和/或虚线键是双键,使得化合物的化学主链基本上保持基本上平面的构象。
    • 9. 发明授权
    • Audio signal recording apparatus and method for use with VTR
    • 用于VTR的音频信号记录装置和方法
    • US5315445A
    • 1994-05-24
    • US757653
    • 1991-09-05
    • Kenji FukumotoIchiro OkamotoKeitaro Yamashita
    • Kenji FukumotoIchiro OkamotoKeitaro Yamashita
    • G11B20/12H04N5/7826H04N5/91H04N5/928H04N9/797H04N9/81G11B5/02
    • H04N9/7973G11B20/1208H04N5/78266H04N5/928H04N9/81
    • An audio signal recording apparatus and method for recording an video signal (e.g., a half field) and at least four channels of audio signals corresponding to the video signal to a plurality of tracks on a tape. The audio signals are recorded to recording blocks in an audio recording area which are separated from a recording area for the corresponding video signal in accordance with a priority rating. More specifically, the at least four channels of audio signals are divided into groups each having a plurality of channels. The audio signal recording area is divided into a plurality of recording blocks in the longitudinal direction of the tracks and each group of audio data is recorded to one of the audio signal recording blocks. Each group of audio data is assigned a priority rating depending on the importance of the data contained therein. Audio data having a high priority are recorded to blocks that are located further away from the track ends than those for audio data having a low priority. Since the contact fit between the tape and a recording head at the track ends is unstable, by recording the audio data of high priorities in blocks located relatively for away from the track ends where the tape-to-head contact fit is more stable, deterioration in sound quality is minimized for the important data upon reproduction.
    • 一种音频信号记录装置和方法,用于将对应于视频信号的视频信号(例如,半场)和至少四个音频信号的信道记录到磁带上的多个磁道。 音频信号被记录在音频记录区中,根据优先等级与对应的视频信号的记录区分开。 更具体地,至少四个声道的音频信号被分成具有多个声道的组。 音频信号记录区域在轨道的纵向被分成多个记录块,并且每组音频数据被记录到音频信号记录块之一。 根据其中包含的数据的重要性,为每组音频数据分配优先级。 具有高优先级的音频数据被记录到比轨道端更远的块比具有低优先级的音频数据的块。 由于磁带和轨道端之间的记录头之间的接触配合是不稳定的,所以通过将高优先级的音频数据记录在相对较远的位置,以便远离磁带头接触配合的轨道端更稳定,劣化 对于重放时的重要数据,音质被最小化。