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1. 发明申请

US20110124550A1 THYMOSIN BETA 4 PROMOTES WOUND REPAIR 审中-公开
公开(公告)号：US20110124550A1
公开(公告)日：2011-05-26
申请号：US12938228
申请日：2010-11-02
申请人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
发明人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
IPC分类号： A61K38/17 , A61P9/00 , A61P9/10
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： The present invention relates to methods of treatment for treating or preventing injury to cardiovascular or heart tissue in a subject in need thereof by administering an effective amount of thymosin β4 (Tβ4) peptide.
摘要翻译：本发明涉及通过施用有效量的胸腺素和4（T＆bgr; 4）肽来治疗或预防有需要的受试者的心血管或心脏组织损伤的治疗方法。

2. 发明授权

US4749690A Treatment of allergy with thymopentin 失效
标题翻译：用胸腺肽治疗过敏
公开(公告)号：US4749690A
公开(公告)日：1988-06-07
申请号：US822704
申请日：1986-01-27
申请人： Gideon Goldstein
发明人： Gideon Goldstein
IPC分类号： A61K38/32 , A61K37/02
CPC分类号： A61K38/32 , Y10S514/885 , Y10S930/18
摘要： A method for treating allergy by administration of the peptide thymopentin.
摘要翻译：通过施用肽胸腺五肽来治疗过敏的方法。

3. 发明授权

US4732859A Method for conferring bacteriophage resistance to bacteria 失效
标题翻译：赋予细菌噬菌体抗性的方法
公开(公告)号：US4732859A
公开(公告)日：1988-03-22
申请号：US647338
申请日：1984-09-05
申请人： Charles L. Hershberger , Paul R. Rosteck, Jr.
发明人： Charles L. Hershberger , Paul R. Rosteck, Jr.
IPC分类号： C12N15/00 , C12P21/02 , C12N9/14 , C12N1/00 , C12N1/20 , C12N9/10 , C12P21/00
CPC分类号： C12P21/02 , C12N15/00 , Y10S930/18
摘要： A novel method for protecting a bacterium from a naturally occurring bacteriophage and the cloning vectors and transformants for carrying out the aforementioned method are disclosed.
摘要翻译：公开了一种用于保护细菌免受天然存在的噬菌体的新方法和用于实施上述方法的克隆载体和转化体。

4. 发明授权

US4612365A Medicaments containing alpha 1-thymosin and having an immuno regulatory action and alpha 1-thymosin fragments 失效
标题翻译：含有α1-胸腺素并具有免疫调节作用的药物和α1-胸腺素片段
公开(公告)号：US4612365A
公开(公告)日：1986-09-16
申请号：US595730
申请日：1984-04-02
申请人： Christian Birr , Ulrich Stollenwerk, deceased , Paul Stollenwerk, heir , Margot Stollenwerk, heir , Ilona Werner
发明人： Christian Birr , Ulrich Stollenwerk, deceased , Paul Stollenwerk, heir , Margot Stollenwerk, heir , Ilona Werner
IPC分类号： A61K38/00 , C07K5/083 , C07K14/575 , C07K7/48 , C07K5/10 , C07K7/06 , C07K7/08
CPC分类号： C07K5/0804 , C07K14/57581 , A61K38/00 , Y10S930/18
摘要： Peptide fragments of the alpha thymosin molecule, ranging from four to eighteen peptides in length, and salts thereof, are disclosed. These fragments possess immunostimulatory and immunoregulatory properties similar to the alpha thymosin molecule, and are useful in the same fashion as in this molecule.
摘要翻译：公开了长度为4至18个肽的α胸腺素分子的肽片段及其盐。这些片段具有类似于α胸腺素分子的免疫刺激和免疫调节特性，并且以与该分子中相同的方式有用。

5. 发明授权

US4466918A Method of preparing thymosin alpha 1 and derivatives thereof 失效
标题翻译：胸腺素α1及其衍生物的制备方法
公开(公告)号：US4466918A
公开(公告)日：1984-08-21
申请号：US403218
申请日：1982-07-29
申请人： Christian Birr , Ulrich Stollenwerk
发明人： Christian Birr , Ulrich Stollenwerk
IPC分类号： C07K1/06 , A61K38/00 , C07C231/00 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07C103/52
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： Polypeptides of the sequence Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile--Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, wherein at least one of the amino acids 10,15,21,25 and/or 28 is present as amide or alkyl amide, and/or amino acid 1 bears an acyl group other than acetyl, having up to 6 carbon atoms, especially an acyl glycine residue. In addition, certain thymosin fragments I to VII are provided and process for producing the substituted thymosin alpha.

6. 发明授权

US4396605A Bis-thymosine .alpha.-1 compounds 失效
标题翻译：双胸腺素α-1化合物
公开(公告)号：US4396605A
公开(公告)日：1983-08-02
申请号：US367817
申请日：1982-04-12
申请人： Christian Birr
发明人： Christian Birr
IPC分类号： C07K1/113 , A61K38/00 , A61K38/22 , A61P37/04 , C07K1/06 , C07K14/00 , C07K14/575 , C07K14/66 , C07C103/52
CPC分类号： C07K14/57581 , A61K38/00 , Y02P20/55 , Y10S514/885 , Y10S530/837 , Y10S930/18
摘要： Bis-thymosine .alpha.-1 consisting of two desacetylthymosine .alpha.-1 un N-terminally linked by a bridge bond of 1 to 10 carbon atoms, especially an .alpha.,.omega.-diacyl residue with 2 to 10 carbon atoms. This new compound is made by converting a synthetic desacetylthymosine .alpha.-1 in which all functional groups of amino acids 1 through 28, except the N-terminal group, are blocked by protective groups conventional in peptide synthesis with a coupling compound of 1 to 10 carbon atoms and that reacts with NH.sub.2 groups, in a polar solvent, and then removing the protective groups.
摘要翻译：由通过1至10个碳原子的桥键N末端连接的两个脱乙酰胸腺嘧啶α-1单元组成的双 - 胸腺素α-1，特别是具有2至10个碳原子的α，ω-二酰基残基。这种新化合物是通过转化合成去乙酰胸腺素α-1制备的，其中氨基酸1至28除了N-末端基团之外的所有官能团被肽合成中常规的保护基团与1至10个碳原子的偶联化合物原子，并与NH2基团在极性溶剂中反应，然后除去保护基团。

7. 发明授权

US4388234A Peptide isolation 失效
标题翻译：肽分离
公开(公告)号：US4388234A
公开(公告)日：1983-06-14
申请号：US335001
申请日：1981-12-28
申请人： Bernard L. Horecker
发明人： Bernard L. Horecker
IPC分类号： A61K35/26 , C07C103/52 , A61K37/02
CPC分类号： A61K35/26 , Y10S930/18
摘要： A process for isolating selected polypeptides from biological specimens. The process employs a guanidinium salt to treat frozen biological specimens from which selected polypeptides are to be obtained. The process is useful in reducing proteolytic modification of the selected polypeptides.
摘要翻译：从生物标本中分离所选多肽的方法。该方法采用胍盐处理要从其中获得选定多肽的冷冻生物标本。该方法可用于减少所选多肽的蛋白水解修饰。

8. 发明授权

US4353821A Method of preparing thymosin .alpha..sub.1 and derivatives thereof 失效
标题翻译：胸腺素α1及其衍生物的制备方法
公开(公告)号：US4353821A
公开(公告)日：1982-10-12
申请号：US133031
申请日：1980-03-24
申请人： Christian Birr , Ulrich Stollenwerk
发明人： Christian Birr , Ulrich Stollenwerk
IPC分类号： C07K1/06 , A61K38/00 , C07C231/00 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07C103/52
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： Polypeptides of the sequence Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, wherein at least one of the amino acids 10, 15, 21, 25 and/or 28 is present as amide or alkyl amide, and/or amino acid 1 bears an acyl group other than acetyl, having up to 6 carbon atoms, especially an acyl glycine residue. In addition, certain thymosin .alpha..sub.1 fragments I to VII are provided.
摘要翻译：序列Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Gl u-Lys-Lys-Glu-Val-Val -Glu-Glu-Ala-Glu-Asn，其中氨基酸10,15,21,25和/或28中的至少一个作为酰胺或烷基酰胺存在，和/或氨基酸1具有除具有至多6个碳原子的乙酰基，特别是酰基甘氨酸残基。此外，提供某些胸腺素α1片段I至VII。

9. 发明授权

US4258151A Pentapeptide modified resin 失效
标题翻译：五肽改性树脂
公开(公告)号：US4258151A
公开(公告)日：1981-03-24
申请号：US47907
申请日：1979-06-12
申请人： Gideon Goldstein , David H. Schlesinger
发明人： Gideon Goldstein , David H. Schlesinger
IPC分类号： A61K38/00 , C07K5/072 , C07K14/575 , C08F8/30
CPC分类号： C07K14/575 , C07K5/06104 , A61K38/00 , Y10S930/18 , Y10S930/28
摘要： There are disclosed new polypeptide compositions having the following amino acid sequence as the active site:TYR-ASN-ILE-GLN-LYSThis polypeptide has the capability of inducing the differentiation of both T-precursor cells as measured by the acquisition of the thymic differentiation antigens TL and THY-1 (.theta.), as well as B-precursor cells as measured by the acquisition of receptors for complement, a distinctive marker of B cells. The peptide is thus useful in thymic function and immunity areas such as in treatment for a congenital absence of thymus. The peptide is active in very low concentrations. Also provided are derivatives of the pentapeptide, novel intermediate polypeptides, methods of manufacture of the peptides, therapeutic compositions, and methods for use of the compositions.
摘要翻译：公开了具有以下氨基酸序列作为活性位点的新的多肽组合物：TYR-ASN-ILE-GLN-LYS该多肽具有诱导两种T前体细胞分化的能力，如通过获得胸腺分化所测量的抗原TL和THY-1（θ），以及通过获得补体受体（B细胞的独特标记物）测量的B前体细胞。因此，该肽可用于胸腺功能和免疫领域，例如先天性缺乏胸腺的治疗。该肽在非常低的浓度下是有活性的。还提供了五肽的衍生物，新的中间体多肽，肽的制备方法，治疗组合物和使用该组合物的方法。

10. 发明授权

US4148886A Polypeptide possessing thymic activity 失效
标题翻译：多肽具有胸腺活性
公开(公告)号：US4148886A
公开(公告)日：1979-04-10
申请号：US900043
申请日：1978-04-25
申请人： Jean-Francois Bach , Jean Hamburger
发明人： Jean-Francois Bach , Jean Hamburger
IPC分类号： A61K38/00 , C07K7/06 , C07K14/575 , A61K37/00 , C07C103/52
CPC分类号： C07K7/062 , C07K14/575 , A61K38/00 , Y10S930/18
摘要： The novel thymic factor polypeptide hormone, elaborated by the thymus and und in the blood serum, is isolated. The hormone is useful for the treatment of autoimmune diseases and for selectively stimulating T-cell activity in aging subjects.
摘要翻译：分离出胸腺精华并在血清中发现的新颖胸腺因子多肽激素。该激素可用于治疗自身免疫性疾病和选择性地刺激衰老受试者的T细胞活性。

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