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1. 发明授权

US06280776B1 Composition comprising Panax pseudo ginseng and Eucommiae ulmoides 有权
标题翻译：组合物包括人参和杜仲
公开(公告)号：US06280776B1
公开(公告)日：2001-08-28
申请号：US09382596
申请日：1999-08-25
申请人： Shinhan Sha , Noboru Yanaihara
发明人： Shinhan Sha , Noboru Yanaihara
IPC分类号： A61K3578
CPC分类号： A61K36/46 , A23K10/30 , A23L33/105 , A61K36/258 , A61K36/48 , A61K2300/00
摘要： A composition comprising “Panax Pseudo Ginseng” and “Eucommia Bark”, a composition comprising gallic acid-containing herbal extracts and “Licorice Root”, together with “Panax Pseudo Ginseng” and “Eucommia Bark”, a drink or food comprising the above composition, and medicines, food supplements, healthcare foods, mixing feed and feed for improvement of nutritional state, hypertension, high blood sugar, immune system and liver disorders.
摘要翻译：包含“人参人参”和“杜仲树皮”的组合物，含有没食子酸的草药提取物和“甘草根”以及“人参人参”和“杜仲树皮”的组合物，包含上述组合物的饮料或食品，药物，食品补充剂，保健食品，混合饲料和饲料用于改善营养状态，高血压，高血糖，免疫系统和肝脏疾病。

2. 发明授权

US06586017B2 Composition comprising panax pseudo ginseng, eucommiae ulmoides and polygonati rhizoma 有权
标题翻译：组成包括人参，人参，杜仲和多角形
公开(公告)号：US06586017B2
公开(公告)日：2003-07-01
申请号：US09801803
申请日：2001-03-09
申请人： Shinhan Sha , Noboru Yanaihara
发明人： Shinhan Sha , Noboru Yanaihara
IPC分类号： A61K3578
CPC分类号： A61K36/258 , A61K36/46 , A61K36/8969 , A61K2300/00
摘要： A composition comprising Denhichi, Tochu and Osei, wherein the Denhichi is Panax pseudo-ginseng, the Tochu is Eucommiae ulmoides and the Osei is selected from the group consisting of Polygonati Rhizoma, Polygonatum falcatum, other plants belonging to the genus Polygonatum, and Siberian Solomonseal Rhizome.
摘要翻译：一种组合物，包括Den ichi，u u and and and i wherein wherein al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al al 根茎。

3. 发明授权

US06509462B2 Estradiol derivative and immunoassy using the same 失效
标题翻译：雌二醇衍生物和免疫应用使用它们
公开(公告)号：US06509462B2
公开(公告)日：2003-01-21
申请号：US09905945
申请日：2001-07-17
申请人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
发明人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
IPC分类号： C07J4300
CPC分类号： C07J43/00 , Y10S436/811 , Y10S436/815 , Y10S436/817
摘要： The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) wherein one of R1 and R2 is hydrogen and the other is a group represented by wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.
摘要翻译：本发明提供了一种用于雌激素的高度灵敏的免疫测定系统，其利用标记化合物作为式（1）的生物素化雌二醇衍生物，其中R 1和R 2之一是氢，另一个是由其中R3表示的基团相同或不同并且表示精氨酸残基或赖氨酸残基，x为0或1，y为1〜5的整数，z为1〜3的整数。

4. 发明授权

US4518527A Polypeptides related to the pre-acetylcholine receptor-.alpha. of the electric organ of Torpedo californica 失效
标题翻译：与加工鱼雷的电器官的乙酰胆碱受体α前相关的多肽
公开(公告)号：US4518527A
公开(公告)日：1985-05-21
申请号：US523787
申请日：1983-08-16
申请人： Shosaku Numa , Noboru Yanaihara
发明人： Shosaku Numa , Noboru Yanaihara
IPC分类号： C07K14/46 , C07K14/705 , C07C103/52
CPC分类号： C07K14/70571 , C07K14/46 , Y10S530/868
摘要： Polypeptides having partial or complete amino acid sequences related to the pre-acetylcholine receptor-.alpha. of the electric organ Torpedo californica are disclosed. These polypeptides having AChR antigenic properties are useful for the production and purification of antibodies to the acetylcholine receptor (AChR) as well as for the diagnosis of myastenia gravis (MG).
摘要翻译：本发明公开了具有部分或完全氨基酸序列的多肽，该序列与电动器官鱼雷银鲫的前乙酰胆碱受体α相关。具有AChR抗原性质的这些多肽可用于生产和纯化乙酰胆碱受体（AChR）的抗体以及重症肌无力（MG）的诊断。

5. 发明授权

US3953418A Novel human proinsulin C-peptide derivatives 失效
标题翻译：新型人胰岛素原C肽衍生物
公开(公告)号：US3953418A
公开(公告)日：1976-04-27
申请号：US488855
申请日：1974-07-15
申请人： Noboru Yanaihara , Osamu Ikeda
发明人： Noboru Yanaihara , Osamu Ikeda
IPC分类号： G01N33/53 , C07K1/113 , C07K14/00 , C07K14/62 , G01N33/74 , G21H5/00 , G21H5/02 , C07C103/52 , A61K37/26
CPC分类号： C07K14/62 , Y10S436/804 , Y10S436/815 , Y10S436/817
摘要： A peptide having an amino acid sequence of Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; or Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; and the N.sup..epsilon. formyl-Lys derivative thereof.
摘要翻译：具有Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pr-Gly-Ala-Gly的氨基酸序列的肽 -Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln -Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; 或Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser- Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; 及其N-甲酰基-Lys衍生物。

6. 发明授权

US06399318B1 Immunoassay for phthalic acid esters 失效
标题翻译：邻苯二甲酸酯的免疫测定
公开(公告)号：US06399318B1
公开(公告)日：2002-06-04
申请号：US09984451
申请日：2001-10-30
申请人： Noboru Yanaihara , Ikuo Kato , Shingo Nagasawa , Tsukasa Kodaira
发明人： Noboru Yanaihara , Ikuo Kato , Shingo Nagasawa , Tsukasa Kodaira
IPC分类号： G01N33532
CPC分类号： G01N33/5308 , C07K16/44 , Y10S436/815
摘要： The present invention provides an immunoassay for phthalic acid esters, which comprises measuring the phthalic acid esters contained in a sample using an antibody produced with a conjugate of a carrier protein and a phthalic acid ester derivative represented by the formula wherein R1 and R2 may be the same or different and are hydrogen, alkyl, cycloalkyl or phenylalkyl, with the proviso that both of R1 and R2 are not hydrogen; m is an integer from 1 to 5; and Y is amino or carboxyl.
摘要翻译：本发明提供了一种邻苯二甲酸酯的免疫测定法，该方法包括用由载体蛋白质和由式R 1和R 2表示的邻苯二甲酸酯衍生物的缀合物产生的抗体测量样品中所含的邻苯二甲酸酯可以相同或者不同的是氢，烷基，环烷基或苯基烷基，条件是R 1和R 2都不是氢; m为1〜5的整数; Y是氨基或羧基。

7. 发明授权

US5712105A Monoclonal antibody to human glicentin, hybridoma for producing said antibody and assay method for human glicentin using said antibody 失效
标题翻译：人glicentin的单克隆抗体，用于产生所述抗体的杂交瘤和使用所述抗体的人glicentin的测定方法
公开(公告)号：US5712105A
公开(公告)日：1998-01-27
申请号：US548152
申请日：1995-10-25
申请人： Noboru Yanaihara , Takeya Sato , Kiyoshi Fukuchi
发明人： Noboru Yanaihara , Takeya Sato , Kiyoshi Fukuchi
IPC分类号： G01N33/53 , C07K16/00 , C07K16/18 , C07K16/26 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/537 , G01N33/543
CPC分类号： C07K16/26 , C07K2317/34
摘要： The present invention describes a monoclonal antibody which recognizes the C-terminal region of human glicentin. The antibody is useful for assaying for the presence of glicentin in a sample.
摘要翻译：本发明描述识别人glicentin的C-末端区域的单克隆抗体。该抗体可用于测定样品中glicentin的存在。

8. 发明授权

US4855406A Oncogene-related peptides 失效
标题翻译：致癌基因相关肽
公开(公告)号：US4855406A
公开(公告)日：1989-08-08
申请号：US72191
申请日：1987-07-10
申请人： Noboru Yanaihara , Kaoru Abe
发明人： Noboru Yanaihara , Kaoru Abe
IPC分类号： C12N15/02 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/82 , C07K16/32 , C07K19/00 , C12N5/00 , C12N5/06 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/68
CPC分类号： C07K16/32 , C07K14/82 , Y02P20/55 , Y10S930/221 , Y10S930/26
摘要： Disclosed are an oncogene-related peptide characterized in that the peptide comprises a portion of the amino acid sequence of a gene product coded for by an oncogene, an antigen or immunogen formed from the oncogene-related peptide and a carrier, an antibody against such antigen or immunogen, and a method of determining a gene product coded for by an oncogene by an immunoreaction with use of such antibody.
摘要翻译：公开了一种致癌基因相关肽，其特征在于该肽包含由癌基因编码的基因产物的氨基酸序列的一部分，由致癌基因相关肽形成的抗原或免疫原和载体，抗这种抗原的抗体或免疫原，以及通过使用这种抗体的免疫反应来确定由致癌基因编码的基因产物的方法。

9. 发明授权

US4407965A Process for preparing antibody 失效
标题翻译：制备抗体的方法
公开(公告)号：US4407965A
公开(公告)日：1983-10-04
申请号：US265926
申请日：1981-05-21
申请人： Noboru Yanaihara
发明人： Noboru Yanaihara
IPC分类号： G01N33/53 , A61K39/395 , C07K14/00 , C07K14/575 , C07K14/605 , C07K14/76 , C07K16/00 , C07K16/26 , C07K19/00 , C07G7/00 , C07C103/52 , G01N23/00 , G01N33/00
CPC分类号： C07K14/605 , C07K16/26 , Y10S436/822 , Y10S436/823 , Y10S530/806 , Y10S930/26
摘要： A process for preparing a gut glucagon antigen composed of a peptide-carrier complex is disclosed, which comprises using as hapten a peptide represented by the following general formula;R-Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala-OHwherein R represents a hydrogen atom, an amino acid group or a peptide group containing 2 to 20 amino acid groups, and reacting it with a carrier in the presence of a binding agent for binding the hapten and the carrier to each other. Also, a process for preparing a gut glucagon antibody, which comprises administering the antigen described to mammals, and collecting the thus-produced antibody, is disclosed.
摘要翻译：公开了一种制备由肽 - 载体复合物组成的肠道胰高血糖素抗原的方法，其包括使用由以下通式表示的肽作为半抗原; R-Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala-OH其中R表示氢原子，氨基酸基团或含有2至20个氨基酸的肽基团，并使其与存在用于将半抗原和载体结合到彼此的结合剂。此外，还公开了一种制备肠胰高血糖素抗体的方法，其包括给予哺乳动物描述的抗原并收集由此产生的抗体。

10. 发明授权

US4404133A Peptides and method for synthesizing the same 失效
标题翻译：肽及其合成方法
公开(公告)号：US4404133A
公开(公告)日：1983-09-13
申请号：US272979
申请日：1981-06-12
申请人： Noboru Yanaihara , Koji Konno
发明人： Noboru Yanaihara , Koji Konno
IPC分类号： A61K38/22 , A61P37/00 , C07C67/00 , C07C231/00 , C07C231/02 , C07K7/06 , G01N33/534 , G01N33/68 , C07C103/52 , G01N33/00
CPC分类号： C07K7/062 , G01N33/534 , G01N33/6863 , Y10S930/18
摘要： Disclosed herein are the peptides possibly radio-labelled and having primary structures represented by the general formula (I):X-Ser-Gln-Gly-Gly-Ser-Asn-Y (I)wherein(1) X is H-Tyr-Gln-Ala-Lys and Y is a hydroxyl group,(2) X is pGlu-Ala-Lys(N.sup..epsilon. -Tyr-H) and Y is a hydroxyl group, or(3) X is pGlu-Ala-Lys and Y is Tyr-OH.These peptides can be synthesized by bonding a pre-determined amino acid or a peptide to the nitrogen at one of the two ends of the starting material, H-Asn-OH or H-Asn-Tyr-OH, while leaving the carboxyl group at the other end thereof in a free state, and by successively repeating the same procedure on the thus prepared peptides.The symbols, Ser, Gln, Gly, Asn, Tyr, Ala and Lys used herein represent respectively a divalent residue formed by removing one hydrogen atom from the amino group of and further removing one hydroxyl group from the carboxyl group of the respective alpha- amino acids, serine, glutamine, glycine, asparagine, tyrosine, alanine and lysine. For instance, Ser represents the divalent residue, --NH--CH(CH.sub.2 OH)--CO--. The symbol, pGlu, represents a monovalent residue formed by removing one hydroxyl group from the carboxyl group of pyroglutamic acid.
摘要翻译：本文公开了可能放射性标记并具有由通式（I）表示的一级结构的肽：X-Ser-Gln-Gly-Gly-Ser-Asn-Y（I）其中（1）X是H-Tyr- Gln-Ala-Lys和Y是羟基，（2）X是pGlu-Ala-Lys（Nε-Tyr-H），Y是羟基，或（3）X是pGlu-Ala-Lys和Y 是Tyr-OH。这些肽可以通过将预定的氨基酸或肽键合在原料H-Asn-OH或H-Asn-Tyr-OH的两端之一的氮中，同时将羧基保留在其另一端处于游离状态，并且依次对由此制备的肽重复相同的程序。本文使用的符号Ser，Gln，Gly，Asn，Tyr，Ala和Lys分别表示通过从相应的α-氨基的羧基从氨基除去一个氢原子并进一步除去一个羟基而形成的二价残基酸，丝氨酸，谷氨酰胺，甘氨酸，天冬酰胺，酪氨酸，丙氨酸和赖氨酸。例如，Ser表示二价残基-NH-CH（CH 2 OH）-CO-。符号pGlu表示通过从焦谷氨酸的羧基除去一个羟基而形成的一价残基。

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